Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Peptide
Adenosine
Neurotensin
Dopamine
AA1R
AA2AR
NTR1
DRD2
NTS1
A1
A2A
D2
TM6 6x37
L
A
4 3 26
3PWH, 6CM4, 5N2R, 4GRV, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQH, 6BQG
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4K5Y, 4Z9G
Intermediate
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon receptor family
GLP1R
CRFR1
GLP-1
CRF1
ECL2 45x52
F
T
A
2 2 3
4K5Y, 4Z9G, 5NX2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NJ6, 5NDD, 5NDZ
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
4GRV, 3ZEV, 4XES, 4XEE, 4BUO, 4BV0, 4BWB, 5T04
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
4BUO, 4BV0, 3ZEV, 4BWB
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5DYS, 5EN0
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NJ6, 5NDD, 5NDZ
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon receptor family
GLR
CRFR1
CRF1
glucagon
TM2 2x48
S
A
L
A
2 2 3
4K5Y, 5EE7, 4Z9G
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NJ6, 5NDD, 5NDZ
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Free fatty acid
FFAR1
NTR1
NTS1
FFA1
TM3 3x49
G
E
A
2 2 5
4PHU, 5TZR, 5TZY, 4GRV, 4XES
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 2
5UIW, 4MBS
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEW, 5VEX
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 18
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 2YCW, 4GPO, 2Y01, 4AMJ, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEW, 5VEX
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 2
5UIW, 4MBS
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM5 5x63
L
Y
A
2 1 24
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEW, 5VEX
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4K5Y, 4Z9G
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 3
4PHU, 5TZR, 5TZY
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5U09, 5XR8, 5XRA, 5TGZ
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7D, 5L7I
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49
D
N
2 1 5
4XNW, 4PY0, 4PXZ, 4XNV, 4NTJ
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 4
4ZWJ, 5DGY, 5W0P, 4A4M
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon receptor family
GLR
GLP1R
CRFR1
GLP-1
CRF1
glucagon
TM6 6x30
K
Y
A
3 2 5
4Z9G, 5VEW, 4K5Y, 5EE7, 5VEX
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36
T
A
2 1 24
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 2
5UIW, 4MBS
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 18
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 2YCW, 4GPO, 2Y01, 4AMJ, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
GLP-1
glucagon
TM2 2x59
I
V
F
2 1 3
5VEW, 5EE7, 5VEX
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CCR9
CXCR4
CCR9
TM6 6x36
T
V
P
A
2 1 4
4RWS, 3OE0, 5LWE, 3OE9
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
GLP-1
glucagon
TM2 2x56
S
A
C
2 1 3
5VEW, 5EE7, 5VEX
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5XPR, 5X93
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52
A
L
2 1 28
3PWH, 5N2R, 5OM4, 5IU8, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 4UHR, 5IU4, 5NLX, 5IUB, 2YDV, 5IUA, 4UG2, 5MZJ, 3RFM, 5OM1, 5OLO, 5OLH, 5IU7, 5OLV, 5MZP, 2YDO, 3UZC
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
GLP-1
glucagon
TM3 3x24
S
G
A
2 1 3
5VEW, 5EE7, 5VEX
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5TGZ, 5XR8, 5XRA
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4K5Y, 4Z9G
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4K5Y, 4Z9G
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Proteinase-activated
FFAR1
PAR2
FFA1
PAR2
TM3 3x34
F
G
A
2 2 5
5NJ6, 4PHU, 5TZR, 5NDD, 5NDZ
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5XPR, 5X93
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM7 7x41
T
S
A
2 1 24
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 2
5UIW, 4MBS
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4K5Y, 4Z9G
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x45
G
A
C
1 1 3
5VEX, 5VEW, 5NX2
Intermediate
Inactive
A (Rhodopsin)
Lipid
Aminergic
Adrenoceptors
Free fatty acid
FFAR1
ADRB1
