Stabilising Mutation Analyser

Group By: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
State Targets Mutations Frequency Sites
State Class Ligand Type Receptor Family Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
GPCRs (PDB IDs) Ionic Lock Sodium Ion Binding Site Residue Switch
Inactive
Class A (Rhodopsin)
Peptide receptors
Aminergic receptors
Adrenoceptors
Apelin receptors
TM3 3x40
I
V
V
A
2 2 3
5A8E, 5VBL, 4BVN
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM3 3x47
S
C
1 1 1
5LWE
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
H8 8x63
C
A
1 1 1
5LWE
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM1 1x35
E
A
1 1 3
5CGC, 4OO9, 5CGD
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM5 5x53
S
A
1 1 3
5CGC, 4OO9, 5CGD
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x48
E
F
1 1 1
5EE7
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM3 3x36
T
A
1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
Active
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Sensory receptors
Proteinase-activated receptors
Opsins
Neurotensin receptors
ECL2
N
D
G
Q
C
A
4 3 18
5NJ6, 4XES, 5NDZ, 2X72, 4BEZ, 5DYS, 5DGY, 3C9M, 4ZWJ, 2J4Y, 5NDD, 4BEY, 5T04, 4XEE, 4A4M, 5W0P, 5EN0, 4GRV
Intermediate
Class A (Rhodopsin)
Peptide receptors
Lipid receptors
Free fatty acid receptors
Neurotensin receptors
TM3 3x49
E
G
A
2 2 5
5TZY, 4PHU, 4GRV, 4XES, 5TZR
Pos Match
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
ICL2
G
M
1 1 3
5CGC, 4OO9, 5CGD
Inactive
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM2 2x52
A
L
1 1 14
5IUB, 3UZA, 5IU8, 3RFM, 2YDV, 5IU4, 5IUA, 2YDO, 3PWH, 4UG2, 5IU7, 4UHR, 3REY, 3UZC
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
Corticotropin-releasing factor receptors
TM2 2x48
S
A
L
A
2 2 3
4K5Y, 5EE7, 4Z9G
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM3 3x32
M
C
1 1 2
5VEW, 5VEX
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM3 3x24
S
G
A
2 1 3
5VEW, 5EE7, 5VEX
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM4 4x61
G
N
1 1 2
5UIW, 4MBS
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM7 7x39
T
A
1 1 1
5LWE
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM1 1x48
G
A
1 1 1
5EE7
Active
Class A (Rhodopsin)
Sensory receptors
Opsins
TM2 2x60
T
I
1 1 2
5EN0, 5DYS
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM2 2x44
W
A
1 1 2
4K5Y, 4Z9G
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM5 5x63
L
A
1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM7 7x38
S
A
1 1 2
4K5Y, 4Z9G
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Endothelin receptors
TM1 1x55
R
Y
1 1 2
5GLH, 5GLI
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM5 5x64
M
A
1 1 3
5NJ6, 5NDD, 5NDZ
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM3 3x31
L
F
1 1 1
5NX2
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM2 2x37
H
A
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
H8 8x49
K
E
1 1 2
5UIW, 4MBS
Intermediate
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x45
G
C
A
1 1 3
5VEW, 5VEX, 5NX2
Active
Inactive
Class A (Rhodopsin)
Lipid receptors
Cannabinoid receptors
TM3 3x46
T
A
1 1 4
5TGZ, 5U09, 5XRA, 5XR8
Inactive
Intermediate
Class A (Rhodopsin)
Peptide receptors
Nucleotide receptors
Adenosine receptors
Neurotensin receptors
TM6 6x37
L
A
2 2 11
5IUB, 3UZA, 5IU8, 3RFM, 5IU4, 5IUA, 3PWH, 5IU7, 3REY, 4GRV, 3UZC
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM2 2x56
S
C
A
2 1 3
5VEW, 5EE7, 5VEX
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM6 6x42
L
A
1 1 3
5NJ6, 5NDD, 5NDZ
Active
Inactive
Class A (Rhodopsin)
Lipid receptors
Cannabinoid receptors
TM6 6x32
R
E
1 1 3
5TGZ, 5XRA, 5XR8
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Endothelin receptors
TM5 5x36
K
A
1 1 2
5GLH, 5GLI
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM7 7x56
V
A
1 1 1
5NX2
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM5 5x63
C
A
1 1 1
5NX2
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM2 2x53
M
V
1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM7 7x53
Y
L
1 1 2
5A8E, 4BVN
Pos Match Pos Match
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM1 1x59
R
S
1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
Active
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM2 2x63
H
C
1 1 2
4QKX, 3PDS
Intermediate
Class A (Rhodopsin)
Peptide receptors
Lipid receptors
Proteinase-activated receptors
Free fatty acid receptors
TM3 3x34
F
G
A
2 2 5
4PHU, 5NJ6, 5NDD, 5NDZ, 5TZR
Inactive
Class A (Rhodopsin)
Peptide receptors
Apelin receptors
TM6 6x48
W
K
1 1 1
5VBL
Pos Match
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x42
P
A
1 1 1
5NX2
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
P2Y receptors
TM7 7x49
D
N
2 1 5
4XNV, 4PY0, 4PXZ, 4XNW, 4NTJ
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM3 3x53
V
E
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM7 7x53
Y
A
1 1 2
4K5Y, 4Z9G
Pos Match
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM5 5x41
T
A
1 1 1
5LWE
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM3 3x37
Q
A
1 1 4
4UHR, 4UG2, 2YDV, 2YDO
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM6 6x33
A
D
1 1 2
5UIW, 4MBS
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM1 1x60
L
A
1 1 2
4K5Y, 4Z9G
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
ICL1 12x50
V
A
1 1 1
5LWE
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM6 6x38
I
A
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM6 6x41
V
A
1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM5 5x48
I
A
1 1 2
4K5Y, 4Z9G
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM5 5x52
G
I
1 1 2
5VEW, 5VEX
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
ECL2 45x51
D
C
1 1 1
4RWS
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM2 2x38
M
A
1 1 1
5LWE
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
ICL1 12x48
T
A
1 1 1
5LWE
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM2 2x39
R
A
1 1 1
5EE7
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM6 6x36
V
T
P
A
2 1 4
4RWS, 5LWE, 3OE0, 3OE9
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM3 3x43
M
L
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM2 2x59
I
V
F
2 1 3
5VEW, 5EE7, 5VEX
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x31
C
F
1 1 2
5VEW, 5VEX
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM5 5x51
I
C
1 1 2
5VEW, 5VEX
Active
Inactive
Intermediate
Class A (Rhodopsin)
Aminergic receptors
Protein receptors
Adrenoceptors
Dopamine receptors
Chemokine receptors
5-Hydroxytryptamine receptors
TM3 3x41
E
M
L
W
6 4 18
4NC3, 3OE8, 4IB4, 4IAQ, 4RWS, 5A8E, 3ODU, 3PBL, 3OE6, 4IAR, 5TUD, 3NYA, 3NY8, 3D4S, 3NY9, 3OE0, 5TVN, 3OE9
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM4 4x48
S
A
1 1 2
5VEW, 5VEX
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM2 2x62
T
A
1 1 4
4UHR, 4UG2, 2YDV, 2YDO
Active
Intermediate
Class A (Rhodopsin)
Peptide receptors
Neurotensin receptors
TM7 7x43
V
A
1 1 4
5T04, 4XEE, 4GRV, 4XES
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM2 2x46
L
A
1 1 4
4UHR, 4UG2, 2YDV, 2YDO
Inactive
Intermediate
Class A (Rhodopsin)
Peptide receptors
Aminergic receptors
Adrenoceptors
Endothelin receptors
TM7 7x48
F
I
M
A
2 2 20
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 5GLI, 5GLH, 2Y01, 2VT4
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM1 1x60
C
Y
1 1 2
5UIW, 4MBS
