gp179_human
NAME
8IRJ
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
gp179_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
N-term | |||||||||
M
|
G
|
T
|
R
|
G
|
A
|
V
|
M
|
P
|
P
|
10 |
P
|
M
|
W
|
G
|
L
|
L
|
G
|
C
|
C
|
F
|
20 |
V
|
C
|
A
|
W
|
A
|
L
|
G
|
G
|
P
|
R
|
30 |
P
|
I
|
R
|
S
|
L
|
P
|
P
|
L
|
S
|
S
|
40 |
Q
|
V
|
K
|
P
|
G
|
S
|
V
|
P
|
M
|
Q
|
50 |
V
|
P
|
L
|
E
|
G
|
A
|
E
|
A
|
A
|
L
|
60 |
A
|
Y
|
L
|
Y
|
S
|
G
|
D
|
A
|
Q
|
Q
|
70 |
L
|
S
|
Q
|
V
|
N
|
C
|
S
|
E
|
R
|
Y
|
80 |
E
|
A
|
R
|
G
|
A
|
G
|
A
|
M
|
P
|
G
|
90 |
L
|
P
|
P
|
S
|
L
|
Q
|
G
|
A
|
A
|
G
|
100 |
T
|
L
|
A
|
Q
|
A
|
A
|
N
|
F
|
L
|
N
|
110 |
M
|
L
|
L
|
Q
|
A
|
N
|
D
|
I
|
R
|
E
|
120 |
S
|
S
|
V
|
E
|
E
|
D
|
V
|
E
|
W
|
Y
|
130 |
Q
|
A
|
L
|
V
|
R
|
S
|
V
|
A
|
E
|
G
|
140 |
D
|
P
|
R
|
V
|
Y
|
R
|
A
|
L
|
L
|
T
|
150 |
F
|
N
|
P
|
P
|
P
|
G
|
A
|
S
|
H
|
L
|
160 |
Q
|
L
|
A
|
L
|
Q
|
A
|
T
|
R
|
T
|
G
|
170 |
E
|
E
|
T
|
I
|
L
|
Q
|
D
|
L
|
S
|
G
|
180 |
N
|
W
|
V
|
Q
|
E
|
E
|
N
|
P
|
P
|
G
|
190 |
D
|
L
|
D
|
T
|
P
|
A
|
L
|
K
|
K
|
R
|
200 |
V
|
L
|
T
|
N
|
D
|
L
|
G
|
S
|
L
|
G
|
210 |
S
|
P
|
K
|
W
|
P
|
Q
|
A
|
D
|
G
|
Y
|
220 |
V
|
G
|
D
|
T
|
Q
|
Q
|
V
|
R
|
L
|
S
|
230 |
P
|
P
|
F
|
L
|
E
|
C
|
Q
|
E
|
G
|
R
|
240 |
L
|
R
|
P
|
G
|
W
|
L
|
I
|
T
|
L
|
S
|
250 |
A
|
T
|
F
|
Y
|
G
|
L
|
K
|
P
|
D
|
L
|
260 |
S
|
P
|
E
|
V
|
R
|
G
|
Q
|
V
|
Q
|
M
|
270 |
D
|
V
|
D
|
L
|
Q
|
S
|
V
|
D
|
I
|
N
|
280 |
Q
|
C
|
A
|
S
|
G
|
P
|
G
|
W
|
Y
|
S
|
290 |
N
|
T
|
H
|
L
|
C
|
D
|
L
|
N
|
S
|
T
|
300 |
Q
|
C
|
V
|
P
|
L
|
E
|
S
|
Q
|
G
|
F
|
310 |
V
|
L
|
G
|
R
|
Y
|
L
|
C
|
R
|
C
|
R
|
320 |
P
|
G
|
F
|
Y
|
G
|
A
|
S
|
P
|
S
|
G
|
330 |
G
|
L
|
E
|
E
|
S
|
D
|
F
|
Q
|
T
|
T
|
340 |
G
|
Q
|
F
|
G
|
F
|
P
|
E
|
G
|
R
|
S
|
350 |
G
|
R
|
L
|
L
|
Q
|
C
|
L
|
P
|
C
|
P
|
360 |
E
|
G
|
C
|
T
|
S
|
C
|
M
|
D
|
A
|
T
|
370 |
TM1 | |||||||||
P
|
C
|
L
|
V
|
E
|
E
|
A
|
A
|
V
|
L
|
380 |
R
|
A
|
A
|
V
|
L
|
A
|
C
|
Q
|
A
|
C
|
390 |
C
|
M
|
L
|
A
|
I
|
F
|
L
|
S
|
M
|
L
|
400 |
V
|
S
|
Y
|
R
|
C
|
R
|
R
|
N
|
K
|
R
|
410 |
ICL1 | TM2 | ||||||||
I
|
W
|
A
|
S
|
G
|
V
|
V
|
L
|
L
|
E
|
420 |
T
|
V
|
L
|
F
|
G
|
F
|
L
|
L
|
L
|
Y
|
430 |
F
|
P
|
V
|
F
|
I
|
L
|
Y
|
F
|
K
|
P
|
440 |
TM3 | |||||||||
S
|
V
|
F
|
R
|
C
|
I
|
A
|
L
|
R
|
W
|
450 |
V
|
R
|
L
|
L
|
G
|
F
|
A
|
I
|
V
|
Y
|
460 |
G
|
T
|
I
|
I
|
L
|
K
|
L
|
Y
|
R
|
V
|
470 |
L
|
Q
|
L
|
F
|
L
|
S
|
R
|
T
|
A
|
Q
|
480 |
ICL2 | TM4 | ||||||||
R
|
S
|
A
|
L
|
L
|
S
|
S
|
G
|
R
|
L
|
490 |
L
|
R
|
R
|
L
|
G
|
L
|
L
|
L
|
L
|
P
|
500 |
V
|
L
|
G
|
F
|
L
|
A
|
V
|
W
|
T
|
V
|
510 |
G
|
A
|
L
|
E
|
R
|
G
|
I
|
Q
|
H
|
A
|
520 |
ECL2 | |||||||||
P
|
L
|
V
|
I
|
R
|
G
|
H
|
T
|
P
|
S
|
530 |
G
|
R
|
H
|
F
|
Y
|
L
|
C
|
H
|
H
|
D
|
540 |
TM5 | |||||||||
R
|
W
|
D
|
Y
|
I
|
M
|
V
|
V
|
A
|
E
|
550 |
L
|
L
|
L
|
L
|
C
|
W
|
G
|
S
|
F
|
L
|
560 |
ICL3 | |||||||||
C
|
Y
|
A
|
T
|
R
|
A
|
V
|
L
|
S
|
A
|
570 |
TM6 | |||||||||
F
|
H
|
E
|
P
|
R
|
Y
|
M
|
G
|
I
|
A
|
580 |
L
|
H
|
N
|
E
|
L
|
L
|
L
|
S
|
A
|
A
|
590 |
F
|
H
|
T
|
A
|
R
|
F
|
V
|
L
|
V
|
P
|
600 |
ECL3 | TM7 | ||||||||
S
|
L
|
H
|
P
|
D
|
W
|
T
|
L
|
L
|
L
|
610 |
F
|
F
|
F
|
H
|
T
|
H
|
S
|
T
|
V
|
T
|
620 |
T
|
T
|
L
|
A
|
L
|
I
|
F
|
I
|
P
|
K
|
630 |
H8 | |||||||||
F
|
W
|
K
|
L
|
G
|
A
|
P
|
P
|
R
|
E
|
640 |
E
|
M
|
V
|
D
|
E
|
V
|
C
|
E
|
D
|
E
|
650 |
C-term | |||||||||
L
|
D
|
L
|
Q
|
H
|
S
|
G
|
S
|
Y
|
L
|
660 |
G
|
S
|
S
|
I
|
A
|
S
|
A
|
W
|
S
|
E
|
670 |
H
|
S
|
L
|
D
|
P
|
G
|
D
|
I
|
R
|
D
|
680 |
E
|
L
|
K
|
K
|
L
|
Y
|
A
|
Q
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L
|
E
|
690 |
V
|
H
|
K
|
T
|
K
|
E
|
M
|
A
|
A
|
N
|
700 |
N
|
P
|
H
|
L
|
P
|
K
|
K
|
R
|
G
|
S
|
710 |
S
|
C
|
Q
|
G
|
L
|
G
|
R
|
S
|
F
|
M
|
720 |
R
|
Y
|
L
|
A
|
E
|
F
|
P
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E
|
A
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L
|
730 |
|
|
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|
|
|||||
A
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R
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Q
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S
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R
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D
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S
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G
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S
