⬤ Gαs ⬤ Gαi/o ⬤ Gαq/11 ⬤ Gα12/13

GPCR selectivity tree. Concentric circles illustrate the G protein-coupling selectivity of each GPCR: the four dots depict both primary and secondary G protein coupling (from inside to outside: s, i/o, q/11, 12/13). Tree nodes can be highlighted and selected to retrieve clade-specific receptor sets, which can be used in dedicated segment specific sequence alignments.


We used the G protein transducer imformation from the GuideToPharmacology (IUPHAR):

Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SPH, Buneman OP, Davenport AP, McGrath JC, Peters JA, Spedding M, Catterall WA, Fabbro D, Davies JA; NC-IUPHAR. (2016) The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucl. Acids Res. 44 (Database Issue): D1054-68. [PMID:26464438]