Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Active
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
Cannabinoid
CNR1
LPAR1
CB1
LPA1
TM5 5x37
D
E
K
C
2 2 4
5XR8, 5XRA, 4Z36, 5TGZ
1
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Peptide
Dopamine
Neurotensin
Adenosine
AA1R
AA2AR
NTR1
DRD2
D2
NTS1
A2A
A1
TM6 6x37
L
A
4 3 26
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 6CM4, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5N2S, 5IUB, 4GRV, 5IU7, 5MZJ
1 1 4
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NDZ, 5NJ6, 5NDD
5
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEX, 5VEW
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C
A
1 1 3
5VEX, 5NX2, 5VEW
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
3
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5IUB, 5IU7, 5MZJ
1 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4Z9G, 4K5Y
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
8
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4Z9G, 4K5Y
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
4
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5XR8, 5XRA, 5TGZ
1 3
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NDZ, 5NJ6, 5NDD
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
5A8E, 4BVN
Pos Match Pos Match 3
Active
Intermediate
Inactive
A (Rhodopsin)
Protein
Aminergic
5-Hydroxytryptamine
Chemokine
Dopamine
Adrenoceptors
5HT2B
5HT1B
CXCR4
ADRB1
DRD3
ADRB2
D3
5-HT1B
β1
5-HT2B
β2
CXCR4
TM3 3x41
L
E
M
W
6 4 20
3NY9, 3OE6, 5A8E, 3OE0, 6G79, 3NYA, 3OE9, 3OE8, 4IAQ, 5TVN, 4RWS, 4IAR, 3ODU, 3PBL, 5TUD, 4IB4, 3D4S, 5V54, 3NY8, 4NC3
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NDZ, 5NJ6, 5NDD
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM3 3x36
T
A
2 1 24
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5N2S, 5IUB, 5IU7, 5MZJ
16
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEX, 5VEW
1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 18
3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 2Y00
2
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 2
4MBS, 5UIW
3 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
4BUO, 4BWB, 4BV0, 3ZEV
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5DYS, 5EN0
13
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
4XEE, 4GRV, 4XES, 5T04
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 18
3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 2Y00
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CCR9
CCR9
CXCR4
TM6 6x36
V
T
P
A
2 1 4
5LWE, 3OE9, 3OE0, 4RWS
2 1 3
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQH, 6BQG
Pos Match 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5X93, 5XPR
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
5TZY, 5KW2, 4PHU, 5TZR
2 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 18
3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 2Y00
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEX, 5VEW
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4Z9G, 4K5Y
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM2 2x52
A
L
2 1 28
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 2YDO, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 4UHR, 3UZC, 5IU8, 4UG2, 2YDV, 5NM2, 5OLO, 5OM4, 5IUA, 5OLV, 5N2S, 5IUB, 5IU7, 5MZJ
1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 5
5W0P, 4ZWJ, 6CMO, 2X72, 5DGY
8
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49
D
N
2 1 5
4XNW, 4XNV, 4PY0, 4NTJ, 4PXZ
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5IUB, 5IU7, 5MZJ
Intermediate
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
CRFR1
GLP-1
CRF1
ECL2 45x52
F
T
A
2 2 3
4Z9G, 4K5Y, 5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM2 2x56
S
C
A
2 1 3
5VEX, 5VEW, 5EE7
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Proteinase-activated
FFAR1
PAR2
PAR2
FFA1
TM3 3x34
F
G
A
2 2 5
5NDZ, 5NJ6, 4PHU, 5NDD, 5TZR
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5X93, 5XPR
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Inactive
A (Rhodopsin)
Aminergic
Peptide
Dopamine
Adrenoceptors
Apelin
APJ
ADRB1
DRD2
β1
apelin
D2
TM3 3x40
I
V
V
A
3 3 4
5VBL, 5A8E, 6CM4, 4BVN
2
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5X93, 5XPR
4
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4Z9G, 4K5Y
1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
4QKX, 3PDS
8
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEX, 5VEW
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 17
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
3