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM3 3x55
R
A
1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
Intermediate
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
ECL1
D
L
G
T
Q
E
R
F
A
2 1 2
5EE7, 5NX2
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM1 1x46
G
A
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM7 7x31
D
K
1 1 1
4BVN
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM3 3x51
Y
A
1 1 3
5NJ6, 5NDD, 5NDZ
Active
Class A (Rhodopsin)
Sensory receptors
Opsins
TM6 6x40
M
Y
2 1 4
4ZWJ, 5W0P, 4A4M, 5DGY
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM1 1x36
V
A
1 1 2
4K5Y, 4Z9G
Active
Inactive
Class A (Rhodopsin)
Lipid receptors
Cannabinoid receptors
Lysophospholipid (LPA) receptors
TM5 5x37
E
D
K
C
2 2 4
5TGZ, 5XRA, 5XR8, 4Z36
Inactive
Class F (Frizzled)
Protein receptors
Frizzled
TM3 3x40
V
F
1 1 2
5L7D, 5L7I
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Endothelin receptors
TM2 2x56
D
A
1 1 2
5GLH, 5GLI
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM7 7x29
N
A
1 1 1
5LWE
Intermediate
Class A (Rhodopsin)
Lipid receptors
Free fatty acid receptors
TM2 2x40
L
A
1 1 3
5TZY, 4PHU, 5TZR
Inactive
Intermediate
Class A (Rhodopsin)
Lipid receptors
Aminergic receptors
Adrenoceptors
Free fatty acid receptors
TM5 5x58
Y
F
A
2 2 21
4GPO, 2Y02, 5TZR, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 4PHU, 5TZY, 2Y01, 2VT4
Inactive
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
Corticotropin-releasing factor receptors
ECL2 45x52
F
T
A
2 2 3
5NX2, 4K5Y, 4Z9G
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM7 7x41
S
A
1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM7 7x39
F
A
1 1 1
5EE7
Active
Class A (Rhodopsin)
Sensory receptors
Opsins
TM3 3x28
E
Q
2 1 4
4ZWJ, 5W0P, 2X72, 5DGY
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM4 4x43
K
A
1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
Inactive
Class A (Rhodopsin)
Peptide receptors
Neurotensin receptors
TM5 5x54
I
A
1 1 4
4BWB, 4BUO, 4BV0, 3ZEV
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
Corticotropin-releasing factor receptors
TM6 6x30
K
Y
A
3 2 5
5VEW, 4K5Y, 5VEX, 5EE7, 4Z9G
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Endothelin receptors
TM6 6x54
S
A
1 1 2
5GLH, 5GLI
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM4 4x54
M
A
1 1 1
5EE7
Active
Inactive
Intermediate
Class A (Rhodopsin)
Peptide receptors
Neurotensin receptors
TM1 1x54
A
L
1 1 8
4XES, 4XEE, 4BWB, 4BUO, 5T04, 4BV0, 4GRV, 3ZEV
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM6 6x27
A
L
1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM6 6x51
F
A
1 1 2
4K5Y, 4Z9G
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM3 3x48
N
Y
1 1 3
5CGC, 4OO9, 5CGD
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x47
H
V
1 1 1
5NX2
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM3 3x50
I
A
1 1 3
5CGC, 4OO9, 5CGD
Pos Match
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
H8 8x59
C
A
1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM5 5x42
T
A
1 1 3
5CGC, 4OO9, 5CGD
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM7 7x36
F
A
1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM4 4x43
K
A
1 1 2
4K5Y, 4Z9G
State Targets Mutations Frequency Data (Mutant) Sites
State Class Ligand Type Receptor Family Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures GPCRs (PDB IDs) Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Residue Switch
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM2 2x44
W
A 1 1 2
4K5Y, 4Z9G
0.07 0 0.50
Active
Inactive
Intermediate
Class A (Rhodopsin)
Peptide receptors
Neurotensin receptors
TM1 1x54
A
L 1 1 8
4XES, 4XEE, 4BWB, 4BUO, 5T04, 4BV0, 4GRV, 3ZEV
0.37 0.21 -1.25
Intermediate
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
ECL1
G
T
E 2 1 2
5EE7, 5NX2
0.40 0.11
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM4 4x61
G
N 1 1 2
5UIW, 4MBS
0.03 0.65 0.85
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM3 3x43
M
L 1 1 3
5NJ6, 5NDD, 5NDZ
0.73 0.5 0.21 -1.25
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM7 7x53
Y
L 1 1 2
5A8E, 4BVN
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM4 4x48
S
A 1 1 2
5VEW, 5VEX
0.07 0.17 0 0.50
Active
Inactive
Class A (Rhodopsin)
Lipid receptors
Cannabinoid receptors
TM3 3x46
T
A 1 1 4
5TGZ, 5U09, 5XRA, 5XR8
0.01 0 0.50
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
H8 8x49
K
E 1 1 2
5UIW, 4MBS
0.12 0.40 0.11
Inactive
Class A (Rhodopsin)
Peptide receptors
Apelin receptors
TM3 3x40
V
A 1 1 1
5VBL
0.06 0 0.50
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02
Inactive
Class A (Rhodopsin)
Peptide receptors
Neurotensin receptors
TM5 5x54
I
A 1 1 4
4BWB, 4BUO, 4BV0, 3ZEV
0.02 0 0.50
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM6 6x36
V
A 1 1 1
5LWE
0.01 0 0.50
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM2 2x53
M
V 1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.23 0.33 0.61 -0.46
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM7 7x56
V
A 1 1 1
5NX2
0.07 0.17 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM2 2x48
S
A 1 1 2
4K5Y, 4Z9G
0.2 0 0.50
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM3 3x53
V
E 1 1 3
5NJ6, 5NDD, 5NDZ
0.01 0.40 0.11
Active
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM2 2x63
H
C 1 1 2
4QKX, 3PDS
0.0 0.68 -0.02
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM5 5x63
L
A 1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
0.06 0 0.50
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
H8 8x63
C
A 1 1 1
5LWE
0 0.50
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM3 3x48
N
Y 1 1 3
5CGC, 4OO9, 5CGD
0.05 0.53 -0.71
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM7 7x29
N
A 1 1 1
5LWE
0.13 0.09 0 0.50
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM7 7x36
F
A 1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.1 0.11 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x45
G
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM6 6x51
F
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
Corticotropin-releasing factor receptors
ECL2 45x52
F
T
A 2 2 3
5NX2, 4K5Y, 4Z9G
0 0.50
Active
Class A (Rhodopsin)
Sensory receptors
Opsins
TM6 6x40
M
Y 2 1 4
4ZWJ, 5W0P, 4A4M, 5DGY
0.01 0.53 -0.71
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM1 1x48
G
A 1 1 1
5EE7
0.33 0.17 0 0.50
Active
Inactive
Class A (Rhodopsin)
Lipid receptors
Cannabinoid receptors
TM6 6x32
R
E 1 1 3
5TGZ, 5XRA, 5XR8
0.04 0.40 0.11
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM6 6x36
T
P 1 1 3
4RWS, 3OE0, 3OE9
0.0 0.04 3.16 0.14
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM6 6x38
I
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.14 0 0.50
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM1 1x46
G
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.11 0 0.50
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Endothelin receptors
TM6 6x54
S
A 1 1 2
5GLH, 5GLI
0.1 0 0.50
Inactive
Class F (Frizzled)
Protein receptors
Frizzled
TM3 3x40
V
F 1 1 2
5L7D, 5L7I
0.54 -1.71
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM6 6x41
V
A 1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
0.05 0 0.50
Intermediate
Class A (Rhodopsin)
Peptide receptors
Lipid receptors
Free fatty acid receptors
Neurotensin receptors
TM3 3x49
E
G
A 2 2 5
5TZY, 4PHU, 4GRV, 4XES, 5TZR
