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Construct Crystallization Sequence modifications
PDB UniProt Receptor Rec. Family Class Species Method Mutations Deletions Modifications Insertions PDB Resolution Reference Date
5V54 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 4 0 5 5V54 3.9 2018-02-07
5YWY PE2R4 EP4 Prostanoid A (Rhodopsin) Human N/A 0 3 0 0 5YWY 3.2 10.1038/S41589-018-0131-3 2018-12-05
4BUO NTR1 NTS1 Neurotensin A (Rhodopsin) Rat vapour diffusion 11 3 0 8 4BUO 2.8 10.1073/PNAS.1317903111 2014-01-29
1F88 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 1F88 2.8 10.1126/SCIENCE.289.5480.739 2000-08-04
6H7N ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey N/A 6 2 0 0 6H7N 2.5 10.1101/436212 2018-10-17
5OM4 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 3 5OM4 2.0 10.1038/S41598-017-18570-W 2018-01-17
5NM4 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5NM4 1.7 10.1038/S41467-017-00630-4 2017-09-27
5IU4 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5IU4 1.7 10.1021/ACS.JMEDCHEM.6B00653 2016-06-29
5XPR EDNRB ETB Endothelin A (Rhodopsin) Human in meso/LCP 7 3 0 7 5XPR 3.6 10.1038/NSMB.3450 2017-08-16
5UVI AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 5UVI 3.2 10.1107/S205225251700570X 2017-05-24
4YAY AGTR1 AT1 Angiotensin A (Rhodopsin) Human in meso/LCP 0 5 0 5 4YAY 2.9 10.1016/J.CELL.2015.04.011 2015-04-22
6IGL EDNRB ETB Endothelin A (Rhodopsin) Human N/A 0 3 0 0 6IGL 2.7 10.1038/S41467-018-07094-0 2018-11-21
5UZ7 CALCR CT Calcitonin B1 (Secretin) Human Cryo-EM 0 5 0 5 5UZ7 4.1 10.1038/NATURE22327 2017-05-03
4U16 ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Rat sponge mesophase 0 3 0 4 4U16 3.7 10.1016/J.STR.2014.08.022 2014-11-26
4QKX ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 5 3 0 5 4QKX 3.3 10.1073/PNAS.1410415111 2014-07-23
5IU7 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5IU7 1.9 10.1021/ACS.JMEDCHEM.6B00653 2016-06-29
5X7D ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 2 0 2 5X7D 2.7 10.1038/NATURE23652 2017-08-16
4O9R SMO SMO Frizzled F (Frizzled) Human in meso/LCP 0 5 0 1 4O9R 3.2 10.1038/NCOMMS4309 2014-03-05
4BEZ OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 3 0 0 0 4BEZ 3.3 10.1038/EMBOR.2013.44 2013-04-24
6IIV TA2R TP Prostanoid A (Rhodopsin) Human N/A 0 3 0 0 6IIV 3.0 10.1038/S41589-018-0170-9 2018-12-19
6DS0 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human N/A 1 3 0 0 6DS0 3.2 10.1038/S41594-018-0116-7 2018-08-29
6FKA OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 2 0 0 0 6FKA 2.7 10.1073/PNAS.1718084115 2018-04-04
2YDV AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 5 1 0 2 2YDV 2.6 10.1038/NATURE10136 2011-05-18
5VRA AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 5VRA 2.4 10.1038/NPROT.2017.135 2017-12-13
5K2C AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 5K2C 1.9 10.1126/SCIADV.1600292 2016-09-21
4IAQ 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 2 0 5 4IAQ 2.8 10.1126/SCIENCE.1232807 2013-03-13
5TVN 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 3 0 5 5TVN 2.9 10.1016/J.CELL.2016.12.033 2017-02-01
2Y04 ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 2Y04 3.1 10.1038/NATURE09746 2011-01-12
5CXV ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human in meso/LCP 3 2 0 4 5CXV 2.7 10.1038/NATURE17188 2016-03-09
2YCY ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 4 0 1 2YCY 3.2 10.1073/PNAS.1100185108 2011-06-08
6HLP NK1R NK1 Tachykinin A (Rhodopsin) Human N/A 0 2 0 0 6HLP 2.2 10.1038/S41467-018-07939-8 2019-01-16
6FJ3 PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human N/A 0 4 0 0 6FJ3 2.5 10.1038/S41594-018-0151-4 2018-11-21
6AKX CCR5 CCR5 Chemokine A (Rhodopsin) Human N/A 4 3 0 0 6AKX 2.8 10.1021/ACS.JMEDCHEM.8B01077 2018-10-24
5WIU DRD4 D4 Dopamine A (Rhodopsin) Human in meso/LCP 0 4 0 5 5WIU 2.0 10.1126/SCIENCE.AAN5468 2017-10-18
6D27 PD2R2 DP2 Prostanoid A (Rhodopsin) Human N/A 0 2 0 0 6D27 2.7 2018-10-03
3ZPQ ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 3ZPQ 2.8 10.1021/JM400140Q 2013-04-03
3NY8 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 2 0 3 3NY8 2.8 10.1021/JA105108Q 2010-08-11
5ZKB ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A 0 2 0 0 5ZKB 3.0 10.1038/S41589-018-0152-Y 2018-11-21
4K5Y CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human in meso/LCP 11 3 0 3 4K5Y 3.0 10.1038/NATURE12357 2013-07-17
5KW2 FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human in meso/LCP 4 1 0 3 5KW2 2.8 10.1038/S41467-017-01240-W 2018-05-02
3AYN OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid vapour diffusion 0 0 0 0 3AYN 2.7 10.1016/J.JMB.2011.08.044 2011-08-17
6GPS CCR2 CCR2 Chemokine A (Rhodopsin) Human N/A 0 2 0 0 6GPS 3.3 10.1016/J.STR.2018.10.027 2019-01-02
6IBL ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey N/A 6 3 0 0 6IBL 2.7 2019-01-09
5ZBH NPY1R Y1 Neuropeptide Y A (Rhodopsin) Human N/A 1 3 0 0 5ZBH 3.0 10.1038/S41586-018-0046-X 2018-04-25
5ZKQ PTAFR PAF Platelet-activating factor A (Rhodopsin) Human N/A 5 3 0 0 5ZKQ 2.9 10.1038/S41594-018-0068-Y 2018-06-20
5YHL PE2R4 EP4 Prostanoid A (Rhodopsin) Human N/A 0 3 0 0 5YHL 4.2 10.1038/S41589-018-0131-3 2018-12-05
4U14 ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Rat sponge mesophase 0 3 0 4 4U14 3.6 10.1016/J.STR.2014.08.022 2014-11-26
5NM2 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5NM2 2.0 10.1038/S41467-017-00630-4 2017-09-27
3VG9 AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 1 1 0 3 3VG9 2.7 10.1038/NATURE10750 2012-02-01
5NLX AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5NLX 2.1 10.1038/S41467-017-00630-4 2017-09-27
5ZKP PTAFR PAF Platelet-activating factor A (Rhodopsin) Human N/A 5 4 0 0 5ZKP 2.8 10.1038/S41594-018-0068-Y 2018-06-20
