ADGRF1 - G12

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7WZ7

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41467-022-33173-4

PUBLICATION DATE

Sept. 28, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 R 623 2x46 G.H5 I 374 G.H5.23
Hydrophobic TM2 R 623 2x46 G.H5 I 374 G.H5.23
Van-der-waals TM2 R 623 2x46 G.H5 I 374 G.H5.23
Polar ICL2 H 692 - G.HN R 38 G.HN.38
Hydrophobic ICL2 H 692 - G.HN R 38 G.HN.38
Van-der-waals ICL2 H 692 - G.HN R 38 G.HN.38
Hydrophobic TM3 L 682 3x54 G.H5 I 374 G.H5.23
Van-der-waals TM3 L 682 3x54 G.H5 I 374 G.H5.23
Polar TM5 K 768 5x60 G.H5 Q 368 G.H5.17
Hydrophobic ICL2 F 690 - G.S1 V 41 G.S1.02
Hydrophobic TM6 K 791 6x40 G.H5 M 375 G.H5.24
Hydrophobic ICL2 F 690 - G.H5 K 363 G.H5.12
Van-der-waals ICL2 F 690 - G.H5 K 363 G.H5.12
Hydrophobic TM2 R 623 2x46 G.H5 M 375 G.H5.24
Polar TM2 T 619 2x42 G.H5 D 373 G.H5.22
Hydrophobic TM2 T 619 2x42 G.H5 D 373 G.H5.22
Van-der-waals TM2 T 619 2x42 G.H5 D 373 G.H5.22
Hydrophobic ICL2 F 690 - G.H5 I 366 G.H5.15
Van-der-waals ICL2 F 690 - G.H5 I 366 G.H5.15
Hydrophobic ICL3 L 769 - G.H5 L 376 G.H5.25
Ionic ICL1 K 616 - G.H5 E 369 G.H5.18
Polar ICL1 K 616 - G.H5 E 369 G.H5.18
Van-der-waals ICL1 K 616 - G.H5 E 369 G.H5.18
Aromatic ICL2 F 690 - G.H5 F 359 G.H5.08
Hydrophobic ICL2 F 690 - G.H5 F 359 G.H5.08
Van-der-waals ICL2 F 690 - G.H5 F 359 G.H5.08
Hydrophobic TM6 L 796 6x45 G.H5 L 376 G.H5.25
Van-der-waals TM6 L 796 6x45 G.H5 L 376 G.H5.25
Hydrophobic TM5 K 768 5x60 G.H5 L 367 G.H5.16
Polar ICL2 H 691 - G.hns1 R 39 G.hns1.03
Aromatic ICL2 H 691 - G.hns1 R 39 G.hns1.03
Van-der-waals ICL2 H 691 - G.hns1 R 39 G.hns1.03
Hydrophobic TM3 R 685 3x57 G.H5 I 374 G.H5.23
Polar TM2 Q 618 2x41 G.HN R 38 G.HN.38
Hydrophobic TM2 Q 618 2x41 G.HN R 38 G.HN.38
Van-der-waals TM2 Q 618 2x41 G.HN R 38 G.HN.38
Polar TM2 S 620 2x43 G.H5 D 373 G.H5.22
Hydrophobic TM2 S 620 2x43 G.H5 D 373 G.H5.22
Van-der-waals TM2 S 620 2x43 G.H5 D 373 G.H5.22
Hydrophobic TM3 I 686 3x58 G.H5 L 367 G.H5.16
Polar TM2 T 619 2x42 G.H5 N 370 G.H5.19
Polar TM6 S 792 6x41 G.H5 L 376 G.H5.25
Hydrophobic TM6 S 792 6x41 G.H5 L 376 G.H5.25
Van-der-waals TM6 S 792 6x41 G.H5 L 376 G.H5.25
Hydrophobic TM6 K 791 6x40 G.H5 L 376 G.H5.25
Hydrophobic TM5 V 765 5x57 G.H5 L 371 G.H5.20
Van-der-waals TM5 V 765 5x57 G.H5 L 371 G.H5.20
Hydrophobic TM2 T 619 2x42 G.H5 I 374 G.H5.23
Van-der-waals TM2 T 619 2x42 G.H5 I 374 G.H5.23
Hydrophobic TM3 L 682 3x54 G.H5 L 371 G.H5.20
Hydrophobic ICL2 V 689 - G.H5 I 366 G.H5.15
Van-der-waals ICL2 V 689 - G.H5 I 366 G.H5.15
Hydrophobic ICL2 F 690 - G.H5 V 362 G.H5.11
Van-der-waals ICL2 F 690 - G.H5 V 362 G.H5.11
Hydrophobic TM5 V 765 5x57 G.H5 L 376 G.H5.25
Van-der-waals TM5 V 765 5x57 G.H5 L 376 G.H5.25
Hydrophobic ICL2 V 689 - G.H5 K 363 G.H5.12
Van-der-waals ICL2 V 689 - G.H5 K 363 G.H5.12
Hydrophobic ICL2 F 690 - G.S3 I 217 G.S3.01
Van-der-waals ICL2 F 690 - G.S3 I 217 G.S3.01
Hydrophobic TM3 L 682 3x54 G.H5 L 376 G.H5.25
Hydrophobic TM6 I 795 6x44 G.H5 M 375 G.H5.24
Van-der-waals TM6 I 795 6x44 G.H5 M 375 G.H5.24
Polar TM3 R 685 3x57 G.H5 N 370 G.H5.19
Hydrophobic TM3 R 685 3x57 G.H5 N 370 G.H5.19
Polar ICL2 M 693 - G.HN R 38 G.HN.38
Hydrophobic TM3 L 681 3x53 G.H5 I 374 G.H5.23
Hydrophobic TM6 I 795 6x44 G.H5 L 376 G.H5.25
Ionic ICL1 K 616 - G.H5 D 373 G.H5.22
Hydrophobic ICL1 K 616 - G.H5 D 373 G.H5.22
Van-der-waals ICL1 K 616 - G.H5 D 373 G.H5.22
Hydrophobic TM3 I 686 3x58 G.H5 L 371 G.H5.20
Van-der-waals TM3 I 686 3x58 G.H5 L 371 G.H5.20
Hydrophobic ICL2 V 689 - G.H5 L 367 G.H5.16