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 2Y00
Intermediate
Inactive
A (Rhodopsin)
Lipid
Aminergic
Free fatty acid
Adrenoceptors
FFAR1
ADRB1
β1
FFA1
TM5 5x58
Y
F
A
2 2 22
3ZPQ, 2Y02, 5A8E, 4AMJ, 4GPO, 5F8U, 2Y01, 2YCW, 4PHU, 4AMI, 3ZPR, 2YCX, 5TZY, 2Y04, 2YCY, 5KW2, 4BVN, 2VT4, 2YCZ, 2Y03, 5TZR, 2Y00
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 2
4MBS, 5UIW
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLR
GLP1R
CRFR1
GLP-1
CRF1
glucagon
TM6 6x30
K
Y
A
3 2 5
4Z9G, 5VEX, 5VEW, 5EE7, 4K5Y
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 2
4MBS, 5UIW
4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEX, 5VEW
1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM5 5x63
L
Y
A
2 1 24
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5N2S, 5IUB, 5IU7, 5MZJ
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NDZ, 5NJ6, 5NDD
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NDZ, 5NJ6, 5NDD
1 3
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5U09, 5XR8, 5XRA, 5TGZ
1
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
4BWB, 4BUO, 4XEE, 3ZEV, 4BV0, 4GRV, 4XES, 5T04
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
2 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4Z9G, 4K5Y
Pos Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM2 2x59
I
V
F
2 1 3
5VEX, 5VEW, 5EE7
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5EE7, 5YQZ
1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
Pos Match
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 2
4MBS, 5UIW
2 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 5
5DGY, 5W0P, 4ZWJ, 6CMO, 4A4M
1 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4Z9G, 4K5Y
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM3 3x24
G
S
A
2 1 3
5VEX, 5VEW, 5EE7
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
12
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
ECL1
D
L
Q
G
T
R
F
E
A
2 1 2
5NX2, 5EE7
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NDZ, 5NJ6, 5NDD
Active
Intermediate
Inactive
A (Rhodopsin)
Lipid
Sensory
Peptide
Leukotriene
Neurotensin
Opsins
OPSD
NTR1
Q9WTK1
OPSD
NTS1
BLT1
Rhodopsin
ECL2
D
G
S
N
C
A
4 3 17
5DGY, 5W0P, 4BEY, 6CMO, 4XEE, 5EN0, 4BEZ, 3C9M, 2X72, 4A4M, 4XES, 4ZWJ, 5X33, 2J4Y, 5DYS, 4GRV, 5T04
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Dopamine
Adenosine
AA1R
AA2AR
DRD2
D2
A2A
A1
TM6 6x41
L
V
A
3 2 25
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 6CM4, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5N2S, 5IUB, 5IU7, 5MZJ
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLR
CRFR1
CRF1
glucagon
TM2 2x48
S
A
L
A
2 2 3
4Z9G, 5EE7, 4K5Y
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NDZ, 5NJ6, 5NDD
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
Inactive
A (Rhodopsin)
Aminergic
Peptide
Endothelin
Adrenoceptors
ADRB1
EDNRB
ETB
β1
TM7 7x48
F
I
M
A
2 2 20
5X93, 3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 5XPR, 2Y00
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM7 7x41
S
T
A
2 1 24
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5N2S, 5IUB, 5IU7, 5MZJ
5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4Z9G, 4K5Y
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Neurotensin
FFAR1
NTR1
NTS1
FFA1
TM3 3x49
G
E
A
2 2 6
5TZR, 5TZY, 5KW2, 4PHU, 4GRV, 4XES
Pos Match 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4Z9G, 4K5Y
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7I, 5L7D
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NDZ, 5NJ6, 5NDD
1 1 1
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5IUB, 5IU7, 5MZJ
0.13 0 0.50
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Peptide
Dopamine
Neurotensin
Adenosine
AA1R
AA2AR
NTR1
DRD2
D2
NTS1
A2A
A1
TM6 6x37
L
A 4 3 26
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 6CM4, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5N2S, 5IUB, 4GRV, 5IU7, 5MZJ
0.04 0 0.50 1 1 4
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4Z9G, 4K5Y
0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
5TZY, 5KW2, 4PHU, 5TZR
0.01 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4Z9G, 4K5Y
0 0.50 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 2Y00
0.11 0.11 0.21 -1.25
Active
Intermediate
Inactive
A (Rhodopsin)
Lipid
Peptide
Leukotriene
Neurotensin
NTR1
Q9WTK1
NTS1
BLT1
ECL2
G
S
A 2 2 5
4XEE, 5X33, 4GRV, 4XES, 5T04
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.13 0 0.50 1 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.01 0 0.50 2 1 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 2
4MBS, 5UIW
0.12 0.40 0.11 3 1 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
0 0.50 Pos & Mutant AA Match
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
D
N
C 2 1 12
5W0P, 4BEY, 6CMO, 5EN0, 4BEZ, 3C9M, 2X72, 4A4M, 4ZWJ, 2J4Y, 5DYS, 5DGY
0.68 -0.02
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.03 0 0.50 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 17
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5IUB, 5IU7, 5MZJ
0.08 0 0.50 1 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.14 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEX, 5VEW
0.68 -0.02 1
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
4BWB, 4BUO, 4XEE, 3ZEV, 4BV0, 4GRV, 4XES, 5T04
0.37 0.21 -1.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.0 0 0.50 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
Q
G
A 1 1 1
5NX2
0 0.50
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
4QKX, 3PDS
0.0 0.68 -0.02 8
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 5
5DGY, 5W0P, 4ZWJ, 6CMO, 4A4M
0.01 0.53 -0.71 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5X93, 5XPR
0.13 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM3 3x24
G
S
A 2 1 3
5VEX, 5VEW, 5EE7
0.07 0 0.50
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5X93, 5XPR
0.1 0 0.50 4
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM7 7x41
S
T
A 2 1 24
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5N2S, 5IUB, 5IU7, 5MZJ
0.38 0 0.50 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 2
4MBS, 5UIW
0.03 0.65 0.85 4
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5X93, 5XPR
0.09 0.53 -0.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.06 0 0.50 1
Intermediate
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
CRFR1
GLP-1
CRF1
ECL2 45x52
F
T
A 2 2 3
4Z9G, 4K5Y, 5NX2
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 2
4MBS, 5UIW
0.69 0.43 2 1 5
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 2Y00
0.03 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
0.05 0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5U09, 5XR8, 5XRA, 5TGZ
0.01 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEX, 5VEW
0.07 0 0.50
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Proteinase-activated
FFAR1
PAR2
PAR2
FFA1
TM3 3x34
F
G
A 2 2 5
5NDZ, 5NJ6, 4PHU, 5NDD, 5TZR
0.07 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7I, 5L7D
0.54 -1.71 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEX, 5VEW
0.07 0.54 -1.71 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
4BUO, 4BWB, 4BV0, 3ZEV
0.02 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLR
GLP1R
CRFR1
GLP-1
CRF1
glucagon
TM6 6x30
K
Y
A 3 2 5
4Z9G, 5VEX, 5VEW, 5EE7, 4K5Y
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 18
3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 2Y00
0.1 0.11 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.05 0 0.50 1 1 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 2 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM3 3x36
T
A 2 1 24
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5N2S, 5IUB, 5IU7, 5MZJ
0.02 0 0.50 16
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
5TZY, 5KW2, 4PHU, 5TZR
0.06 0 0.50 2 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 18
3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 2Y00
0.05 0.24 -0.67
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
5A8E, 4BVN
0.24 0.61 -0.46 2
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 3
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 5
5W0P, 4ZWJ, 6CMO, 2X72, 5DGY
0.01 0.39 0.77 8
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM2 2x52
A
L 2 1 28
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 2YDO, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 4UHR, 3UZC, 5IU8, 4UG2, 2YDV, 5NM2, 5OLO, 5OM4, 5IUA, 5OLV, 5N2S, 5IUB, 5IU7, 5MZJ
0.63 0.21 -1.25 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEX, 5VEW
0.07 0.41 -1.12
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 18
3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 2Y00
0.04 0.50 0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 3
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5XR8, 5XRA, 5TGZ
0.04 0.40 0.11 1 3
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Neurotensin
FFAR1
NTR1
NTS1
FFA1
TM3 3x49
G
E
A 2 2 6
5TZR, 5TZY, 5KW2, 4PHU, 4GRV, 4XES
0.01 0 0.50 Pos & Mutant AA Match 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
3OE9, 3OE0, 4RWS
0.0 3.16 0.14 2 1 3
Inactive
A (Rhodopsin)
Aminergic
Peptide
Dopamine
Apelin
APJ
DRD2
apelin
D2
TM3 3x40
V
I
A 2 2 2
5VBL, 6CM4
