Structure information

D2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6CM4

SPECIES

Homo sapiens

RESOLUTION

2.870

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE25758

PUBLICATION DATE

March 14, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
risperidone W100 23.50x50 ECL1 hydrophobic
risperidone D114 3.32x32 TM3 polar (charge-assisted hydrogen bond)
risperidone V115 3.33x33 TM3 Van der Waals
risperidone C118 3.36x36 TM3 polar (hydrogen bond with backbone)
risperidone C118 3.36x36 TM3 Van der Waals
risperidone T119 3.37x37 TM3 Van der Waals
risperidone S193 5.42x43 TM5 Van der Waals
risperidone S197 5.46x461 TM5 Van der Waals
risperidone F198 5.47x47 TM5 hydrophobic
risperidone F198 5.47x47 TM5 Van der Waals
risperidone W386 6.48x48 TM6 aromatic (face-to-edge)
risperidone W386 6.48x48 TM6 Van der Waals
risperidone F389 6.51x51 TM6 hydrophobic
risperidone F389 6.51x51 TM6 Van der Waals
risperidone F390 6.52x52 TM6 aromatic (edge-to-face)
risperidone F390 6.52x52 TM6 Van der Waals
risperidone Y408 7.35x34 TM7 Van der Waals
risperidone Y408 7.35x34 TM7 hydrophobic
risperidone T412 7.39x38 TM7 Van der Waals
risperidone Y416 7.43x42 TM7 polar (hydrogen bond)

Ligands

risperidone

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Residue Diagrams

V N G F V I V A I L L T L L T A Y Y N Y 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F I D 3 V T V M I S I V W V L S F T I S C P L 4 Y V L L T V I F P V Y F S V I S S Y V V F 5 A I V L G V F I I C W L P F F I T H I L 6 I P N V A S N V Y G L W T F A S Y L V 7
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ICL1 K A L Q ICL1ECL1 E W K F ECL1ICL2 P M L Y N ICL2ECL2 L N N A D Q N E C I I A ECL2ICL3 R S S R A F R A H L R A P L K G N C T H P E D M K L C T V I M K S N G S F P V N R R R V E A A R R A Q E L E M E M L S S T S P P E R T R Y S P I P P S H H Q L T L P D P S H H G L H S T P D S P A K P E K N G H A K D H P K I A K I F E I Q T M P N G K T R T S L K T M S R R ICL3ECL3 D C N I ECL3N-term M D P L N L S W Y D D D L E R Q N W S R P F N G S D G K A D N-termC-term C C-term R P H Y N Y Y A T L L T L L I A V I V F G N V L V C M A V S R E T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M T R Y S S K R R V T V M I S I V W V L S F T I S C P L L F G N P A F V V Y S S I V S F Y V P F I V T L L V Y I K I Y I V L R R R R K R V N T K K L S Q Q K E K K A T Q M L A I V L G V F I I C W L P F F I T H I L N I H C P P V L Y S A F T W L G Y V N S A V N P I I Y T T F N I E F L K F R K A I L H
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Residue Table


GPCRdb(A)
GPCRdb(A)
D2 receptor
ECL1
23x50 23.50x50 W100
TM3
3x32 3.32x32 D114
3x33 3.33x33 V115
3x36 3.36x36 C118
3x37 3.37x37 T119
TM5
5x43 5.42x43 S193
5x461 5.46x461 S197
5x47 5.47x47 F198
TM6
6x48 6.48x48 W386
6x51 6.51x51 F389
6x52 6.52x52 F390
TM7
7x34 7.35x34 Y408
7x38 7.39x38 T412
7x42 7.43x42 Y416