Refined structure (7CZ5) of Gs - GHRH receptor

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 228 from structure (57.9%), 166 from model (42.1%)
Residue sidechains - 220 from structure (55.8%), 174 from model (44.2%)

REFINED GPCR RESIDUES

Residue backbones - 269 from structure (64.8%), 146 from model (35.2%)
Residue sidechains - 268 from structure (64.6%), 147 from model (35.4%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
C01G.S6R12R17Q22E24L25G.H5GproteinR2x46N8x47Q-R6x37S3x60Q8x48K5x64L3x58GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.S6G.H5GPCR segments:TM2TM3ICL3TM5TM6H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x493x503x533x543x565x655x685x696x326x366x408x478x48G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.13G.H5.12G.H5.08G.S6.01G.h4s6.20G.H4.16G.S3.01G.S1.02G.hns1.03Res. Pos.GHRH (7CZ5_REFINED)- (7CZ5_REFINED)---------------RYLLLSLKLRSLNQRYLLLSLKLRSLNQQQYLHRQLLDRELFHVCYA

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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