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740 |
|
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750 |
|
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R
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R
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L
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L
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760 |
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770 |
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S
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Y
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D
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R
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R
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780 |
|
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L
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L
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790 |
|
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R
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R
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K
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L
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A
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K
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K
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A
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S
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R
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800 |
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810 |
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820 |
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840 |
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A
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850 |
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L
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M
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860 |
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870 |
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890 |
|
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900 |
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960 |
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970 |
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T
|
P
|
A
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P
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A
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L
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A
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V
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|
980 |
|
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V
|
S
|
P
|
Q
|
S
|
P
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N
|
L
|
L
|
T
|
990 |
|
|
|
|
|
|
|
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|
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Y
|
I
|
C
|
P
|
W
|
E
|
N
|
A
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E
|
L
|
1000 |
|
|
|
|
|
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|
|
|
|
P
|
A
|
K
|
Q
|
E
|
N
|
V
|
P
|
Q
|
E
|
1010 |
|
|
|
|
|
|
|
|
|
|
G
|
P
|
S
|
G
|
P
|
E
|
R
|
G
|
H
|
H
|
1020 |
|
|
|
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|
|
|
|
S
|
P
|
A
|
P
|
A
|
R
|
A
|
R
|
L
|
W
|
1030 |
|
|
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|
R
|
A
|
L
|
S
|
V
|
A
|
V
|
E
|
K
|
S
|
1040 |
|
|
|
|
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|
|
|
|
R
|
A
|
G
|
E
|
N
|
E
|
M
|
D
|
A
|
E
|
1050 |
|
|
|
|
|
|
|
|
|
|
D
|
A
|
H
|
H
|
Q
|
R
|
E
|
A
|
N
|
D
|
1060 |
|
|
|
|
|
|
|
|
|
|
V
|
D
|
E
|
D
|
R
|
P
|
K
|
I
|
F
|
P
|
1070 |
|
|
|
|
|
|
|
|
|
|
K
|
S
|
H
|
S
|
L
|
K
|
A
|
P
|
V
|
Q
|
1080 |
|
|
|
|
|
|
|
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1120 |
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1380 |
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1390 |
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1400 |
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1420 |
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1430 |
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1460 |
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1470 |
