GPR119 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9L79

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Dec. 31, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

40 interactions (Click to see)

LIGANDS

AR231453 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

SEA, N-palmitoylethanolamine, N-oleoylethanolamide, anandamide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 111 34x51 G.H5 I 373 G.H5.15
Hydrophobic TM6 V 227 6x37 G.H5 L 383 G.H5.25
Aromatic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 I 191 5x65 G.H5 L 378 G.H5.20
Hydrophobic ICL2 K 115 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM3 I 107 3x54 G.H5 L 378 G.H5.20
Hydrophobic TM5 A 192 5x66 G.H5 L 384 G.H5.26
Aromatic TM5 H 195 5x69 G.H5 R 375 G.H5.17
Hydrophobic TM5 H 195 5x69 G.H5 R 375 G.H5.17
Hydrophobic ICL2 L 114 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 P 110 34x50 G.H5 I 373 G.H5.15
Hydrophobic TM5 S 196 5x70 G.H5 L 384 G.H5.26
Ionic TM6 K 222 6x32 G.H5 E 382 G.H5.24
Polar TM6 K 222 6x32 G.H5 E 382 G.H5.24
Hydrophobic TM6 K 222 6x32 G.H5 E 382 G.H5.24
Van-der-waals TM6 K 222 6x32 G.H5 E 382 G.H5.24
Polar ICL2 K 115 34x55 G.s2s3 K 216 G.s2s3.02
Polar ICL2 M 117 34x57 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 M 117 34x57 G.hns1 R 38 G.hns1.02
Ionic ICL1 D 37 - G.HN K 34 G.HN.51
Polar ICL2 L 114 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 114 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 L 114 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 I 107 3x54 G.H5 H 377 G.H5.19
Hydrophobic ICL2 P 110 34x50 G.H5 R 370 G.H5.12
Polar TM3 I 107 3x54 G.H5 Q 374 G.H5.16
Hydrophobic TM3 I 107 3x54 G.H5 Q 374 G.H5.16
Van-der-waals TM3 I 107 3x54 G.H5 Q 374 G.H5.16
Aromatic TM3 R 103 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 103 3x50 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 F 111 34x51 G.H5 R 370 G.H5.12
Hydrophobic TM3 I 107 3x54 G.H5 Y 381 G.H5.23
Hydrophobic TM5 M 202 5x76 G.h4s6 T 340 G.h4s6.03
Hydrophobic TM6 A 223 6x33 G.H5 L 383 G.H5.25
Hydrophobic TM5 I 199 5x73 G.H5 R 375 G.H5.17
Polar TM6 T 226 6x36 G.H5 E 382 G.H5.24
Hydrophobic TM5 M 202 5x76 G.H4 L 336 G.H4.16
Polar TM3 A 106 3x53 G.H5 H 377 G.H5.19
Hydrophobic TM3 A 106 3x53 G.H5 H 377 G.H5.19
Polar TM5 H 195 5x69 G.H5 Q 374 G.H5.16
Hydrophobic TM5 H 195 5x69 G.H5 Q 374 G.H5.16
Van-der-waals TM5 H 195 5x69 G.H5 Q 374 G.H5.16
Hydrophobic TM5 A 192 5x66 G.H5 L 378 G.H5.20
Hydrophobic TM5 E 203 5x77 G.h4s6 T 340 G.h4s6.03
Van-der-waals TM5 E 203 5x77 G.h4s6 T 340 G.h4s6.03
Hydrophobic ICL3 M 208 - G.H4 R 337 G.H4.17
Van-der-waals ICL3 M 208 - G.H4 R 337 G.H4.17
Hydrophobic TM5 I 199 5x73 G.h4s6 Y 348 G.h4s6.20
Hydrophobic TM5 G 206 5x80 G.H4 L 336 G.H4.16
Hydrophobic TM6 K 222 6x32 G.H5 L 384 G.H5.26
Hydrophobic TM5 K 201 5x75 G.hgh4 D 313 G.hgh4.13
Hydrophobic TM5 H 195 5x69 G.H5 L 378 G.H5.20
Hydrophobic TM5 M 188 5x62 G.H5 L 383 G.H5.25
Polar TM5 G 206 5x80 G.h4s6 T 340 G.h4s6.03
Aromatic ICL2 F 111 34x51 G.H5 F 366 G.H5.08
Hydrophobic ICL2 F 111 34x51 G.H5 F 366 G.H5.08
Van-der-waals ICL2 F 111 34x51 G.H5 F 366 G.H5.08