Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Sensory
Lipid
Opsins
Neurotensin
Leukotriene
OPSD
NTR1
Q9WTK1
OPSD
BLT1
Rhodopsin
NTS1
ECL2
S
D
G
N
A
C
4 3 17
3C9M, 5DYS, 4BEZ, 2J4Y, 5DGY, 2X72, 4A4M, 5W0P, 5T04, 4GRV, 4BEY, 4ZWJ, 5X33, 5EN0, 4XES, 4XEE, 6CMO
Inactive
A (Rhodopsin)
Aminergic
Peptide
Endothelin
Adrenoceptors
ADRB1
EDNRB
ETB
β1
TM7 7x48
I
F
A
M
2 2 20
2Y03, 2YCZ, 5X93, 5F8U, 2YCY, 3ZPQ, 2Y02, 5A8E, 2VT4, 5XPR, 2Y00, 4BVN, 2YCW, 2Y04, 3ZPR, 4AMI, 4GPO, 2YCX, 2Y01, 4AMJ
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
4
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7I, 5L7D
1
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLP1R
CRFR1
CRF1
GLP-1
ECL2 45x52
F
T
A
2 2 3
5NX2, 4K5Y, 4Z9G
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NDZ, 5NJ6, 5NDD
5
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Peptide
Aminergic
Adenosine
Dopamine
Neurotensin
AA1R
AA2AR
NTR1
DRD2
D2
A1
NTS1
A2A
TM6 6x37
L
A
4 3 26
5IUB, 5N2R, 4GRV, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 6CM4, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
1 1 4
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
Pos Match
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM7 7x41
S
T
A
2 1 24
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
5
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 17
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5TGZ, 5XRA, 5XR8
1 3
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
2 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
12
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A
C
1 1 3
5NX2, 5VEX, 5VEW
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5X93, 5XPR
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CCR9
CCR9
CXCR4
TM6 6x36
V
T
A
P
2 1 4
5LWE, 3OE0, 3OE9, 4RWS
2 1 3
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5X93, 5XPR
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEX, 5VEW
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
4UHR, 4UG2, 2YDV, 2YDO
8
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
3
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
ECL1
L
G
D
T
Q
A
F
R
E
2 1 2
5NX2, 5EE7
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLR
GLP1R
CRFR1
CRF1
glucagon
GLP-1
TM6 6x30
Y
K
A
3 2 5
4Z9G, 5VEX, 4K5Y, 5EE7, 5VEW
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5U09, 5XRA, 5TGZ, 5XR8
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NDZ, 5NJ6, 5NDD
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NDZ, 5NJ6, 5NDD
1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5X93, 5XPR
4
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
Lysophospholipid (LPA)
CNR1
LPAR1
LPA1
CB1
TM5 5x37
D
E
C
K
2 2 4
5TGZ, 5XRA, 4Z36, 5XR8
1
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
4BUO, 4XEE, 4XES, 3ZEV, 5T04, 4GRV, 4BWB, 4BV0
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
3
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA1R
AA2AR
DRD2
D2
A1
A2A
TM6 6x41
V
L
A
3 2 25
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 6CM4, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5YQZ, 5EE7
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NDZ, 5NJ6, 5NDD
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 5
2X72, 5W0P, 6CMO, 4ZWJ, 5DGY
8
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
1 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQH, 6BQG
Pos Match 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4K5Y, 4Z9G
Pos Match 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
3PDS, 4QKX
8
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 2
4MBS, 5UIW
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4K5Y, 4Z9G
1
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
5KW2, 4PHU, 5TZR, 5TZY
2 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEX, 5VEW
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLR
CRFR1
CRF1
glucagon
TM2 2x48
A
S
A
L
2 2 3
4K5Y, 5EE7, 4Z9G