5OLZ AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 3 5OLZ 1.9 10.1038/S41598-017-18570-W 2018-01-17
6FK9 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 2 0 0 0 6FK9 2.6 10.1073/PNAS.1718084115 2018-04-04
5ZK3 ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A 0 3 0 0 5ZK3 2.6 10.1038/S41589-018-0152-Y 2018-11-21
3C9M OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NA 2 0 0 0 3C9M 3.4 10.1107/S0907444908017162 2008-08-05
5CGC GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human in meso/LCP 6 2 0 3 5CGC 3.1 10.1021/ACS.JMEDCHEM.5B00892 2015-08-12
4RWD OPRD δ Opioid A (Rhodopsin) Human in meso/LCP 0 2 0 5 4RWD 2.7 10.1038/NSMB.2965 2015-01-14
4DJH OPRK κ Opioid A (Rhodopsin) Human in meso/LCP 1 3 0 5 4DJH 2.9 10.1038/NATURE10939 2012-03-21
4RWS CXCR4 CXCR4 Chemokine A (Rhodopsin) Human in meso/LCP 3 3 0 5 4RWS 3.1 10.1126/SCIENCE.1261064 2015-02-11
3OE9 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human in meso/LCP 2 4 0 6 3OE9 3.1 10.1126/SCIENCE.1194396 2010-10-27
5N2R AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5N2R 2.8 10.1016/J.STR.2017.06.012 2017-07-26
5ZK8 ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A 0 3 0 0 5ZK8 3.0 10.1038/S41589-018-0152-Y 2018-11-21
6AK3 PE2R3 EP3 Prostanoid A (Rhodopsin) Human N/A 0 2 0 0 6AK3 2.9 10.1038/S41589-018-0171-8 2018-12-05
6FFI GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human in meso/LCP 6 3 0 3 6FFI 2.2 10.1021/ACS.JMEDCHEM.7B01722 2018-03-07
5D5A ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 2 0 2 5D5A 2.5 10.1107/S2059798315021683 2016-01-13
5A8E ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey in meso/LCP 10 3 0 1 5A8E 2.4 10.1124/MOL.115.101030 2015-09-30
5UNG AGTR2 AT2 Angiotensin A (Rhodopsin) Human in meso/LCP 0 2 0 6 5UNG 2.8 10.1038/NATURE22035 2017-04-05
6NIY CALCR CT Calcitonin B1 (Secretin) Human N/A 0 0 0 0 6NIY 3.3 2019-01-23
6BD4 FZD4 FZD4 Frizzled F (Frizzled) Human N/A 0 3 0 0 6BD4 2.4 10.1038/S41586-018-0447-X 2018-08-22
2Y03 ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 2Y03 2.9 10.1038/NATURE09746 2011-01-12
6N4B CNR1 CB1 Cannabinoid A (Rhodopsin) Human N/A 0 0 0 0 6N4B 3.0 10.1016/J.CELL.2018.11.040 2019-01-30
5ZTY CNR2 CB2 Cannabinoid A (Rhodopsin) Human N/A 0 3 0 0 5ZTY 2.8 10.1016/J.CELL.2018.12.011 2019-01-30
6A93 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human N/A 0 3 0 0 6A93 3.0 10.1038/S41594-018-0180-Z 2019-02-13
6FKC OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 2 0 0 0 6FKC 2.5 10.1073/PNAS.1718084115 2018-04-04
3VGA AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 1 1 0 3 3VGA 3.1 10.1038/NATURE10750 2012-02-01
4N4W SMO SMO Frizzled F (Frizzled) Human in meso/LCP 0 2 0 5 4N4W 2.8 10.1038/NCOMMS5355 2014-01-22
3OE6 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human in meso/LCP 1 2 0 7 3OE6 3.2 10.1126/SCIENCE.1194396 2010-10-27
6A94 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human N/A 0 3 0 0 6A94 2.9 10.1038/S41594-018-0180-Z 2019-02-13
4A4M OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 3 0 0 0 4A4M 3.3 10.1073/PNAS.1114089108 2012-01-25
6DO1 AGTR1 AT1 Angiotensin A (Rhodopsin) Human N/A 0 2 0 0 6DO1 2.9 10.1016/J.CELL.2018.12.006 2019-01-30
2VT4 ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 4 0 1 2VT4 2.7 10.1038/NATURE07101 2008-06-24
4RWA OPRD δ Opioid A (Rhodopsin) Human in meso/LCP 0 2 0 5 4RWA 3.3 10.1038/NSMB.2965 2015-01-14
2X72 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 3 0 0 0 2X72 3.0 10.1038/NATURE09795 2011-03-16
4ZUD AGTR1 AT1 Angiotensin A (Rhodopsin) Human in meso/LCP 0 5 0 5 4ZUD 2.8 10.1074/JBC.M115.689000 2015-10-07
5OLV AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 3 5OLV 2.0 10.1038/S41598-017-18570-W 2018-01-17
6FK6 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 2 1 0 0 6FK6 2.4 2018-04-04
5DSG ACM4 M4 Acetylcholine (muscarinic) A (Rhodopsin) Human in meso/LCP 0 3 0 3 5DSG 2.6 10.1038/NATURE17188 2016-03-16
4X1H OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 4X1H 2.3 10.1016/J.STR.2015.09.015 2015-11-04
6DDE OPRM μ Opioid A (Rhodopsin) Mouse Cryo-EM 0 2 0 4 6DDE 3.5 10.1038/S41586-018-0219-7 2018-06-13
5WS3 OX2R OX2 Orexin A (Rhodopsin) Human in meso/LCP 1 3 0 4 5WS3 2.3 10.1016/J.STR.2017.11.005 2017-12-13
6D26 PD2R2 DP2 Prostanoid A (Rhodopsin) Human N/A 0 2 0 0 6D26 2.8 2018-10-03
5VBL APJ apelin Apelin A (Rhodopsin) Human in meso/LCP 5 3 0 5 5VBL 2.6 10.1016/J.STR.2017.04.008 2017-05-31
4IB4 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 3 0 5 4IB4 2.7 10.1126/SCIENCE.1232808 2013-03-13
6M9T PE2R3 EP3 Prostanoid A (Rhodopsin) Human N/A 0 3 0 0 6M9T 2.5 10.1038/S41589-018-0160-Y 2018-12-05
6BQG 5HT2C 5-HT2C 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 3 0 5 6BQG 3.0 10.1016/J.CELL.2018.01.001 2018-02-14
4XNW P2RY1 P2Y1 P2Y A (Rhodopsin) Human in meso/LCP 1 2 0 5 4XNW 2.7 10.1038/NATURE14287 2015-04-01
5YQZ GLR glucagon Glucagon B1 (Secretin) Human in meso/LCP 1 3 0 5 5YQZ 3.0 10.1038/NATURE25153 2018-01-17
5K2B AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 5K2B 2.5 10.1126/SCIADV.1600292 2016-09-21
5G53 AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 1 1 0 2 5G53 3.4 10.1038/NATURE18966 2016-08-03
6DRX 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human N/A 1 3 0 0 6DRX 3.1 10.1038/S41594-018-0116-7 2018-08-29
5O9H C5AR1 C5a1 Complement peptide A (Rhodopsin) Human in meso/LCP 11 2 0 1 5O9H 2.7 10.1038/NATURE25025 2018-01-10
6E59 NK1R NK1 Tachykinin A (Rhodopsin) Human N/A 0 2 0 0 6E59 3.4 10.1073/PNAS.1812717115 2018-12-12
5WB1 Q80KM9 US28 Unclassified A (Rhodopsin) strain AD169 in meso/LCP 0 1 0 9 5WB1 3.5 10.7554/ELIFE.35850 2018-06-13
6H7O ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey N/A 5 2 0 0 6H7O 2.8 10.1101/436212 2018-10-17
