Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
2YDO, 4UG2, 4UHR, 2YDV
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
Active
Inactive
Intermediate
A (Rhodopsin)
Peptide
Lipid
Sensory
Neurotensin
Leukotriene
Opsins
OPSD
NTR1
Q9WTK1
OPSD
NTS1
BLT1
Rhodopsin
ECL2
D
G
N
S
C
A
4 3 17
6CMO, 4BEZ, 5DYS, 5EN0, 5T04, 4GRV, 5DGY, 2X72, 4XES, 3C9M, 5W0P, 5X33, 4A4M, 4ZWJ, 4BEY, 2J4Y, 4XEE
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y12
P2Y1
TM7 7x49
D
N
2 1 5
4PY0, 4NTJ, 4PXZ, 4XNV, 4XNW
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
2 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 2
5UIW, 4MBS
3 1 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
2YDO, 4UG2, 4UHR, 2YDV
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
3
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
Intermediate
A (Rhodopsin)
Peptide
Lipid
Free fatty acid
Proteinase-activated
FFAR1
PAR2
FFA1
PAR2
TM3 3x34
G
F
A
2 2 5
4PHU, 5NJ6, 5NDD, 5NDZ, 5TZR
1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 18
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
2
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
2YDO, 4UG2, 4UHR, 2YDV
8
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
Intermediate
A (Rhodopsin)
Lipid
Aminergic
Free fatty acid
Adrenoceptors
FFAR1
ADRB1
β1
FFA1
TM5 5x58
Y
F
A
2 2 22
2Y03, 5KW2, 2Y00, 2VT4, 4GPO, 4AMI, 5A8E, 4PHU, 5TZR, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 5TZY, 2Y04, 4BVN, 2YCX, 2Y01, 2YCY
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEW, 5VEX
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 18
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
4
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
4BVN, 5A8E
Pos Match Pos Match 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEW, 5VEX
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7D, 5L7I
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CCR9
CXCR4
CCR9
TM6 6x36
T
V
P
A
2 1 4
4RWS, 5LWE, 3OE9, 3OE0
2 1 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 5
6CMO, 5DGY, 4A4M, 4ZWJ, 5W0P
1 1
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C
A
1 1 3
5NX2, 5VEW, 5VEX
Intermediate
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Free fatty acid
FFAR1
NTR1
NTS1
FFA1
TM3 3x49
E
G
A
2 2 6
4PHU, 4GRV, 5TZY, 5KW2, 4XES, 5TZR
Pos Match 2
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQH, 6BQG
Pos Match 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NJ6, 5NDD, 5NDZ
1 3
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5XR8, 5XRA, 5U09, 5TGZ
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Inactive
Intermediate
A (Rhodopsin)
Peptide
Nucleotide
Aminergic
Neurotensin
Adenosine
Dopamine
AA1R
AA2AR
NTR1
DRD2
A2A
NTS1
A1
D2
TM6 6x37
L
A
4 3 26
5NM4, 5NM2, 4GRV, 6CM4, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
1 1 4
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLR
CRFR1
glucagon
CRF1
TM2 2x48
S
A
L
A
2 2 3
4K5Y, 5EE7, 4Z9G
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEW, 5VEX
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
3
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NJ6, 5NDD, 5NDZ
1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4K5Y, 4Z9G
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
ECL1
T
L
G
Q
D
E
R
F
A
2 1 2
5NX2, 5EE7
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5X93, 5XPR
4
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4K5Y, 4Z9G
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLR
GLP1R
CRFR1
CRF1
GLP-1
glucagon
TM6 6x30
Y
K
A
3 2 5
4Z9G, 5VEW, 4K5Y, 5VEX, 5EE7
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
2
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5X93, 5XPR
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5EN0, 5DYS
13
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5X93, 5XPR
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NJ6, 5NDD, 5NDZ
1 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 2
5UIW, 4MBS
1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM3 3x36
T
A
2 1 24
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
16
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NJ6, 5NDD, 5NDZ
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA1R
AA2AR
DRD2
A2A
A1
D2
TM6 6x41
V
L
A
3 2 25
5NM4, 5NM2, 6CM4, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
Inactive
A (Rhodopsin)
Peptide
Aminergic
Endothelin
Adrenoceptors
ADRB1
EDNRB
β1
ETB
TM7 7x48
I
F
