Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4K5Y, 4Z9G
Pos Match 1
Intermediate
A (Rhodopsin)
Lipid
Peptide
Proteinase-activated
Free fatty acid
FFAR1
PAR2
PAR2
FFA1
TM3 3x34
G
F
A
2 2 5
5NDD, 5NDZ, 5TZR, 5NJ6, 4PHU
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEX, 5VEW
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5EN0, 5DYS
13
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 2
4MBS, 5UIW
2 1 5
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5XPR, 5X93
4
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM2 2x52
A
L
2 1 28
2YDO, 2YDV, 5N2S, 4UG2, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 4UHR, 5IUB, 5OM1
1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5XR8, 5TGZ, 5XRA
1 3
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM2 2x56
S
C
A
2 1 3
5VEX, 5VEW, 5EE7
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NDD, 5NDZ, 5NJ6
1 1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NDD, 5NDZ, 5NJ6
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49
D
N
2 1 5
4PY0, 4XNW, 4PXZ, 4XNV, 4NTJ
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM7 7x41
T
S
A
2 1 24
5N2S, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY, 5A8E, 5F8U, 2Y02, 3ZPQ, 2YCW, 2YCZ, 2Y00, 2VT4, 4AMJ, 4BVN, 2Y03
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
Pos Match
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NDD, 5NDZ, 5NJ6
1
Inactive
A (Rhodopsin)
Aminergic
Peptide
Endothelin
Adrenoceptors
ADRB1
EDNRB
ETB
β1
TM7 7x48
F
I
A
M
2 2 20
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY, 5A8E, 5F8U, 2Y02, 5X93, 3ZPQ, 2YCW, 2YCZ, 5XPR, 2Y00, 2VT4, 4AMJ, 4BVN, 2Y03
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 2
4MBS, 5UIW
3 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLR
GLP1R
CRFR1
glucagon
CRF1
GLP-1
TM6 6x30
K
Y
A
3 2 5
4Z9G, 4K5Y, 5VEX, 5VEW, 5EE7
Intermediate
Active
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
4GRV, 4BV0, 4XEE, 4XES, 4BWB, 4BUO, 3ZEV, 5T04
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
4BVN, 5A8E
Pos Match Pos Match 3
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
2YDO, 2YDV, 4UHR, 4UG2
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 5
2X72, 5W0P, 5DGY, 4ZWJ, 6CMO
8
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM3 3x36
T
A
2 1 24
5N2S, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
16
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7D, 5L7I
1
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
4XES, 4GRV, 4XEE, 5T04
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
1
Active
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
Cannabinoid
CNR1
LPAR1
LPA1
CB1
TM5 5x37
E
D
K
C
2 2 4
5XR8, 5TGZ, 5XRA, 4Z36
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
2 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5YQZ, 5EE7
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CCR9
CCR9
CXCR4
TM6 6x36
T
V
A
P
2 1 4
3OE9, 4RWS, 3OE0, 5LWE
2 1 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEX, 5VEW
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4K5Y, 4Z9G
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 2
4MBS, 5UIW
1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
1 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEX, 5VEW
1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLR
CRFR1
CRF1
glucagon
TM2 2x48
A
S
L
A
2 2 3
4K5Y, 4Z9G, 5EE7
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEX, 5VEW
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Peptide
Aminergic
Neurotensin
Adenosine
Dopamine
AA1R
AA2AR
NTR1
DRD2
A2A
A1
D2
NTS1
TM6 6x37
L
A
4 3 26
4GRV, 5N2S, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 6CM4, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
1 1 4
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NDD, 5NDZ, 5NJ6
1 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEX, 5VEW
1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
2YDO, 2YDV, 4UHR, 4UG2
8
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
2YDO, 2YDV, 4UHR, 4UG2
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Free fatty acid
FFAR1
NTR1
FFA1
NTS1
TM3 3x49
G
E
A
2 2 6
4GRV, 5TZR, 4PHU, 5KW2, 4XES, 5TZY
Pos Match 2
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 5
4A4M, 5W0P, 5DGY, 4ZWJ, 6CMO
1 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM5 5x63
L
Y
A
2 1 24
5N2S, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
Inactive
A (Rhodopsin)
Aminergic
Peptide
Apelin
Dopamine
Adrenoceptors
APJ
ADRB1
DRD2
apelin
D2
β1
TM3 3x40
I
V
A
V
3 3 4
6CM4, 5VBL, 4BVN, 5A8E
2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM3 3x24
G
S
A
2 1 3
5VEX, 5VEW, 5EE7
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 18
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY, 5A8E, 5F8U, 2Y02, 3ZPQ, 2YCW, 2YCZ, 2Y00, 2VT4, 4AMJ, 4BVN, 2Y03
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4K5Y, 4Z9G
Intermediate
Inactive
A (Rhodopsin)
Lipid
Aminergic
Free fatty acid
Adrenoceptors
FFAR1
ADRB1
FFA1
β1
TM5 5x58
Y
F
A
2 2 22
2YCX, 4AMI, 2Y04, 3ZPR, 4GPO, 2YCY, 5A8E, 2Y02, 5TZR, 2YCZ, 5TZY, 5KW2, 2Y00, 4AMJ, 4BVN, 2Y03, 4PHU, 5F8U, 3ZPQ, 2YCW, 2VT4, 2Y01
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4K5Y, 4Z9G
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4K5Y, 4Z9G
1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5XR8, 5U09, 5TGZ, 5XRA
1
Inactive
Active
Intermediate
A (Rhodopsin)
Sensory
Lipid
Peptide
Opsins
Neurotensin
Leukotriene
OPSD
NTR1
Q9WTK1
OPSD
BLT1
NTS1
Rhodopsin
ECL2
G
N
D
S
C
A
4 3 17
4GRV, 6CMO, 5EN0, 4BEZ, 5X33, 4A4M, 5W0P, 5DGY, 3C9M, 4XES, 4XEE, 2J4Y, 2X72, 4ZWJ, 5DYS, 4BEY, 5T04
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4K5Y, 4Z9G
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 18
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY, 5A8E, 5F8U, 2Y02, 3ZPQ, 2YCW, 2YCZ, 2Y00, 2VT4, 4AMJ, 4BVN, 2Y03
2
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
4PHU, 5KW2, 5TZR, 5TZY
2 1 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
12
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5XPR, 5X93
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA1R
AA2AR
DRD2
A2A
A1
D2
TM6 6x41
L
V
A
3 2 25
5N2S, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 6CM4, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5XPR, 5X93
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
3PDS, 4QKX
8
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4K5Y, 4Z9G
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
ECL1
L
G
D
Q
T
E
F
A
R
2 1 2
5NX2, 5EE7
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 17
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 1
Inactive
Active
Intermediate
A (Rhodopsin)
Protein
Aminergic
Dopamine
5-Hydroxytryptamine
Chemokine
Adrenoceptors
5HT2B
5HT1B
CXCR4
ADRB1
DRD3
ADRB2
β2
5-HT2B
D3
CXCR4
5-HT1B
β1
TM3 3x41
L
E
M
W
6 4 20
3NY9, 4IAQ, 3OE0, 6G79, 5A8E, 4IAR, 5V54, 3ODU, 4NC3, 3OE6, 3NY8, 3PBL, 3OE8, 4IB4, 5TUD, 3D4S, 5TVN, 4RWS, 3NYA, 3OE9
1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 18
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY, 5A8E, 5F8U, 2Y02, 3ZPQ, 2YCW, 2YCZ, 2Y00, 2VT4, 4AMJ, 4BVN, 2Y03
Intermediate
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
CRFR1
CRF1
GLP-1
ECL2 45x52
T
F
A
2 2 3
4K5Y, 5NX2, 4Z9G
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NDD, 5NDZ, 5NJ6
5
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
4BUO, 4BWB, 3ZEV, 4BV0
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQH, 6BQG
Pos Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 2
4MBS, 5UIW
4
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C
A
1 1 3
5NX2, 5VEX, 5VEW
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM2 2x59
I
V
F
2 1 3
5VEX, 5VEW, 5EE7
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
2
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5XPR, 5X93
0.07 0 0.50 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5XPR, 5X93