5WB2 Q80KM9 US28 Unclassified A (Rhodopsin) strain AD169 in meso/LCP 0 1 0 9 5WB2 3.5 10.7554/ELIFE.35850 2018-06-13
6D35 Q98SW5 SMO Frizzled F (Frizzled) African clawed frog in meso/LCP 0 3 0 0 6D35 3.9 10.1016/J.CELL.2018.04.029 2018-05-23
6HLO NK1R NK1 Tachykinin A (Rhodopsin) Human N/A 0 4 0 0 6HLO 2.4 10.1038/S41467-018-07939-8 2019-01-16
6H7M ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey N/A 6 2 0 0 6H7M 2.8 10.1101/436212 2018-10-17
5YC8 ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A 0 3 0 0 5YC8 2.5 10.1038/S41589-018-0152-Y 2018-11-21
6HLL NK1R NK1 Tachykinin A (Rhodopsin) Human N/A 0 2 0 0 6HLL 3.3 10.1038/S41467-018-07939-8 2019-01-16
5WIV DRD4 D4 Dopamine A (Rhodopsin) Human in meso/LCP 0 4 0 5 5WIV 2.1 10.1126/SCIENCE.AAN5468 2017-10-18
5OLG AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5OLG 1.9 10.1038/S41598-017-18570-W 2018-01-17
6D9H AA1R A1 Adenosine A (Rhodopsin) Human Cryo-EM 0 1 0 6 6D9H 3.6 10.1038/S41586-018-0236-6 2018-06-20
2Y02 ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 2Y02 2.6 10.1038/NATURE09746 2011-01-12
3OAX OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 3OAX 2.6 10.1016/J.BPJ.2010.08.003 2011-01-19
6H7J ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey N/A 5 2 0 0 6H7J 2.8 10.1101/436212 2018-10-17
5TUD 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 3 0 5 5TUD 3.0 10.1073/PNAS.1700891114 2017-07-26
6FUF OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A 0 2 0 0 6FUF 3.1 10.1126/SCIADV.AAT7052 2018-10-03
6MXT ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A 1 3 0 0 6MXT 3.0 10.1038/S41589-018-0145-X 2018-11-14
5MZJ AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5MZJ 2.0 10.1016/J.STR.2017.06.012 2017-07-26
2R4R ADRB2 β2 Adrenoceptors A (Rhodopsin) Human vapour diffusion 2 1 0 4 2R4R 3.4 10.1038/NATURE06325 2007-11-06
2Z73 OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid vapour diffusion 0 0 0 0 2Z73 2.5 10.1038/NATURE06925 2008-05-13
6MET CCR5 CCR5 Chemokine A (Rhodopsin) Human N/A 0 1 0 0 6MET 4.5 10.1038/S41586-018-0804-9 2018-12-12
5TZY FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human in meso/LCP 3 1 0 6 5TZY 3.2 10.1038/NSMB.3417 2017-06-07
6H7L ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey N/A 6 2 0 0 6H7L 2.7 10.1101/436212 2018-10-17
5TGZ CNR1 CB1 Cannabinoid A (Rhodopsin) Human in meso/LCP 4 3 0 5 5TGZ 2.8 10.1016/J.CELL.2016.10.004 2016-11-02
2I35 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 2I35 3.8 10.1073/PNAS.0608022103 2006-10-17
5JQH ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 3 0 4 5JQH 3.2 10.1038/NATURE18636 2016-07-13
4Z34 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human in meso/LCP 0 3 0 5 4Z34 3.0 10.1016/J.CELL.2015.06.002 2015-06-03
4MBS CCR5 CCR5 Chemokine A (Rhodopsin) Human in meso/LCP 4 2 0 5 4MBS 2.7 10.1126/SCIENCE.1241475 2013-09-11
4EJ4 OPRD δ Opioid A (Rhodopsin) Mouse in meso/LCP 0 3 0 4 4EJ4 3.4 10.1038/NATURE11111 2012-05-16
4XES NTR1 NTS1 Neurotensin A (Rhodopsin) Rat in meso/LCP 4 3 0 5 4XES 2.6 10.1038/NCOMMS8895 2015-07-29
4NTJ P2Y12 P2Y12 P2Y A (Rhodopsin) Human in meso/LCP 1 6 0 5 4NTJ 2.6 10.1038/NATURE13083 2014-03-26
4J4Q OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 4J4Q 2.7 10.1002/ANIE.201302374 2013-10-30
4BWB NTR1 NTS1 Neurotensin A (Rhodopsin) Rat vapour diffusion 26 3 0 8 4BWB 3.6 10.1073/PNAS.1317903111 2014-01-29
2I37 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 2I37 4.2 10.1073/PNAS.0608022103 2006-10-17
5F8U ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 4 0 2 5F8U 3.4 10.1038/NSMB.3130 2015-12-23
6DRZ 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human N/A 1 3 0 0 6DRZ 3.1 10.1038/S41594-018-0116-7 2018-08-29
3AYM OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid vapour diffusion 0 0 0 0 3AYM 2.8 10.1016/J.JMB.2011.08.044 2011-08-17
3VW7 PAR1 PAR1 Proteinase-activated A (Rhodopsin) Human in meso/LCP 2 3 0 5 3VW7 2.2 10.1038/NATURE11701 2012-12-12
6CMO OPSD Rhodopsin Opsins A (Rhodopsin) Human Cryo-EM 3 2 0 5 6CMO 4.5 10.1038/S41586-018-0215-Y 2018-06-20
4BEY OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 3 0 0 0 4BEY 2.9 10.1038/EMBOR.2013.44 2013-05-08
6E3Y CALRL calcitonin-like Calcitonin B1 (Secretin) Human N/A 0 1 0 0 6E3Y 3.3 10.1038/S41586-018-0535-Y 2018-09-19
5CGD GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human in meso/LCP 6 2 0 3 5CGD 2.6 10.1021/ACS.JMEDCHEM.5B00892 2015-08-12
6C1Q C5AR1 C5a1 Complement peptide A (Rhodopsin) Human in meso/LCP 1 2 0 0 6C1Q 2.9 10.1038/S41594-018-0067-Z 2018-05-30
2YDO AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 5 3 0 2 2YDO 3.0 10.1038/NATURE10136 2011-05-18
5VAI G1SGD4 GLP-1 Glucagon B1 (Secretin) Rabbit Cryo-EM 3 2 0 5 5VAI 4.1 10.1038/NATURE22394 2017-05-24
5TZR FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human in meso/LCP 4 1 0 6 5TZR 2.2 10.1038/NSMB.3417 2017-06-07
3OE0 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human in meso/LCP 2 3 0 6 3OE0 2.9 10.1126/SCIENCE.1194396 2010-10-27
6J20 NK1R NK1 Tachykinin A (Rhodopsin) Human N/A 0 3 0 0 6J20 2.7 10.1038/S41467-019-08568-5 2019-03-06
6IIU TA2R TP Prostanoid A (Rhodopsin) Human N/A 0 3 0 0 6IIU 2.5 10.1038/S41589-018-0170-9 2018-12-19
5XJM AGTR2 AT2 Angiotensin A (Rhodopsin) Human N/A 0 3 0 0 5XJM 3.2 10.1038/S41594-018-0079-8 2018-07-11
2ZIY OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid vapour diffusion 1 2 0 0 2ZIY 3.7 10.1074/JBC.C800040200 2008-05-06
6N52 GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human N/A 0 2 0 0 6N52 4.0 10.1038/S41586-019-0881-4 2019-01-23
6J21 NK1R NK1 Tachykinin A (Rhodopsin) Human N/A 0 3 0 0 6J21 3.2 10.1038/S41467-019-08568-5 2019-03-06
5VEW GLP1R GLP-1 Glucagon B1 (Secretin) Human in meso/LCP 10 5 0 5 5VEW 2.7 10.1038/NATURE22378 2017-05-24