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4K5Y, 4Z9G
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
4UHR, 4UG2, 2YDV, 2YDO
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
2Y03, 2YCZ, 5F8U, 2YCY, 3ZPQ, 2Y02, 5A8E, 2VT4, 2Y00, 4BVN, 2YCW, 2Y04, 3ZPR, 4AMI, 4GPO, 2YCX, 2Y01, 4AMJ
Active
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Protein
Chemokine
Dopamine
5-Hydroxytryptamine
Adrenoceptors
5HT2B
5HT1B
CXCR4
ADRB1
DRD3
ADRB2
β1
β2
D3
5-HT1B
5-HT2B
CXCR4
TM3 3x41
M
L
E
W
6 4 20
3ODU, 3OE0, 6G79, 4IB4, 3NY8, 5A8E, 3OE8, 3PBL, 4NC3, 3OE9, 4IAQ, 5TUD, 5TVN, 3NY9, 3D4S, 4RWS, 4IAR, 3OE6, 3NYA, 5V54
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NDZ, 5NJ6, 5NDD
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
5A8E, 4BVN
Pos Match Pos Match 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4K5Y, 4Z9G
1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 18
2Y03, 2YCZ, 5F8U, 2YCY, 3ZPQ, 2Y02, 5A8E, 2VT4, 2Y00, 4BVN, 2YCW, 2Y04, 3ZPR, 4AMI, 4GPO, 2YCX, 2Y01, 4AMJ
2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NDZ, 5NJ6, 5NDD
1 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 2
4MBS, 5UIW
3 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM3 3x24
S
G
A
2 1 3
5VEX, 5EE7, 5VEW
Intermediate
A (Rhodopsin)
Peptide
Lipid
Free fatty acid
Neurotensin
FFAR1
NTR1
FFA1
NTS1
TM3 3x49
G
E
A
2 2 6
4PHU, 5KW2, 4XES, 4GRV, 5TZR, 5TZY
Pos Match 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM5 5x63
Y
L
A
2 1 24
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
Intermediate
A (Rhodopsin)
Peptide
Lipid
Proteinase-activated
Free fatty acid
FFAR1
PAR2
FFA1
PAR2
TM3 3x34
F
G
A
2 2 5
5NDZ, 5NJ6, 4PHU, 5TZR, 5NDD
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 2
4MBS, 5UIW
4
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36
T
A
2 1 24
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
16
Inactive
A (Rhodopsin)
Aminergic
Peptide
Apelin
Dopamine
Adrenoceptors
APJ
ADRB1
DRD2
apelin
D2
β1
TM3 3x40
I
V
A
V
3 3 4
5A8E, 4BVN, 5VBL, 6CM4
2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5DYS, 5EN0
13
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NDZ, 5NJ6, 5NDD
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 18
2Y03, 2YCZ, 5F8U, 2YCY, 3ZPQ, 2Y02, 5A8E, 2VT4, 2Y00, 4BVN, 2YCW, 2Y04, 3ZPR, 4AMI, 4GPO, 2YCX, 2Y01, 4AMJ
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEX, 5VEW
1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEX, 5VEW
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEX, 5VEW
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 2
4MBS, 5UIW
2 1 5
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM2 2x56
S
A
C
2 1 3
5VEX, 5EE7, 5VEW
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Lipid
Free fatty acid
Adrenoceptors
FFAR1
ADRB1
FFA1
β1
TM5 5x58
Y
A
F
2 2 22
5F8U, 2YCY, 3ZPQ, 2Y02, 2Y00, 5TZY, 4BVN, 3ZPR, 4GPO, 2Y01, 2Y03, 2YCZ, 5A8E, 5KW2, 2VT4, 5TZR, 2YCW, 4PHU, 2Y04, 4AMI, 2YCX, 4AMJ
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 5
5W0P, 4A4M, 6CMO, 4ZWJ, 5DGY
1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NDZ, 5NJ6, 5NDD
1 1 1
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52
A
L
2 1 28
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 2YDO, 4UHR, 5IU8, 5NLX, 3PWH, 5NM2, 2YDV, 3REY, 5NM4, 4UG2, 5OM1, 5OLO, 3UZA
1
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
4BUO, 3ZEV, 4BWB, 4BV0
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 18
2Y03, 2YCZ, 5F8U, 2YCY, 3ZPQ, 2Y02, 5A8E, 2VT4, 2Y00, 4BVN, 2YCW, 2Y04, 3ZPR, 4AMI, 4GPO, 2YCX, 2Y01, 4AMJ
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
4XES, 4XEE, 5T04, 4GRV
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49
D
N
2 1 5
4PY0, 4XNV, 4NTJ, 4XNW, 4PXZ
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
4UHR, 4UG2, 2YDV, 2YDO
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM2 2x59
I
V
F
2 1 3
5VEX, 5EE7, 5VEW
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
2
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