M
A
2 2 20
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 5XPR, 2Y02, 5X93, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM2 2x52
A
L
2 1 28
5NM4, 5NM2, 3REY, 2YDO, 4UHR, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 2YDV, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 4UG2, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 2
5UIW, 4MBS
2 1 5
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NJ6, 5NDD, 5NDZ
Active
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
Cannabinoid
CNR1
LPAR1
CB1
LPA1
TM5 5x37
E
D
C
K
2 2 4
4Z36, 5XR8, 5XRA, 5TGZ
1
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
5T04, 4GRV, 4XEE, 4XES
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEW, 5VEX
1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 1
Inactive
A (Rhodopsin)
Peptide
Aminergic
Apelin
Adrenoceptors
Dopamine
APJ
ADRB1
DRD2
β1
apelin
D2
TM3 3x40
I
V
V
A
3 3 4
6CM4, 4BVN, 5VBL, 5A8E
2
Active
Inactive
Intermediate
A (Rhodopsin)
Protein
Aminergic
Chemokine
Adrenoceptors
5-Hydroxytryptamine
Dopamine
5HT2B
5HT1B
CXCR4
ADRB1
DRD3
ADRB2
5-HT2B
D3
5-HT1B
β2
β1
CXCR4
TM3 3x41
E
M
L
W
6 4 20
6G79, 4IAQ, 5TUD, 3D4S, 5V54, 3NY9, 3OE0, 3ODU, 4RWS, 5TVN, 3NYA, 3NY8, 3OE8, 4NC3, 3PBL, 4IAR, 4IB4, 3OE6, 3OE9, 5A8E
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM2 2x59
I
V
F
2 1 3
5VEW, 5VEX, 5EE7
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 18
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4K5Y, 4Z9G
1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM7 7x41
T
S
A
2 1 24
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
5
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
1 2
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
4PHU, 5TZY, 5KW2, 5TZR
2 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM3 3x24
G
S
A
2 1 3
5VEW, 5VEX, 5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 5
6CMO, 5DGY, 2X72, 4ZWJ, 5W0P
8
Active
Inactive
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
3ZEV, 4BUO, 4BWB, 5T04, 4GRV, 4XEE, 4BV0, 4XES
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4K5Y, 4Z9G
Pos Match 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NJ6, 5NDD, 5NDZ
5
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 17
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5XR8, 5XRA, 5TGZ
1 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 2
5UIW, 4MBS
4
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLP1R
CRFR1
GLP-1
CRF1
ECL2 45x52
T
F
A
2 2 3
5NX2, 4K5Y, 4Z9G
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM2 2x56
S
C
A
2 1 3
5VEW, 5VEX, 5EE7
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
4QKX, 3PDS
8
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
Pos Match
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
12
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5EE7, 5YQZ
1
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
4BUO, 3ZEV, 4BWB, 4BV0
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM5 5x63
Y
L
A
2 1 24
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEW, 5VEX
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4K5Y, 4Z9G
1
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
0.03 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.11 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM2 2x59
I
V
F 2 1 3
5VEW, 5VEX, 5EE7
0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEW, 5VEX
0.07 0.54 -1.71 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
4BVN, 5A8E
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 3
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
0.24 -0.67
Inactive
Intermediate
A (Rhodopsin)
Peptide
Nucleotide
Aminergic
Neurotensin
Adenosine
Dopamine
AA1R
AA2AR
NTR1
DRD2
A2A
NTS1
A1
D2
TM6 6x37
L
A 4 3 26
5NM4, 5NM2, 4GRV, 6CM4, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.04 0 0.50 1 1 4
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5XR8, 5XRA, 5U09, 5TGZ
0.01 0 0.50 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 4
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5XR8, 5XRA, 5TGZ
0.11 0.26 2.80 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM3 3x24
G
S
A 2 1 3
5VEW, 5VEX, 5EE7
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4K5Y, 4Z9G
0 0.50 1
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
4PHU, 5TZY, 5KW2, 5TZR
0.01 0.54 -1.71
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 12
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 5