0.01 0 0.50 Pos & Mutant AA Match
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM3 3x24
S
G
A 2 1 3
5VEW, 5EE7, 5VEX
0.07 0.17 0 0.50
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM6 6x42
L
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.14 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x31
C
F 1 1 2
5VEW, 5VEX
0.07 0.17 0.54 -1.71
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM7 7x53
Y
A 1 1 2
4K5Y, 4Z9G
0 0.50 Pos & Mutant AA Match
Active
Intermediate
Class A (Rhodopsin)
Peptide receptors
Neurotensin receptors
ECL2
G
A 1 1 4
5T04, 4XEE, 4GRV, 4XES
0 0.50
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50
Active
Class A (Rhodopsin)
Sensory receptors
Opsins
TM2 2x60
T
I 1 1 2
5EN0, 5DYS
0.04 0.29 0.41 -1.12
Inactive
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM2 2x52
A
L 1 1 14
5IUB, 3UZA, 5IU8, 3RFM, 2YDV, 5IU4, 5IUA, 2YDO, 3PWH, 4UG2, 5IU7, 4UHR, 3REY, 3UZC
0.63 0.21 -1.25
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
ICL2
G
M 1 1 3
5CGC, 4OO9, 5CGD
0.24 -0.67
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM2 2x56
S
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
P2Y receptors
TM7 7x49
D
N 2 1 5
4XNV, 4PY0, 4PXZ, 4XNW, 4NTJ
0.72 0.65 0.85
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.17 0.54 -1.71
Intermediate
Class A (Rhodopsin)
Lipid receptors
Free fatty acid receptors
TM5 5x58
Y
F 1 1 3
5TZY, 4PHU, 5TZR
0.01 0.54 -1.71
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
ICL1 12x50
V
A 1 1 1
5LWE
0.06 0.14 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM2 2x39
R
A 1 1 1
5EE7
0 0.50
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM5 5x53
S
A 1 1 3
5CGC, 4OO9, 5CGD
0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM4 4x54
M
A 1 1 1
5EE7
0.27 0.33 0 0.50
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Endothelin receptors
TM5 5x36
K
A 1 1 2
5GLH, 5GLI
0.07 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
Corticotropin-releasing factor receptors
TM6 6x30
K
Y
A 3 2 5
5VEW, 4K5Y, 5VEX, 5EE7, 4Z9G
0 0.50
Active
Inactive
Class A (Rhodopsin)
Lipid receptors
Cannabinoid receptors
TM5 5x37
E
K 1 1 3
5TGZ, 5XRA, 5XR8
0.11 0.26 2.80
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM3 3x55
R
A 1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
0.08 0 0.50
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Endothelin receptors
TM1 1x55
R
Y 1 1 2
5GLH, 5GLI
0.09 0.53 -0.71
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM1 1x35
E
A 1 1 3
5CGC, 4OO9, 5CGD
0.05 0 0.50
Inactive
Intermediate
Class A (Rhodopsin)
Peptide receptors
Nucleotide receptors
Adenosine receptors
Neurotensin receptors
TM6 6x37
L
A 2 2 11
5IUB, 3UZA, 5IU8, 3RFM, 5IU4, 5IUA, 3PWH, 5IU7, 3REY, 4GRV, 3UZC
0.04 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM5 5x48
I
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM4 4x43
K
A 1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
0.13 0.25 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM5 5x52
G
I 1 1 2
5VEW, 5VEX
0.07 0.41 -1.12
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM6 6x33
A
D 1 1 2
5UIW, 4MBS
0.69 0.43
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Endothelin receptors
TM7 7x48
I
A 1 1 2
5GLH, 5GLI
0.13 0 0.50
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Endothelin receptors
TM2 2x56
D
A 1 1 2
5GLH, 5GLI
0.08 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM7 7x38
S
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM7 7x48
F
M 1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.05 0.24 -0.67
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Inactive
Class A (Rhodopsin)
Peptide receptors
Apelin receptors
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA)
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM7 7x39
F
A 1 1 1
5EE7
0.07 0.17 0 0.50
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM3 3x37
Q
A 1 1 4
4UHR, 4UG2, 2YDV, 2YDO
0.03 0 0.50
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
H8 8x59
C
A 1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.02 0 0.50
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM6 6x27
A
L 1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.11 0.11 0.21 -1.25
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM7 7x41
S
A 1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
0.38 0 0.50
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
ICL1 12x48
T
A 1 1 1
5LWE
0.03 0 0.50
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM5 5x58
Y
A 1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.03 0 0.50
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
ECL1
Q
G
A 1 1 1
5NX2
0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM1 1x36
V
A 1 1 2
4K5Y, 4Z9G
0 0.50
Intermediate
Class A (Rhodopsin)
Peptide receptors
Lipid receptors
Proteinase-activated receptors
Free fatty acid receptors
TM3 3x34
F
G
A 2 2 5
4PHU, 5NJ6, 5NDD, 5NDZ, 5TZR
0.07 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM5 5x51
I
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Intermediate
Class A (Rhodopsin)
Lipid receptors
Free fatty acid receptors
TM2 2x40
L
A 1 1 3
5TZY, 4PHU, 5TZR
0.06 0.2 0 0.50
Active
Intermediate
Class A (Rhodopsin)
Peptide receptors
Neurotensin receptors
TM7 7x43
V
A 1 1 4
5T04, 4XEE, 4GRV, 4XES
0.19 0 0.50
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
ECL2
N
Q 1 1 3
5NJ6, 5NDD, 5NDZ
0.39 0.77
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM1 1x60
C
Y 1 1 2
5UIW, 4MBS
0.07 0.39 0.53 -0.71
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM1 1x59
R
S 1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.04 0.50 0.46
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM7 7x39
T
A 1 1 1
5LWE
0.08 0.13 0 0.50
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM3 3x40
I
V 1 1 2
5A8E, 4BVN
0.24 0.61 -0.46
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM5 5x42
T
A 1 1 3
5CGC, 4OO9, 5CGD
0.05 0.12 0 0.50
Inactive
Class A (Rhodopsin)
Lipid receptors
Lysophospholipid (LPA) receptors
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM5 5x64
M
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.13 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM2 2x59
I
V
F 2 1 3
5VEW, 5EE7, 5VEX
0.54 -1.71
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM3 3x32
M
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM2 2x62
T
A 1 1 4
4UHR, 4UG2, 2YDV, 2YDO
0.13 0 0.50
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46
Active
Inactive
Intermediate
Class A (Rhodopsin)
Aminergic receptors
Protein receptors
Adrenoceptors
Dopamine receptors
Chemokine receptors
5-Hydroxytryptamine receptors
TM3 3x41
E
M
L
W 6 4 18
4NC3, 3OE8, 4IB4, 4IAQ, 4RWS, 5A8E, 3ODU, 3PBL, 3OE6, 4IAR, 5TUD, 3NYA, 3NY8, 3D4S, 3NY9, 3OE0, 5TVN, 3OE9
0.03 0.49 -2.09
Active
Class A (Rhodopsin)
Sensory receptors
Opsins
TM3 3x28
E
Q 2 1 4
4ZWJ, 5W0P, 2X72, 5DGY
0.01 0.39 0.77
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM5 5x41
T
A 1 1 1
5LWE
0.07 0.04 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM1 1x60
L
A 1 1 2
4K5Y, 4Z9G
0 0.50
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM2 2x46
L
A 1 1 4
4UHR, 4UG2, 2YDV, 2YDO
0 0.50
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM3 3x50
I
A 1 1 3
5CGC, 4OO9, 5CGD
0 0.50 Pos & Mutant AA Match
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM3 3x51
Y
