NTS1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.6 Å

REFERENCE

PUBLICATION DATE

June 3, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

JMV449 - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

large neuromedin N (Mouse), neurotensin (Human), neuromedin N (Human), large neuromedin N (Human), large neuromedin N (Rat), large neurotensin (Human), neuromedin N (Mouse)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM5 I 259 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 170 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 170 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 174 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 174 34x51 G.H5 I 343 G.H5.15
Polar ICL2 T 178 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 178 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 174 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 174 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL2 P 173 34x50 G.H5 I 344 G.H5.16
Polar TM3 R 166 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 C 351 G.H5.23
Polar TM6 G 301 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 G 301 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 G 301 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM2 Q 98 2x36 G.H5 D 350 G.H5.22
Van-der-waals TM2 Q 98 2x36 G.H5 D 350 G.H5.22
Polar ICL2 M 180 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 180 34x57 G.hns1 R 32 G.hns1.03
Polar TM3 A 169 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 169 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM4 S 181 4x38 G.HN E 28 G.HN.52
Hydrophobic TM3 R 166 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 166 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 263 5x65 G.H5 F 354 G.H5.26
Hydrophobic TM6 A 297 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 G 301 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 K 177 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 174 34x51 G.S3 L 194 G.S3.01