6CMO, 5DGY, 4A4M, 4ZWJ, 5W0P
0.01 0.53 -0.71 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5EE7, 5YQZ
0 0.50 1
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM2 2x52
A
L 2 1 28
5NM4, 5NM2, 3REY, 2YDO, 4UHR, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 2YDV, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 4UG2, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.63 0.21 -1.25 1
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 2
5UIW, 4MBS
0.69 0.43 2 1 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4K5Y, 4Z9G
0.2 0 0.50
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 17
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
2YDO, 4UG2, 4UHR, 2YDV
0.03 0 0.50 8
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NJ6, 5NDD, 5NDZ
0.01 0.40 0.11 5
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y12
P2Y1
TM7 7x49
D
N 2 1 5
4PY0, 4NTJ, 4PXZ, 4XNV, 4XNW
0.72 0.65 0.85
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM5 5x63
Y
L
A 2 1 24
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.06 0 0.50
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
D
N
C 2 1 12
6CMO, 4BEZ, 5DYS, 5EN0, 5DGY, 2X72, 5W0P, 3C9M, 4A4M, 4ZWJ, 4BEY, 2J4Y
0.68 -0.02
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.13 0 0.50
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 5
6CMO, 5DGY, 2X72, 4ZWJ, 5W0P
0.01 0.39 0.77 8
Intermediate
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Free fatty acid
FFAR1
NTR1
NTS1
FFA1
TM3 3x49
E
G
A 2 2 6
4PHU, 4GRV, 5TZY, 5KW2, 4XES, 5TZR
0.01 0 0.50 Pos & Mutant AA Match 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 2
5UIW, 4MBS
0.12 0.40 0.11 3 1 1
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
4BUO, 3ZEV, 4BWB, 4BV0
0.02 0 0.50
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
5T04, 4GRV, 4XEE, 4XES
0.19 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
4BVN, 5A8E
0.24 0.61 -0.46 2
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5X93, 5XPR
0.1 0 0.50 4
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQH, 6BQG
0.67 0.65 0.85 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.03 0 0.50 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.01 0 0.50 2 1 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.14 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEW, 5VEX
0.07 0.41 -1.12
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.2 1.00 1.15
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.08 0 0.50 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM3 3x36
T
A 2 1 24
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.02 0 0.50 16
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4K5Y, 4Z9G
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
2YDO, 4UG2, 4UHR, 2YDV
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
0 0.50 Pos & Mutant AA Match
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 3
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
ECL1
T
G
E 2 1 2
5NX2, 5EE7
0.40 0.11
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5X93, 5XPR
0.09 0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLR
GLP1R
CRFR1
CRF1
GLP-1
glucagon
TM6 6x30
Y
K
A 3 2 5
4Z9G, 5VEW, 4K5Y, 5VEX, 5EE7
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEW, 5VEX
0.07 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
0.05 0.53 -0.71
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 18
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
0.1 0.11 0 0.50
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.67 1.00 1.15 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
4RWS, 3OE9, 3OE0
0.0 3.16 0.14 2 1 3
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
Q
G
A 1 1 1
5NX2
0 0.50
Active
Inactive
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
3ZEV, 4BUO, 4BWB, 5T04, 4GRV, 4XEE, 4BV0, 4XES
0.37 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4K5Y, 4Z9G
0 0.50 Pos & Mutant AA Match 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
4PHU, 5TZY, 5KW2, 5TZR
0.06 0 0.50 2 1 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 18
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
0.05 0.24 -0.67
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.13 0 0.50
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7D, 5L7I
0.54 -1.71 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 18
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
0.04 0.50 0.46
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA1R