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.0 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM4 4x43
K
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM3 3x36
T
A 1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
0.02 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM2 2x56
S
A 1 1 1
5EE7
0.27 0.5 0 0.50
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM2 2x37
H
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.05 0 0.50
Active
Inactive
Class A (Rhodopsin)
Sensory receptors
Opsins
N-term
N
D
C 2 1 11
2X72, 4BEZ, 5DYS, 5DGY, 3C9M, 4ZWJ, 2J4Y, 4BEY, 5W0P, 4A4M, 5EN0
0.68 -0.02
State Targets Mutations Frequency Data (Wild Type) Sites
State Class Ligand Type Receptor Family Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures GPCRs (PDB IDs) Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Residue Switch
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
ICL2 G
M
1 1 3
5CGC, 4OO9, 5CGD
1.00 1.15
Active
Inactive
Class A (Rhodopsin)
Lipid receptors
Cannabinoid receptors
TM3 3x46 T
A
1 1 4
5TGZ, 5U09, 5XRA, 5XR8
0.01 1.0 0.66 0.25
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM6 6x38 I
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.08 0.25 0.41 -1.12
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM7 7x53 Y
L
1 1 2
5A8E, 4BVN
0.89 1.0 0.53 -0.71 Pos & Wild Type AA Match Pos & Wild Type AA Match
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM1 1x48 G
A
1 1 1
5EE7
0.13 0.17 1.00 1.15
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM3 3x24 G
A
1 1 1
5EE7
0.4 0.33 1.00 1.15
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM7 7x41 S
A
1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
0.16 0.75 0.50 0.46
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM3 3x47 S
C
1 1 1
5LWE
0.56 0.61 0.50 0.46
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM7 7x36 F
A
1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.14 0.44 0.54 -1.71
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM3 3x34 G
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.02 0.75 1.00 1.15
Active
Class A (Rhodopsin)
Sensory receptors
Opsins
TM6 6x40 M
Y
2 1 4
4ZWJ, 5W0P, 4A4M, 5DGY
0.05 0.71 0.24 -0.67
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM6 6x42 L
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.24 0.75 0.21 -1.25
Active
Intermediate
Class A (Rhodopsin)
Aminergic receptors
5-Hydroxytryptamine receptors
TM3 3x41 M
W
1 1 4
4NC3, 4IB4, 5TVN, 5TUD
0.04 0.33 0.24 -0.67
Active
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM2 2x63 H
C
1 1 2
4QKX, 3PDS
0.03 0.11 0.61 0.11
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x47 H
V
1 1 1
5NX2
0.73 1.0 0.61 0.11
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Endothelin receptors
TM1 1x55 R
Y
1 1 2
5GLH, 5GLI
0.02 1.0 0.21 1.81
Intermediate
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x45 G
C
A
1 1 3
5VEW, 5VEX, 5NX2
1.0 1.0 1.00 1.15
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM5 5x63 L
A
1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
0.13 0.5 0.21 -1.25
Active
Inactive
Class A (Rhodopsin)
Lipid receptors
Cannabinoid receptors
TM5 5x37 E
K
1 1 3
5TGZ, 5XRA, 5XR8
0.03 0.5 0.40 0.11
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM2 2x38 M
A
1 1 1
5LWE
0.04 0.39 0.24 -0.67
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM5 5x63 C
A
1 1 1
5NX2
0.07 0.17 0.68 -0.02
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM2 2x56 S
C
A
2 1 3
5VEW, 5EE7, 5VEX
0.47 0.5 0.50 0.46
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Endothelin receptors
TM7 7x48 I
A
1 1 2
5GLH, 5GLI
0.15 1.0 0.41 -1.12
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM7 7x48 F
M
1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.06 0.33 0.54 -1.71
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x31 C
F
1 1 2
5VEW, 5VEX
0.07 0.17 0.68 -0.02
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM5 5x64 M
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.01 0.25 0.24 -0.67
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM5 5x48 I
A
1 1 2
4K5Y, 4Z9G
0.2 1.0 0.41 -1.12
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM1 1x60 L
A
1 1 2
4K5Y, 4Z9G
0.33 1.0 0.21 -1.25
Inactive
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM2 2x52 A
L
1 1 14
5IUB, 3UZA, 5IU8, 3RFM, 2YDV, 5IU4, 5IUA, 2YDO, 3PWH, 4UG2, 5IU7, 4UHR, 3REY, 3UZC
0.06 1.0 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM3 3x32 M
C
1 1 2
5VEW, 5VEX
0.13 0.33 0.24 -0.67
Inactive
Class A (Rhodopsin)
Lipid receptors
Lysophospholipid (LPA) receptors
TM5 5x37 D
C
1 1 1
4Z36
0.01 0.17 0.69 0.43
Active
Class A (Rhodopsin)
Sensory receptors
Opsins
TM3 3x28 E
Q
2 1 4
4ZWJ, 5W0P, 2X72, 5DGY
0.02 0.57 0.40 0.11
Intermediate
Class A (Rhodopsin)
Peptide receptors
Neurotensin receptors
TM3 3x49 E
A
1 1 2
4GRV, 4XES
0.21 1.0 0.40 0.11 Pos & Wild Type AA Match
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
ECL2 45x51 D
C
1 1 1
4RWS
0.03 0.09 0.69 0.43
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM2 2x46 L
A
1 1 4
4UHR, 4UG2, 2YDV, 2YDO
0.9 1.0 0.21 -1.25
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM1 1x35 E
A
1 1 3
5CGC, 4OO9, 5CGD
0.09 0.25 0.40 0.11
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM6 6x51 F
A
1 1 2
4K5Y, 4Z9G
0.93 1.0 0.54 -1.71
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM4 4x54 M
A
1 1 1
5EE7
0.07 0.17 0.24 -0.67
Active
Intermediate
Class A (Rhodopsin)
Peptide receptors
Neurotensin receptors
ECL2 G
A
1 1 4
5T04, 4XEE, 4GRV, 4XES
1.00 1.15
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM3 3x37 Q
A
1 1 4
4UHR, 4UG2, 2YDV, 2YDO
0.02 0.75 0.39 0.77
Intermediate
Class A (Rhodopsin)
Lipid receptors
Free fatty acid receptors
TM2 2x40 L
A
1 1 3
5TZY, 4PHU, 5TZR
0.03 0.2 0.21 -1.25
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM3 3x48 N
Y
1 1 3
5CGC, 4OO9, 5CGD
0.41 1.0 0.65 0.85
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM4 4x48 S
A
1 1 2
5VEW, 5VEX
0.07 0.17 0.50 0.46
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM2 2x48 A
L
1 1 1
5EE7
0.2 0.5 0 0.50
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Endothelin receptors
TM5 5x36 K
A
1 1 2
5GLH, 5GLI
0.06 0.5 0.26 2.80
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM7 7x56 V
A
1 1 1
5NX2
0.07 0.17 0.61 -0.46
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM7 7x29 N
A
1 1 1
5LWE
0.04 0.13 0.65 0.85
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM6 6x33 A
D
1 1 2
5UIW, 4MBS
0.3 0.77 0 0.50
Inactive
Class A (Rhodopsin)
Peptide receptors
Neurotensin receptors
TM5 5x54 I
A
1 1 4
4BWB, 4BUO, 4BV0, 3ZEV
0.33 0.5 0.41 -1.12
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM1 1x60 C
Y
1 1 2
5UIW, 4MBS
0.02 0.17 0.68 -0.02
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
H8 8x49 K
E
1 1 2
5UIW, 4MBS
0.13 0.57 0.26 2.80
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM7 7x39 T
A
1 1 1
5LWE
0.03 0.22 0.66 0.25
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM1 1x36 V
A
1 1 2
4K5Y, 4Z9G
0.07 0.5 0.61 -0.46
Intermediate
Class A (Rhodopsin)
Lipid receptors
Free fatty acid receptors
TM3 3x34 F
A
1 1 2
4PHU, 5TZR
0.11 0.2 0.54 -1.71
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM3 3x36 T
A
1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
0.05 1.0 0.66 0.25
Inactive
Class A (Rhodopsin)
Peptide receptors
Apelin receptors
TM6 6x48 W
K