FFA1
β1
TM5 5x58
Y
F
A
2 2 21
2Y03, 4PHU, 2Y02, 2Y04, 2VT4, 2Y00, 4GPO, 4AMJ, 4BVN, 2Y01, 2YCW, 5TZY, 5TZR, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
GLP-1
glucagon
ECL1
T
Q
L
G
D
F
A
E
R
2 1 2
5EE7, 5NX2
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
5A8E, 4BVN
Active
Intermediate
Inactive
A (Rhodopsin)
Sensory
Lipid
Peptide
Neurotensin
Opsins
Leukotriene
OPSD
NTR1
OPSD
Q9WTK1
NTS1
Rhodopsin
BLT1
N-term
G
S
D
N
A
C
4 3 16
4A4M, 4ZWJ, 5DGY, 5X33, 4XES, 5T04, 2X72, 4BEZ, 3C9M, 4GRV, 5EN0, 5W0P, 4XEE, 5DYS, 2J4Y, 4BEY
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEW, 5VEX
Inactive
A (Rhodopsin)
Aminergic
Peptide
Adrenoceptors
Apelin
Dopamine
APJ
ADRB1
DRD2
apelin
β1
D2
TM3 3x40
I
V
V
A
3 3 4
5A8E, 6CM4, 5VBL, 4BVN
Active
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
Cannabinoid
CNR1
LPAR1
LPA1
CB1
TM5 5x37
E
D
K
C
2 2 4
5TGZ, 5XR8, 5XRA, 4Z36
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM2 2x39
R
A
1 1 2
5YQZ, 5EE7
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
Active
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Protein
Chemokine
Adrenoceptors
5-Hydroxytryptamine
Dopamine
CXCR4
ADRB1
DRD3
ADRB2
5HT2B
5HT1B
CXCR4
5-HT1B
5-HT2B
β1
β2
D3
TM3 3x41
L
E
M
W
6 4 19
4RWS, 3NYA, 5TVN, 5TUD, 3NY8, 3ODU, 4IAQ, 4IAR, 4NC3, 3OE8, 3OE0, 3D4S, 3NY9, 5A8E, 3OE6, 3PBL, 3OE9, 4IB4, 5V54
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 4
4ZWJ, 5DGY, 2X72, 5W0P
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 18
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 2YCW, 4GPO, 2Y01, 4AMJ, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
3PDS, 4QKX
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5XPR, 5X93
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA1R
AA2AR
DRD2
A1
A2A
D2
TM6 6x41
L
V
A
3 2 25
3PWH, 6CM4, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
4XEE, 4GRV, 5T04, 4XES
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
Inactive
A (Rhodopsin)
Aminergic
Peptide
Adrenoceptors
Endothelin
ADRB1
EDNRB
β1
ETB
TM7 7x48
I
F
A
M
2 2 20
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 4GPO, 4AMJ, 2Y01, 5XPR, 3ZPQ, 5X93, 2YCW, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 2YCW, 4GPO, 2Y01, 4AMJ, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEW, 5VEX
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49
D
N 2 1 5
4XNW, 4PY0, 4PXZ, 4XNV, 4NTJ
0.65 0.85
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NJ6, 5NDD, 5NDZ
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
5A8E, 4BVN
0.21 -1.25
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5TGZ, 5XR8, 5XRA
0.26 2.80
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.68 -0.02
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQH, 6BQG
0.65 0.85
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
4RWS, 3OE0, 3OE9
3.16 0.14
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEW, 5VEX
0.41 -1.12
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5XPR, 5X93
0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM5 5x63
L
Y
A 2 1 24
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NJ6, 5NDD, 5NDZ
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NJ6, 5NDD, 5NDZ
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NJ6, 5NDD, 5NDZ
0.40 0.11
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 3
4PHU, 5TZR, 5TZY
0.54 -1.71
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Proteinase-activated
FFAR1
PAR2
FFA1
PAR2
TM3 3x34
F
G
A 2 2 5
5NJ6, 4PHU, 5TZR, 5NDD, 5NDZ
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.17 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
ECL1
Q
G
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.17 0.54 -1.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
0.24 -0.67
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
4BUO, 4BV0, 3ZEV, 4BWB
0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NJ6, 5NDD, 5NDZ
0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 3
4PHU, 5TZR, 5TZY
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEW, 5VEX
0.17 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
GLP-1
glucagon
TM2 2x59
I
V
F 2 1 3