AA2AR
DRD2
A2A
A1
D2
TM6 6x41
V
L
A 3 2 25
5NM4, 5NM2, 6CM4, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.05 0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5XR8, 5XRA, 5TGZ
0.04 0.40 0.11 1 3
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.05 0 0.50 1 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 2
5UIW, 4MBS
0.03 0.65 0.85 4
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.13 0 0.50 1 3
Intermediate
A (Rhodopsin)
Peptide
Lipid
Free fatty acid
Proteinase-activated
FFAR1
PAR2
FFA1
PAR2
TM3 3x34
G
F
A 2 2 5
4PHU, 5NJ6, 5NDD, 5NDZ, 5TZR
0.07 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.06 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
4QKX, 3PDS
0.0 0.68 -0.02 8
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4K5Y, 4Z9G
0 0.50 1
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLP1R
CRFR1
GLP-1
CRF1
ECL2 45x52
T
F
A 2 2 3
5NX2, 4K5Y, 4Z9G
0 0.50
Active
Inactive
Intermediate
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Leukotriene
NTR1
Q9WTK1
NTS1
BLT1
ECL2
G
S
A 2 2 5
5X33, 5T04, 4GRV, 4XEE, 4XES
0 0.50
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5EN0, 5DYS
0.04 0.29 0.41 -1.12 13
Active
Inactive
Intermediate
A (Rhodopsin)
Protein
Aminergic
Chemokine
Adrenoceptors
5-Hydroxytryptamine
Dopamine
5HT2B
5HT1B
CXCR4
ADRB1
DRD3
ADRB2
5-HT2B
D3
5-HT1B
β2
β1
CXCR4
TM3 3x41
E
M
L
W 6 4 20
6G79, 4IAQ, 5TUD, 3D4S, 5V54, 3NY9, 3OE0, 3ODU, 4RWS, 5TVN, 3NYA, 3NY8, 3OE8, 4NC3, 3PBL, 4IAR, 4IB4, 3OE6, 3OE9, 5A8E
0.03 0.49 -2.09 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5X93, 5XPR
0.13 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NJ6, 5NDD, 5NDZ
0.73 0.21 -1.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5X93, 5XPR
0.07 0 0.50 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.0 0 0.50 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.13 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEW, 5VEX
0.68 -0.02 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 18
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
0.23 0.33 0.61 -0.46 2
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
0.11 0.11 0.21 -1.25
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
2YDO, 4UG2, 4UHR, 2YDV
0.13 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM7 7x41
T
S
A 2 1 24
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.38 0 0.50 5
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
0.05 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.08 0 0.50 1 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 2 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 2
5UIW, 4MBS
0.07 0.53 -0.71 1
Inactive
A (Rhodopsin)
Peptide
Aminergic
Apelin
Dopamine
APJ
DRD2
apelin
D2
TM3 3x40
I
V
A 2 2 2
6CM4, 5VBL
0.06 0 0.50 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4K5Y, 4Z9G
0.07 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
0.05 0 0.50
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM3 3x24 G
A
1 1 1
5EE7
0.4 1.00 1.15
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38 M
A
1 1 1
5LWE
0.04 0.24 -0.67 1
Inactive
Intermediate
A (Rhodopsin)
Peptide
Nucleotide
Aminergic
Neurotensin
Adenosine
Dopamine
AA1R
AA2AR
NTR1
DRD2
A2A
NTS1
A1
D2
TM6 6x37 L
A
4 3 26
5NM4, 5NM2, 4GRV, 6CM4, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.38 0.21 -1.25 1 1 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41 T
A
1 1 1
5LWE
0.09 0.66 0.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x59 I
F
1 1 2
5VEW, 5VEX
0.4 0.41 -1.12
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21 K
G
1 1 1
5X33
0.01 0.26 2.80 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60 L
A
1 1 2
4K5Y, 4Z9G
0.33 0.21 -1.25
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62 T
A
1 1 4
2YDO, 4UG2, 4UHR, 2YDV
0.1 0.66 0.25
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45 C
N
1 1 2
6BQH, 6BQG
0.01 0.68 -0.02 Pos & Wild Type AA Match 1
Active
Intermediate
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2B
5-HT2B
TM3 3x41 M
W
1 1 4
5TVN, 5TUD, 4IB4, 4NC3
0.04 0.24 -0.67 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x30 Y
A
1 1 2
4K5Y, 4Z9G
0.73 0.53 -0.71
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53 M
V
1 1 18
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
0.07 0.33 0.24 -0.67 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47 S
C
1 1 1
5LWE
0.56 0.50 0.46
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31 L