4BUO, 4XEE, 4XES, 3ZEV, 5T04, 4GRV, 4BWB, 4BV0
0.37 0.21 -1.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.14 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
0.05 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.01 0 0.50 2 1 3
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 1
Intermediate
A (Rhodopsin)
Peptide
Lipid
Free fatty acid
Neurotensin
FFAR1
NTR1
FFA1
NTS1
TM3 3x49
G
E
A 2 2 6
4PHU, 5KW2, 4XES, 4GRV, 5TZR, 5TZY
0.01 0 0.50 Pos & Mutant AA Match 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4K5Y, 4Z9G
0.07 0 0.50
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
4BUO, 3ZEV, 4BWB, 4BV0
0.02 0 0.50
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 3
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 12
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
Q
G
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 2
4MBS, 5UIW
0.12 0.40 0.11 3 1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.11 0 0.50
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Peptide
Aminergic
Adenosine
Dopamine
Neurotensin
AA1R
AA2AR
NTR1
DRD2
D2
A1
NTS1
A2A
TM6 6x37
L
A 4 3 26
5IUB, 5N2R, 4GRV, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 6CM4, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
0.04 0 0.50 1 1 4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5YQZ, 5EE7
0 0.50 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM5 5x63
Y
L
A 2 1 24
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
0.06 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 4
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 2 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.06 0 0.50 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
5A8E, 4BVN
0.24 0.61 -0.46 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4K5Y, 4Z9G
0.2 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.13 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
4XES, 4XEE, 5T04, 4GRV
0.19 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4K5Y, 4Z9G
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.05 0 0.50 1 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEX, 5VEW
0.68 -0.02 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
0.24 -0.67
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
5KW2, 4PHU, 5TZR, 5TZY
0.01 0.54 -1.71
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
4UHR, 4UG2, 2YDV, 2YDO
0.03 0 0.50 8
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NDZ, 5NJ6, 5NDD
0.01 0.40 0.11 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 2
4MBS, 5UIW
0.69 0.43 2 1 5
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7I, 5L7D
0.54 -1.71 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
5A8E, 4BVN
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 3
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA1R
AA2AR
DRD2
D2
A1
A2A
TM6 6x41
V
L
A 3 2 25
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 6CM4, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
0.05 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
ECL1
G
T
E 2 1 2
5NX2, 5EE7
0.40 0.11
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
0.08 0 0.50 1 2
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52
A
L 2 1 28
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 2YDO, 4UHR, 5IU8, 5NLX, 3PWH, 5NM2, 2YDV, 3REY, 5NM4, 4UG2, 5OM1, 5OLO, 3UZA
0.63 0.21 -1.25 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.2 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM3 3x24
S
G
A 2 1 3
5VEX, 5EE7, 5VEW
0.07 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
0.05 0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5X93, 5XPR
0.1 0 0.50 4
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4K5Y, 4Z9G
0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5U09, 5XRA, 5TGZ, 5XR8
0.01 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLR
GLP1R
CRFR1
CRF1
glucagon
GLP-1
TM6 6x30
Y
K
A 3 2 5
4Z9G, 5VEX, 4K5Y, 5EE7, 5VEW
