Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4Z9G, 4K5Y
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
Corticotropin-releasing factor
GLR
CRFR1
glucagon
CRF1
TM2 2x48
A
S
A
L
2 2 3
4Z9G, 4K5Y, 5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
glucagon
GLP-1
TM2 2x59
V
I
F
2 1 3
5VEX, 5EE7, 5VEW
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEX, 5VEW
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
4GRV, 4XES, 5T04, 4XEE
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Peptide
Nucleotide
Dopamine
Adenosine
Neurotensin
AA1R
AA2AR
NTR1
DRD2
A1
NTS1
D2
A2A
TM6 6x37
L
A
4 3 26
4GRV, 5IUB, 5MZP, 5IU7, 5OLO, 5N2S, 6CM4, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5XRA, 5U09, 5XR8, 5TGZ
Active
Inactive
Intermediate
A (Rhodopsin)
Protein
Aminergic
Chemokine
Dopamine
5-Hydroxytryptamine
Adrenoceptors
CXCR4
ADRB1
DRD3
ADRB2
5HT2B
5HT1B
5-HT1B
β1
D3
β2
5-HT2B
CXCR4
TM3 3x41
L
E
M
W
6 4 19
3PBL, 3OE0, 4IAR, 4IB4, 5TVN, 3ODU, 4RWS, 3NY9, 4IAQ, 5A8E, 5V54, 3OE8, 3NY8, 3D4S, 5TUD, 3OE9, 4NC3, 3NYA, 3OE6
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
glucagon
GLP-1
TM2 2x56
S
A
C
2 1 3
5VEX, 5EE7, 5VEW
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
Inactive
Intermediate
A (Rhodopsin)
Lipid
Aminergic
Free fatty acid
Adrenoceptors
FFAR1
ADRB1
FFA1
β1
TM5 5x58
Y
A
F
2 2 21
2Y02, 2YCX, 4PHU, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 5TZR, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 5TZY, 2YCY, 4AMJ
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 2
4MBS, 5UIW
Inactive
A (Rhodopsin)
Peptide
Aminergic
Apelin
Dopamine
Adrenoceptors
APJ
ADRB1
DRD2
apelin
β1
D2
TM3 3x40
V
I
A
V
3 3 4
4BVN, 5A8E, 5VBL, 6CM4
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7D, 5L7I
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
Corticotropin-releasing factor
GLP1R
CRFR1
CRF1
GLP-1
ECL2 45x52
F
T
A
2 2 3
4Z9G, 4K5Y, 5NX2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
5IUB, 5MZP, 5IU7, 5OLO, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 2
4MBS, 5UIW
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4Z9G, 4K5Y
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 4
5W0P, 5DGY, 4ZWJ, 2X72
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4Z9G, 4K5Y
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
4QKX, 3PDS
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5X93, 5XPR
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52
A
L
2 1 28
5IUB, 5MZP, 4UHR, 5IU7, 5OLO, 5N2S, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 4UG2, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 2YDV, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 2YDO, 5NM4, 5NM2, 3UZC, 5NLX
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 3
5TZY, 4PHU, 5TZR
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5DYS, 5EN0
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
4BUO, 3ZEV, 4BWB, 4BV0
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
2YDO, 2YDV, 4UHR, 4UG2
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
glucagon
GLP-1
TM3 3x24
S
G
A
2 1 3
5VEX, 5EE7, 5VEW
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQG, 6BQH
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
2YDO, 2YDV, 4UHR, 4UG2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 2
4MBS, 5UIW
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4Z9G, 4K5Y
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4Z9G, 4K5Y
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x45
G
A
C
1 1 3
5VEX, 5NX2, 5VEW
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4Z9G, 4K5Y
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM5 5x63
L
Y
A
2 1 24
5IUB, 5MZP, 5IU7, 5OLO, 5N2S, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
glucagon
GLP-1
ECL1
Q
T
D
L
G
A
R
F
E
2 1 2
5NX2, 5EE7
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM2 2x39
R
A
1 1 2
5YQZ, 5EE7
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5X93, 5XPR
Intermediate
A (Rhodopsin)
Peptide
Lipid
Free fatty acid
Proteinase-activated
FFAR1
PAR2
FFA1
PAR2
TM3 3x34
F
G
A
2 2 5
5NDD, 4PHU, 5TZR, 5NDZ, 5NJ6
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEX, 5VEW
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 2
4MBS, 5UIW