F
1 1 1
5NX2
0.2 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x59 V
F
1 1 1
5EE7
0.4 0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51 F
A
1 1 2
4K5Y, 4Z9G
0.93 0.54 -1.71 1
Active
Inactive
Intermediate
A (Rhodopsin)
Protein
Aminergic
Chemokine
5-Hydroxytryptamine
Dopamine
CXCR4
DRD3
5HT1B
D3
5-HT1B
CXCR4
TM3 3x41 L
W
3 3 11
6G79, 3ODU, 4IAQ, 5V54, 3OE0, 3OE8, 3PBL, 4IAR, 3OE6, 3OE9, 4RWS
0.31 0.21 -1.25 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35 E
A
1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
0.09 0.40 0.11
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48 A
L
1 1 1
5EE7
0.2 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.04 0.65 0.85
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
ECL2 G
A
1 1 4
5T04, 4GRV, 4XEE, 4XES
1.00 1.15
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL2 45x52 T
A
1 1 1
5NX2
0.2 0.66 0.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48 I
A
1 1 2
4K5Y, 4Z9G
0.2 0.41 -1.12
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37 Q
A
1 1 4
2YDO, 4UG2, 4UHR, 2YDV
0.02 0.39 0.77 8
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38 I
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.08 0.41 -1.12
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM3 3x36 T
A
2 1 24
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.05 0.66 0.25 16
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44 W
A
1 1 2
4K5Y, 4Z9G
0.13 0.49 -2.09
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54 M
A
1 1 1
5EE7
0.07 0.24 -0.67
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA1R
DRD2
A1
D2
TM6 6x41 L
A
2 2 2
6CM4, 5N2S
0.19 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4K5Y, 4Z9G
0.13 0.26 2.80
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM3 3x49 E
A
1 1 2
4GRV, 4XES
0.21 0.40 0.11 Pos & Wild Type AA Match 2
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
ECL2 G
E
A
2 1 2
5NX2, 5EE7
1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48 G
A
1 1 1
5EE7
0.13 1.00 1.15
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42 P
A
1 1 1
5NX2
0.93 3.16 0.14
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 5
6CMO, 5DGY, 2X72, 4ZWJ, 5W0P
0.02 0.57 0.40 0.11 8
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39 F
A
1 1 1
5EE7
0.33 0.54 -1.71
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 Q
A
1 1 1
5NX2
0.39 0.77
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36 K
A
1 1 2
5X93, 5XPR
0.06 0.26 2.80 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x34 G
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.02 1.00 1.15 1
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM3 3x40 V
A
1 1 1
5VBL
0.24 0.61 -0.46 2
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.68 0.49 -2.09 Pos & Wild Type AA Match 17
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56 D
A
1 1 1
5X93
0.01 0.69 0.43
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
ECL2 45x52 F
A
1 1 2
4K5Y, 4Z9G
0.13 0.54 -1.71
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 D
R
1 1 1
5NX2
0.69 0.43
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 2
5UIW, 4MBS
0.02 1.00 1.15 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.03 0.66 0.25 3
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53 S
A
1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
0.14 0.50 0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37 H
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.03 0.61 0.11 1 1 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
0.08 0.11 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53 Y
L
1 1 2
4BVN, 5A8E
0.89 1.0 0.53 -0.71 Pos & Wild Type AA Match Pos & Wild Type AA Match 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36 T
P
1 1 3
4RWS, 3OE9, 3OE0
0.25 0.66 0.25 2 1 3
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39 S
A
1 1 1
5WF6
0.72 0.50 0.46 Pos & Wild Type AA Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49 K
E
1 1 2
5UIW, 4MBS
0.13 0.26 2.80 3 1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64 M
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.01 0.24 -0.67 1 3
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x34 F
A
1 1 2
4PHU, 5TZR
0.11 0.54 -1.71 1
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
ECL3 D
C
1 1 8
4BEZ, 4A4M, 4BEY, 5DYS, 5EN0, 2J4Y, 2X72, 3C9M
0.69 0.43
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42 T
A
