Structure information

β2-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4QKX

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

A

REFERENCE

10.1073/PNAS.1410415111

PUBLICATION DATE

July 23, 2014

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Q27453560 C1093 2.64x63 TM2 polar (hydrogen bond)
Q27453560 C1093 2.64x63 TM2 polar (hydrogen bond)
Q27453560 I1094 2.65x64 TM2 Van der Waals
Q27453560 W1109 3.28x28 TM3 aromatic (edge-to-face)
Q27453560 W1109 3.28x28 TM3 Van der Waals
Q27453560 D1113 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Q27453560 V1114 3.33x33 TM3 hydrophobic
Q27453560 V1114 3.33x33 TM3 Van der Waals
Q27453560 V1117 3.36x36 TM3 hydrophobic
Q27453560 V1117 3.36x36 TM3 Van der Waals
Q27453560 C1191 45.50x50 ECL2 Van der Waals
Q27453560 C1191 45.50x50 ECL2 hydrophobic
Q27453560 D1192 45.51x51 ECL2 Van der Waals
Q27453560 F1193 45.52x52 ECL2 Van der Waals
Q27453560 F1193 45.52x52 ECL2 hydrophobic
Q27453560 S1203 5.42x43 TM5 polar (hydrogen bond)
Q27453560 S1203 5.42x43 TM5 Van der Waals
Q27453560 S1207 5.46x461 TM5 polar (hydrogen bond)
Q27453560 S1207 5.46x461 TM5 Van der Waals
Q27453560 F1289 6.51x51 TM6 Van der Waals
Q27453560 F1289 6.51x51 TM6 hydrophobic
Q27453560 N1312 7.39x38 TM7 polar (hydrogen bond)
Q27453560 N1312 7.39x38 TM7 polar (hydrogen bond)
Q27453560 Y1316 7.43x42 TM7 polar (hydrogen bond)

Ligands

Q27453560

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Residue Diagrams

V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7
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ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM2
2x63 2.64x63 H93
2x64 2.65x64 I94
TM3
3x28 3.28x28 W109
3x32 3.32x32 D113
3x33 3.33x33 V114
3x36 3.36x36 V117
ECL2
45x50 45.50x50 C191
45x51 45.51x51 D192
45x52 45.52x52 F193
TM5
5x43 5.42x43 S203
5x461 5.46x461 S207
TM6
6x51 6.51x51 F289
TM7
7x38 7.39x38 N312
7x42 7.43x42 Y316