1 1 1
5VBL
0.68 1.0 0.49 -2.09 Pos & Wild Type AA Match
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM2 2x44 W
A
1 1 2
4K5Y, 4Z9G
0.13 1.0 0.49 -2.09
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM5 5x41 T
A
1 1 1
5LWE
0.09 0.09 0.66 0.25
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM6 6x36 T
P
1 1 3
4RWS, 3OE0, 3OE9
0.25 0.04 0.66 0.25
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
H8 8x59 C
A
1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.22 0.56 0.68 -0.02
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM4 4x61 G
N
1 1 2
5UIW, 4MBS
0.02 0.17 1.00 1.15
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM2 2x37 H
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.03 0.25 0.61 0.11
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM6 6x30 Y
A
1 1 2
4K5Y, 4Z9G
0.73 1.0 0.53 -0.71
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM7 7x38 S
A
1 1 2
4K5Y, 4Z9G
0.13 1.0 0.50 0.46
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM7 7x39 F
A
1 1 1
5EE7
0.33 0.33 0.54 -1.71
Active
Inactive
Class A (Rhodopsin)
Sensory receptors
Opsins
ECL3 D
C
1 1 8
3C9M, 2J4Y, 4BEY, 2X72, 4A4M, 5EN0, 4BEZ, 5DYS
0.69 0.43
Inactive
Intermediate
Class A (Rhodopsin)
Aminergic receptors
Protein receptors
Dopamine receptors
Chemokine receptors
5-Hydroxytryptamine receptors
TM3 3x41 L
W
3 3 9
3OE6, 3OE8, 4IAR, 4IAQ, 4RWS, 3ODU, 3PBL, 3OE0, 3OE9
0.31 0.21 -1.25
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x42 P
A
1 1 1
5NX2
0.93 1.0 3.16 0.14
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Endothelin receptors
TM2 2x56 D
A
1 1 2
5GLH, 5GLI
0.01 1.0 0.69 0.43
Active
Class A (Rhodopsin)
Sensory receptors
Opsins
TM2 2x60 T
I
1 1 2
5EN0, 5DYS
0.08 0.43 0.66 0.25
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
ICL1 12x50 V
A
1 1 1
5LWE
0.02 0.05 0.61 -0.46
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x30 K
A
2 1 3
5VEW, 5EE7, 5VEX
0.2 0.5 0.26 2.80
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM6 6x41 V
A
1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
0.41 0.5 0.61 -0.46
Intermediate
Class A (Rhodopsin)
Lipid receptors
Free fatty acid receptors
TM3 3x49 G
A
1 1 3
5TZY, 4PHU, 5TZR
0.01 0.2 1.00 1.15 Pos & Wild Type AA Match
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM3 3x53 V
E
1 1 3
5NJ6, 5NDD, 5NDZ
0.07 0.25 0.61 -0.46
Intermediate
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
ECL2 G
E
A
2 1 2
5EE7, 5NX2
1.00 1.15
Intermediate
Inactive
Class A (Rhodopsin)
Peptide receptors
Endothelin receptors
TM6 6x54 S
A
1 1 2
5GLH, 5GLI
0.05 1.0 0.50 0.46
Active
Inactive
Intermediate
Class A (Rhodopsin)
Peptide receptors
Neurotensin receptors
TM1 1x54 A
L
1 1 8
4XES, 4XEE, 4BWB, 4BUO, 5T04, 4BV0, 4GRV, 3ZEV
0.04 1.0 0 0.50
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
ECL1 Q
A
1 1 1
5NX2
0.39 0.77
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
ECL1 D
R
1 1 1
5NX2
0.69 0.43
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM2 2x59 V
F
1 1 1
5EE7
0.4 0.33 0.61 -0.46
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
P2Y receptors
TM7 7x49 D
N
2 1 5
4XNV, 4PY0, 4PXZ, 4XNW, 4NTJ
0.2 0.88 0.69 0.43
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM3 3x50 I
A
1 1 3
5CGC, 4OO9, 5CGD
0.5 1.0 0.41 -1.12 Pos & Wild Type AA Match
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
ICL1 12x48 T
A
1 1 1
5LWE
0.05 0.05 0.66 0.25
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM3 3x40 I
V
1 1 2
5A8E, 4BVN
0.4 1.0 0.41 -1.12
Inactive
Intermediate
Class A (Rhodopsin)
Peptide receptors
Nucleotide receptors
Adenosine receptors
Neurotensin receptors
TM6 6x37 L
A
2 2 11
5IUB, 3UZA, 5IU8, 3RFM, 5IU4, 5IUA, 3PWH, 5IU7, 3REY, 4GRV, 3UZC
0.38 0.21 -1.25
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM7 7x31 D
K
1 1 1
4BVN
0.1 0.22 0.69 0.43
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM1 1x46 G
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.54 0.75 1.00 1.15
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM3 3x51 Y
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.66 0.75 0.53 -0.71
Inactive
Class F (Frizzled)
Protein receptors
Frizzled
TM3 3x40 V
F
1 1 2
5L7D, 5L7I
0.09 0.09 0.61 -0.46
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM6 6x48 E
F
1 1 1
5EE7
0.27 0.67 0.40 0.11
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM3 3x31 L
F
1 1 1
5NX2
0.2 0.5 0.21 -1.25
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM3 3x24 S
A
1 1 2
5VEW, 5VEX
0.27 0.33 0.50 0.46
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM6 6x27 A
L
1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.09 0.11 0 0.50
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM4 4x43 K
A
1 1 2
4K5Y, 4Z9G
0.13 1.0 0.26 2.80
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM3 3x55 R
A
1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
0.05 0.25 0.21 1.81
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM5 5x42 T
A
1 1 3
5CGC, 4OO9, 5CGD
0.09 0.12 0.66 0.25
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM2 2x53 M
V
1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.07 0.33 0.24 -0.67
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM1 1x59 R
S
1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.24 0.21 1.81
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM2 2x39 R
A
1 1 1
5EE7
1.0 1.0 0.21 1.81
Active
Inactive
Intermediate
Class A (Rhodopsin)
Sensory receptors
Peptide receptors
Proteinase-activated receptors
Opsins
N-term N
Q
C
3 2 14
5NJ6, 5NDZ, 2X72, 4BEZ, 5DYS, 5DGY, 3C9M, 4ZWJ, 2J4Y, 5NDD, 4BEY, 5W0P, 4A4M, 5EN0
0.65 0.85
Intermediate
Class A (Rhodopsin)
Peptide receptors
Proteinase-activated receptors
TM3 3x43 M
L
1 1 3
5NJ6, 5NDD, 5NDZ
0.05 0.5 0.24 -0.67
Intermediate
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
ECL2 45x52 T
A
1 1 1
5NX2
0.2 0.5 0.66 0.25
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM2 2x48 S
A
1 1 2
4K5Y, 4Z9G
0.07 0.5 0.50 0.46
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
ECL2 45x52 F
A
1 1 2
4K5Y, 4Z9G
0.13 1.0 0.54 -1.71
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM5 5x52 G
I
1 1 2
5VEW, 5VEX
0.2 0.33 1.00 1.15
Inactive
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM4 4x43 K
A
1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
0.16 0.25 0.26 2.80
Inactive
Class A (Rhodopsin)
Peptide receptors
Apelin receptors
TM3 3x40 V
A
1 1 1
5VBL
0.24 1.0 0.61 -0.46
Inactive
Class A (Rhodopsin)
Aminergic receptors
Adrenoceptors
TM3 3x41 E
W
2 1 5
5A8E, 3NYA, 3NY8, 3D4S, 3NY9
0.01 0.33 0.40 0.11
Active
Intermediate
Class A (Rhodopsin)
Peptide receptors
Neurotensin receptors
TM7 7x43 V
A
1 1 4
5T04, 4XEE, 4GRV, 4XES
0.1 1.0 0.61 -0.46
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM5 5x51 I
C
1 1 2
5VEW, 5VEX
0.6 0.67 0.41 -1.12
Inactive
Class B1 (Secretin)
Peptide receptors
Glucagon receptor family
TM2 2x59 I
F
1 1 2
5VEW, 5VEX
0.4 0.33 0.41 -1.12
Intermediate
Class A (Rhodopsin)
Nucleotide receptors
Adenosine receptors
TM2 2x62 T
A
1 1 4
4UHR, 4UG2, 2YDV, 2YDO
0.1 0.5 0.66 0.25
Inactive
Intermediate
Class A (Rhodopsin)
Lipid receptors
Aminergic receptors
Adrenoceptors
Free fatty acid receptors
TM5 5x58 Y
F
A
2 2 21
4GPO, 2Y02, 5TZR, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 4PHU, 5TZY, 2Y01, 2VT4
0.72 0.53 -0.71
Active
Inactive
Class A (Rhodopsin)
Lipid receptors
Cannabinoid receptors