5VEW, 5EE7, 5VEX
0.54 -1.71
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.11 0.26 2.80
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.54 -1.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
0.53 -0.71
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 18
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 2YCW, 4GPO, 2Y01, 4AMJ, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
0.11 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.17 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4K5Y, 4Z9G
0 0.50
Active
Intermediate
Inactive
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Leukotriene
NTR1
Q9WTK1
NTS1
BLT1
ECL2
G
S
A 2 2 5
4XEE, 4GRV, 5T04, 5X33, 4XES
0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5TGZ, 5XR8, 5XRA
0.40 0.11
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Peptide
Adenosine
Neurotensin
Dopamine
AA1R
AA2AR
NTR1
DRD2
NTS1
A1
A2A
D2
TM6 6x37
L
A 4 3 26
3PWH, 6CM4, 5N2R, 4GRV, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
4XEE, 4GRV, 5T04, 4XES
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.21 -1.25
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.17 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon receptor family
GLR
GLP1R
CRFR1
GLP-1
CRF1
glucagon
TM6 6x30
K
Y
A 3 2 5
4Z9G, 5VEW, 4K5Y, 5EE7, 5VEX
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEW, 5VEX
0.17 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
5A8E, 4BVN
0.61 -0.46
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 18
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 2YCW, 4GPO, 2Y01, 4AMJ, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
0.50 0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 2YCW, 4GPO, 2Y01, 4AMJ, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
0.11 0.21 -1.25
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM7 7x41
T
S
A 2 1 24
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
GLP-1
glucagon
TM3 3x24
S
G
A 2 1 3
5VEW, 5EE7, 5VEX
0.17 0 0.50
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
4GRV, 3ZEV, 4XES, 4XEE, 4BUO, 4BV0, 4BWB, 5T04
0.21 -1.25
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5XPR, 5X93
0.53 -0.71
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
D
N
C 2 1 11
4BEY, 4ZWJ, 5DGY, 2X72, 4BEZ, 3C9M, 5EN0, 5W0P, 5DYS, 2J4Y, 4A4M
0.68 -0.02
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
1.00 1.15
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.5 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 2
5UIW, 4MBS
0.40 0.11
Inactive
A (Rhodopsin)
Aminergic
Peptide
Apelin
Dopamine
APJ
DRD2
apelin
D2
TM3 3x40
I
V
A 2 2 2
6CM4, 5VBL
0 0.50
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.65 0.85
Active
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Protein
Chemokine
Adrenoceptors
5-Hydroxytryptamine
Dopamine
CXCR4
ADRB1
DRD3
ADRB2
5HT2B
5HT1B
CXCR4
5-HT1B
5-HT2B
β1
β2
D3
TM3 3x41
L
E
M
W 6 4 19
4RWS, 3NYA, 5TVN, 5TUD, 3NY8, 3ODU, 4IAQ, 4IAR, 4NC3, 3OE8, 3OE0, 3D4S, 3NY9, 5A8E, 3OE6, 3PBL, 3OE9, 4IB4, 5V54
0.49 -2.09
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5XPR, 5X93
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
GLP-1
glucagon
ECL1
T
G
E 2 1 2
5EE7, 5NX2
0.40 0.11
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NJ6, 5NDD, 5NDZ
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 2
5UIW, 4MBS
0.69 0.43
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 4
4ZWJ, 5DGY, 5W0P, 4A4M
0.53 -0.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.68 -0.02
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
3PDS, 4QKX
0.68 -0.02
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.33 0 0.50
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Free fatty acid
FFAR1
NTR1
NTS1
FFA1
TM3 3x49
G
E
A 2 2 5
4PHU, 5TZR, 5TZY, 4GRV, 4XES
0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5U09, 5XR8, 5XRA, 5TGZ
0 0.50
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
1.00 1.15
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 18
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 2YCW, 4GPO, 2Y01, 4AMJ, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
0.24 -0.67
Intermediate
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon receptor family
GLP1R
CRFR1
GLP-1
CRF1
ECL2 45x52
F
T
A 2 2 3
4K5Y, 4Z9G, 5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4K5Y, 4Z9G
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NJ6, 5NDD, 5NDZ
0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 18
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 2YCW, 4GPO, 2Y01, 4AMJ, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
0.33 0.61 -0.46
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA1R
AA2AR
DRD2
A1
A2A
D2
TM6 6x41
L
V
A 3 2 25
3PWH, 6CM4, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
0 0.50
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5DYS, 5EN0
0.29 0.41 -1.12
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 2
5UIW, 4MBS
0.53 -0.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 2YCW, 4GPO, 2Y01, 4AMJ, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NJ6, 5NDD, 5NDZ
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM2 2x39
R
A 1 1 2
5YQZ, 5EE7
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7D, 5L7I
0.54 -1.71
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52
A
L 2 1 28
3PWH, 5N2R, 5OM4, 5IU8, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 4UHR, 5IU4, 5NLX, 5IUB, 2YDV, 5IUA, 4UG2, 5MZJ, 3RFM, 5OM1, 5OLO, 5OLH, 5IU7, 5OLV, 5MZP, 2YDO, 3UZC
0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 2
5UIW, 4MBS
0.65 0.85
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
0 0.50
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 4
4ZWJ, 5DGY, 2X72, 5W0P
0.39 0.77
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36
T
A 2 1 24
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5XPR, 5X93
0 0.50
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM2 2x59 I
F
1 1 2
5VEW, 5VEX
0.33 0.41 -1.12
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53 M
V
1 1 18
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 2YCW, 4GPO, 2Y01, 4AMJ, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
0.33 0.24 -0.67
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x42 P
A
1 1 1
5NX2
1.0 3.16 0.14
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
GLP-1
glucagon
TM2 2x56 S
A
C
2 1 3
5VEW, 5EE7, 5VEX
0.5 0.50 0.46
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63 H
C
1 1 2
3PDS, 4QKX
0.11 0.61 0.11
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.65 0.85
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54 S
A
1 1 2
5XPR, 5X93
0.50 0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.61 -0.46
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Peptide
Adenosine
Neurotensin
Dopamine
AA1R
AA2AR
NTR1
DRD2
NTS1
A1
A2A
D2
TM6 6x37 L
A
4 3 26
3PWH, 6CM4, 5N2R, 4GRV, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
ECL2 45x52 F
A
1 1 2
4K5Y, 4Z9G
0.54 -1.71
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55 R
A
1 1 23
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
0.21 1.81
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x47 H
V
1 1 1
5NX2
1.0 0.61 0.11
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NJ6, 5NDD, 5NDZ
0.61 -0.46
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32 R
E
1 1 3
5TGZ, 5XR8, 5XRA
0.21 1.81
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55 R
Y
1 1 2
5XPR, 5X93
0.21 1.81
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48 T
A
1 1 1
5LWE
0.66 0.25
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54 I
A
1 1 4
4BUO, 4BV0, 3ZEV, 4BWB
0.41 -1.12
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37 D
C
1 1 1
4Z36
0.69 0.43
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35 E
A
1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
0.40 0.11
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37 Q
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0.39 0.77
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48 I
A
1 1 2
5XPR, 5X93
0.41 -1.12
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM7 7x41 T
A
1 1 1
5N2S
0.66 0.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46 G
A
1 1 3
5NJ6, 5NDD, 5NDZ
1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM2 2x48 A
L
1 1 1
5EE7
0.5 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39 S
A
1 1 1
5WF6
0.50 0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x34 G
A
1 1 3
5NJ6, 5NDD, 5NDZ
1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM3 3x24 S
A
1 1 2
5VEW, 5VEX
0.33 0.50 0.46
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
ECL1 D
R
1 1 1
5NX2
0.69 0.43
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x63 C
A
1 1 1
5NX2
0.17 0.68 -0.02
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49 D
N
2 1 5
4XNW, 4PY0, 4PXZ, 4XNV, 4NTJ
0.69 0.43
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
Dopamine
ADRB1
DRD2
β1
D2
TM3 3x40 I
V
A
2 2 3
5A8E, 6CM4, 4BVN
0.41 -1.12
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40 V
F
1 1 2
5L7D, 5L7I
0.09 0.61 -0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47 S
C
1 1 1
5LWE
0.50 0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49 K
E
1 1 2
5UIW, 4MBS
0.26 2.80
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37 E
K
1 1 3
5TGZ, 5XR8, 5XRA
0.40 0.11
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.66 0.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60 L
A
1 1 2
4K5Y, 4Z9G
0.21 -1.25
Active
Intermediate
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2B
5-HT2B
TM3 3x41 M
W
1 1 4
5TUD, 5TVN, 4NC3, 4IB4
0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36 V
A
1 1 2
4K5Y, 4Z9G
0.61 -0.46
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 2YCW, 4GPO, 2Y01, 4AMJ, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
0.11 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36 T
P
1 1 3
4RWS, 3OE0, 3OE9
0.66 0.25
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM4 4x48 S
A
1 1 2
5VEW, 5VEX
0.17 0.50 0.46
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36 F
A
1 1 18
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 2YCW, 4GPO, 2Y01, 4AMJ, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
0.44 0.54 -1.71
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43 V
A
1 1 4
4XEE, 4GRV, 5T04, 4XES
0.61 -0.46
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36 K
A
1 1 2
5XPR, 5X93
0.26 2.80
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Protein
Chemokine
5-Hydroxytryptamine
Dopamine
CXCR4
DRD3
5HT1B
CXCR4
5-HT1B
D3
TM3 3x41 L
W
3 3 10
4RWS, 3OE0, 3ODU, 4IAQ, 3OE6, 4IAR, 3PBL, 3OE9, 3OE8, 5V54
0.21 -1.25
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x49 G
A
1 1 3
4PHU, 5TZR, 5TZY
1.00 1.15
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43 K
A
1 1 23
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
0.26 2.80
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x31 C
F
1 1 2
5VEW, 5VEX
0.17 0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4K5Y, 4Z9G
0.26 2.80
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5DYS, 5EN0
0.43 0.66 0.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x30 Y
A
1 1 2
4K5Y, 4Z9G
0.53 -0.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38 I
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.41 -1.12
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.49 -2.09
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37 H
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.61 0.11
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM7 7x39 F
A
1 1 1
5EE7
0.33 0.54 -1.71
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45 C
N
1 1 2
6BQH, 6BQG
0.68 -0.02
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33 A
D
1 1 2
5UIW, 4MBS
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62 T
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0.66 0.25
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM3 3x32 M
C
1 1 2
5VEW, 5VEX
0.33 0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM3 3x24 G
A
1 1 1
5EE7
0.33 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM6 6x48 E
F
1 1 1
5EE7
0.67 0.40 0.11
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
ECL1 Q
A
1 1 1
5NX2
0.39 0.77
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x34 F
A
1 1 2
4PHU, 5TZR
0.54 -1.71
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21 K
G
1 1 1
5X33
0.26 2.80