0.06 0 0.50 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4Z9G, 4K5Y
0 0.50
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5DYS, 5EN0
0.04 0.29 0.41 -1.12 13
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.08 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 12
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4Z9G, 4K5Y
0.2 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4Z9G, 4K5Y
0.07 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 2
4MBS, 5UIW
0.07 0.53 -0.71 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.13 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NDZ, 5NJ6, 5NDD
0.01 0.40 0.11 5
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQH, 6BQG
0.67 0.65 0.85 Pos & AA Mutant Match 1
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
ECL1
G
T
E 2 1 2
5NX2, 5EE7
0.40 0.11
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Dopamine
Adenosine
AA1R
AA2AR
DRD2
D2
A2A
A1
TM6 6x41
L
V
A 3 2 25
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 6CM4, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5N2S, 5IUB, 5IU7, 5MZJ
0.05 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4Z9G, 4K5Y
0 0.50 Pos & Mutant AA Match 1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5XR8, 5XRA, 5TGZ
0.11 0.26 2.80 1
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
4XEE, 4GRV, 4XES, 5T04
0.19 0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5X93, 5XPR
0.07 0 0.50 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM5 5x63
L
Y
A 2 1 24
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5N2S, 5IUB, 5IU7, 5MZJ
0.06 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5EE7, 5YQZ
0 0.50 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NDZ, 5NJ6, 5NDD
0.73 0.21 -1.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.11 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49
D
N 2 1 5
4XNW, 4XNV, 4PY0, 4NTJ, 4PXZ
0.72 0.65 0.85
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
5A8E, 4BVN
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 3
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.13 0 0.50
Active
Intermediate
Inactive
A (Rhodopsin)
Protein
Aminergic
5-Hydroxytryptamine
Chemokine
Dopamine
Adrenoceptors
5HT2B
5HT1B
CXCR4
ADRB1
DRD3
ADRB2
D3
5-HT1B
β1
5-HT2B
β2
CXCR4
TM3 3x41
L
E
M
W 6 4 20
3NY9, 3OE6, 5A8E, 3OE0, 6G79, 3NYA, 3OE9, 3OE8, 4IAQ, 5TVN, 4RWS, 4IAR, 3ODU, 3PBL, 5TUD, 4IB4, 3D4S, 5V54, 3NY8, 4NC3
0.03 0.49 -2.09 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
0.05 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
0.05 0.53 -0.71
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.67 1.00 1.15 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
0.24 -0.67
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0.13 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4Z9G, 4K5Y
0 0.50 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.2 1.00 1.15
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 18
3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 2Y00
0.23 0.33 0.61 -0.46 2
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0.03 0 0.50 8
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM2 2x59
I
V
F 2 1 3
5VEX, 5VEW, 5EE7
0.54 -1.71
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40 M
Y
2 1 5
5DGY, 5W0P, 4ZWJ, 6CMO, 4A4M
0.05 0.71 0.24 -0.67 1 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54 S
A
1 1 2
5X93, 5XPR
0.05 0.50 0.46 4
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM3 3x36 T
A
2 1 24
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5N2S, 5IUB, 5IU7, 5MZJ
0.05 0.66 0.25 16
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.04 0.65 0.85
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64 M
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.01 0.24 -0.67 1 3
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Dopamine
Adenosine
AA1R
DRD2
A1
D2
TM6 6x41 L
A
2 2 2
5N2S, 6CM4
0.19 0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 2
4MBS, 5UIW
0.02 1.00 1.15 4
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42 T
A
1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
0.09 0.66 0.25
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Peptide
Dopamine
Neurotensin
Adenosine
AA1R
AA2AR
NTR1
DRD2
D2
NTS1
A2A
A1
TM6 6x37 L
A
4 3 26
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 6CM4, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5N2S, 5IUB, 4GRV, 5IU7, 5MZJ
0.38 0.21 -1.25 1 1 4
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.68 0.49 -2.09 Pos & Wild Type AA Match 17
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
ECL2 G