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1480 |
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1490 |
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1580 |
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1600 |
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1610 |
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|
1620 |
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1630 |
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1640 |
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|
1650 |
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|
1660 |
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|
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|
1670 |
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|
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|
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L
|
L
|
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|
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|
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|
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|
1680 |
|
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|
G
|
S
|
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|
A
|
A
|
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|
1690 |
|
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|
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|
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|
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|
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|
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|
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|
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|
1700 |
|
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|
A
|
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|
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|
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|
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|
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|
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|
1710 |
|
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|
A
|
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|
A
|
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|
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|
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|
R
|
A
|
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|
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|
1720 |
|
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|
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|
A
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|
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|
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|
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|
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|
N
|
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|
1730 |
|
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|
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|
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|
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|
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|
A
|
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|
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|
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|
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|
1740 |
|
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|
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|
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|
R
|
A
|
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|
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|
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|
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|
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|
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|
1750 |
|
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|
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|
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|
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|
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|
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|
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|
W
|
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|
V
|
1760 |
|
|
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|
A
|
C
|
P
|
W
|
G
|
S
|
V
|
G
|
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|
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|
1770 |
|
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A
|
C
|
S
|
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|
H
|
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|
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|
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|
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|
D
|
1780 |
|
|
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|
A
|
D
|
G
|
P
|
K
|
A
|
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|
F
|
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|
E
|
1790 |
|
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|
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|
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|
|
L
|
D
|
H
|
M
|
G
|
C
|
R
|
P
|
G
|
E
|
1800 |
|
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|
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|
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|
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|
|
V
|
C
|
P
|
W
|
E
|
A
|
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|
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|
A
|
A
|
1810 |
|
|
|
|
|
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|
|
T
|
S
|
E
|
K
|
A
|
K
|
I
|
C
|
P
|
W
|
1820 |
|
|
|
|
|
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|
|
|
|
E
|
V
|
S
|
E
|
G
|
T
|
T
|
G
|
K
|
G
|
1830 |
|
|
|
|
|
|
|
|
|
|
L
|
D
|
Q
|
K
|
A
|
G
|
S
|
E
|
S
|
A
|
1840 |
|
|
|
|
|
|
|
|
|
|
E
|
Q
|
R
|
E
|
K
|
A
|
L
|
E
|
K
|
G
|
1850 |
|
|
|
|
|
|
|
|
|
|
R
|
L
|
T
|
S
|
L
|
G
|
E
|
D
|
V
|
S
|
1860 |
|
|
|
|
|
|
|
|
|
|
K
|
G
|
M
|
A
|
K
|
L
|
C
|
Q
|
Q
|
Q
|
1870 |
|
|
|
|
|
|
|
|
|
|
E
|
T
|
I
|
C
|
I
|
W
|
E
|
N
|
K
|
D
|
1880 |
|
|
|
|
|
|
|
|
|
|
L
|
R
|
E
|
S
|
P
|
A
|
Q
|
A
|
P
|
K
|
1890 |
|
|
|
|
|
|
|
|
|
|
I
|
S
|
D
|
L
|
P
|
S
|
S
|
M
|
S
|
S
|
1900 |
|
|
|
|
|
|
|
|
|
|
E
|
V
|
A
|
E
|
G
|
H
|
S
|
L
|
E
|
A
|
1910 |
|
|
|
|
|
|
|
|
|
|
T
|
E
|
K
|
G
|
D
|
L
|
R
|
Q
|
D
|
P
|
1920 |
|
|
|
|
|
|
|
|
|
|
K
|
T
|
G
|
S
|
F
|
P
|
E
|
H
|
I
|
T
|
1930 |
|
|
|
|
|
|
|
|
|
|
Q
|
E
|
K
|
A
|
P
|
A
|
A
|
D
|
T
|
E
|
1940 |
|
|
|
|
|
|
|
|
|
|
E
|
F
|
T
|
T
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E
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D
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|
1950 |
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1960 |
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1970 |
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D
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1980 |
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1990 |
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2000 |
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2010 |
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120 |
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280 |
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290 |
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300 |
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320 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
600 |
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|
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|
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|
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|
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|
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A
|
P
|
P
|
R
|
E
|
640 |
E
|
M
|
V
|
D
|
E
|
V
|
C
|
E
|
D
|
E
|
650 |
C-term | |||||||||
L
|
D
|
L
|
Q
|
H
|
S
|
G
|
S
|
Y
|
L
|
660 |
G
|
S
|
S
|
I
|
A
|
S
|
A
|
W
|
S
|
E
|
670 |
H
|
S
|
L
|
D
|
P
|
G
|
D
|
I
|
R
|
D
|
680 |
E
|
L
|
K
|
K
|
L
|
Y
|
A
|
Q
|
L
|
E
|
690 |
V
|
H
|
K
|
T
|
K
|
E
|
M
|
A
|
A
|
N
|
700 |
N
|
P
|
H
|
L
|
P
|
K
|
K
|
R
|
G
|
S
|
710 |
S
|
C
|
Q
|
G
|
L
|
G
|
R
|
S
|
F
|
M
|
720 |
R
|
Y
|
L
|
A
|
E
|
F
|
P
|
E
|
A
|
L
|
730 |
|
|||||
A
|
R
|
Q
|
H
|
S
|
|
SCHEMATIC
Perspective:
Wild-type
Construct
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|