0.13 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
G
Q
A 1 1 1
5NX2
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
0.08 0 0.50 1 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
0.24 -0.67
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
0.05 0 0.50
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.67 1.00 1.15 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
2YDO, 2YDV, 4UHR, 4UG2
0.13 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 4
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
0 0.50 Pos & Mutant AA Match
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 5
4A4M, 5W0P, 5DGY, 4ZWJ, 6CMO
0.01 0.53 -0.71 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.13 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5YQZ, 5EE7
0 0.50 1
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM2 2x52
A
L 2 1 28
2YDO, 2YDV, 5N2S, 4UG2, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 4UHR, 5IUB, 5OM1
0.63 0.21 -1.25 1
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
4XES, 4GRV, 4XEE, 5T04
0.19 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
ECL1
G
T
E 2 1 2
5NX2, 5EE7
0.40 0.11
Inactive
Active
Intermediate
A (Rhodopsin)
Protein
Aminergic
Dopamine
5-Hydroxytryptamine
Chemokine
Adrenoceptors
5HT2B
5HT1B
CXCR4
ADRB1
DRD3
ADRB2
β2
5-HT2B
D3
CXCR4
5-HT1B
β1
TM3 3x41
L
E
M
W 6 4 20
3NY9, 4IAQ, 3OE0, 6G79, 5A8E, 4IAR, 5V54, 3ODU, 4NC3, 3OE6, 3NY8, 3PBL, 3OE8, 4IB4, 5TUD, 3D4S, 5TVN, 4RWS, 3NYA, 3OE9
0.03 0.49 -2.09 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
0 0.50
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Peptide
Aminergic
Neurotensin
Adenosine
Dopamine
AA1R
AA2AR
NTR1
DRD2
A2A
A1
D2
NTS1
TM6 6x37
L
A 4 3 26
4GRV, 5N2S, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 6CM4, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
0.04 0 0.50 1 1 4
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7D, 5L7I
0.54 -1.71 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NDD, 5NDZ, 5NJ6
0.13 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
0.13 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4K5Y, 4Z9G
0 0.50 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM7 7x41
T
S
A 2 1 24
5N2S, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
0.38 0 0.50 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
0.05 0.53 -0.71
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49
D
N 2 1 5
4PY0, 4XNW, 4PXZ, 4XNV, 4NTJ
0.72 0.65 0.85
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NDD, 5NDZ, 5NJ6
0.73 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4K5Y, 4Z9G
0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5XR8, 5U09, 5TGZ, 5XRA
0.01 0 0.50 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4K5Y, 4Z9G
0 0.50
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Free fatty acid
FFAR1
NTR1
FFA1
NTS1
TM3 3x49
G
E
A 2 2 6
4GRV, 5TZR, 4PHU, 5KW2, 4XES, 5TZY
0.01 0 0.50 Pos & Mutant AA Match 2
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 18
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY, 5A8E, 5F8U, 2Y02, 3ZPQ, 2YCW, 2YCZ, 2Y00, 2VT4, 4AMJ, 4BVN, 2Y03
0.05 0.24 -0.67
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5XR8, 5TGZ, 5XRA
0.04 0.40 0.11 1 3
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
N
D
C 2 1 12
5EN0, 4BEZ, 4A4M, 5W0P, 5DGY, 3C9M, 2J4Y, 2X72, 4ZWJ, 5DYS, 4BEY, 6CMO
0.68 -0.02
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEX, 5VEW
0.68 -0.02 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
4RWS, 3OE0, 3OE9
0.0 3.16 0.14 2 1 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50
Inactive
Active
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Leukotriene
NTR1
Q9WTK1
BLT1
NTS1
ECL2
G
S
A 2 2 5
4XES, 4GRV, 4XEE, 5X33, 5T04
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 2
4MBS, 5UIW
0.03 0.65 0.85 4
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM5 5x63
L
Y
A 2 1 24