5IU8 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5IU8 2.0 2016-06-29
6GPX CCR2 CCR2 Chemokine A (Rhodopsin) Human N/A 0 3 0 0 6GPX 2.7 10.1016/J.STR.2018.10.027 2019-01-02
5T04 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat in meso/LCP 4 3 0 5 5T04 3.3 10.1038/SREP38564 2016-12-21
6N51 GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human N/A 0 2 0 0 6N51 4.0 10.1038/S41586-019-0881-4 2019-01-23
2YCW ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 4 0 1 2YCW 3.0 10.1073/PNAS.1100185108 2011-06-01
4ZJ8 OX1R OX1 Orexin A (Rhodopsin) Human in meso/LCP 1 2 0 4 4ZJ8 2.8 10.1038/NSMB.3183 2016-03-09
5XRA CNR1 CB1 Cannabinoid A (Rhodopsin) Human in meso/LCP 4 3 0 5 5XRA 2.8 10.1038/NATURE23272 2017-07-12
3PXO OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 3PXO 3.0 10.1038/NATURE09789 2011-03-09
3REY AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 8 1 0 1 3REY 3.3 10.1016/J.STR.2011.06.014 2011-09-07
5L7I SMO SMO Frizzled F (Frizzled) Human in meso/LCP 1 3 0 2 5L7I 3.3 10.1038/NATURE18934 2016-07-20
3SN6 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human sponge mesophase 3 2 0 4 3SN6 3.2 10.1038/NATURE10361 2011-07-20
4Z9G CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human in meso/LCP 11 3 0 3 4Z9G 3.2 10.2174/1874467210666170110114727 2016-06-29
5OLO AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5OLO 3.1 10.1038/S41598-017-18570-W 2018-01-17
3ODU CXCR4 CXCR4 Chemokine A (Rhodopsin) Human in meso/LCP 1 2 0 7 3ODU 2.5 10.1126/SCIENCE.1194396 2010-10-27
2R4S ADRB2 β2 Adrenoceptors A (Rhodopsin) Human vapour diffusion 1 2 0 3 2R4S 3.4 10.1038/NATURE06325 2007-11-06
4ZWJ OPSD Rhodopsin Opsins A (Rhodopsin) Human in meso/LCP 4 0 0 7 4ZWJ 3.3 10.1038/NATURE14656 2015-07-29
4NC3 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 3 0 5 4NC3 2.8 10.1126/SCIENCE.1244142 2013-12-18
3PBL DRD3 D3 Dopamine A (Rhodopsin) Human in meso/LCP 1 2 0 5 3PBL 2.9 10.1126/SCIENCE.1197410 2010-11-03
5WKT OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 5WKT 3.2 10.1038/NPROT.2017.135 2017-12-13
2I36 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 2I36 4.1 10.1073/PNAS.0608022103 2006-10-17
4LDL ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 3 0 3 4LDL 3.1 10.1038/NATURE12572 2013-09-25
5D6L ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 2 0 2 5D6L 3.2 10.1038/NPROT.2017.057 2016-08-17
5OLH AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 3 5OLH 2.6 10.1038/S41598-017-18570-W 2018-01-17
3PDS ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 3 0 3 3PDS 3.5 10.1038/NATURE09665 2011-01-12
5WQC OX2R OX2 Orexin A (Rhodopsin) Human in meso/LCP 1 3 0 4 5WQC 2.0 10.1016/J.STR.2017.11.005 2017-11-29
3PWH AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 8 1 0 2 3PWH 3.3 10.1016/J.STR.2011.06.014 2011-09-07
5UIW CCR5 CCR5 Chemokine A (Rhodopsin) Human in meso/LCP 4 3 0 5 5UIW 2.2 10.1016/J.IMMUNI.2017.05.002 2017-06-28
3OE8 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human in meso/LCP 1 3 0 7 3OE8 3.1 10.1126/SCIENCE.1194396 2010-10-27
6B3J GLP1R GLP-1 Glucagon B1 (Secretin) Human Cryo-EM 0 1 0 5 6B3J 3.3 10.1038/NATURE25773 2018-02-21
6FK8 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 2 0 0 0 6FK8 2.9 10.1073/PNAS.1718084115 2018-04-04
2J4Y OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 2 0 0 0 2J4Y 3.4 10.1016/J.JMB.2007.03.007 2007-09-25
6C1R C5AR1 C5a1 Complement peptide A (Rhodopsin) Human in meso/LCP 1 2 0 0 6C1R 2.2 10.1038/S41594-018-0067-Z 2018-05-30
1GZM OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 1GZM 2.7 10.1016/J.JMB.2004.08.090 2003-11-20
4XT3 US28 US28 Unclassified A (Rhodopsin) strain AD169 in meso/LCP 0 2 0 1 4XT3 3.8 10.1126/SCIENCE.AAA5026 2015-03-04
5V56 SMO SMO Frizzled F (Frizzled) Human in meso/LCP 1 3 0 6 5V56 2.9 10.1038/NCOMMS15383 2017-05-24
5D5B ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 2 0 2 5D5B 3.8 10.1107/S2059798315021683 2016-01-13
4Z36 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human in meso/LCP 2 3 0 5 4Z36 2.9 10.1016/J.CELL.2015.06.002 2015-06-03
1HZX OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 1HZX 2.8 10.1021/BI0155091 2001-07-04
2HPY OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 2HPY 2.8 10.1073/PNAS.0601765103 2006-08-22
5NJ6 PAR2 PAR2 Proteinase-activated A (Rhodopsin) Human in meso/LCP 10 3 0 2 5NJ6 4.0 10.1038/NATURE22309 2017-05-03
5OM1 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 3 5OM1 2.1 10.1038/S41598-017-18570-W 2018-01-17
4AMJ ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 4AMJ 2.3 10.1016/J.STR.2012.03.014 2012-05-23
4IAR 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 2 0 5 4IAR 2.7 10.1126/SCIENCE.1232807 2013-03-13
4EA3 OPRX NOP Opioid A (Rhodopsin) Human in meso/LCP 0 2 0 5 4EA3 3.0 10.1038/NATURE11085 2012-04-25
5IUB AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5IUB 2.1 10.1021/ACS.JMEDCHEM.6B00653 2016-06-29
6FK7 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 2 0 0 0 6FK7 2.6 10.1073/PNAS.1718084115 2018-04-04
5K2D AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 5K2D 1.9 10.1126/SCIADV.1600292 2016-09-21
4UHR AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 5 4 0 2 4UHR 2.6 10.1124/MOL.114.097360 2015-04-08
5U09 CNR1 CB1 Cannabinoid A (Rhodopsin) Human in meso/LCP 1 3 0 5 5U09 2.6 10.1038/NATURE20613 2016-12-07
6GDG AA2AR A2A Adenosine A (Rhodopsin) Human Cryo-EM 1 2 0 5 6GDG 4.1 10.7554/ELIFE.35946 2018-05-16
4OR2 GRM1 mGlu1 Metabotropic glutamate C (Glutamate) Human in meso/LCP 0 2 0 5 4OR2 2.8 10.1126/SCIENCE.1249489 2014-03-19
4GBR ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 3 0 5 4GBR 4.0 10.1371/JOURNAL.PONE.0046039 2012-10-24
3UZA AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 8 1 0 2 3UZA 3.3 10.1021/JM201376W 2012-03-21