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51 D
C
1 1 1
4RWS
0.69 0.43
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM5 5x63 Y
A
1 1 1
5N2S
0.53 -0.71
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM3 3x49 E
A
1 1 2
4GRV, 4XES
0.40 0.11
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31 D
K
1 1 1
4BVN
0.22 0.69 0.43
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48 F
M
1 1 18
2Y03, 2Y02, 2Y04, 2VT4, 2Y00, 4BVN, 2YCW, 4GPO, 2Y01, 4AMJ, 3ZPQ, 2YCY, 5F8U, 2YCZ, 5A8E, 2YCX, 4AMI, 3ZPR
0.33 0.54 -1.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51 Y
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.53 -0.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2 G
M
1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
1.00 1.15
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x45 G
A
C
1 1 3
5VEX, 5VEW, 5NX2
1.0 1.00 1.15
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42 T
A
1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
0.66 0.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48 I
A
1 1 2
4K5Y, 4Z9G
0.41 -1.12
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64 M
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51 F
A
1 1 2
4K5Y, 4Z9G
0.54 -1.71
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56 D
A
1 1 1
5X93
0.69 0.43
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM3 3x31 L
F
1 1 1
5NX2
0.5 0.21 -1.25
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.61 -0.46
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 4
4ZWJ, 5DGY, 2X72, 5W0P
0.57 0.40 0.11
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60 C
Y
1 1 2
5UIW, 4MBS
0.68 -0.02
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM7 7x56 V
A
1 1 1
5NX2
0.17 0.61 -0.46
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52 A
L
2 1 28
3PWH, 5N2R, 5OM4, 5IU8, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 4UHR, 5IU4, 5NLX, 5IUB, 2YDV, 5IUA, 4UG2, 5MZJ, 3RFM, 5OM1, 5OLO, 5OLH, 5IU7, 5OLV, 5MZP, 2YDO, 3UZC
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM4 4x54 M
A
1 1 1
5EE7
0.17 0.24 -0.67
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50 D
N
1 1 1
5WF5
0.69 0.43
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53 S
A
1 1 5
6FFI, 5CGC, 4OO9, 5CGD, 6FFH
0.50 0.46
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
GLP-1
glucagon
ECL2 G
A
E
2 1 2
5EE7, 5NX2
1.00 1.15
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54 A
L
1 1 8
4GRV, 3ZEV, 4XES, 4XEE, 4BUO, 4BV0, 4BWB, 5T04
0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM6 6x41 V
A
1 1 23
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38 S
A
1 1 2
4K5Y, 4Z9G
0.50 0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36 T
A
2 1 24
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5N2S, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
0.66 0.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NJ6, 5NDD, 5NDZ
0.24 -0.67
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40 M
Y
2 1 4
4ZWJ, 5DGY, 5W0P, 4A4M
0.71 0.24 -0.67
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
ADRB2
β1
β2
TM3 3x41 E
W
2 1 5
5A8E, 3NYA, 3D4S, 3NY8, 3NY9
0.33 0.40 0.11
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x51 I
C
1 1 2
5VEW, 5VEX
0.67 0.41 -1.12
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
ECL2 45x52 T
A
1 1 1
5NX2
0.5 0.66 0.25
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67 V
A
1 1 1
5X33
0.61 -0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36 V
A
1 1 1
5LWE
0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x52 G
I
1 1 2
5VEW, 5VEX
0.33 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM1 1x48 G
A
1 1 1
5EE7
0.17 1.00 1.15
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM7 7x41 S
A
1 1 23
3PWH, 5N2R, 5IU8, 5OM4, 3REY, 5OLG, 3UZA, 5NM2, 5NM4, 5OLZ, 5IU4, 5IUB, 5NLX, 5IUA, 5MZJ, 5OM1, 3RFM, 5OLO, 5OLH, 5IU7, 5OLV, 3UZC, 5MZP
0.50 0.46
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
ECL3 D
C
1 1 8
4BEZ, 3C9M, 4A4M, 5EN0, 5DYS, 2J4Y, 2X72, 4BEY
0.69 0.43
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46 L
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 2
5UIW, 4MBS
1.00 1.15
Inactive