H1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8YN2

RESOLUTION

2.7 Å

REFERENCE

10.1038/S41467-024-52585-Y

PUBLICATION DATE

Oct. 9, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

10 interactions (Click to see)

LIGANDS

histamine - Agonist pubchem gtoplig chembl_ligand drug_central drugbank gtoplig

PHYSIOLOGICAL LIGANDS

histamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 A 413 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 413 6x33 G.H5 L 358 G.H5.25
Polar TM5 R 224 5x72 G.H2 Y 212 G.H2.03
Van-der-waals TM5 R 224 5x72 G.H2 Y 212 G.H2.03
Hydrophobic ICL2 K 137 34x55 G.HN R 32 G.HN.50
Van-der-waals ICL2 K 137 34x55 G.HN R 32 G.HN.50
Hydrophobic TM5 I 213 5x61 G.H5 L 358 G.H5.25
Van-der-waals TM5 I 213 5x61 G.H5 L 358 G.H5.25
Polar TM3 S 128 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 S 128 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 S 128 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 125 3x50 G.H5 Y 356 G.H5.23
Polar TM3 S 128 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 S 128 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 S 128 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM5 V 217 5x65 G.H5 V 359 G.H5.26
Polar TM5 R 224 5x72 G.H5 D 346 G.H5.13
Polar ICL2 R 139 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 139 34x57 G.H5 Y 356 G.H5.23
Ionic TM5 H 223 5x71 G.H5 D 346 G.H5.13
Polar TM5 H 223 5x71 G.H5 D 346 G.H5.13
Ionic TM5 H 220 5x68 G.H5 D 346 G.H5.13
Hydrophobic TM5 H 220 5x68 G.H5 D 346 G.H5.13
Van-der-waals TM5 H 220 5x68 G.H5 D 346 G.H5.13
Ionic ICL2 R 139 34x57 G.H5 E 355 G.H5.22
Polar ICL2 R 139 34x57 G.H5 E 355 G.H5.22
Hydrophobic ICL2 L 133 34x51 G.H5 K 345 G.H5.12
Polar TM6 Q 416 6x36 G.H5 N 357 G.H5.24
Hydrophobic TM6 Q 416 6x36 G.H5 N 357 G.H5.24
Van-der-waals TM6 Q 416 6x36 G.H5 N 357 G.H5.24
Hydrophobic TM5 H 220 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 H 220 5x68 G.H5 L 349 G.H5.16
Hydrophobic ICL2 L 133 34x51 H.HA V 79 H.HA.11
Hydrophobic ICL2 L 136 34x54 G.HN L 34 G.HN.52
Hydrophobic TM6 Q 416 6x36 G.H5 L 358 G.H5.25
Hydrophobic TM3 V 129 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 V 129 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 L 133 34x51 H.HA F 81 H.HA.13
Polar TM5 H 220 5x68 G.H5 Q 350 G.H5.17
Hydrophobic TM5 H 220 5x68 G.H5 Q 350 G.H5.17
Van-der-waals TM5 H 220 5x68 G.H5 Q 350 G.H5.17
Polar TM6 K 412 6x32 G.H5 N 357 G.H5.24
Hydrophobic TM6 K 412 6x32 G.H5 N 357 G.H5.24
Van-der-waals TM6 K 412 6x32 G.H5 N 357 G.H5.24
Hydrophobic TM6 L 417 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM3 V 129 3x54 G.H5 Y 356 G.H5.23
Hydrophobic TM5 R 224 5x72 G.H2 I 210 G.H2.01
Van-der-waals TM5 R 224 5x72 G.H2 I 210 G.H2.01
Hydrophobic ICL2 P 132 34x50 G.H5 K 345 G.H5.12
Hydrophobic TM5 C 221 5x69 G.H5 V 359 G.H5.26
Hydrophobic TM3 V 129 3x54 G.H5 L 353 G.H5.20
Polar ICL2 R 139 34x57 G.H5 N 352 G.H5.19
Hydrophobic ICL2 P 132 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 132 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 L 133 34x51 G.S4 F 228 G.S4.04
Van-der-waals ICL2 L 133 34x51 G.S4 F 228 G.S4.04
Hydrophobic TM5 V 217 5x65 G.H5 L 353 G.H5.20
Van-der-waals TM5 V 217 5x65 G.H5 L 353 G.H5.20
Hydrophobic ICL2 L 133 34x51 G.HN L 34 G.HN.52
Van-der-waals ICL2 L 133 34x51 G.HN L 34 G.HN.52
Ionic ICL2 R 134 34x52 H.HA D 77 H.HA.09
Hydrophobic TM5 H 220 5x68 G.H5 L 353 G.H5.20
Polar TM6 K 412 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM6 K 412 6x32 G.H5 V 359 G.H5.26
Hydrophobic ICL2 L 133 34x51 G.S4 C 231 G.S4.07
Hydrophobic TM4 K 141 4x39 G.HN R 31 G.HN.49
Van-der-waals TM4 K 141 4x39 G.HN R 31 G.HN.49
Hydrophobic TM5 V 217 5x65 G.H5 L 358 G.H5.25
Polar TM7 C 471 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM7 C 471 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 C 471 7x56 G.H5 N 357 G.H5.24
Hydrophobic ICL2 L 133 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 133 34x51 G.H5 I 348 G.H5.15
Polar TM5 R 224 5x72 G.H5 Q 350 G.H5.17
Hydrophobic TM5 R 224 5x72 G.H5 Q 350 G.H5.17
Van-der-waals TM5 R 224 5x72 G.H5 Q 350 G.H5.17
Hydrophobic ICL2 P 132 34x50 G.H5 L 349 G.H5.16
Hydrophobic TM6 K 412 6x32 G.H5 L 358 G.H5.25