gasr_human
NAME
7F8V
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
gasr_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
|
E
|
L
|
L
|
K
|
L
|
N
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R
|
S
|
V
|
10 |
Q
|
G
|
T
|
G
|
P
|
G
|
P
|
G
|
A
|
S
|
20 |
L
|
C
|
R
|
P
|
G
|
A
|
P
|
L
|
L
|
N
|
30 |
S
|
S
|
S
|
V
|
G
|
N
|
L
|
S
|
C
|
E
|
40 |
P
|
P
|
R
|
I
|
R
|
G
|
A
|
G
|
T
|
R
|
50 |
TM1 | |||||||||
E
|
L
|
E
|
L
|
A
|
I
|
R
|
I
|
T
|
L
|
60 |
Y
|
A
|
V
|
I
|
F
|
L
|
M
|
S
|
V
|
G
|
70 |
G
|
N
|
M
|
L
|
I
|
I
|
V
|
V
|
L
|
G
|
80 |
ICL1 | TM2 | ||||||||
L
|
S
|
R
|
R
|
L
|
R
|
T
|
V
|
T
|
N
|
90 |
A
|
F
|
L
|
L
|
S
|
L
|
A
|
V
|
S
|
D
|
100 |
L
|
L
|
L
|
A
|
V
|
A
|
C
|
M
|
P
|
F
|
110 |
T
|
L
|
L
|
P
|
N
|
L
|
M
|
G
|
T
|
F
|
120 |
ECL1 | TM3 | ||||||||
I
|
F
|
G
|
T
|
V
|
I
|
C
|
K
|
A
|
V
|
130 |
S
|
Y
|
L
|
M
|
G
|
V
|
S
|
V
|
S
|
V
|
140 |
S
|
T
|
L
|
S
|
L
|
V
|
A
|
I
|
A
|
L
|
150 |
E
|
R
|
Y
|
S
|
A
|
I
|
C
|
R
|
P
|
L
|
160 |
ICL2 | TM4 | ||||||||
Q
|
A
|
R
|
V
|
W
|
Q
|
T
|
R
|
S
|
H
|
170 |
A
|
A
|
R
|
V
|
I
|
V
|
A
|
T
|
W
|
L
|
180 |
L
|
S
|
G
|
L
|
L
|
M
|
V
|
P
|
Y
|
P
|
190 |
ECL2 | |||||||||
V
|
Y
|
T
|
V
|
V
|
Q
|
P
|
V
|
G
|
P
|
200 |
R
|
V
|
L
|
Q
|
C
|
V
|
H
|
R
|
W
|
P
|
210 |
TM5 | |||||||||
S
|
A
|
R
|
V
|
R
|
Q
|
T
|
W
|
S
|
V
|
220 |
L
|
L
|
L
|
L
|
L
|
L
|
F
|
F
|
I
|
P
|
230 |
G
|
V
|
V
|
M
|
A
|
V
|
A
|
Y
|
G
|
L
|
240 |
I
|
S
|
R
|
E
|
L
|
Y
|
L
|
G
|
L
|
R
|
250 |
ICL3 | |||||||||
F
|
D
|
G
|
D
|
S
|
D
|
S
|
D
|
S
|
Q
|
260 |
S
|
R
|
V
|
R
|
N
|
Q
|
G
|
G
|
L
|
P
|
270 |
G
|
A
|
V
|
H
|
Q
|
N
|
G
|
R
|
C
|
R
|
280 |
P
|
E
|
T
|
G
|
A
|
V
|
G
|
E
|
D
|
S
|
290 |
D
|
G
|
C
|
Y
|
V
|
Q
|
L
|
P
|
R
|
S
|
300 |
R
|
P
|
A
|
L
|
E
|
L
|
T
|
A
|
L
|
T
|
310 |
A
|
P
|
G
|
P
|
G
|
S
|
G
|
S
|
R
|
P
|
320 |
TM6 | |||||||||
T
|
Q
|
A
|
K
|
L
|
L
|
A
|
K
|
K
|
R
|
330 |
V
|
V
|
R
|
M
|
L
|
L
|
V
|
I
|
V
|
V
|
340 |
L
|
F
|
F
|
L
|
C
|
W
|
L
|
P
|
V
|
Y
|
350 |
S
|
A
|
N
|
T
|
W
|
R
|
A
|
F
|
D
|
G
|
360 |
ECL3 | |||||||||
P
|
G
|
A
|
H
|
R
|
A
|
L
|
S
|
G
|
A
|
370 |
TM7 | |||||||||
P
|
I
|
S
|
F
|
I
|
H
|
L
|
L
|
S
|
Y
|
380 |
A
|
S
|
A
|
C
|
V
|
N
|
P
|
L
|
V
|
Y
|
390 |
H8 | |||||||||
C
|
F
|
M
|
H
|
R
|
R
|
F
|
R
|
Q
|
A
|
400 |
C
|
L
|
E
|
T
|
C
|
A
|
R
|
C
|
C
|
P
|
410 |
|
|
||||||||
C-term | |||||||||
R
|
P
|
P
|
R
|
A
|
R
|
P
|
R
|
A
|
L
|
420 |
|
|
|
|
|
|
|
|
|
|
P
|
D
|
E
|
D
|
P
|
P
|
T
|
P
|
S
|
I
|
430 |
|
|
|
|
|
|
|
|
|
|
A
|
S
|
L
|
S
|
R
|
L
|
S
|
Y
|
T
|
T
|
440 |