0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM7 7x41
S
T
A 2 1 24
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
0.38 0 0.50 5
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5DYS, 5EN0
0.04 0.29 0.41 -1.12 13
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
D
N
C 2 1 12
3C9M, 5DYS, 4BEZ, 2J4Y, 5DGY, 2X72, 4A4M, 5W0P, 4BEY, 4ZWJ, 5EN0, 6CMO
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4K5Y, 4Z9G
0 0.50 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 18
2Y03, 2YCZ, 5F8U, 2YCY, 3ZPQ, 2Y02, 5A8E, 2VT4, 2Y00, 4BVN, 2YCW, 2Y04, 3ZPR, 4AMI, 4GPO, 2YCX, 2Y01, 4AMJ
0.1 0.11 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
0.13 0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5X93, 5XPR
0.07 0 0.50 1
Active
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Protein
Chemokine
Dopamine
5-Hydroxytryptamine
Adrenoceptors
5HT2B
5HT1B
CXCR4
ADRB1
DRD3
ADRB2
β1
β2
D3
5-HT1B
5-HT2B
CXCR4
TM3 3x41
M
L
E
W 6 4 20
3ODU, 3OE0, 6G79, 4IB4, 3NY8, 5A8E, 3OE8, 3PBL, 4NC3, 3OE9, 4IAQ, 5TUD, 5TVN, 3NY9, 3D4S, 4RWS, 4IAR, 3OE6, 3NYA, 5V54
0.03 0.49 -2.09 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NDZ, 5NJ6, 5NDD
0.73 0.21 -1.25
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 18
2Y03, 2YCZ, 5F8U, 2YCY, 3ZPQ, 2Y02, 5A8E, 2VT4, 2Y00, 4BVN, 2YCW, 2Y04, 3ZPR, 4AMI, 4GPO, 2YCX, 2Y01, 4AMJ
0.05 0.24 -0.67
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 5
2X72, 5W0P, 6CMO, 4ZWJ, 5DGY
0.01 0.39 0.77 8
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEX, 5VEW
0.07 0.41 -1.12
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 2
4MBS, 5UIW
0.03 0.65 0.85 4
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4K5Y, 4Z9G
0 0.50 Pos & Mutant AA Match 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.13 0 0.50 1 3
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.67 1.00 1.15 1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5TGZ, 5XRA, 5XR8
0.04 0.40 0.11 1 3
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
4UHR, 4UG2, 2YDV, 2YDO
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEX, 5VEW
0.07 0 0.50
Inactive
A (Rhodopsin)
Peptide
Aminergic
Apelin
Dopamine
APJ
DRD2
apelin
D2
TM3 3x40
I
V
A 2 2 2
6CM4, 5VBL
0.06 0 0.50 2
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLP1R
CRFR1
CRF1
GLP-1
ECL2 45x52
F
T
A 2 2 3
5NX2, 4K5Y, 4Z9G
0 0.50
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQH, 6BQG
0.67 0.65 0.85 Pos & AA Mutant Match 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.03 0 0.50 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 2
4MBS, 5UIW
0.07 0.53 -0.71 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
3OE0, 3OE9, 4RWS
0.0 3.16 0.14 2 1 3
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
5KW2, 4PHU, 5TZR, 5TZY
0.06 0 0.50 2 1 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
2Y03, 2YCZ, 5F8U, 2YCY, 3ZPQ, 2Y02, 5A8E, 2VT4, 2Y00, 4BVN, 2YCW, 2Y04, 3ZPR, 4AMI, 4GPO, 2YCX, 2Y01, 4AMJ
0.03 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4K5Y, 4Z9G
0 0.50 1
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Leukotriene
NTR1
Q9WTK1
BLT1
NTS1
ECL2
S
G
A 2 2 5
4XES, 4XEE, 5X33, 5T04, 4GRV
0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5TGZ, 5XRA, 5XR8
0.11 0.26 2.80 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.08 0 0.50 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
4UHR, 4UG2, 2YDV, 2YDO
0.13 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36
T
A 2 1 24
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
0.02 0 0.50 16
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.0 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEX, 5VEW
0.07 0.54 -1.71 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
2Y03, 2YCZ, 5F8U, 2YCY, 3ZPQ, 2Y02, 5A8E, 2VT4, 2Y00, 4BVN, 2YCW, 2Y04, 3ZPR, 4AMI, 4GPO, 2YCX, 2Y01, 4AMJ
0.11 0.11 0.21 -1.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
0 0.50 Pos & Mutant AA Match
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 18
