o51g2_human
NAME
8UXV
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
o51g2_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
N-term | |||||||||
M
|
T
|
L
|
G
|
S
|
L
|
G
|
N
|
S
|
S
|
10 |
S
|
S
|
V
|
S
|
A
|
T
|
F
|
L
|
L
|
S
|
20 |
G
|
I
|
P
|
G
|
L
|
E
|
R
|
M
|
H
|
I
|
30 |
TM1 | |||||||||
W
|
I
|
S
|
I
|
P
|
L
|
C
|
F
|
M
|
Y
|
40 |
L
|
V
|
S
|
I
|
P
|
G
|
N
|
C
|
T
|
I
|
50 |
L
|
F
|
I
|
I
|
K
|
T
|
E
|
R
|
S
|
L
|
60 |
ICL1 | TM2 | ||||||||
H
|
E
|
P
|
M
|
Y
|
L
|
F
|
L
|
S
|
M
|
70 |
L
|
A
|
L
|
I
|
D
|
L
|
G
|
L
|
S
|
L
|
80 |
C
|
T
|
L
|
P
|
T
|
V
|
L
|
G
|
I
|
F
|
90 |
ECL1 | TM3 | ||||||||
W
|
V
|
G
|
A
|
R
|
E
|
I
|
S
|
H
|
D
|
100 |
A
|
C
|
F
|
A
|
Q
|
L
|
F
|
F
|
I
|
H
|
110 |
C
|
F
|
S
|
F
|
L
|
E
|
S
|
S
|
V
|
L
|
120 |
L
|
S
|
M
|
A
|
F
|
D
|
R
|
F
|
V
|
A
|
130 |
ICL2 | |||||||||
I
|
C
|
H
|
P
|
L
|
H
|
Y
|
V
|
S
|
I
|
140 |
|
|
|
|
|
|||||
TM4 | |||||||||
L
|
T
|
N
|
T
|
V
|
I
|
G
|
R
|
I
|
G
|
150 |
|
|
|
|
|
|
|
|
|
|
L
|
V
|
S
|
L
|
G
|
R
|
S
|
V
|
A
|
L
|
160 |
|
|
|
|
|
|
|
|
|
|
I
|
F
|
P
|
L
|
P
|
F
|
M
|
L
|
K
|
R
|
170 |
|
|
|
|
|
|
|
|
|
|
ECL2 | |||||||||
F
|
P
|
Y
|
C
|
G
|
S
|
P
|
V
|
L
|
S
|
180 |
|
|
|
|
|
|
|
|
|
|
H
|
S
|
Y
|
C
|
L
|
H
|
Q
|
E
|
V
|
M
|
190 |
|
|
|
|
|
|
|
|
|
|
TM5 | |||||||||
K
|
L
|
A
|
C
|
A
|
D
|
M
|
K
|
A
|
N
|
200 |
|
|
|
|
|
|
|
|
|
|
S
|
I
|
Y
|
G
|
M
|
F
|
V
|
I
|
V
|
S
|
210 |
|
|
|
|
|
|
|
|
|
|
T
|
V
|
G
|
I
|
D
|
S
|
L
|
L
|
I
|
L
|
220 |
|
|
|
|
|
|
|
|
|
|
F
|
S
|
Y
|
A
|
L
|
I
|
L
|
R
|
T
|
V
|
230 |
|
|
|
|
|
|
|
|
|
|
ICL3 | TM6 | ||||||||
L
|
S
|
I
|
A
|
S
|
R
|
A
|
E
|
R
|
F
|
240 |
|
|
|
|
|
|
|
|
|
|
K
|
A
|
L
|
N
|
T
|
C
|
V
|
S
|
H
|
I
|
250 |
|
|
|
|
|
|
|
|
|
|
C
|
A
|
V
|
L
|
L
|
F
|
Y
|
T
|
P
|
M
|
260 |
|
|
|
|
|
|
|
|
|
|
I
|
G
|
L
|
S
|
V
|
I
|
H
|
R
|
F
|
G
|
270 |
|
|
|
|
|
|
|
|
|
|
ECL3 | TM7 | ||||||||
K
|
Q
|
A
|
P
|
H
|
L
|
V
|
Q
|
V
|
V
|
280 |
|
|
|
|
|
|
|
|
|
|
M
|
G
|
F
|
M
|
Y
|
L
|
L
|
F
|
P
|
P
|
290 |
|
|
|
|
|
|
|
|
|
|
V
|
M
|
N
|
P
|
I
|
V
|
Y
|
S
|
V
|
K
|
300 |
|
|
|
|
|
|
|
|
|
|
H8 | |||||||||
T
|
K
|
Q
|
I
|
R
|
D
|
R
|
V
|
T
|
H
|
310 |
|
|
|
|
A
|
F
|
C
|
Y
|
N-term | |||||||||
M
|
T
|
L
|
G
|
S
|
L
|
G
|
N
|
S
|
S
|
10 |
S
|
S
|
V
|
S
|
A
|
T
|
F
|
L
|
L
|
S
|
20 |
G
|
I
|
P
|
G
|
L
|
E
|
R
|
M
|
H
|
I
|
30 |
TM1 | |||||||||
W
|
I
|
S
|
I
|
P
|
L
|
C
|
F
|
M
|
Y
|
40 |
L
|
V
|
S
|
I
|
P
|
G
|
N
|
C
|
T
|
I
|
50 |
L
|
F
|
I
|
I
|
K
|
T
|
E
|
R
|
S
|
L
|
60 |
ICL1 | TM2 | ||||||||
H
|
E
|
P
|
M
|
Y
|
L
|
F
|
L
|
S
|
M
|
70 |
L
|
A
|
L
|
I
|
D
|
L
|
G
|
L
|
S
|
L
|
80 |
C
|
T
|
L
|
P
|
T
|
V
|
L
|
G
|
I
|
F
|
90 |
ECL1 | TM3 | ||||||||
W
|
V
|
G
|
A
|
R
|
E
|
I
|
S
|
H
|
D
|
100 |
A
|
C
|
F
|
A
|
Q
|
L
|
F
|
F
|
I
|
H
|
110 |
C
|
F
|
S
|
F
|
L
|
E
|
S
|
S
|
V
|
L
|
120 |
L
|
S
|
M
|
A
|
F
|
D
|
R
|
F
|
V
|
A
|
130 |
ICL2 | |||||||||
I
|
C
|
H
|
P
|
L
|
H
|
Y
|
V
|
S
|
I
|
140 |
|
|||||
TM4 | |||||
L
|
T
|
N
|
T
|
V
|
|
SCHEMATIC
Perspective:
Wild-type
Construct
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|