5N2S, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
0.06 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4K5Y, 4Z9G
0 0.50 Pos & Mutant AA Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 18
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY, 5A8E, 5F8U, 2Y02, 3ZPQ, 2YCW, 2YCZ, 2Y00, 2VT4, 4AMJ, 4BVN, 2Y03
0.1 0.11 0 0.50
Intermediate
Active
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
4GRV, 4BV0, 4XEE, 4XES, 4BWB, 4BUO, 3ZEV, 5T04
0.37 0.21 -1.25
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.08 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4K5Y, 4Z9G
0.2 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4K5Y, 4Z9G
0 0.50 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
3PDS, 4QKX
0.0 0.68 -0.02 8
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 12
Intermediate
A (Rhodopsin)
Lipid
Peptide
Proteinase-activated
Free fatty acid
FFAR1
PAR2
PAR2
FFA1
TM3 3x34
G
F
A 2 2 5
5NDD, 5NDZ, 5TZR, 5NJ6, 4PHU
0.07 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY, 5A8E, 5F8U, 2Y02, 3ZPQ, 2YCW, 2YCZ, 2Y00, 2VT4, 4AMJ, 4BVN, 2Y03
0.11 0.11 0.21 -1.25
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5XPR, 5X93
0.1 0 0.50 4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM2 2x59
I
V
F 2 1 3
5VEX, 5VEW, 5EE7
0.54 -1.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NDD, 5NDZ, 5NJ6
0.13 0 0.50 1 3
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 5
2X72, 5W0P, 5DGY, 4ZWJ, 6CMO
0.01 0.39 0.77 8
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5XR8, 5TGZ, 5XRA
0.11 0.26 2.80 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NDD, 5NDZ, 5NJ6
0.11 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 18
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY, 5A8E, 5F8U, 2Y02, 3ZPQ, 2YCW, 2YCZ, 2Y00, 2VT4, 4AMJ, 4BVN, 2Y03
0.23 0.33 0.61 -0.46 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NDD, 5NDZ, 5NJ6
0.05 0 0.50 1 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 2
4MBS, 5UIW
0.69 0.43 2 1 5
Inactive
A (Rhodopsin)
Peptide
Aminergic
Apelin
Dopamine
APJ
DRD2
apelin
D2
TM3 3x40
V
I
A 2 2 2
6CM4, 5VBL
0.06 0 0.50 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.06 0 0.50 1
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
4PHU, 5KW2, 5TZR, 5TZY
0.01 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4K5Y, 4Z9G
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM3 3x24
G
S
A 2 1 3
5VEX, 5VEW, 5EE7
0.07 0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
4PHU, 5KW2, 5TZR, 5TZY
0.06 0 0.50 2 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEX, 5VEW
0.07 0.41 -1.12
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NDD, 5NDZ, 5NJ6
0.14 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 2
4MBS, 5UIW
0.07 0.53 -0.71 1
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA1R
AA2AR
DRD2
A2A
A1
D2
TM6 6x41
L
V
A 3 2 25
5N2S, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 6CM4, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
0.05 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
0.05 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
2YDO, 2YDV, 4UHR, 4UG2
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEX, 5VEW
0.07 0 0.50
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
4BUO, 4BWB, 3ZEV, 4BV0
0.02 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.01 0 0.50 2 1 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4K5Y, 4Z9G
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NDD, 5NDZ, 5NJ6
0.0 0 0.50 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.2 1.00 1.15
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM3 3x36
T
A 2 1 24
5N2S, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
0.02 0 0.50 16
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 1
Intermediate
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
CRFR1
CRF1
GLP-1
ECL2 45x52
T
F
A 2 2 3
4K5Y, 5NX2, 4Z9G
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 2
4MBS, 5UIW