2Y03, 2YCZ, 5F8U, 2YCY, 3ZPQ, 2Y02, 5A8E, 2VT4, 2Y00, 4BVN, 2YCW, 2Y04, 3ZPR, 4AMI, 4GPO, 2YCX, 2Y01, 4AMJ
0.23 0.33 0.61 -0.46 2
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5X93, 5XPR
0.09 0.53 -0.71
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49
D
N 2 1 5
4PY0, 4XNV, 4NTJ, 4XNW, 4PXZ
0.72 0.65 0.85
Intermediate
A (Rhodopsin)
Peptide
Lipid
Proteinase-activated
Free fatty acid
FFAR1
PAR2
FFA1
PAR2
TM3 3x34
F
G
A 2 2 5
5NDZ, 5NJ6, 4PHU, 5TZR, 5NDD
0.07 0 0.50 1
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 17
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 18
2Y03, 2YCZ, 5F8U, 2YCY, 3ZPQ, 2Y02, 5A8E, 2VT4, 2Y00, 4BVN, 2YCW, 2Y04, 3ZPR, 4AMI, 4GPO, 2YCX, 2Y01, 4AMJ
0.04 0.50 0.46
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5X93, 5XPR
0.13 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
0.05 0.53 -0.71
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 5
5W0P, 4A4M, 6CMO, 4ZWJ, 5DGY
0.01 0.53 -0.71 1 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
3PDS, 4QKX
0.0 0.68 -0.02 8
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM2 2x59
I
V
F 2 1 3
5VEX, 5EE7, 5VEW
0.54 -1.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.13 0 0.50
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM3 3x24 G
A
1 1 1
5EE7
0.4 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4K5Y, 4Z9G
0.13 0.26 2.80
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32 R
E
1 1 3
5TGZ, 5XRA, 5XR8
0.31 0.21 1.81 1 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47 S
C
1 1 1
5LWE
0.56 0.50 0.46
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
ADRB2
β2
β1
TM3 3x41 E
W
2 1 5
5A8E, 3D4S, 3NY9, 3NY8, 3NYA
0.01 0.33 0.40 0.11 1
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term N
C
2 1 12
3C9M, 5DYS, 4BEZ, 2J4Y, 5DGY, 2X72, 4A4M, 5W0P, 4BEY, 4ZWJ, 5EN0, 6CMO
0.65 0.85
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51 I
C
1 1 2
5VEX, 5VEW
0.6 0.41 -1.12 1
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52 A
L
2 1 28
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 2YDO, 4UHR, 5IU8, 5NLX, 3PWH, 5NM2, 2YDV, 3REY, 5NM4, 4UG2, 5OM1, 5OLO, 3UZA
0.06 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53 Y
A
1 1 2
4K5Y, 4Z9G
0.93 0.53 -0.71 Pos & Wild Type AA Match 1
Active
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Protein
Dopamine
5-Hydroxytryptamine
Chemokine
CXCR4
DRD3
5HT1B
D3
5-HT1B
CXCR4
TM3 3x41 L
W
3 3 11
3ODU, 3OE0, 6G79, 3OE8, 3PBL, 3OE9, 4IAQ, 4RWS, 4IAR, 3OE6, 5V54
0.31 0.21 -1.25 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48 S
A
1 1 2
4K5Y, 4Z9G
0.07 0.50 0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM7 7x41 S
A
1 1 23
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
0.16 0.50 0.46 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.02 0.61 -0.46 1
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
ECL3 D
C
1 1 8
3C9M, 4BEY, 5DYS, 4BEZ, 5EN0, 2J4Y, 2X72, 4A4M
0.69 0.43
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39 F
A
1 1 1
5EE7
0.33 0.54 -1.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33 A
D
1 1 2
4MBS, 5UIW
0.29 0 0.50 2 1 5
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49 D
N
2 1 5
4PY0, 4XNV, 4NTJ, 4XNW, 4PXZ
0.2 0.69 0.43
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x59 I
F
1 1 2
5VEX, 5VEW
0.4 0.41 -1.12
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM5 5x63 L
A
1 1 23
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
0.13 0.21 -1.25
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40 V
F
1 1 2
5L7I, 5L7D
0.09 0.09 0.61 -0.46 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2 G
M
1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
1.00 1.15
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48 T
A
1 1 1
5LWE
0.05 0.66 0.25 2
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36 F
A
1 1 18
2Y03, 2YCZ, 5F8U, 2YCY, 3ZPQ, 2Y02, 5A8E, 2VT4, 2Y00, 4BVN, 2YCW, 2Y04, 3ZPR, 4AMI, 4GPO, 2YCX, 2Y01, 4AMJ