TM6 6x32 R
E
1 1 3
5TGZ, 5XRA, 5XR8
0.31 1.0 0.21 1.81
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
H8 8x63 C
A
1 1 1
5LWE
0.3 0.71 0.68 -0.02
Inactive
Class A (Rhodopsin)
Protein receptors
Chemokine receptors
TM6 6x36 V
A
1 1 1
5LWE
0.15 0.39 0.61 -0.46
Inactive
Class C (Glutamate)
Amino acid receptors
Metabotropic glutamate receptors
TM5 5x53 S
A
1 1 3
5CGC, 4OO9, 5CGD
0.14 0.25 0.50 0.46
Inactive
Class B1 (Secretin)
Peptide receptors
Corticotropin-releasing factor receptors
TM7 7x53 Y
A
1 1 2
4K5Y, 4Z9G
0.93 1.0 0.53 -0.71 Pos & Wild Type AA Match
State Targets Mutations Frequency Data (Fold Change (Mutant/Wild Type)) Sites
State Class Ligand Type Receptor Family Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures GPCRs (PDB IDs) Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Residue Switch
Intermediate
Class B1 (Secretin) Peptide receptors Glucagon receptor family ECL1 Q A 1 1 1
5NX2
— (—−—) — (—−—) -0.39 (0−0.39) -0.27 (0.50−0.77)
Active
Class A (Rhodopsin) Sensory receptors Opsins TM6 6x40 M Y 2 1 4
4ZWJ, 5W0P, 4A4M, 5DGY
-0.04 (0.01−0.05) — (—−0.71) 0.29 (0.53−0.24) -0.04 (-0.71−-0.67)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM3 3x24 G A 1 1 1
5EE7
-0.33 (0.07−0.4) -0.16 (0.17−0.33) -1.00 (0−1.00) -0.65 (0.50−1.15)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors TM3 3x47 S C 1 1 1
5LWE
-0.54 (0.02−0.56) — (—−0.61) 0.18 (0.68−0.50) -0.48 (-0.02−0.46)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors ICL1 12x50 V A 1 1 1
5LWE
0.04 (0.06−0.02) 0.09 (0.14−0.05) -0.61 (0−0.61) 0.96 (0.50−-0.46)
Inactive
Class A (Rhodopsin) Aminergic receptors Adrenoceptors TM7 7x31 D K 1 1 1
4BVN
-0.06 (0.04−0.1) -0.11 (0.11−0.22) -0.43 (0.26−0.69) 2.37 (2.80−0.43)
Intermediate
Class A (Rhodopsin) Peptide receptors Proteinase-activated receptors ECL2 N Q 1 1 3
5NJ6, 5NDD, 5NDZ
— (—−—) — (—−—) -0.26 (0.39−0.65) -0.08 (0.77−0.85)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors H8 8x63 C A 1 1 1
5LWE
— (—−0.3) — (—−0.71) -0.68 (0−0.68) 0.52 (0.50−-0.02)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM6 6x30 K A 2 1 3
5VEW, 5EE7, 5VEX
— (—−0.2) — (—−0.5) -0.26 (0−0.26) -2.30 (0.50−2.80)
Active
Inactive
Intermediate
Class A (Rhodopsin) Peptide receptors Neurotensin receptors TM1 1x54 A L 1 1 8
4XES, 4XEE, 4BWB, 4BUO, 5T04, 4BV0, 4GRV, 3ZEV
0.33 (0.37−0.04) — (—−1.0) 0.21 (0.21−0) -1.75 (-1.25−0.50)
Active
Inactive
Class A (Rhodopsin) Sensory receptors Opsins ECL3 D C 1 1 8
3C9M, 2J4Y, 4BEY, 2X72, 4A4M, 5EN0, 4BEZ, 5DYS
— (—−—) — (—−—) -0.01 (0.68−0.69) -0.45 (-0.02−0.43)
Inactive
Class A (Rhodopsin) Aminergic receptors Adrenoceptors TM5 5x58 Y A 1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
-0.69 (0.03−0.72) — (—−1.0) -0.53 (0−0.53) 1.21 (0.50−-0.71)
Inactive
Class A (Rhodopsin) Aminergic receptors Adrenoceptors TM3 3x40 I V 1 1 2
5A8E, 4BVN
-0.16 (0.24−0.4) — (—−1.0) 0.20 (0.61−0.41) 0.66 (-0.46−-1.12)
Intermediate
Class B1 (Secretin) Peptide receptors Glucagon receptor family ECL2 G A 1 1 1
5NX2
— (—−—) — (—−—) -1.00 (0−1.00) -0.65 (0.50−1.15)
Inactive
Class F (Frizzled) Protein receptors Frizzled TM3 3x40 V F 1 1 2
5L7D, 5L7I
— (—−0.09) — (—−0.09) -0.07 (0.54−0.61) -1.25 (-1.71−-0.46)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors TM2 2x38 M A 1 1 1
5LWE
0.08 (0.12−0.04) — (—−0.39) -0.24 (0−0.24) 1.17 (0.50−-0.67)
Intermediate
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM6 6x45 G A 1 1 1
5NX2
— (—−1.0) — (—−1.0) -1.00 (0−1.00) -0.65 (0.50−1.15)
Inactive
Class A (Rhodopsin) Aminergic receptors Adrenoceptors TM2 2x53 M V 1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.16 (0.23−0.07) 0.0 (0.33−0.33) 0.37 (0.61−0.24) 0.21 (-0.46−-0.67)
Inactive
Class A (Rhodopsin) Lipid receptors Lysophospholipid (LPA) receptors TM5 5x37 D C 1 1 1
4Z36
— (—−0.01) — (—−0.17) -0.01 (0.68−0.69) -0.45 (-0.02−0.43)
Intermediate
Inactive
Class A (Rhodopsin) Peptide receptors Endothelin receptors TM6 6x54 S A 1 1 2
5GLH, 5GLI
0.05 (0.1−0.05) — (—−1.0) -0.50 (0−0.50) 0.04 (0.50−0.46)
Active
Inactive
Class A (Rhodopsin) Lipid receptors Cannabinoid receptors TM5 5x37 E K 1 1 3
5TGZ, 5XRA, 5XR8
0.08 (0.11−0.03) — (—−0.5) -0.14 (0.26−0.40) 2.69 (2.80−0.11)
Inactive
Class B1 (Secretin) Peptide receptors Corticotropin-releasing factor receptors TM7 7x53 Y A 1 1 2
4K5Y, 4Z9G
— (—−0.93) — (—−1.0) -0.53 (0−0.53) 1.21 (0.50−-0.71) Removed
Inactive
Class C (Glutamate) Amino acid receptors Metabotropic glutamate receptors TM5 5x42 T A 1 1 3
5CGC, 4OO9, 5CGD
-0.04 (0.05−0.09) 0.0 (0.12−0.12) -0.66 (0−0.66) 0.25 (0.50−0.25)
Active
Class A (Rhodopsin) Sensory receptors Opsins TM2 2x60 T I 1 1 2
5EN0, 5DYS
-0.04 (0.04−0.08) -0.14 (0.29−0.43) -0.25 (0.41−0.66) -1.37 (-1.12−0.25)
Active
Inactive
Class A (Rhodopsin) Lipid receptors Cannabinoid receptors TM6 6x32 R E 1 1 3
5TGZ, 5XRA, 5XR8
-0.27 (0.04−0.31) — (—−1.0) 0.19 (0.40−0.21) -1.70 (0.11−1.81)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM2 2x59 V F 1 1 1
5EE7
— (—−0.4) — (—−0.33) -0.07 (0.54−0.61) -1.25 (-1.71−-0.46)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM5 5x51 I C 1 1 2
5VEW, 5VEX
— (—−0.6) — (—−0.67) 0.27 (0.68−0.41) 1.10 (-0.02−-1.12)
Inactive
Class A (Rhodopsin) Peptide receptors Neurotensin receptors TM5 5x54 I A 1 1 4
4BWB, 4BUO, 4BV0, 3ZEV
-0.31 (0.02−0.33) — (—−0.5) -0.41 (0−0.41) 1.62 (0.50−-1.12)
Intermediate
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM3 3x31 L F 1 1 1
5NX2
0.2 (0.4−0.2) -0.33 (0.17−0.5) 0.33 (0.54−0.21) -0.46 (-1.71−-1.25)
Intermediate
Class A (Rhodopsin) Peptide receptors Proteinase-activated receptors TM2 2x37 H A 1 1 3
5NJ6, 5NDD, 5NDZ
0.02 (0.05−0.03) — (—−0.25) -0.61 (0−0.61) 0.39 (0.50−0.11)
Intermediate
Class A (Rhodopsin) Peptide receptors Proteinase-activated receptors TM6 6x42 L A 1 1 3
5NJ6, 5NDD, 5NDZ
-0.1 (0.14−0.24) — (—−0.75) -0.21 (0−0.21) 1.75 (0.50−-1.25)
Inactive
Intermediate
Class A (Rhodopsin) Nucleotide receptors Adenosine receptors TM2 2x52 A L 1 1 14
5IUB, 3UZA, 5IU8, 3RFM, 2YDV, 5IU4, 5IUA, 2YDO, 3PWH, 4UG2, 5IU7, 4UHR, 3REY, 3UZC
0.57 (0.63−0.06) — (—−1.0) 0.21 (0.21−0) -1.75 (-1.25−0.50)
Inactive
Class A (Rhodopsin) Aminergic receptors Adrenoceptors TM1 1x59 R S 1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
-0.2 (0.04−0.24) — (—−—) 0.29 (0.50−0.21) -1.35 (0.46−1.81)
Inactive
Class B1 (Secretin) Peptide receptors Corticotropin-releasing factor receptors TM6 6x51 F A 1 1 2
4K5Y, 4Z9G
— (—−0.93) — (—−1.0) -0.54 (0−0.54) 2.21 (0.50−-1.71)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors ECL2 45x51 D C 1 1 1
4RWS
— (—−0.03) — (—−0.09) -0.01 (0.68−0.69) -0.45 (-0.02−0.43)
Intermediate
Class A (Rhodopsin) Peptide receptors Proteinase-activated receptors TM5 5x64 M A 1 1 3
5NJ6, 5NDD, 5NDZ
0.12 (0.13−0.01) — (—−0.25) -0.24 (0−0.24) 1.17 (0.50−-0.67)
Intermediate
Class A (Rhodopsin) Peptide receptors Proteinase-activated receptors TM3 3x34 G A 1 1 3
5NJ6, 5NDD, 5NDZ
0.05 (0.07−0.02) — (—−0.75) -1.00 (0−1.00) -0.65 (0.50−1.15)
Inactive
Class B1 (Secretin) Peptide receptors Corticotropin-releasing factor receptors TM1 1x36 V A 1 1 2
4K5Y, 4Z9G
— (—−0.07) — (—−0.5) -0.61 (0−0.61) 0.96 (0.50−-0.46)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM4 4x48 S A 1 1 2
5VEW, 5VEX
0.0 (0.07−0.07) 0.0 (0.17−0.17) -0.50 (0−0.50) 0.04 (0.50−0.46)
Inactive