0.12 0.40 0.11 3 1 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 17
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.03 0 0.50 2
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5EN0, 5DYS
0.04 0.29 0.41 -1.12 13
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
2YDO, 2YDV, 4UHR, 4UG2
0.03 0 0.50 8
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5XPR, 5X93
0.09 0.53 -0.71
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
4BVN, 5A8E
0.24 0.61 -0.46 2
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY, 5A8E, 5F8U, 2Y02, 3ZPQ, 2YCW, 2YCZ, 2Y00, 2VT4, 4AMJ, 4BVN, 2Y03
0.03 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71 1
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLR
GLP1R
CRFR1
glucagon
CRF1
GLP-1
TM6 6x30
K
Y
A 3 2 5
4Z9G, 4K5Y, 5VEX, 5VEW, 5EE7
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 2 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEX, 5VEW
0.07 0.54 -1.71 1
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQH, 6BQG
0.67 0.65 0.85 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 3
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
4BVN, 5A8E
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 3
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 18
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY, 5A8E, 5F8U, 2Y02, 3ZPQ, 2YCW, 2YCZ, 2Y00, 2VT4, 4AMJ, 4BVN, 2Y03
0.04 0.50 0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NDD, 5NDZ, 5NJ6
0.01 0.40 0.11 5
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38 S
A
1 1 2
4K5Y, 4Z9G
0.13 0.50 0.46 1
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
ECL3 D
C
1 1 8
4A4M, 3C9M, 2J4Y, 5EN0, 2X72, 4BEZ, 5DYS, 4BEY
0.69 0.43
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36 K
A
1 1 2
5XPR, 5X93
0.06 0.26 2.80 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51 I
C
1 1 2
5VEX, 5VEW
0.6 0.41 -1.12 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56 D
A
1 1 1
5X93
0.01 0.69 0.43
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52 G
I
1 1 2
5VEX, 5VEW
0.2 1.00 1.15
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 Q
A
1 1 1
5NX2
0.39 0.77
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x49 G
A
1 1 4
4PHU, 5KW2, 5TZR, 5TZY
0.01 1.00 1.15 Pos & Wild Type AA Match 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49 K
E
1 1 2
4MBS, 5UIW
0.13 0.26 2.80 3 1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46 G
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.54 1.00 1.15
Intermediate
Inactive
A (Rhodopsin)
Lipid
Aminergic
Free fatty acid
Adrenoceptors
FFAR1
ADRB1
FFA1
β1
TM5 5x58 Y
F
A
2 2 22
2YCX, 4AMI, 2Y04, 3ZPR, 4GPO, 2YCY, 5A8E, 2Y02, 5TZR, 2YCZ, 5TZY, 5KW2, 2Y00, 4AMJ, 4BVN, 2Y03, 4PHU, 5F8U, 3ZPQ, 2YCW, 2VT4, 2Y01
0.72 0.53 -0.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42 T
A
1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
0.09 0.66 0.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54 M
A
1 1 1
5EE7
0.07 0.24 -0.67
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.12 0.61 -0.46 3
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40 M
Y
2 1 5
4A4M, 5W0P, 5DGY, 4ZWJ, 6CMO
0.05 0.71 0.24 -0.67 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 2
4MBS, 5UIW
0.02 1.00 1.15 4
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39 S
A
1 1 1
5WF6
0.72 0.50 0.46 Pos & Wild Type AA Match 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NDD, 5NDZ, 5NJ6
0.05 0.24 -0.67
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM7 7x41 T
A
1 1 1
5N2S
0.07 0.66 0.25 5
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x59 I
F
1 1 2
5VEX, 5VEW
0.4 0.41 -1.12
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36 T
P
1 1 3
4RWS, 3OE0, 3OE9
0.25 0.66 0.25 2 1 3
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM3 3x36 T
A
2 1 24
5N2S, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
0.05 0.66 0.25 16
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51 F
A
1 1 2
