Refined structure (7XAV) of Gi1 - SST2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 222 from structure (62.7%), 132 from model (37.3%)
Residue sidechains - 171 from structure (48.3%), 183 from model (51.7%)

REFINED GPCR RESIDUES

Residue backbones - 278 from structure (82.2%), 60 from model (17.8%)
Residue sidechains - 206 from structure (60.9%), 132 from model (39.1%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
K08D09K11E12G.h4s6D13C23G.H5GproteinG-R6x26R3x50GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.h4s6G.H5GPCR segments:TM3ICL3TM6

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null3x503x533x5434x5034x5134x544x385x585x615x655x686x246x266x296x326x336x366x378x478x48G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.16G.H5.15G.H5.13G.H5.09G.H5.08G.h4s6.12G.h4s6.11G.h4s6.09G.h4s6.08G.s2s3.02G.hns1.03G.HN.52Res. Pos.SST2 (7XAV_REFINED)- (7XAV_REFINED)---------------------RAVPIARYIVSSRSKVMVSDPIARAVRYIVSSRSKVMVSDVIIFDRCLNLEDEKDKFDGD

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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