Class C (Glutamate) Amino acid receptors Metabotropic glutamate receptors TM3 3x50 I A 1 1 3
5CGC, 4OO9, 5CGD
— (—−0.5) — (—−1.0) -0.41 (0−0.41) 1.62 (0.50−-1.12)
Inactive
Class A (Rhodopsin) Nucleotide receptors Adenosine receptors TM3 3x36 T A 1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
-0.03 (0.02−0.05) — (—−1.0) -0.66 (0−0.66) 0.25 (0.50−0.25)
Intermediate
Inactive
Class A (Rhodopsin) Peptide receptors Endothelin receptors TM2 2x56 D A 1 1 2
5GLH, 5GLI
0.07 (0.08−0.01) — (—−1.0) -0.69 (0−0.69) 0.07 (0.50−0.43)
Intermediate
Class A (Rhodopsin) Peptide receptors Proteinase-activated receptors TM3 3x43 M L 1 1 3
5NJ6, 5NDD, 5NDZ
0.68 (0.73−0.05) 0.0 (0.5−0.5) -0.03 (0.21−0.24) -0.58 (-1.25−-0.67)
Inactive
Class A (Rhodopsin) Aminergic receptors Adrenoceptors TM7 7x36 F A 1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
-0.04 (0.1−0.14) -0.33 (0.11−0.44) -0.54 (0−0.54) 2.21 (0.50−-1.71)
Inactive
Class A (Rhodopsin) Nucleotide receptors Adenosine receptors TM4 4x43 K A 1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
-0.03 (0.13−0.16) 0.0 (0.25−0.25) -0.26 (0−0.26) -2.30 (0.50−2.80)
Inactive
Class C (Glutamate) Amino acid receptors Metabotropic glutamate receptors ICL2 G M 1 1 3
5CGC, 4OO9, 5CGD
— (—−—) — (—−—) -0.76 (0.24−1.00) -1.82 (-0.67−1.15)
Intermediate
Class B1 (Secretin) Peptide receptors Glucagon receptor family ICL2 L F 1 1 1
5NX2
— (—−—) — (—−—) 0.33 (0.54−0.21) -0.46 (-1.71−-1.25)
Intermediate
Class A (Rhodopsin) Peptide receptors Neurotensin receptors TM3 3x49 E A 1 1 2
4GRV, 4XES
-0.2 (0.01−0.21) — (—−1.0) -0.40 (0−0.40) 0.39 (0.50−0.11)
Inactive
Class B1 (Secretin) Peptide receptors Corticotropin-releasing factor receptors TM4 4x43 K A 1 1 2
4K5Y, 4Z9G
— (—−0.13) — (—−1.0) -0.26 (0−0.26) -2.30 (0.50−2.80)
Intermediate
Class B1 (Secretin) Peptide receptors Glucagon receptor family ECL1 T E 1 1 1
5NX2
— (—−—) — (—−—) -0.26 (0.40−0.66) -0.14 (0.11−0.25)
Inactive
Class A (Rhodopsin) Aminergic receptors Adrenoceptors H8 8x59 C A 1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
-0.2 (0.02−0.22) — (—−0.56) -0.68 (0−0.68) 0.52 (0.50−-0.02)
Intermediate
Class A (Rhodopsin) Lipid receptors Free fatty acid receptors TM2 2x40 L A 1 1 3
5TZY, 4PHU, 5TZR
0.03 (0.06−0.03) 0.0 (0.2−0.2) -0.21 (0−0.21) 1.75 (0.50−-1.25)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors TM7 7x29 N A 1 1 1
5LWE
0.09 (0.13−0.04) -0.04 (0.09−0.13) -0.65 (0−0.65) -0.35 (0.50−0.85)
Intermediate
Class A (Rhodopsin) Nucleotide receptors P2Y receptors TM7 7x49 D N 2 1 5
4XNV, 4PY0, 4PXZ, 4XNW, 4NTJ
0.52 (0.72−0.2) — (—−0.88) -0.04 (0.65−0.69) 0.42 (0.85−0.43)
Inactive
Class C (Glutamate) Amino acid receptors Metabotropic glutamate receptors TM1 1x35 E A 1 1 3
5CGC, 4OO9, 5CGD
-0.04 (0.05−0.09) — (—−0.25) -0.40 (0−0.40) 0.39 (0.50−0.11)
Inactive
Class A (Rhodopsin) Peptide receptors Apelin receptors TM3 3x40 V A 1 1 1
5VBL
-0.18 (0.06−0.24) — (—−1.0) -0.61 (0−0.61) 0.96 (0.50−-0.46)
Intermediate
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM5 5x63 C A 1 1 1
5NX2
— (—−0.07) — (—−0.17) -0.68 (0−0.68) 0.52 (0.50−-0.02)
Intermediate
Class A (Rhodopsin) Lipid receptors Free fatty acid receptors TM5 5x58 Y F 1 1 3
5TZY, 4PHU, 5TZR
-0.71 (0.01−0.72) — (—−1.0) 0.01 (0.54−0.53) -1.00 (-1.71−-0.71)
Inactive
Class C (Glutamate) Amino acid receptors Metabotropic glutamate receptors TM5 5x53 S A 1 1 3
5CGC, 4OO9, 5CGD
— (—−0.14) — (—−0.25) -0.50 (0−0.50) 0.04 (0.50−0.46)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors TM4 4x61 G N 1 1 2
5UIW, 4MBS
0.01 (0.03−0.02) — (—−0.17) -0.35 (0.65−1.00) -0.30 (0.85−1.15)
Active
Intermediate
Class A (Rhodopsin) Peptide receptors Neurotensin receptors TM7 7x43 V A 1 1 4
5T04, 4XEE, 4GRV, 4XES
0.09 (0.19−0.1) — (—−1.0) -0.61 (0−0.61) 0.96 (0.50−-0.46)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM7 7x39 F A 1 1 1
5EE7
-0.26 (0.07−0.33) -0.16 (0.17−0.33) -0.54 (0−0.54) 2.21 (0.50−-1.71)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM3 3x24 S A 1 1 2
5VEW, 5VEX
-0.2 (0.07−0.27) -0.16 (0.17−0.33) -0.50 (0−0.50) 0.04 (0.50−0.46)
Intermediate
Class A (Rhodopsin) Lipid receptors Free fatty acid receptors TM3 3x49 G A 1 1 3
5TZY, 4PHU, 5TZR
0.0 (0.01−0.01) — (—−0.2) -1.00 (0−1.00) -0.65 (0.50−1.15)
Intermediate
Class A (Rhodopsin) Peptide receptors Proteinase-activated receptors TM3 3x51 Y A 1 1 3
5NJ6, 5NDD, 5NDZ
-0.66 (0.0−0.66) — (—−0.75) -0.53 (0−0.53) 1.21 (0.50−-0.71)
Active
Inactive
Class A (Rhodopsin) Lipid receptors Cannabinoid receptors TM3 3x46 T A 1 1 4
5TGZ, 5U09, 5XRA, 5XR8
0.0 (0.01−0.01) — (—−1.0) -0.66 (0−0.66) 0.25 (0.50−0.25)
Inactive
Class B1 (Secretin) Peptide receptors Corticotropin-releasing factor receptors TM7 7x38 S A 1 1 2
4K5Y, 4Z9G
— (—−0.13) — (—−1.0) -0.50 (0−0.50) 0.04 (0.50−0.46)
Active
Intermediate
Class A (Rhodopsin) Peptide receptors Neurotensin receptors ECL2 G A 1 1 4
5T04, 4XEE, 4GRV, 4XES
— (—−—) — (—−—) -1.00 (0−1.00) -0.65 (0.50−1.15)
Inactive
Class A (Rhodopsin) Aminergic receptors Adrenoceptors TM7 7x48 F M 1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
-0.01 (0.05−0.06) — (—−0.33) -0.30 (0.24−0.54) 1.04 (-0.67−-1.71)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors ICL1 12x48 T A 1 1 1
5LWE
-0.02 (0.03−0.05) — (—−0.05) -0.66 (0−0.66) 0.25 (0.50−0.25)
Inactive
Class A (Rhodopsin) Aminergic receptors Adrenoceptors TM3 3x41 E W 2 1 5
5A8E, 3NYA, 3NY8, 3D4S, 3NY9
0.02 (0.03−0.01) — (—−0.33) 0.09 (0.49−0.40) -2.20 (-2.09−0.11)
Intermediate
Class A (Rhodopsin) Peptide receptors Proteinase-activated receptors TM3 3x53 V E 1 1 3
5NJ6, 5NDD, 5NDZ
-0.06 (0.01−0.07) — (—−0.25) -0.21 (0.40−0.61) 0.57 (0.11−-0.46)
Inactive
Class A (Rhodopsin) Nucleotide receptors Adenosine receptors TM5 5x63 L A 1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
-0.07 (0.06−0.13) — (—−0.5) -0.21 (0−0.21) 1.75 (0.50−-1.25)
Active
Class A (Rhodopsin) Sensory receptors Opsins TM3 3x28 E Q 2 1 4
4ZWJ, 5W0P, 2X72, 5DGY
-0.01 (0.01−0.02) — (—−0.57) -0.01 (0.39−0.40) 0.66 (0.77−0.11)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors TM1 1x60 C Y 1 1 2
5UIW, 4MBS
0.05 (0.07−0.02) 0.22 (0.39−0.17) -0.15 (0.53−0.68) -0.69 (-0.71−-0.02)
Intermediate
Inactive
Class A (Rhodopsin) Peptide receptors Endothelin receptors TM5 5x36 K A 1 1 2
5GLH, 5GLI
0.01 (0.07−0.06) — (—−0.5) -0.26 (0−0.26) -2.30 (0.50−2.80)
Active
Intermediate
Class A (Rhodopsin) Aminergic receptors 5-Hydroxytryptamine receptors TM3 3x41 M W 1 1 4
4NC3, 4IB4, 5TVN, 5TUD
-0.01 (0.03−0.04) -0.25 (0.08−0.33) 0.25 (0.49−0.24) -1.42 (-2.09−-0.67)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors TM6 6x33 A D 1 1 2
5UIW, 4MBS
— (—−0.3) — (—−0.77) 0.69 (0.69−0) -0.07 (0.43−0.50)
Intermediate
Inactive
Class A (Rhodopsin) Peptide receptors Endothelin receptors TM7 7x48 I A 1 1 2
5GLH, 5GLI
-0.02 (0.13−0.15) — (—−1.0) -0.41 (0−0.41) 1.62 (0.50−-1.12)
Inactive
Class B1 (Secretin) Peptide receptors Corticotropin-releasing factor receptors ECL2 45x52 F A 1 1 2
4K5Y, 4Z9G
— (—−0.13) — (—−1.0) -0.54 (0−0.54) 2.21 (0.50−-1.71)
Inactive
Class A (Rhodopsin) Aminergic receptors Adrenoceptors TM7 7x53 Y L 1 1 2
5A8E, 4BVN
-0.86 (0.03−0.89) — (—−1.0) -0.32 (0.21−0.53) -0.54 (-1.25−-0.71) Removed
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM2 2x59 I F 1 1 2
5VEW, 5VEX
— (—−0.4) — (—−0.33) 0.13 (0.54−0.41) -0.59 (-1.71−-1.12)
Active
Inactive
Class A (Rhodopsin) Sensory receptors Opsins N-term N C 2 1 11