5C1M OPRM μ Opioid A (Rhodopsin) Mouse in meso/LCP 0 2 0 4 5C1M 2.1 10.1038/NATURE14886 2015-08-05
3NY9 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 2 0 3 3NY9 2.8 10.1021/JA105108Q 2010-08-11
6D32 Q98SW5 SMO Frizzled F (Frizzled) African clawed frog in meso/LCP 0 3 0 0 6D32 3.8 10.1016/J.CELL.2018.04.029 2018-05-23
5W0P OPSD Rhodopsin Opsins A (Rhodopsin) Human in meso/LCP 4 1 0 7 5W0P 3.0 10.1016/J.CELL.2017.07.002 2017-08-09
4BV0 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat vapour diffusion 29 3 0 8 4BV0 3.1 10.1073/PNAS.1317903111 2014-01-29
4XEE NTR1 NTS1 Neurotensin A (Rhodopsin) Rat in meso/LCP 3 3 0 5 4XEE 2.9 10.1038/NCOMMS8895 2015-07-29
4PY0 P2Y12 P2Y12 P2Y A (Rhodopsin) Human in meso/LCP 1 1 0 5 4PY0 3.1 10.1038/NATURE13288 2014-04-30
4L6R GLR glucagon Glucagon B1 (Secretin) Human in meso/LCP 0 2 0 5 4L6R 3.3 10.1038/NATURE12393 2013-07-24
4S0V OX2R OX2 Orexin A (Rhodopsin) Human in meso/LCP 1 3 0 4 4S0V 2.5 10.1038/NATURE14035 2015-01-14
4PXZ P2Y12 P2Y12 P2Y A (Rhodopsin) Human in meso/LCP 1 1 0 5 4PXZ 2.5 10.1038/NATURE13288 2014-04-30
6FKB OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 2 1 0 0 6FKB 3.0 10.1073/PNAS.1718084115 2018-04-04
5VEX GLP1R GLP-1 Glucagon B1 (Secretin) Human in meso/LCP 10 5 0 5 5VEX 3.0 10.1038/NATURE22378 2017-05-17
5DGY OPSD Rhodopsin Opsins A (Rhodopsin) Human in meso/LCP 4 0 0 7 5DGY 7.7 10.1038/SDATA.2016.21 2016-03-23
3C9L OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NA 0 0 0 0 3C9L 2.7 10.1107/S0907444908017162 2008-08-05
6G79 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human Cryo-EM 1 5 0 2 6G79 3.8 10.1038/S41586-018-0241-9 2018-06-20
5MZP AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5MZP 2.1 10.1016/J.STR.2017.06.012 2017-07-26
3UON ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human in meso/LCP 4 1 0 1 3UON 3.0 10.1038/NATURE10753 2012-02-01
5X33 Q9WTK1 BLT1 Leukotriene A (Rhodopsin) Guinea pig in meso/LCP 4 1 0 5 5X33 3.7 10.1038/NCHEMBIO.2547 2018-01-03
4ZJC OX1R OX1 Orexin A (Rhodopsin) Human in meso/LCP 1 2 0 4 4ZJC 2.8 10.1038/NSMB.3183 2016-03-09
3V2W S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human in meso/LCP 2 4 0 5 3V2W 3.4 10.1126/SCIENCE.1215904 2012-02-15
6CM4 DRD2 D2 Dopamine A (Rhodopsin) Human in meso/LCP 3 2 0 5 6CM4 2.9 10.1038/NATURE25758 2018-03-14
3KJ6 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human vapour diffusion 3 2 0 3 3KJ6 3.4 10.1038/NATURE08650 2010-02-16
3NYA ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 2 0 3 3NYA 3.2 10.1021/JA105108Q 2010-08-11
3RFM AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 8 1 0 2 3RFM 3.6 10.1016/J.STR.2011.06.014 2011-09-07
5XSZ Q08BG4 LPA6 Lysophospholipid (LPA) A (Rhodopsin) Zebrafish in meso/LCP 0 2 0 6 5XSZ 3.2 10.1038/NATURE23448 2017-08-16
5TE3 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 5TE3 2.7 10.1073/PNAS.1617446114 2017-03-15
5DHG OPRX NOP Opioid A (Rhodopsin) Human in meso/LCP 0 2 0 5 5DHG 3.0 10.1016/J.STR.2015.07.024 2015-10-21
5UNF AGTR2 AT2 Angiotensin A (Rhodopsin) Human in meso/LCP 0 2 0 6 5UNF 2.8 10.1038/NATURE22035 2017-04-05
3P0G ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 2 0 3 3P0G 3.5 10.1038/NATURE09648 2011-01-19
5IUA AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5IUA 2.2 10.1021/ACS.JMEDCHEM.6B00653 2016-06-29
5JTB AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 5JTB 2.8 10.1126/SCIADV.1602952 2017-05-31
4Z35 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human in meso/LCP 0 3 0 5 4Z35 2.9 10.1016/J.CELL.2015.06.002 2015-06-03
4LDO ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 3 0 3 4LDO 3.2 10.1038/NATURE12572 2013-09-25
4GRV NTR1 NTS1 Neurotensin A (Rhodopsin) Rat in meso/LCP 6 3 0 5 4GRV 2.8 10.1038/NATURE11558 2012-10-17
2PED OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 2PED 3.0 10.1529/BIOPHYSJ.107.108225 2007-10-30
2G87 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 2G87 2.6 10.1002/ANIE.200600595 2006-09-02
4MQS ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human in meso/LCP 6 1 0 3 4MQS 3.5 10.1038/NATURE12735 2013-11-27
4DAJ ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Rat in meso/LCP 0 2 0 4 4DAJ 3.4 10.1038/NATURE10867 2012-02-22
4N6H OPRD δ Opioid A (Rhodopsin) Human in meso/LCP 1 2 0 5 4N6H 1.8 10.1038/NATURE12944 2013-12-25
5WF5 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 1 3 0 4 5WF5 2.6 10.1016/J.STR.2017.12.013 2018-02-21
5LWE CCR9 CCR9 Chemokine A (Rhodopsin) Human in meso/LCP 10 2 0 2 5LWE 2.8 10.1038/NATURE20606 2016-12-07
5NX2 GLP1R GLP-1 Glucagon B1 (Secretin) Human vapour diffusion 12 2 0 5 5NX2 3.7 10.1038/NATURE22800 2017-06-14
4XT1 US28 US28 Unclassified A (Rhodopsin) strain AD169 in meso/LCP 0 2 0 1 4XT1 2.9 10.1126/SCIENCE.AAA5026 2015-03-04
5XEZ GLR glucagon Glucagon B1 (Secretin) Human in meso/LCP 0 3 0 5 5XEZ 3.0 10.1038/NATURE22363 2017-05-24
6AKY CCR5 CCR5 Chemokine A (Rhodopsin) Human N/A 4 3 0 0 6AKY 2.8 10.1021/ACS.JMEDCHEM.8B01077 2018-10-24
4BVN ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey in meso/LCP 11 3 0 1 4BVN 2.1 10.1371/JOURNAL.PONE.0092727 2014-04-02
2RH1 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 2 0 2 2RH1 2.4 10.1126/SCIENCE.1150577 2007-10-30
6MEO CCR5 CCR5 Chemokine A (Rhodopsin) Human N/A 0 1 0 0 6MEO 3.9 10.1038/S41586-018-0804-9 2018-12-12
5NDZ PAR2 PAR2 Proteinase-activated A (Rhodopsin) Human in meso/LCP 10 3 0 4 5NDZ 3.6 10.1038/NATURE22309 2017-05-03
5UNH AGTR2 AT2 Angiotensin A (Rhodopsin) Human in meso/LCP 0 2 0 6 5UNH 2.9 10.1038/NATURE22035 2017-04-05
5DYS OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 3 0 0 0 5DYS 2.3 10.15252/EMBR.201642671 2016-08-10
5UEN AA1R A1 Adenosine A (Rhodopsin) Human in meso/LCP 1 3 0 8 5UEN 3.2 10.1016/J.CELL.2017.01.042 2017-03-01
5EE7 GLR glucagon Glucagon B1 (Secretin) Human in meso/LCP 11 3 0 2 5EE7 2.5 10.1038/NATURE17414 2016-04-20
4EIY AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 4EIY 1.8 10.1126/SCIENCE.1219218 2012-07-25
3ZPR ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 3ZPR 2.7 10.1021/JM400140Q 2013-04-03
4AMI ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 4AMI 3.2 10.1016/J.STR.2012.03.014 2012-05-23
6FKD OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 2 0 0 0 6FKD 2.5 10.1073/PNAS.1718084115 2018-04-04
3UZC AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 8 1 0 2 3UZC 3.3 10.1021/JM201376W 2012-03-21
6IGK EDNRB ETB Endothelin A (Rhodopsin) Human N/A 0 3 0 0 6IGK 2.0 10.1038/S41467-018-07094-0 2018-11-21
4PHU FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human in meso/LCP 4 1 0 6 4PHU 2.3 10.1038/NATURE13494 2014-07-16
3D4S ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 2 0 3 3D4S 2.8 10.1016/J.STR.2008.05.001 2008-06-17
6DRY 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human N/A 1 3 0 0 6DRY 2.9 10.1038/S41594-018-0116-7 2018-08-29
4QIN SMO SMO Frizzled F (Frizzled) Human in meso/LCP 0 3 0 5 4QIN 2.6 10.1038/NCOMMS5355 2014-07-23
2Y00 ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 2Y00 2.5 10.1038/NATURE09746 2011-01-12
5NDD PAR2 PAR2 Proteinase-activated A (Rhodopsin) Human in meso/LCP 10 3 0 4 5NDD 2.8 10.1038/NATURE22309 2017-05-03
6FFH GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human in meso/LCP 6 2 0 3 6FFH 2.7 10.1021/ACS.JMEDCHEM.7B01722 2018-03-07
4GPO ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 4 0 2 4GPO 3.5 10.1038/NSMB.2504 2013-02-27
4QIM SMO SMO Frizzled F (Frizzled) Human in meso/LCP 0 3 0 5 4QIM 2.6 10.1038/NCOMMS5355 2014-07-23
4OO9 GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human in meso/LCP 6 3 0 3 4OO9 2.6 10.1038/NATURE13396 2014-07-02
5ZKC ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A 0 3 0 0 5ZKC 2.3 10.1038/S41589-018-0152-Y 2018-11-21
4U15 ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Rat in meso/LCP 0 3 0 4 4U15 2.8 10.1016/J.STR.2014.08.022 2014-11-26
6B73 OPRK κ Opioid A (Rhodopsin) Human in meso/LCP 1 2 0 6 6B73 3.1 10.1016/J.CELL.2017.12.011 2018-01-17
5ZBQ NPY1R Y1 Neuropeptide Y A (Rhodopsin) Human in meso/LCP 1 2 0 5 5ZBQ 2.7 10.1038/S41586-018-0046-X 2018-04-25
6AQF AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 3 6AQF 2.5 10.1016/J.CELL.2017.12.004 2018-01-10
5UIG AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 0 2 0 5 5UIG 3.5 10.1073/PNAS.1621423114 2017-02-08
5TE5 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 5TE5 4.0 10.1073/PNAS.1617446114 2017-03-15
4JKV SMO SMO Frizzled F (Frizzled) Human in meso/LCP 0 2 0 5 4JKV 2.5 10.1038/NATURE12167 2013-04-24
5K2A AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 5K2A 2.5 10.1126/SCIADV.1600292 2016-09-21
4MQT ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human in meso/LCP 6 1 0 3 4MQT 3.7 10.1038/NATURE12735 2013-11-27
5XR8 CNR1 CB1 Cannabinoid A (Rhodopsin) Human in meso/LCP 4 3 0 5 5XR8 3.0 10.1038/NATURE23272 2017-07-12
5V57 SMO SMO Frizzled F (Frizzled) Human in meso/LCP 0 3 0 6 5V57 3.0 10.1038/NCOMMS15383 2017-05-24
6DDF OPRM μ Opioid A (Rhodopsin) Mouse Cryo-EM 0 2 0 4 6DDF 3.5 10.1038/S41586-018-0219-7 2018-06-13
3DQB OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 3DQB 3.2 10.1038/NATURE07330 2008-09-23
4WW3 OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid vapour diffusion 0 2 0 1 4WW3 2.8 10.1371/JOURNAL.PONE.0126970 2015-06-17
2Y01 ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 2Y01 2.6 10.1038/NATURE09746 2011-03-30
5WF6 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 1 3 0 4 5WF6 2.9 10.1016/J.STR.2017.12.013 2018-02-21
3RZE HRH1 H1 Histamine A (Rhodopsin) Human in meso/LCP 0 2 0 4 3RZE 3.1 10.1038/NATURE10236 2011-06-15
4DKL OPRM μ Opioid A (Rhodopsin) Mouse in meso/LCP 0 3 0 5 4DKL 2.8 10.1038/NATURE10954 2012-03-21
4UG2 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 5 1 0 3 4UG2 2.6 10.1124/MOL.114.097360 2015-04-08
4XNV P2RY1 P2Y1 P2Y A (Rhodopsin) Human in meso/LCP 1 2 0 5 4XNV 2.2 10.1038/NATURE14287 2015-04-01
4PXF OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 4PXF 2.8 10.1038/NCOMMS5801 2014-09-17
5GLH EDNRB ETB Endothelin A (Rhodopsin) Human in meso/LCP 0 5 0 7 5GLH 2.8 10.1038/NATURE19319 2016-09-07
1L9H OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 1L9H 2.6 10.1073/PNAS.082666399 2002-05-15
3ZEV NTR1 NTS1 Neurotensin A (Rhodopsin) Rat vapour diffusion 11 3 0 8 3ZEV 3.0 10.1073/PNAS.1317903111 2014-01-29
3V2Y S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human in meso/LCP 2 4 0 5 3V2Y 2.8 10.1126/SCIENCE.1215904 2012-02-15
6BQH 5HT2C 5-HT2C 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 3 0 5 6BQH 2.7 10.1016/J.CELL.2018.01.001 2018-02-14
5EN0 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 3 0 0 0 5EN0 2.8 10.15252/EMBR.201642671 2016-08-10
5X93 EDNRB ETB Endothelin A (Rhodopsin) Human in meso/LCP 8 3 0 7 5X93 2.2 10.1038/NSMB.3450 2017-08-16
2YCZ ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 4 0 1 2YCZ 3.7 10.1073/PNAS.1100185108 2011-06-01
3EML AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 5 3EML 2.6 10.1126/SCIENCE.1164772 2008-10-14
1U19 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 1U19 2.2 10.1016/J.JMB.2004.07.044 2004-10-12
5DHH OPRX NOP Opioid A (Rhodopsin) Human in meso/LCP 0 2 0 5 5DHH 3.0 10.1016/J.STR.2015.07.024 2015-10-21
5T1A CCR2 CCR2 Chemokine A (Rhodopsin) Human in meso/LCP 0 3 0 6 5T1A 2.8 10.1038/NATURE20605 2016-12-14
5L7D SMO SMO Frizzled F (Frizzled) Human in meso/LCP 1 3 0 2 5L7D 3.2 10.1038/NATURE18934 2016-07-20
3QAK AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 4 0 5 3QAK 2.7 10.1126/SCIENCE.1202793 2011-03-09