4K5Y, 4Z9G
0.93 0.54 -1.71 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48 G
A
1 1 1
5EE7
0.13 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48 A
L
1 1 1
5EE7
0.2 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48 F
M
1 1 18
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY, 5A8E, 5F8U, 2Y02, 3ZPQ, 2YCW, 2YCZ, 2Y00, 2VT4, 4AMJ, 4BVN, 2Y03
0.06 0.33 0.54 -1.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.04 0.65 0.85
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39 R
A
1 1 2
5YQZ, 5EE7
1.0 0.21 1.81 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53 Y
A
1 1 2
4K5Y, 4Z9G
0.93 0.53 -0.71 Pos & Wild Type AA Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.02 0.61 -0.46 1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5EN0, 5DYS
0.08 0.43 0.66 0.25 13
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY, 5A8E, 5F8U, 2Y02, 3ZPQ, 2YCW, 2YCZ, 2Y00, 2VT4, 4AMJ, 4BVN, 2Y03
0.08 0.11 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44 W
A
1 1 2
4K5Y, 4Z9G
0.13 0.49 -2.09
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47 S
C
1 1 1
5LWE
0.56 0.50 0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39 F
A
1 1 1
5EE7
0.33 0.54 -1.71
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31 L
F
1 1 1
5NX2
0.2 0.21 -1.25
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55 R
A
1 1 23
5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
0.05 0.21 1.81 1 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
ECL2 G
A
1 1 4
4XES, 4GRV, 4XEE, 5T04
1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x24 S
A
1 1 2
5VEX, 5VEW
0.27 0.50 0.46
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59 R
S
1 1 18
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY, 5A8E, 5F8U, 2Y02, 3ZPQ, 2YCW, 2YCZ, 2Y00, 2VT4, 4AMJ, 4BVN, 2Y03
0.24 0.21 1.81
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM7 7x41 S
A
1 1 23
5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
0.16 0.50 0.46 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48 I
A
1 1 2
4K5Y, 4Z9G
0.2 0.41 -1.12
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35 E
A
1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
0.09 0.40 0.11
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32 R
E
1 1 3
5XR8, 5TGZ, 5XRA
0.31 0.21 1.81 1 3
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NDD, 5NDZ, 5NJ6
0.07 0.61 -0.46 5
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47 H
V
1 1 1
5NX2
0.73 0.61 0.11
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37 H
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.03 0.61 0.11 1 1 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM5 5x63 Y
A
1 1 1
5N2S
0.03 0.53 -0.71
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40 L
A
1 1 4
4PHU, 5KW2, 5TZR, 5TZY
0.03 0.21 -1.25 2 1 1
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.68 0.49 -2.09 Pos & Wild Type AA Match 17
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45 C
N
1 1 2
6BQH, 6BQG
0.01 0.68 -0.02 Pos & Wild Type AA Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM3 3x24 G
A
1 1 1
5EE7
0.4 1.00 1.15
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37 D
C
1 1 1
4Z36
0.01 0.69 0.43 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41 T
A
1 1 1
5LWE
0.09 0.66 0.25
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54 I
A
1 1 4
4BUO, 4BWB, 3ZEV, 4BV0
0.33 0.41 -1.12
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21 K
G
1 1 1
5X33
0.01 0.26 2.80 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x30 Y
A
1 1 2
4K5Y, 4Z9G
0.73 0.53 -0.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60 C
Y
1 1 2
4MBS, 5UIW
0.02 0.68 -0.02 1
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM2 2x52 A
L
2 1 28
2YDO, 2YDV, 5N2S, 4UG2, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 4UHR, 5IUB, 5OM1
0.06 0 0.50 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56 V
A
1 1 1
5NX2
0.07 0.61 -0.46 2 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42 L