A
1 1 4
4XEE, 4GRV, 4XES, 5T04
1.00 1.15
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21 K
G
1 1 1
5X33
0.01 0.26 2.80 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM7 7x41 T
A
1 1 1
5N2S
0.07 0.66 0.25 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51 D
C
1 1 1
4RWS
0.03 0.69 0.43 12
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60 L
A
1 1 2
4Z9G, 4K5Y
0.33 0.21 -1.25
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32 R
E
1 1 3
5XR8, 5XRA, 5TGZ
0.31 0.21 1.81 1 3
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59 R
S
1 1 18
3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 2Y00
0.24 0.21 1.81
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NDZ, 5NJ6, 5NDD
0.05 0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52 G
I
1 1 2
5VEX, 5VEW
0.2 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4Z9G, 4K5Y
0.13 0.26 2.80
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31 C
F
1 1 2
5VEX, 5VEW
0.07 0.68 -0.02 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38 S
A
1 1 2
4Z9G, 4K5Y
0.13 0.50 0.46 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53 S
A
1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
0.14 0.50 0.46
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31 L
F
1 1 1
5NX2
0.2 0.21 -1.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47 H
V
1 1 1
5NX2
0.73 0.61 0.11
Inactive
A (Rhodopsin)
Aminergic
Dopamine
Adrenoceptors
ADRB1
DRD2
β1
D2
TM3 3x40 I
V
A
2 2 3
5A8E, 6CM4, 4BVN
0.4 0.41 -1.12 2
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36 K
A
1 1 2
5X93, 5XPR
0.06 0.26 2.80 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53 M
V
1 1 18
3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 2Y00
0.07 0.33 0.24 -0.67 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39 R
A
1 1 2
5EE7, 5YQZ
1.0 0.21 1.81 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35 E
A
1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
0.09 0.40 0.11
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 2Y00
0.08 0.11 0 0.50
Active
Intermediate
Inactive
A (Rhodopsin)
Protein
Aminergic
5-Hydroxytryptamine
Chemokine
Dopamine
CXCR4
DRD3
5HT1B
D3
5-HT1B
CXCR4
TM3 3x41 L
W
3 3 11
3OE6, 3OE0, 6G79, 3OE9, 4RWS, 3OE8, 4IAQ, 4IAR, 3ODU, 3PBL, 5V54
0.31 0.21 -1.25 1
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45 G
C
A
1 1 3
5VEX, 5NX2, 5VEW
1.0 1.00 1.15
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM5 5x63 Y
A
1 1 1
5N2S
0.03 0.53 -0.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33 A
D
1 1 2
4MBS, 5UIW
0.29 0 0.50 2 1 5
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5U09, 5XR8, 5XRA, 5TGZ
0.01 0.66 0.25 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67 V
A
1 1 1
5X33
0.02 0.61 -0.46 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53 Y
L
1 1 2
5A8E, 4BVN
0.89 1.0 0.53 -0.71 Pos & Wild Type AA Match Pos & Wild Type AA Match 3
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63 C
A
1 1 1
5NX2
0.07 0.68 -0.02
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60 C
Y
1 1 2
4MBS, 5UIW
0.02 0.68 -0.02 1
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM3 3x49 E
A
1 1 2
4GRV, 4XES
0.21 0.40 0.11 Pos & Wild Type AA Match 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x59 I
F
1 1 2
5VEX, 5VEW
0.4 0.41 -1.12
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37 H
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.03 0.61 0.11 1 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48 A
L
1 1 1
5EE7
0.2 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM6 6x30 K
A
2 1 3
5VEX, 5VEW, 5EE7
0.2 0.26 2.80
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49 D
N
2 1 5
4XNW, 4XNV, 4PY0, 4NTJ, 4PXZ
0.2 0.69 0.43
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM3 3x40 V
A
1 1 1
5VBL
0.24 0.61 -0.46 2
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term N
C
2 1 12
5W0P, 4BEY, 6CMO, 5EN0, 4BEZ, 3C9M, 2X72, 4A4M, 4ZWJ, 2J4Y, 5DYS, 5DGY
0.65 0.85
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55 R
Y
1 1 2
5X93, 5XPR
0.02 0.21 1.81
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36 F
A
1 1 18
3ZPQ, 4AMI, 2Y02, 5A8E, 3ZPR, 2YCX, 2Y04, 2YCY, 4BVN, 2VT4, 2YCZ, 4AMJ, 2Y03, 5F8U, 4GPO, 2Y01, 2YCW, 2Y00
0.14 0.44 0.54 -1.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48 N
Y
1 1 5
4OO9, 6FFI, 6FFH, 5CGD, 5CGC
0.41 0.65 0.85
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46 L
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0.9 0.21 -1.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56 V
A
1 1 1
5NX2