0.14 0.44 0.54 -1.71
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
ECL2 G
A
E
2 1 2
5NX2, 5EE7
1.00 1.15
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM3 3x40 V
A
1 1 1
5VBL
0.24 0.61 -0.46 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42 P
A
1 1 1
5NX2
0.93 3.16 0.14
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62 T
A
1 1 4
4UHR, 4UG2, 2YDV, 2YDO
0.1 0.66 0.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48 G
A
1 1 1
5EE7
0.13 1.00 1.15
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM7 7x41 T
A
1 1 1
5N2S
0.07 0.66 0.25 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.03 0.66 0.25 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31 C
F
1 1 2
5VEX, 5VEW
0.07 0.68 -0.02 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46 G
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.54 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x59 V
F
1 1 1
5EE7
0.4 0.61 -0.46
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63 C
A
1 1 1
5NX2
0.07 0.68 -0.02
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37 D
C
1 1 1
4Z36
0.01 0.69 0.43 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37 H
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.03 0.61 0.11 1 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48 S
A
1 1 2
5VEX, 5VEW
0.07 0.50 0.46
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA1R
DRD2
D2
A1
TM6 6x41 L
A
2 2 2
6CM4, 5N2S
0.19 0.21 -1.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x34 G
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.02 1.00 1.15 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60 L
A
1 1 2
4K5Y, 4Z9G
0.33 0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41 T
A
1 1 1
5LWE
0.09 0.66 0.25
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Lipid
Free fatty acid
Adrenoceptors
FFAR1
ADRB1
FFA1
β1
TM5 5x58 Y
A
F
2 2 22
5F8U, 2YCY, 3ZPQ, 2Y02, 2Y00, 5TZY, 4BVN, 3ZPR, 4GPO, 2Y01, 2Y03, 2YCZ, 5A8E, 5KW2, 2VT4, 5TZR, 2YCW, 4PHU, 2Y04, 4AMI, 2YCX, 4AMJ
0.72 0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
ECL2 45x52 F
A
1 1 2
4K5Y, 4Z9G
0.13 0.54 -1.71
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56 V
A
1 1 1
5NX2
0.07 0.61 -0.46 2 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50 I
A
1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
0.5 0.41 -1.12 Pos & Wild Type AA Match
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39 S
A
1 1 1
5WF6
0.72 0.50 0.46 Pos & Wild Type AA Match 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55 R
A
1 1 23
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
0.05 0.21 1.81 1 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NDZ, 5NJ6, 5NDD
0.07 0.61 -0.46 5
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43 V
A
1 1 4
4XES, 4XEE, 5T04, 4GRV
0.1 0.61 -0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43 K
A
1 1 23
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
0.16 0.26 2.80
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x49 G
A
1 1 4
5KW2, 4PHU, 5TZR, 5TZY
0.01 1.00 1.15 Pos & Wild Type AA Match 2
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54 I
A
1 1 4
4BUO, 3ZEV, 4BWB, 4BV0
0.33 0.41 -1.12
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36 V
A
1 1 2
4K5Y, 4Z9G
0.07 0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM6 6x30 K
A
2 1 3
5VEX, 5EE7, 5VEW
0.2 0.26 2.80
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47 H
V
1 1 1
5NX2
0.73 0.61 0.11
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5DYS, 5EN0
0.08 0.43 0.66 0.25 13
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38 S
A
1 1 2
4K5Y, 4Z9G
0.13 0.50 0.46 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39 R
A
1 1 2
5YQZ, 5EE7
1.0 0.21 1.81 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36 K
A
1 1 2
5X93, 5XPR
0.06 0.26 2.80 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31 L
F
1 1 1
5NX2
0.2 0.21 -1.25
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45 G