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
4BVN, 5A8E
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEX, 5VEW
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
Lysophospholipid (LPA)
CNR1
LPAR1
LPA1
CB1
TM5 5x37
D
E
C
K
2 2 4
5XRA, 4Z36, 5XR8, 5TGZ
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Dopamine
Adenosine
AA1R
AA2AR
DRD2
A1
D2
A2A
TM6 6x41
V
L
A
3 2 25
5IUB, 5MZP, 5IU7, 5OLO, 5N2S, 6CM4, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEX, 5VEW
Active
Inactive
Intermediate
A (Rhodopsin)
Sensory
Peptide
Lipid
Leukotriene
Neurotensin
Opsins
OPSD
NTR1
OPSD
Q9WTK1
BLT1
NTS1
Rhodopsin
N-term
D
G
S
N
A
C
4 3 16
4GRV, 5DYS, 4A4M, 4ZWJ, 3C9M, 5EN0, 4XES, 5T04, 2X72, 5DGY, 4XEE, 4BEY, 5W0P, 4BEZ, 5X33, 2J4Y
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49
D
N
2 1 5
4PY0, 4XNV, 4NTJ, 4XNW, 4PXZ
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
Corticotropin-releasing factor
GLR
GLP1R
CRFR1
glucagon
GLP-1
CRF1
TM6 6x30
Y
K
A
3 2 5
5VEX, 4Z9G, 4K5Y, 5EE7, 5VEW
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CCR9
CCR9
CXCR4
TM6 6x36
V
T
A
P
2 1 4
5LWE, 3OE0, 3OE9, 4RWS
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5X93, 5XPR
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 4
5W0P, 5DGY, 4ZWJ, 4A4M
Inactive
A (Rhodopsin)
Peptide
Aminergic
Endothelin
Adrenoceptors
ADRB1
EDNRB
ETB
β1
TM7 7x48
F
I
A
M
2 2 20
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 5XPR, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 5X93, 4BVN, 2YCY, 4AMJ
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4Z9G, 4K5Y
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4Z9G, 4K5Y
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36
T
A
2 1 24
5IUB, 5MZP, 5IU7, 5OLO, 5N2S, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEX, 5VEW
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM7 7x41
S
T
A
2 1 24
5IUB, 5MZP, 5IU7, 5OLO, 5N2S, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Active
Inactive
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
4GRV, 4XEE, 4BV0, 4BUO, 4BWB, 3ZEV, 4XES, 5T04
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
2YDO, 2YDV, 4UHR, 4UG2
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5XRA, 5XR8, 5TGZ
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NDD, 5NDZ, 5NJ6
Intermediate
A (Rhodopsin)
Peptide
Lipid
Free fatty acid
Neurotensin
FFAR1
NTR1
FFA1
NTS1
TM3 3x49
E
G
A
2 2 5
4GRV, 5TZY, 4PHU, 5TZR, 4XES
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
5IUB, 5MZP, 5IU7, 5OLO, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch
Inactive
A (Rhodopsin)
Peptide
Aminergic
Apelin
Dopamine
APJ
DRD2
apelin
D2
TM3 3x40
V
I
A 2 2 2
5VBL, 6CM4
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
glucagon
GLP-1
TM3 3x24
S
G
A 2 1 3
5VEX, 5EE7, 5VEW
0.17 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
0.11 0.21 -1.25
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 3
5TZY, 4PHU, 5TZR
0 0.50
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.68 -0.02
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.17 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
0 0.50
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
Corticotropin-releasing factor
GLR
GLP1R
CRFR1
glucagon
GLP-1
CRF1
TM6 6x30
Y
K
A 3 2 5
5VEX, 4Z9G, 4K5Y, 5EE7, 5VEW
0 0.50
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52
A
L 2 1 28
5IUB, 5MZP, 4UHR, 5IU7, 5OLO, 5N2S, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 4UG2, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 2YDV, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 2YDO, 5NM4, 5NM2, 3UZC, 5NLX
0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.33 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.21 -1.25
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 2
4MBS, 5UIW
0.40 0.11
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
2YDO, 2YDV, 4UHR, 4UG2
0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5XRA, 5XR8, 5TGZ
0.26 2.80
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
1.00 1.15
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NDD, 5NDZ, 5NJ6
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.11 0.26 2.80
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5XRA, 5U09, 5XR8, 5TGZ
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NDD, 5NDZ, 5NJ6
0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0 0.50
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
4GRV, 4XES, 5T04, 4XEE
0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5X93, 5XPR
0.53 -0.71
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
D
N
C 2 1 11
5DYS, 4A4M, 4ZWJ, 3C9M, 5EN0, 2X72, 5DGY, 4BEY, 5W0P, 4BEZ, 2J4Y
0.68 -0.02
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NDD, 5NDZ, 5NJ6
0 0.50
Active
Inactive
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
4GRV, 4XEE, 4BV0, 4BUO, 4BWB, 3ZEV, 4XES, 5T04
0.21 -1.25
Active
Inactive
Intermediate
A (Rhodopsin)
Protein
Aminergic
Chemokine
Dopamine
5-Hydroxytryptamine
Adrenoceptors
CXCR4
ADRB1
DRD3
ADRB2
5HT2B
5HT1B
5-HT1B
β1
D3
β2
5-HT2B
CXCR4
TM3 3x41
L
E
M
W 6 4 19
3PBL, 3OE0, 4IAR, 4IB4, 5TVN, 3ODU, 4RWS, 3NY9, 4IAQ, 5A8E, 5V54, 3OE8, 3NY8, 3D4S, 5TUD, 3OE9, 4NC3, 3NYA, 3OE6
0.49 -2.09
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.68 -0.02
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5DYS, 5EN0
0.29 0.41 -1.12
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM5 5x63
L
Y
A 2 1 24
5IUB, 5MZP, 5IU7, 5OLO, 5N2S, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NDD, 5NDZ, 5NJ6
0.40 0.11
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.17 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
0.50 0.46
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7D, 5L7I
0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4Z9G, 4K5Y
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.65 0.85
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQG, 6BQH
0.65 0.85
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Peptide
Nucleotide
Dopamine
Adenosine
Neurotensin
AA1R
AA2AR
NTR1
DRD2
A1
NTS1
D2
A2A
TM6 6x37
L
A 4 3 26
4GRV, 5IUB, 5MZP, 5IU7, 5OLO, 5N2S, 6CM4, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM2 2x39
R
A 1 1 2
5YQZ, 5EE7
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.17 0.54 -1.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 2
4MBS, 5UIW
0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.5 0 0.50
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
1.00 1.15
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 3
5TZY, 4PHU, 5TZR
0.54 -1.71
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5X93, 5XPR
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
glucagon
GLP-1
TM2 2x59
V
I
F 2 1 3
5VEX, 5EE7, 5VEW
0.54 -1.71
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5X93, 5XPR
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEX, 5VEW
0.41 -1.12
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 2
4MBS, 5UIW
0.65 0.85
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NDD, 5NDZ, 5NJ6
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
2YDO, 2YDV, 4UHR, 4UG2
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
0.24 -0.67
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
4BVN, 5A8E
0.61 -0.46
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
4BVN, 5A8E
0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
0.33 0.61 -0.46
Intermediate
A (Rhodopsin)
Peptide
Lipid
Free fatty acid
Proteinase-activated
FFAR1
PAR2
FFA1
PAR2
TM3 3x34
F
G
A 2 2 5
5NDD, 4PHU, 5TZR, 5NDZ, 5NJ6
0 0.50
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
4QKX, 3PDS
0.68 -0.02
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
0.53 -0.71
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0 0.50
Active
Inactive
Intermediate
A (Rhodopsin)
Peptide
Lipid
Leukotriene
Neurotensin
NTR1
Q9WTK1
BLT1
NTS1
ECL2
G
S
A 2 2 5
4GRV, 5X33, 4XES, 5T04, 4XEE
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NDD, 5NDZ, 5NJ6
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
ECL1
Q
G
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 2
4MBS, 5UIW
0.69 0.43
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
glucagon
GLP-1
ECL1
G
T
E 2 1 2
5NX2, 5EE7
0.40 0.11
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
0.11 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.17 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEX, 5VEW
0.17 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4Z9G, 4K5Y
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Lipid
Free fatty acid
Neurotensin
FFAR1
NTR1
FFA1
NTS1
TM3 3x49
E
G
A 2 2 5
4GRV, 5TZY, 4PHU, 5TZR, 4XES
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
2YDO, 2YDV, 4UHR, 4UG2
0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5XRA, 5XR8, 5TGZ
0.40 0.11
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
Corticotropin-releasing factor
GLP1R
CRFR1
CRF1
GLP-1
ECL2 45x52
F
T
A 2 2 3
4Z9G, 4K5Y, 5NX2
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
3OE0, 3OE9, 4RWS
3.16 0.14
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
5IUB, 5MZP, 5IU7, 5OLO, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NDD, 5NDZ, 5NJ6
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.54 -1.71
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
4BUO, 3ZEV, 4BWB, 4BV0
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5X93, 5XPR
0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM7 7x41
S
T
A 2 1 24
5IUB, 5MZP, 5IU7, 5OLO, 5N2S, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4Z9G, 4K5Y
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NDD, 5NDZ, 5NJ6
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49
D
N 2 1 5
4PY0, 4XNV, 4NTJ, 4XNW, 4PXZ
0.65 0.85
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 4
5W0P, 5DGY, 4ZWJ, 4A4M
0.53 -0.71
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36
T
A 2 1 24
5IUB, 5MZP, 5IU7, 5OLO, 5N2S, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
0 0.50
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 4
5W0P, 5DGY, 4ZWJ, 2X72
0.39 0.77
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Dopamine
Adenosine
AA1R
AA2AR
DRD2
A1
D2
A2A
TM6 6x41
V
L
A 3 2 25
5IUB, 5MZP, 5IU7, 5OLO, 5N2S, 6CM4, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
0.24 -0.67
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEX, 5VEW
0.17 0.54 -1.71
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
5IUB, 5MZP, 5IU7, 5OLO, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
0 0.50
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54 S
A
1 1 2
5X93, 5XPR
0.50 0.46
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63 H
C
1 1 2
4QKX, 3PDS
0.11 0.61 0.11
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41 T
A
1 1 1
5LWE
0.66 0.25
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM7 7x41 S
A
1 1 23
5IUB, 5MZP, 5IU7, 5OLO, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
0.50 0.46
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35 E
A
1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
0.40 0.11
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32 R
E
1 1 3
5XRA, 5XR8, 5TGZ
0.21 1.81
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36 T
P
1 1 3
3OE0, 3OE9, 4RWS
0.66 0.25
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54 I
A
1 1 4
4BUO, 3ZEV, 4BWB, 4BV0
0.41 -1.12
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4Z9G, 4K5Y
0.26 2.80
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
0.11 0 0.50
Inactive
Intermediate
A (Rhodopsin)
Protein
Aminergic
Chemokine
Dopamine
5-Hydroxytryptamine
CXCR4
DRD3
5HT1B
5-HT1B
D3
CXCR4
TM3 3x41 L
W
3 3 10
4IAR, 3OE0, 3ODU, 4RWS, 5V54, 4IAQ, 3OE9, 3OE8, 3OE6, 3PBL
0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM6 6x48 E
F
1 1 1
5EE7
0.67 0.40 0.11
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36 V
A
1 1 2
4Z9G, 4K5Y
0.61 -0.46
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40 L
A
1 1 3
5TZY, 4PHU, 5TZR
0.21 -1.25
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48 F
M
1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
0.33 0.54 -1.71
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x49 G
A
1 1 3
5TZY, 4PHU, 5TZR
1.00 1.15
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59 R
S
1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
0.21 1.81
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
ECL2 G
A
1 1 4
4GRV, 4XES, 5T04, 4XEE
1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
glucagon
GLP-1
TM2 2x56 S
A
C
2 1 3
5VEX, 5EE7, 5VEW
0.5 0.50 0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64 M
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.24 -0.67
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67 V
A
1 1 1
5X33
0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM3 3x24 S
A
1 1 2
5VEX, 5VEW
0.33 0.50 0.46
Active
Intermediate
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2B
5-HT2B
TM3 3x41 M
W
1 1 4
4IB4, 5TUD, 5TVN, 4NC3
0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
ECL2 45x52 F
A
1 1 2
4Z9G, 4K5Y
0.54 -1.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46 G
A
1 1 3
5NDD, 5NDZ, 5NJ6
1.00 1.15
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM3 3x31 L
F
1 1 1
5NX2
0.5 0.21 -1.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50 I
A
1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
0.41 -1.12
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60 C
Y
1 1 2
4MBS, 5UIW
0.68 -0.02
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51 Y
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.53 -0.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 2
4MBS, 5UIW
1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
GLP1R
glucagon
GLP-1
TM6 6x30 K
A
2 1 3
5VEX, 5EE7, 5VEW
0.5 0.26 2.80
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45 C
N
1 1 2
6BQG, 6BQH
0.68 -0.02
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50 D
N
1 1 1
5WF5
0.69 0.43
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53 M
V
1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
0.33 0.24 -0.67
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43 K
A
1 1 23
5IUB, 5MZP, 5IU7, 5OLO, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
0.26 2.80
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.61 -0.46
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55 R
Y
1 1 2
5X93, 5XPR
0.21 1.81
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x51 I
C
1 1 2
5VEX, 5VEW
0.67 0.41 -1.12
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36 T
A
2 1 24
5IUB, 5MZP, 5IU7, 5OLO, 5N2S, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
0.66 0.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42 L
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.21 -1.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NDD, 5NDZ, 5NJ6
0.61 -0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38 I
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.41 -1.12
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37 E
K
1 1 3
5XRA, 5XR8, 5TGZ
0.40 0.11
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x31 C
F
1 1 2
5VEX, 5VEW
0.17 0.68 -0.02
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40 M
Y
2 1 4
5W0P, 5DGY, 4ZWJ, 4A4M
0.71 0.24 -0.67
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42 T
A
1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
0.66 0.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48 S
A
1 1 2
4Z9G, 4K5Y
0.50 0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x30 Y
A
1 1 2
4Z9G, 4K5Y
0.53 -0.71
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM7 7x56 V
A
1 1 1
5NX2
0.17 0.61 -0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33 A
D
1 1 2
4MBS, 5UIW
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62 T
A
1 1 4
2YDO, 2YDV, 4UHR, 4UG2
0.66 0.25
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
ECL1 Q
A
1 1 1
5NX2
0.39 0.77
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37 H
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.61 0.11
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM3 3x32 M
C
1 1 2
5VEX, 5VEW
0.33 0.24 -0.67
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM5 5x63 L
A
1 1 23
5IUB, 5MZP, 5IU7, 5OLO, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.66 0.25
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM3 3x49 E
A
1 1 2
4GRV, 4XES
0.40 0.11
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51 F
A
1 1 2
4Z9G, 4K5Y
0.54 -1.71
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53 Y
L
1 1 2
4BVN, 5A8E
1.0 0.53 -0.71
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x45 G
A
C
1 1 3
5VEX, 5NX2, 5VEW
1.0 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53 Y
A
1 1 2
4Z9G, 4K5Y
0.53 -0.71
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49 D
N
2 1 5
4PY0, 4XNV, 4NTJ, 4XNW, 4PXZ
0.69 0.43
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40 V
F
1 1 2
5L7D, 5L7I
0.09 0.61 -0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55 R
A
1 1 23
5IUB, 5MZP, 5IU7, 5OLO, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
0.21 1.81
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NDD, 5NDZ, 5NJ6
0.24 -0.67
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56 D
A
1 1 1
5X93
0.69 0.43
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5XRA, 5U09, 5XR8, 5TGZ
0.66 0.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38 M
A
1 1 1
5LWE
0.24 -0.67
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM6 6x42 P
A
1 1 1
5NX2
1.0 3.16 0.14
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.65 0.85
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM7 7x39 F
A
1 1 1
5EE7
0.33 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x52 G
I
1 1 2
5VEX, 5VEW
0.33 1.00 1.15
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM3 3x40 V
A
1 1 1
5VBL
0.61 -0.46
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM5 5x63 C
A
1 1 1
5NX2
0.17 0.68 -0.02
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51 D
C
1 1 1
4RWS
0.69 0.43
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31 D
K
1 1 1
4BVN
0.22 0.69 0.43
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5DYS, 5EN0
0.43 0.66 0.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x34 G
A
1 1 3
5NDD, 5NDZ, 5NJ6
1.00 1.15
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Peptide
Nucleotide
Dopamine
Adenosine
Neurotensin
AA1R
AA2AR
NTR1
DRD2
A1
NTS1
D2
A2A
TM6 6x37 L
A
4 3 26
4GRV, 5IUB, 5MZP, 5IU7, 5OLO, 5N2S, 6CM4, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
0.21 -1.25
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM6 6x41 V
A
1 1 23
5IUB, 5MZP, 5IU7, 5OLO, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 5NM4, 3UZC, 5NM2, 5NLX
0.61 -0.46
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36 K
A
1 1 2
5X93, 5XPR
0.26 2.80
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48 T
A
1 1 1
5LWE
0.66 0.25
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x34 F
A
1 1 2
4PHU, 5TZR
0.54 -1.71
Inactive
A (Rhodopsin)
Aminergic
Dopamine
Adrenoceptors
ADRB1
DRD2
β1
D2
TM3 3x40 I
A
V
2 2 3
4BVN, 5A8E, 6CM4
0.41 -1.12
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
C-term S
A
1 1 1
5X33
0.50 0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM7 7x41 T
A
1 1 1
5N2S
0.66 0.25
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.49 -2.09
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53 S
A
1 1 5
6FFH, 5CGC, 4OO9, 6FFI, 5CGD
0.50 0.46
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43 V
A
1 1 4
4GRV, 4XES, 5T04, 4XEE
0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM2 2x59 I
F
1 1 2
5VEX, 5VEW
0.33 0.41 -1.12
Intermediate
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLP1R
GLP-1
TM4 4x48 S
A
1 1 2
5VEX, 5VEW
0.17 0.50 0.46
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 4
5W0P, 5DGY, 4ZWJ, 2X72
0.57 0.40 0.11
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
ADRB2
β1
β2
TM3 3x41 E
W
2 1 5
3NY9, 5A8E, 3D4S, 3NYA, 3NY8
0.33 0.40 0.11
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44 W
A
1 1 2
4Z9G, 4K5Y
0.49 -2.09
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.61 -0.46
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36 F
A
1 1 18
2Y02, 2YCX, 4AMI, 2Y01, 2YCW, 2Y03, 5A8E, 3ZPQ, 5F8U, 3ZPR, 2Y04, 2Y00, 2VT4, 2YCZ, 4GPO, 4BVN, 2YCY, 4AMJ
0.44 0.54 -1.71
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67 H
G
1 1 1
5X33
0.61 0.11
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM2 2x59 V
F
1 1 1
5EE7
0.33 0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM1 1x48 G
A
1 1 1
5EE7
0.17 1.00 1.15
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48 I
A
1 1 2
5X93, 5XPR
0.41 -1.12
Active
Inactive
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54 A
L
1 1 8
4GRV, 4XEE, 4BV0, 4BUO, 4BWB, 3ZEV, 4XES, 5T04
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon receptor family
GLR
glucagon
TM3 3x24 G
A
1 1 1
5EE7
0.33 1.00 1.15
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52 A
L
2 1 28
5IUB, 5MZP, 4UHR, 5IU7, 5OLO, 5N2S, 5OM4, 5OLG, 5IU4, 5IU8, 5OLZ, 4UG2, 5IUA, 3UZA, 3RFM, 5N2R, 5MZJ, 2YDV, 5OM1, 5OLV, 3REY, 5OLH, 3PWH, 2YDO, 5NM4, 5NM2, 3UZC, 5NLX
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5