0.07 0.61 -0.46 2 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
ADRB2
β2
β1
TM3 3x41 E
W
2 1 5
3NYA, 5A8E, 3D4S, 3NY8, 3NY9
0.01 0.33 0.40 0.11 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56 D
A
1 1 1
5X93
0.01 0.69 0.43
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
ECL2 G
E
A
2 1 2
5NX2, 5EE7
1.00 1.15
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x34 F
A
1 1 2
4PHU, 5TZR
0.11 0.54 -1.71 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38 I
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.08 0.41 -1.12
Intermediate
Inactive
A (Rhodopsin)
Lipid
Aminergic
Free fatty acid
Adrenoceptors
FFAR1
ADRB1
β1
FFA1
TM5 5x58 Y
F
A
2 2 22
3ZPQ, 2Y02, 5A8E, 4AMJ, 4GPO, 5F8U, 2Y01, 2YCW, 4PHU, 4AMI, 3ZPR, 2YCX, 5TZY, 2Y04, 2YCY, 5KW2, 4BVN, 2VT4, 2YCZ, 2Y03, 5TZR, 2Y00
0.72 0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x24 S
A
1 1 2
5VEX, 5VEW
0.27 0.50 0.46
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43 V
A
1 1 4
4XEE, 4GRV, 4XES, 5T04
0.1 0.61 -0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41 T
A
1 1 1
5LWE
0.09 0.66 0.25
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48 I
A
1 1 2
5X93, 5XPR
0.15 0.41 -1.12
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54 A
L
1 1 8
4BWB, 4BUO, 4XEE, 3ZEV, 4BV0, 4GRV, 4XES, 5T04
0.04 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x30 Y
A
1 1 2
4Z9G, 4K5Y
0.73 0.53 -0.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NDZ, 5NJ6, 5NDD
0.07 0.61 -0.46 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48 I
A
1 1 2
4Z9G, 4K5Y
0.2 0.41 -1.12
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54 M
A
1 1 1
5EE7
0.07 0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM2 2x56 S
C
A
2 1 3
5VEX, 5VEW, 5EE7
0.47 0.50 0.46
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31 D
K
1 1 1
4BVN
0.1 0.22 0.69 0.43 4
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40 L
A
1 1 4
5TZY, 5KW2, 4PHU, 5TZR
0.03 0.21 -1.25 2 1 1
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45 C
N
1 1 2
6BQH, 6BQG
0.01 0.68 -0.02 Pos & Wild Type AA Match 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50 D
N
1 1 1
5WF5
0.92 0.69 0.43 Pos & Wild Type AA Match 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36 V
A
1 1 2
4Z9G, 4K5Y
0.07 0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x59 V
F
1 1 1
5EE7
0.4 0.61 -0.46
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.12 0.61 -0.46 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49 K
E
1 1 2
4MBS, 5UIW
0.13 0.26 2.80 3 1 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
C-term S
A
1 1 1
5X33
0.50 0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53 Y
A
1 1 2
4Z9G, 4K5Y
0.93 0.53 -0.71 Pos & Wild Type AA Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36 T
P
1 1 3
3OE9, 3OE0, 4RWS
0.25 0.66 0.25 2 1 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39 F
A
1 1 1
5EE7
0.33 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51 F
A
1 1 2
4Z9G, 4K5Y
0.93 0.54 -1.71 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48 S
A
1 1 2
4Z9G, 4K5Y
0.07 0.50 0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36 V
A
1 1 1
5LWE
0.15 0.61 -0.46 2 1 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
ECL2 45x52 F
A
1 1 2
4Z9G, 4K5Y
0.13 0.54 -1.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48 T
A
1 1 1
5LWE
0.05 0.66 0.25 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM6 6x41 V
A
1 1 23
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5IUB, 5IU7, 5MZJ
0.41 0.61 -0.46
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37 Q
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0.02 0.39 0.77 8
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 5
5W0P, 4ZWJ, 6CMO, 2X72, 5DGY
0.02 0.57 0.40 0.11 8
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62 T
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0.1 0.66 0.25
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5DYS, 5EN0
0.08 0.43 0.66 0.25 13
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 Q
A
1 1 1
5NX2
0.39 0.77
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55 R
A
1 1 23
5OM1, 3PWH, 5N2R, 3REY, 5OLG, 5OLH, 3UZA, 5MZP, 5NLX, 5NM4, 3RFM, 5OLZ, 5IU4, 3UZC, 5IU8, 5OLO, 5NM2, 5OM4, 5IUA, 5OLV, 5IUB, 5IU7, 5MZJ
0.05 0.21 1.81 1 2
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63 H
C
1 1 2
4QKX, 3PDS
0.03 0.11 0.61 0.11 8
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 D
R
1 1 1
5NX2
0.69 0.43
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67 H
G
1 1 1
5X33
0.1 0.61 0.11
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51 I
C
1 1 2