2X72, 4BEZ, 5DYS, 5DGY, 3C9M, 4ZWJ, 2J4Y, 4BEY, 5W0P, 4A4M, 5EN0
— (—−—) — (—−—) 0.03 (0.68−0.65) -0.87 (-0.02−0.85)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM2 2x56 S A 1 1 1
5EE7
-0.2 (0.27−0.47) 0.0 (0.5−0.5) -0.50 (0−0.50) 0.04 (0.50−0.46)
Intermediate
Class A (Rhodopsin) Nucleotide receptors Adenosine receptors TM2 2x62 T A 1 1 4
4UHR, 4UG2, 2YDV, 2YDO
0.03 (0.13−0.1) — (—−0.5) -0.66 (0−0.66) 0.25 (0.50−0.25)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM5 5x52 G I 1 1 2
5VEW, 5VEX
-0.13 (0.07−0.2) — (—−0.33) -0.59 (0.41−1.00) -2.27 (-1.12−1.15)
Inactive
Class B1 (Secretin) Peptide receptors Corticotropin-releasing factor receptors TM2 2x48 S A 1 1 2
4K5Y, 4Z9G
0.13 (0.2−0.07) — (—−0.5) -0.50 (0−0.50) 0.04 (0.50−0.46)
Inactive
Class C (Glutamate) Amino acid receptors Metabotropic glutamate receptors TM3 3x48 N Y 1 1 3
5CGC, 4OO9, 5CGD
-0.36 (0.05−0.41) — (—−1.0) -0.12 (0.53−0.65) -1.56 (-0.71−0.85)
Intermediate
Class A (Rhodopsin) Lipid receptors Free fatty acid receptors TM3 3x34 F A 1 1 2
4PHU, 5TZR
-0.04 (0.07−0.11) — (—−0.2) -0.54 (0−0.54) 2.21 (0.50−-1.71)
Inactive
Class A (Rhodopsin) Nucleotide receptors Adenosine receptors TM7 7x41 S A 1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
0.22 (0.38−0.16) — (—−0.75) -0.50 (0−0.50) 0.04 (0.50−0.46)
Active
Inactive
Class A (Rhodopsin) Aminergic receptors Adrenoceptors TM2 2x63 H C 1 1 2
4QKX, 3PDS
-0.03 (0.0−0.03) — (—−0.11) 0.07 (0.68−0.61) -0.13 (-0.02−0.11)
Inactive
Class A (Rhodopsin) Aminergic receptors Adrenoceptors TM6 6x27 A L 1 1 18
4GPO, 2Y02, 5F8U, 2YCW, 5A8E, 2Y00, 4AMI, 4AMJ, 2YCZ, 3ZPQ, 3ZPR, 4BVN, 2YCY, 2YCX, 2Y03, 2Y04, 2Y01, 2VT4
0.02 (0.11−0.09) 0.0 (0.11−0.11) 0.21 (0.21−0) -1.75 (-1.25−0.50)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors H8 8x49 K E 1 1 2
5UIW, 4MBS
-0.01 (0.12−0.13) — (—−0.57) 0.14 (0.40−0.26) -2.69 (0.11−2.80)
Inactive
Class B1 (Secretin) Peptide receptors Corticotropin-releasing factor receptors TM6 6x30 Y A 1 1 2
4K5Y, 4Z9G
— (—−0.73) — (—−1.0) -0.53 (0−0.53) 1.21 (0.50−-0.71)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM2 2x48 A L 1 1 1
5EE7
0.0 (0.2−0.2) — (—−0.5) 0.21 (0.21−0) -1.75 (-1.25−0.50)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM6 6x48 E F 1 1 1
5EE7
-0.14 (0.13−0.27) — (—−0.67) 0.14 (0.54−0.40) -1.82 (-1.71−0.11)
Intermediate
Class A (Rhodopsin) Peptide receptors Proteinase-activated receptors TM1 1x46 G A 1 1 3
5NJ6, 5NDD, 5NDZ
-0.43 (0.11−0.54) — (—−0.75) -1.00 (0−1.00) -0.65 (0.50−1.15)
Inactive
Class A (Rhodopsin) Nucleotide receptors Adenosine receptors TM6 6x41 V A 1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
-0.36 (0.05−0.41) — (—−0.5) -0.61 (0−0.61) 0.96 (0.50−-0.46)
Inactive
Class B1 (Secretin) Peptide receptors Corticotropin-releasing factor receptors TM5 5x48 I A 1 1 2
4K5Y, 4Z9G
— (—−0.2) — (—−1.0) -0.41 (0−0.41) 1.62 (0.50−-1.12)
Intermediate
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM6 6x42 P A 1 1 1
5NX2
— (—−0.93) — (—−1.0) -3.16 (0−3.16) 0.36 (0.50−0.14)
Intermediate
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM7 7x56 V A 1 1 1
5NX2
0.0 (0.07−0.07) 0.0 (0.17−0.17) -0.61 (0−0.61) 0.96 (0.50−-0.46)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM4 4x54 M A 1 1 1
5EE7
0.2 (0.27−0.07) 0.16 (0.33−0.17) -0.24 (0−0.24) 1.17 (0.50−-0.67)
Inactive
Class A (Rhodopsin) Peptide receptors Apelin receptors TM6 6x48 W K 1 1 1
5VBL
— (—−0.68) — (—−1.0) -0.23 (0.26−0.49) 4.89 (2.80−-2.09)
Inactive
Class B1 (Secretin) Peptide receptors Corticotropin-releasing factor receptors TM2 2x44 W A 1 1 2
4K5Y, 4Z9G
-0.06 (0.07−0.13) — (—−1.0) -0.49 (0−0.49) 2.59 (0.50−-2.09)
Inactive
Intermediate
Class A (Rhodopsin) Aminergic receptors Protein receptors Dopamine receptors Chemokine receptors 5-Hydroxytryptamine receptors TM3 3x41 L W 3 3 9
3OE6, 3OE8, 4IAR, 4IAQ, 4RWS, 3ODU, 3PBL, 3OE0, 3OE9
-0.28 (0.03−0.31) 0.28 (0.49−0.21) -0.84 (-2.09−-1.25)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM3 3x32 M C 1 1 2
5VEW, 5VEX
— (—−0.13) — (—−0.33) 0.44 (0.68−0.24) 0.65 (-0.02−-0.67)
Inactive
Intermediate
Class A (Rhodopsin) Peptide receptors Nucleotide receptors Adenosine receptors Neurotensin receptors TM6 6x37 L A 2 2 11
5IUB, 3UZA, 5IU8, 3RFM, 5IU4, 5IUA, 3PWH, 5IU7, 3REY, 4GRV, 3UZC
-0.34 (0.04−0.38) -0.21 (0−0.21) 1.75 (0.50−-1.25)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family ECL1 G E 1 1 1
5EE7
— (—−—) — (—−—) -0.60 (0.40−1.00) -1.04 (0.11−1.15)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM6 6x45 G C 1 1 2
5VEW, 5VEX
— (—−1.0) — (—−1.0) -0.32 (0.68−1.00) -1.17 (-0.02−1.15)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors TM6 6x36 T P 1 1 3
4RWS, 3OE0, 3OE9
-0.25 (0.0−0.25) 0.0 (0.04−0.04) 2.50 (3.16−0.66) -0.11 (0.14−0.25)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors TM5 5x41 T A 1 1 1
5LWE
-0.02 (0.07−0.09) -0.05 (0.04−0.09) -0.66 (0−0.66) 0.25 (0.50−0.25)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM2 2x56 S C 1 1 2
5VEW, 5VEX
— (—−0.47) — (—−0.5) 0.18 (0.68−0.50) -0.48 (-0.02−0.46)
Inactive
Class B1 (Secretin) Peptide receptors Corticotropin-releasing factor receptors TM1 1x60 L A 1 1 2
4K5Y, 4Z9G
— (—−0.33) — (—−1.0) -0.21 (0−0.21) 1.75 (0.50−-1.25)
Intermediate
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM6 6x47 H V 1 1 1
5NX2
— (—−0.73) — (—−1.0) 0.00 (0.61−0.61) -0.57 (-0.46−0.11)
Inactive
Class A (Rhodopsin) Nucleotide receptors Adenosine receptors TM3 3x55 R A 1 1 10
5IUB, 3UZC, 3PWH, 3UZA, 5IU7, 5IU8, 3REY, 3RFM, 5IU4, 5IUA
0.03 (0.08−0.05) — (—−0.25) -0.21 (0−0.21) -1.31 (0.50−1.81)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM6 6x31 C F 1 1 2
5VEW, 5VEX
0.0 (0.07−0.07) 0.0 (0.17−0.17) -0.14 (0.54−0.68) -1.69 (-1.71−-0.02)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors TM6 6x36 V A 1 1 1
5LWE
-0.14 (0.01−0.15) — (—−0.39) -0.61 (0−0.61) 0.96 (0.50−-0.46)
Inactive
Class A (Rhodopsin) Protein receptors Chemokine receptors TM7 7x39 T A 1 1 1
5LWE
0.05 (0.08−0.03) -0.09 (0.13−0.22) -0.66 (0−0.66) 0.25 (0.50−0.25)
Intermediate
Class B1 (Secretin) Peptide receptors Glucagon receptor family ECL2 45x52 T A 1 1 1
5NX2
— (—−0.2) — (—−0.5) -0.66 (0−0.66) 0.25 (0.50−0.25)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM2 2x39 R A 1 1 1
5EE7
— (—−1.0) — (—−1.0) -0.21 (0−0.21) -1.31 (0.50−1.81)
Intermediate
Class B1 (Secretin) Peptide receptors Glucagon receptor family ECL1 D R 1 1 1
5NX2
— (—−—) — (—−—) -0.48 (0.21−0.69) 1.38 (1.81−0.43)
Intermediate
Inactive
Class A (Rhodopsin) Peptide receptors Endothelin receptors TM1 1x55 R Y 1 1 2
5GLH, 5GLI
0.07 (0.09−0.02) — (—−1.0) 0.32 (0.53−0.21) -2.52 (-0.71−1.81)
Intermediate
Class A (Rhodopsin) Peptide receptors Proteinase-activated receptors TM6 6x38 I A 1 1 3
5NJ6, 5NDD, 5NDZ
0.06 (0.14−0.08) — (—−0.25) -0.41 (0−0.41) 1.62 (0.50−-1.12)
Intermediate
Class A (Rhodopsin) Nucleotide receptors Adenosine receptors TM2 2x46 L A 1 1 4
4UHR, 4UG2, 2YDV, 2YDO
— (—−0.9) — (—−1.0) -0.21 (0−0.21) 1.75 (0.50−-1.25)
Inactive
Class B1 (Secretin) Peptide receptors Glucagon receptor family TM1 1x48 G A 1 1 1
5EE7
0.2 (0.33−0.13) 0.0 (0.17−0.17) -1.00 (0−1.00) -0.65 (0.50−1.15)
Intermediate
Class A (Rhodopsin) Nucleotide receptors Adenosine receptors TM3 3x37 Q A 1 1 4
4UHR, 4UG2, 2YDV, 2YDO
0.01 (0.03−0.02) — (—−0.75) -0.39 (0−0.39) -0.27 (0.50−0.77)