3PQR OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 3PQR 2.9 10.1038/NATURE09789 2011-03-09
4LDE ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 3 0 3 4LDE 2.8 10.1038/NATURE12572 2013-09-25
5GLI EDNRB ETB Endothelin A (Rhodopsin) Human in meso/LCP 0 3 0 7 5GLI 2.5 10.1038/NATURE19319 2016-09-07
5N2S AA1R A1 Adenosine A (Rhodopsin) Human in meso/LCP 8 2 0 3 5N2S 3.3 10.1016/J.STR.2017.06.012 2017-07-26
3CAP OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 3CAP 2.9 10.1038/NATURE07063 2008-06-24
2YCX ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 4 0 1 2YCX 3.3 10.1073/PNAS.1100185108 2011-06-01
5XF1 GLR glucagon Glucagon B1 (Secretin) Human in meso/LCP 0 3 0 5 5XF1 3.2 10.1038/NATURE22363 2017-05-24
PDB UniProt Receptor
5V54 5HT1B 5-HT1B
5YWY PE2R4 EP4
4BUO NTR1 NTS1
1F88 OPSD Rhodopsin
6H7N ADRB1 β1
5OM4 AA2AR A2A
5NM4 AA2AR A2A
5IU4 AA2AR A2A
5XPR EDNRB ETB
5UVI AA2AR A2A
4YAY AGTR1 AT1
6IGL EDNRB ETB
5UZ7 CALCR CT
4U16 ACM3 M3
4QKX ADRB2 β2
5IU7 AA2AR A2A
5X7D ADRB2 β2
4O9R SMO SMO
4BEZ OPSD Rhodopsin
6IIV TA2R TP
6DS0 5HT2B 5-HT2B
6FKA OPSD Rhodopsin
2YDV AA2AR A2A
5VRA AA2AR A2A
5K2C AA2AR A2A
4IAQ 5HT1B 5-HT1B
5TVN 5HT2B 5-HT2B
2Y04 ADRB1 β1
5CXV ACM1 M1
2YCY ADRB1 β1
6HLP NK1R NK1
6FJ3 PTH1R PTH1
6AKX CCR5 CCR5
5WIU DRD4 D4
6D27 PD2R2 DP2
3ZPQ ADRB1 β1
3NY8 ADRB2 β2
5ZKB ACM2 M2
4K5Y CRFR1 CRF1
5KW2 FFAR1 FFA1
3AYN OPSD Rhodopsin
6GPS CCR2 CCR2
6IBL ADRB1 β1
5ZBH NPY1R Y1
5ZKQ PTAFR PAF
5YHL PE2R4 EP4
4U14 ACM3 M3
5NM2 AA2AR A2A
3VG9 AA2AR A2A
5NLX AA2AR A2A
5ZKP PTAFR PAF
5OLZ AA2AR A2A
6FK9 OPSD Rhodopsin
5ZK3 ACM2 M2
3C9M OPSD Rhodopsin
5CGC GRM5 mGlu5
4RWD OPRD δ
4DJH OPRK κ
4RWS CXCR4 CXCR4
3OE9 CXCR4 CXCR4
5N2R AA2AR A2A
5ZK8 ACM2 M2
6AK3 PE2R3 EP3
6FFI GRM5 mGlu5
5D5A ADRB2 β2
5A8E ADRB1 β1
5UNG AGTR2 AT2
6NIY CALCR CT
6BD4 FZD4 FZD4
2Y03 ADRB1 β1
6N4B CNR1 CB1
5ZTY CNR2 CB2
6A93 5HT2A 5-HT2A
6FKC OPSD Rhodopsin
3VGA AA2AR A2A
4N4W SMO SMO
3OE6 CXCR4 CXCR4
6A94 5HT2A 5-HT2A
4A4M OPSD Rhodopsin
6DO1 AGTR1 AT1
2VT4 ADRB1 β1
4RWA OPRD δ
2X72 OPSD Rhodopsin
4ZUD AGTR1 AT1
5OLV AA2AR A2A
6FK6 OPSD Rhodopsin
5DSG ACM4 M4
4X1H OPSD Rhodopsin
6DDE OPRM μ
5WS3 OX2R OX2
6D26 PD2R2 DP2
5VBL APJ apelin
4IB4 5HT2B 5-HT2B
6M9T PE2R3 EP3
6BQG 5HT2C 5-HT2C
4XNW P2RY1 P2Y1
5YQZ GLR glucagon
5K2B AA2AR A2A
5G53 AA2AR A2A
6DRX 5HT2B 5-HT2B
5O9H C5AR1 C5a1
6E59 NK1R NK1
5WB1 Q80KM9 US28
6H7O ADRB1 β1
5WB2 Q80KM9 US28
6D35 Q98SW5 SMO
6HLO NK1R NK1
6H7M ADRB1 β1
5YC8 ACM2 M2
6HLL NK1R NK1
5WIV DRD4 D4
5OLG AA2AR A2A
6D9H AA1R A1
2Y02 ADRB1 β1
3OAX OPSD Rhodopsin
6H7J ADRB1 β1
5TUD 5HT2B 5-HT2B
6FUF OPSD Rhodopsin
6MXT ADRB2 β2
5MZJ AA2AR A2A
2R4R ADRB2 β2
2Z73 OPSD Rhodopsin
6MET CCR5 CCR5
5TZY FFAR1 FFA1
6H7L ADRB1 β1
5TGZ CNR1 CB1
2I35 OPSD Rhodopsin
5JQH ADRB2 β2
4Z34 LPAR1 LPA1
4MBS CCR5 CCR5
4EJ4 OPRD δ
4XES NTR1 NTS1
4NTJ P2Y12 P2Y12
4J4Q OPSD Rhodopsin
4BWB NTR1 NTS1
2I37 OPSD Rhodopsin
5F8U ADRB1 β1
6DRZ 5HT2B 5-HT2B
3AYM OPSD Rhodopsin
3VW7 PAR1 PAR1
6CMO OPSD Rhodopsin
4BEY OPSD Rhodopsin
6E3Y CALRL calcitonin-like
5CGD GRM5 mGlu5
6C1Q C5AR1 C5a1
2YDO AA2AR A2A
5VAI G1SGD4 GLP-1
5TZR FFAR1 FFA1
3OE0 CXCR4 CXCR4
6J20 NK1R NK1
6IIU TA2R TP
5XJM AGTR2 AT2
2ZIY OPSD Rhodopsin
6N52 GRM5 mGlu5
6J21 NK1R NK1
5VEW GLP1R GLP-1
5IU8 AA2AR A2A
6GPX CCR2 CCR2
5T04 NTR1 NTS1
6N51 GRM5 mGlu5
2YCW ADRB1 β1
4ZJ8 OX1R OX1
5XRA CNR1 CB1
3PXO OPSD Rhodopsin
3REY AA2AR A2A
5L7I SMO SMO
3SN6 ADRB2 β2
4Z9G CRFR1 CRF1
5OLO AA2AR A2A
3ODU CXCR4 CXCR4
2R4S ADRB2 β2
4ZWJ OPSD Rhodopsin
4NC3 5HT2B 5-HT2B
3PBL DRD3 D3
5WKT OPSD Rhodopsin
2I36 OPSD Rhodopsin
4LDL ADRB2 β2
5D6L ADRB2 β2
5OLH AA2AR A2A
3PDS ADRB2 β2
5WQC OX2R OX2
3PWH AA2AR A2A
5UIW CCR5 CCR5
3OE8 CXCR4 CXCR4
6B3J GLP1R GLP-1
6FK8 OPSD Rhodopsin
2J4Y OPSD Rhodopsin
6C1R C5AR1 C5a1
1GZM OPSD Rhodopsin
4XT3 US28 US28
5V56 SMO SMO
5D5B ADRB2 β2
4Z36 LPAR1 LPA1
1HZX OPSD Rhodopsin
2HPY OPSD Rhodopsin
5NJ6 PAR2 PAR2
5OM1 AA2AR A2A
4AMJ ADRB1 β1
4IAR 5HT1B 5-HT1B
4EA3 OPRX NOP
5IUB AA2AR A2A
6FK7 OPSD Rhodopsin
5K2D AA2AR A2A
4UHR AA2AR A2A
5U09 CNR1 CB1
6GDG AA2AR A2A
4OR2 GRM1 mGlu1
4GBR ADRB2 β2
3UZA AA2AR A2A
5C1M OPRM μ
3NY9 ADRB2 β2
6D32 Q98SW5 SMO
5W0P OPSD Rhodopsin
4BV0 NTR1 NTS1
4XEE NTR1 NTS1
4PY0 P2Y12 P2Y12
4L6R GLR glucagon
4S0V OX2R OX2
4PXZ P2Y12 P2Y12
6FKB OPSD Rhodopsin
5VEX GLP1R GLP-1
5DGY OPSD Rhodopsin
3C9L OPSD Rhodopsin
6G79 5HT1B 5-HT1B
5MZP AA2AR A2A
3UON ACM2 M2
5X33 Q9WTK1 BLT1
4ZJC OX1R OX1
3V2W S1PR1 S1P1
6CM4 DRD2 D2
3KJ6 ADRB2 β2
3NYA ADRB2 β2
3RFM AA2AR A2A
5XSZ Q08BG4 LPA6
5TE3 OPSD Rhodopsin
5DHG OPRX NOP
5UNF AGTR2 AT2
3P0G ADRB2 β2
5IUA AA2AR A2A
5JTB AA2AR A2A
4Z35 LPAR1 LPA1
4LDO ADRB2 β2
4GRV NTR1 NTS1
2PED OPSD Rhodopsin
2G87 OPSD Rhodopsin
4MQS ACM2 M2
4DAJ ACM3 M3
4N6H OPRD δ
5WF5 AA2AR A2A
5LWE CCR9 CCR9
5NX2 GLP1R GLP-1
4XT1 US28 US28
5XEZ GLR glucagon
6AKY CCR5 CCR5
4BVN ADRB1 β1
2RH1 ADRB2 β2
6MEO CCR5 CCR5
5NDZ PAR2 PAR2
5UNH AGTR2 AT2
5DYS OPSD Rhodopsin
5UEN AA1R A1
5EE7 GLR glucagon
4EIY AA2AR A2A
3ZPR ADRB1 β1
4AMI ADRB1 β1
6FKD OPSD Rhodopsin
3UZC AA2AR A2A
6IGK EDNRB ETB
4PHU FFAR1 FFA1
3D4S ADRB2 β2
6DRY 5HT2B 5-HT2B
4QIN SMO SMO
2Y00 ADRB1 β1
5NDD PAR2 PAR2
6FFH GRM5 mGlu5
4GPO ADRB1 β1
4QIM SMO SMO
4OO9 GRM5 mGlu5
5ZKC ACM2 M2
4U15 ACM3 M3
6B73 OPRK κ
5ZBQ NPY1R Y1
6AQF AA2AR A2A
5UIG AA2AR A2A
5TE5 OPSD Rhodopsin
4JKV SMO SMO
5K2A AA2AR A2A
4MQT ACM2 M2
5XR8 CNR1 CB1
5V57 SMO SMO
6DDF OPRM μ
3DQB OPSD Rhodopsin
4WW3 OPSD Rhodopsin
2Y01 ADRB1 β1
5WF6 AA2AR A2A
3RZE HRH1 H1
4DKL OPRM μ
4UG2 AA2AR A2A
4XNV P2RY1 P2Y1
4PXF OPSD Rhodopsin
5GLH EDNRB ETB
1L9H OPSD Rhodopsin
3ZEV NTR1 NTS1
3V2Y S1PR1 S1P1
6BQH 5HT2C 5-HT2C
5EN0 OPSD Rhodopsin
5X93 EDNRB ETB
2YCZ ADRB1 β1
3EML AA2AR A2A
1U19 OPSD Rhodopsin
5DHH OPRX NOP
5T1A CCR2 CCR2
5L7D SMO SMO
3QAK AA2AR A2A
3PQR OPSD Rhodopsin
4LDE ADRB2 β2
5GLI EDNRB ETB
5N2S AA1R A1
3CAP OPSD Rhodopsin
2YCX ADRB1 β1
5XF1 GLR glucagon
 