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.24 0.21 -1.25
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
C-term S
A
1 1 1
5X33
0.50 0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38 M
A
1 1 1
5LWE
0.04 0.24 -0.67 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 D
R
1 1 1
5NX2
0.69 0.43
Active
Intermediate
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2B
5-HT2B
TM3 3x41 M
W
1 1 4
5TUD, 4NC3, 5TVN, 4IB4
0.04 0.24 -0.67 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46 L
A
1 1 4
2YDO, 2YDV, 4UHR, 4UG2
0.9 0.21 -1.25
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM6 6x41 V
A
1 1 23
5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
0.41 0.61 -0.46
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term N
C
2 1 12
5EN0, 4BEZ, 4A4M, 5W0P, 5DGY, 3C9M, 2J4Y, 2X72, 4ZWJ, 5DYS, 4BEY, 6CMO
0.65 0.85
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x34 F
A
1 1 2
5TZR, 4PHU
0.11 0.54 -1.71 1
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Peptide
Aminergic
Neurotensin
Adenosine
Dopamine
AA1R
AA2AR
NTR1
DRD2
A2A
A1
D2
NTS1
TM6 6x37 L
A
4 3 26
4GRV, 5N2S, 5IU8, 5NM4, 3PWH, 5OLG, 5OLZ, 5IU4, 5OLH, 3UZC, 5OM4, 5MZP, 3RFM, 5NM2, 5NLX, 5OLO, 5IU7, 5MZJ, 6CM4, 3REY, 5OLV, 5N2R, 5IUA, 3UZA, 5IUB, 5OM1
0.38 0.21 -1.25 1 1 4
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60 L
A
1 1 2
4K5Y, 4Z9G
0.33 0.21 -1.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42 P
A
1 1 1
5NX2
0.93 3.16 0.14
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31 C
F
1 1 2
5VEX, 5VEW
0.07 0.68 -0.02 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32 M
C
1 1 2
5VEX, 5VEW
0.13 0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4K5Y, 4Z9G
0.13 0.26 2.80
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37 Q
A
1 1 4
2YDO, 2YDV, 4UHR, 4UG2
0.02 0.39 0.77 8
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48 E
F
1 1 1
5EE7
0.27 0.40 0.11 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
ADRB2
β2
β1
TM3 3x41 E
W
2 1 5
3NY9, 3NY8, 3NYA, 5A8E, 3D4S
0.01 0.33 0.40 0.11 1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 5
2X72, 5W0P, 5DGY, 4ZWJ, 6CMO
0.02 0.57 0.40 0.11 8
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38 I
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.08 0.41 -1.12
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48 S
A
1 1 2
4K5Y, 4Z9G
0.07 0.50 0.46
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5XR8, 5U09, 5TGZ, 5XRA
0.01 0.66 0.25 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51 Y
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.66 0.53 -0.71 1
Intermediate
Active
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54 A
L
1 1 8
4GRV, 4BV0, 4XEE, 4XES, 4BWB, 4BUO, 3ZEV, 5T04
0.04 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL2 45x52 T
A
1 1 1
5NX2
0.2 0.66 0.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53 S
A
1 1 5
5CGC, 6FFI, 6FFH, 4OO9, 5CGD
0.14 0.50 0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51 D
C
1 1 1
4RWS
0.03 0.69 0.43 12
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63 H
C
1 1 2
3PDS, 4QKX
0.03 0.11 0.61 0.11 8
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49 D
N
2 1 5
4PY0, 4XNW, 4PXZ, 4XNV, 4NTJ
0.2 0.69 0.43
Inactive
A (Rhodopsin)
Aminergic
Dopamine
Adrenoceptors
ADRB1
DRD2
D2
β1
TM3 3x40 I
A
V
2 2 3
6CM4, 4BVN, 5A8E
0.4 0.41 -1.12 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33 A
D
1 1 2
4MBS, 5UIW
0.29 0 0.50 2 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48 T
A
1 1 1
5LWE
0.05 0.66 0.25 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x59 V
F
1 1 1
5EE7
0.4 0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48 S
A
1 1 2
5VEX, 5VEW
0.07 0.50 0.46
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45 G
C
A
1 1 3
5NX2, 5VEX, 5VEW
1.0 1.00 1.15
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36 F
A
1 1 18
2YCX, 4AMI, 2Y04, 3ZPR, 2Y01, 4GPO, 2YCY,