|
|
|
|
|
|
|
I
|
S
|
T
|
L
|
G
|
P
|
G
|
|
|||||||||
N-term | |||||||||
|
E
|
L
|
L
|
K
|
L
|
N
|
R
|
S
|
V
|
10 |
Q
|
G
|
T
|
G
|
P
|
G
|
P
|
G
|
A
|
S
|
20 |
L
|
C
|
R
|
P
|
G
|
A
|
P
|
L
|
L
|
N
|
30 |
S
|
S
|
S
|
V
|
G
|
N
|
L
|
S
|
C
|
E
|
40 |
P
|
P
|
R
|
I
|
R
|
G
|
A
|
G
|
T
|
R
|
50 |
TM1 | |||||||||
E
|
L
|
E
|
L
|
A
|
I
|
R
|
I
|
T
|
L
|
60 |
Y
|
A
|
V
|
I
|
F
|
L
|
M
|
S
|
V
|
G
|
70 |
G
|
N
|
M
|
L
|
I
|
I
|
V
|
V
|
L
|
G
|
80 |
ICL1 | TM2 | ||||||||
L
|
S
|
R
|
R
|
L
|
R
|
T
|
V
|
T
|
N
|
90 |
A
|
F
|
L
|
L
|
S
|
L
|
A
|
V
|
S
|
D
|
100 |
L
|
L
|
L
|
A
|
V
|
A
|
C
|
M
|
P
|
F
|
110 |
T
|
L
|
L
|
P
|
N
|
L
|
M
|
G
|
T
|
F
|
120 |
ECL1 | TM3 | ||||||||
I
|
F
|
G
|
T
|
V
|
I
|
C
|
K
|
A
|
V
|
130 |
S
|
Y
|
L
|
M
|
G
|
V
|
S
|
V
|
S
|
V
|
140 |
S
|
T
|
L
|
S
|
L
|
V
|
A
|
I
|
A
|
L
|
150 |
E
|
R
|
Y
|
S
|
A
|
I
|
C
|
R
|
P
|
L
|
160 |
ICL2 | TM4 | ||||||||
Q
|
A
|
R
|
V
|
W
|
Q
|
T
|
R
|
S
|
H
|
170 |
A
|
A
|
R
|
V
|
I
|
V
|
A
|
T
|
W
|
L
|
180 |
L
|
S
|
G
|
L
|
L
|
M
|
V
|
P
|
Y
|
P
|
190 |
ECL2 | |||||||||
V
|
Y
|
T
|
V
|
V
|
Q
|
P
|
V
|
G
|
P
|
200 |
R
|
V
|
L
|
Q
|
C
|
V
|
H
|
R
|
W
|
P
|
210 |
TM5 | |||||||||
S
|
A
|
R
|
V
|
R
|
Q
|
T
|
W
|
S
|
V
|
220 |
L
|
L
|
L
|
L
|
L
|
L
|
F
|
F
|
I
|
P
|
230 |
G
|
V
|
V
|
M
|
A
|
V
|
A
|
Y
|
G
|
L
|
240 |
I
|
S
|
R
|
E
|
L
|
Y
|
L
|
G
|
L
|
R
|
250 |
ICL3 | |||||||||
F
|
D
|
G
|
D
|
S
|
D
|
S
|
D
|
S
|
Q
|
260 |
S
|
R
|
V
|
R
|
N
|
Q
|
G
|
G
|
L
|
P
|
270 |
G
|
A
|
V
|
H
|
Q
|
N
|
G
|
R
|
C
|
R
|
280 |
P
|
E
|
T
|
G
|
A
|
V
|
G
|
E
|
D
|
S
|
290 |
D
|
G
|
C
|
Y
|
V
|
Q
|
L
|
P
|
R
|
S
|
300 |
R
|
P
|
A
|
L
|
E
|
L
|
T
|
A
|
L
|
T
|
310 |
A
|
P
|
G
|
P
|
G
|
S
|
G
|
S
|
R
|
P
|
320 |
TM6 | |||||||||
T
|
Q
|
A
|
K
|
L
|
L
|
A
|
K
|
K
|
R
|
330 |
V
|
V
|
R
|
M
|
L
|
L
|
V
|
I
|
V
|
V
|
340 |
L
|
F
|
F
|
L
|
C
|
W
|
L
|
P
|
V
|
Y
|
350 |
S
|
A
|
N
|
T
|
W
|
R
|
A
|
F
|
D
|
G
|
360 |
ECL3 | |||||||||
P
|
G
|
A
|
H
|
R
|
A
|
L
|
S
|
G
|
A
|
370 |
TM7 | |||||||||
P
|
I
|
S
|
F
|
I
|
H
|
L
|
L
|
S
|
Y
|
380 |
A
|
S
|
A
|
C
|
V
|
N
|
P
|
L
|
V
|
Y
|
390 |
H8 | |||||||||
C
|
F
|
M
|
H
|
R
|
R
|
F
|
R
|
Q
|
A
|
400 |
C
|
L
|
E
|
T
|
C
|
A
|
R
|
C
|
C
|
P
|
410 |
|
||||||||
C-term | ||||||||
R
|
P
|
P
|
R
|
A
|
R
|
P
|
R
|
|
SCHEMATIC
Perspective:
Wild-type
Construct
|
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DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
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DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|