A
C
1 1 3
5NX2, 5VEX, 5VEW
1.0 1.00 1.15
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53 S
A
1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
0.14 0.50 0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36 V
A
1 1 1
5LWE
0.15 0.61 -0.46 2 1 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60 C
Y
1 1 2
4MBS, 5UIW
0.02 0.68 -0.02 1
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45 C
N
1 1 2
6BQH, 6BQG
0.01 0.68 -0.02 Pos & Wild Type AA Match 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50 D
N
1 1 1
5WF5
0.92 0.69 0.43 Pos & Wild Type AA Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48 A
L
1 1 1
5EE7
0.2 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53 M
V
1 1 18
2Y03, 2YCZ, 5F8U, 2YCY, 3ZPQ, 2Y02, 5A8E, 2VT4, 2Y00, 4BVN, 2YCW, 2Y04, 3ZPR, 4AMI, 4GPO, 2YCX, 2Y01, 4AMJ
0.07 0.33 0.24 -0.67 2
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35 E
A
1 1 5
6FFH, 5CGD, 6FFI, 4OO9, 5CGC
0.09 0.40 0.11
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5U09, 5XRA, 5TGZ, 5XR8
0.01 0.66 0.25 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38 I
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.08 0.41 -1.12
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51 Y
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.66 0.53 -0.71 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38 M
A
1 1 1
5LWE
0.04 0.24 -0.67 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 Q
A
1 1 1
5NX2
0.39 0.77
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM3 3x49 E
A
1 1 2
4XES, 4GRV
0.21 0.40 0.11 Pos & Wild Type AA Match 2
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Peptide
Aminergic
Adenosine
Dopamine
Neurotensin
AA1R
AA2AR
NTR1
DRD2
D2
A1
NTS1
A2A
TM6 6x37 L
A
4 3 26
5IUB, 5N2R, 4GRV, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 6CM4, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
0.38 0.21 -1.25 1 1 4
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NDZ, 5NJ6, 5NDD
0.05 0.24 -0.67
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40 L
A
1 1 4
5KW2, 4PHU, 5TZR, 5TZY
0.03 0.21 -1.25 2 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52 G
I
1 1 2
5VEX, 5VEW
0.2 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x30 Y
A
1 1 2
4K5Y, 4Z9G
0.73 0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44 W
A
1 1 2
4K5Y, 4Z9G
0.13 0.49 -2.09
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM5 5x63 Y
A
1 1 1
5N2S
0.03 0.53 -0.71
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 5
2X72, 5W0P, 6CMO, 4ZWJ, 5DGY
0.02 0.57 0.40 0.11 8
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 D
R
1 1 1
5NX2
0.69 0.43
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54 M
A
1 1 1
5EE7
0.07 0.24 -0.67
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56 D
A
1 1 1
5X93
0.01 0.69 0.43
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48 E
F
1 1 1
5EE7
0.27 0.40 0.11 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67 H
G
1 1 1
5X33
0.1 0.61 0.11
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36 T
A
2 1 24
5IUB, 5N2R, 5IUA, 5OM4, 5MZJ, 3UZC, 5OLV, 5OLH, 5MZP, 5N2S, 5IU7, 3RFM, 5IU4, 5OLZ, 5OLG, 5IU8, 5NLX, 3PWH, 5NM2, 3REY, 5NM4, 5OM1, 5OLO, 3UZA
0.05 0.66 0.25 16
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64 M
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.01 0.24 -0.67 1 3
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
C-term S
A
1 1 1
5X33
0.50 0.46
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40 M
Y
2 1 5
5W0P, 4A4M, 6CMO, 4ZWJ, 5DGY
0.05 0.71 0.24 -0.67 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x24 S
A
1 1 2
5VEX, 5VEW
0.27 0.50 0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42 L
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.24 0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49 K
E
1 1 2
4MBS, 5UIW
0.13 0.26 2.80 3 1 1
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.68 0.49 -2.09 Pos & Wild Type AA Match 17