N-term
TM1
ICL1
TM2
ECL1
TM3
ICL2
TM4
ECL2
TM5
ICL3
TM6
ECL3
TM7
H8
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
 
 
 
 
 
 
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
TM6
 
ECL3
 
TM7
 
H8
 
 
C-term
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
 
 
TM1
 
ICL1
 
 
 
 
TM2
 
ECL1
 
 
 
 
 
TM3
 
ICL2
 
TM4
 
 
 
ECL2
 
 
 
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
 
TM6
 
ECL3
 
 
 
 
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
 
 
 
 
 
 
TM1
 
ICL1
 
 
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
ICL3
 
TM6
 
ECL3
 
 
 
 
 
TM7
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
TM1
 
ICL1
 
 
 
TM2
 
ECL1
 
 
 
 
 
TM3
 
ICL2
 
 
 
TM4
 
 
 
ECL2
 
 
 
 
 
 
TM5
 
 
 
 
 
ICL3
 
 
 
 
 
TM6
 
ECL3
 
 
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
TM1
 
ICL1
 
 
 
TM2
 
ECL1
 
 
 
 
 
TM3
 
ICL2
 
 
 
TM4
 
 
 
ECL2
 
 
 
 
 
 
TM5
 
 
 
 
 
ICL3
 
 
 
 
 
TM6
 
ECL3
 
 
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
TM1
 
ICL1
 
 
 
TM2
 
ECL1
 
 
 
 
 
TM3
 
ICL2
 
 
 
TM4
 
 
 
ECL2
 
 
 
 
 
 
TM5
 
 
 
 
 
ICL3
 
 
 
 
 
TM6
 
ECL3
 
 
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
 
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
 
TM5
 
 
 
 
ICL3
 
 
 
TM6
 
ECL3
 
 
 
TM7
 
 
 
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
 
 
 
 
 
 
 
 
 
ECL2
 
 
TM5
 
 
 
ICL3
 
 
 
 
TM6
 
ECL3
 
TM7
 
 
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
TM5
 
 
 
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
 
 
TM1
 
ICL1
 
TM2
 
 
 
 
 
 
 
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
 
 
 
 
 
 
ICL3
 
 
TM6
 
 
 
 
ECL3
 
TM7
 
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
 
 
TM1
 
ICL1
 
 
 
 
TM2
 
 
 
ECL1
 
TM3
 
ICL2
 
TM4
 
 
 
ECL2
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
TM1
 
ICL1
 
 
 
TM2
 
ECL1
 
 
 
 
 
TM3
 
ICL2
 
 
 
TM4
 
 
 
ECL2
 
 
 
 
 
 
TM5
 
 
 
 
 
ICL3
 
 
 
 
 
TM6
 
ECL3
 
 
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
N-term
 
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
 
 
ECL2
 
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
 
 
 
TM3
 
 
 
 
ICL2
 
 
 
TM4
 
ECL2
 
TM5
 
 
 
 
 
 
 
 
ICL3
 
TM6
 
 
 
 
 
 
 
 
 
ECL3
 
TM7
 
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
N-term
 
TM1
 
ICL1
 
 
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
ICL3
 
TM6
 
 
 
ECL3
 
TM7
 
H8
 
C-term
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
TM5
 
 
 
 
ICL3
 
 
 
TM6
 
ECL3
 
TM7
 
 
 
 
 
 
 
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
ICL3
 
TM6
 
 
 
ECL3
 
TM7
 
H8
 
C-term
 
TM1
 
ICL1
 
 
 
 
 
 
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
 
 
ECL2
 
TM5
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
TM6
 
ECL3
 
TM7
 
H8
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
 
 
TM1
 
ICL1
</
 
 
 
TM2