MRGPRX1 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

Jan. 10, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Conorfamide-Tx2 - Agonist

PHYSIOLOGICAL LIGANDS

bovine adrenal medulla peptide 8-22



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 P 127 34x50 G.H5 I 343 G.H5.15
Polar ICL2 R 131 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 131 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 L 198 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 L 198 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Polar ICL2 R 131 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 131 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 131 34x54 G.hns1 R 32 G.hns1.03
Polar TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 C 351 G.H5.23
Polar ICL2 C 132 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 C 132 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 C 132 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 R 134 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 134 34x57 G.hns1 R 32 G.hns1.03
Polar ICL2 C 132 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 C 132 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 131 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM3 V 124 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 I 128 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 I 128 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 I 128 34x51 G.H5 I 343 G.H5.15
Polar ICL2 R 131 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 131 34x54 G.S1 E 33 G.S1.01
Polar ICL2 P 127 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 120 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 120 3x50 G.H5 L 353 G.H5.25
Polar TM3 S 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 C 132 34x55 G.S3 L 194 G.S3.01
Hydrophobic TM6 L 214 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 214 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM2 F 61 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 61 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 214 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 214 6x33 G.H5 L 353 G.H5.25