1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
0.09 0.66 0.25
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term N
C
2 1 12
6CMO, 4BEZ, 5DYS, 5EN0, 5DGY, 2X72, 5W0P, 3C9M, 4A4M, 4ZWJ, 4BEY, 2J4Y
0.65 0.85
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5EN0, 5DYS
0.08 0.43 0.66 0.25 13
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2 G
M
1 1 5
5CGC, 6FFH, 6FFI, 5CGD, 4OO9
1.00 1.15
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36 F
A
1 1 18
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
0.14 0.44 0.54 -1.71
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y12
P2Y1
TM7 7x49 D
N
2 1 5
4PY0, 4NTJ, 4PXZ, 4XNV, 4XNW
0.2 0.69 0.43
Inactive
Intermediate
A (Rhodopsin)
Lipid
Aminergic
Free fatty acid
Adrenoceptors
FFAR1
ADRB1
β1
FFA1
TM5 5x58 Y
F
A
2 2 22
2Y03, 5KW2, 2Y00, 2VT4, 4GPO, 4AMI, 5A8E, 4PHU, 5TZR, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 5TZY, 2Y04, 4BVN, 2YCX, 2Y01, 2YCY
0.72 0.53 -0.71
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32 R
E
1 1 3
5XR8, 5XRA, 5TGZ
0.31 0.21 1.81 1 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM2 2x56 S
C
A
2 1 3
5VEW, 5VEX, 5EE7
0.47 0.50 0.46
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43 V
A
1 1 4
5T04, 4GRV, 4XEE, 4XES
0.1 0.61 -0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM7 7x41 T
A
1 1 1
5N2S
0.07 0.66 0.25 5
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NJ6, 5NDD, 5NDZ
0.05 0.24 -0.67
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48 F
M
1 1 18
2Y03, 4AMI, 2Y01, 4GPO, 5A8E, 2YCW, 2Y02, 3ZPR, 3ZPQ, 4AMJ, 5F8U, 2YCZ, 2Y04, 2Y00, 4BVN, 2YCX, 2VT4, 2YCY
0.06 0.33 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51 I
C
1 1 2
5VEW, 5VEX
0.6 0.41 -1.12 1
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.12 0.61 -0.46 3
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM5 5x63 Y
A
1 1 1
5N2S
0.03 0.53 -0.71
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54 I
A
1 1 4
4BUO, 3ZEV, 4BWB, 4BV0
0.33 0.41 -1.12
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55 R
A
1 1 23
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.05 0.21 1.81 1 2
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46 L
A
1 1 4
2YDO, 4UG2, 4UHR, 2YDV
0.9 0.21 -1.25
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67 H
G
1 1 1
5X33
0.1 0.61 0.11
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40 M
Y
2 1 5
6CMO, 5DGY, 4A4M, 4ZWJ, 5W0P
0.05 0.71 0.24 -0.67 1 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM7 7x41 S
A
1 1 23
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.16 0.50 0.46 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60 C
Y
1 1 2
5UIW, 4MBS
0.02 0.68 -0.02 1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5XR8, 5XRA, 5U09, 5TGZ
0.01 0.66 0.25 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50 D
N
1 1 1
5WF5
0.92 0.69 0.43 Pos & Wild Type AA Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32 M
C
1 1 2
5VEW, 5VEX
0.13 0.24 -0.67
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM6 6x30 K
A
2 1 3
5VEW, 5VEX, 5EE7
0.2 0.26 2.80
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
ADRB2
β1
β2
TM3 3x41 E
W
2 1 5
3NYA, 3NY8, 3D4S, 3NY9, 5A8E
0.01 0.33 0.40 0.11 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51 D
C
1 1 1
4RWS
0.03 0.69 0.43 12
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33 A
D
1 1 2
5UIW, 4MBS
0.29 0 0.50 2 1 5
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48 I
A
1 1 2
5X93, 5XPR
0.15 0.41 -1.12
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43 K
A
1 1 23
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.16 0.26 2.80
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37 E
K
1 1 3
5XR8, 5XRA, 5TGZ
0.03 0.40 0.11 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM5 5x63 L
A
1 1 23
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.13 0.21 -1.25
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM2 2x52 A
L
2 1 28
5NM4, 5NM2, 3REY, 2YDO, 4UHR, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5N2S, 5IU4, 5MZJ, 5OLZ, 5NLX, 2YDV, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 4UG2, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.06 0 0.50 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM6 6x41 V
A
1 1 23
5NM4, 5NM2, 3REY, 5IU7, 5IUB, 5OM1, 5N2R, 3UZC, 5OLH, 5IU4, 5MZJ, 5OLZ, 5NLX, 3RFM, 5OLG, 3UZA, 5MZP, 5OLO, 3PWH, 5IU8, 5IUA, 5OLV, 5OM4
0.41 0.61 -0.46
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate