Structure information

apelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7W0O

SPECIES

Homo sapiens

RESOLUTION

3.780

PREFERRED CHAIN

R

REFERENCE

10.1038/S41594-022-00797-5

PUBLICATION DATE

July 27, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
apelin receptor early endogenous ligand W85 2.60x60 TM2 aromatic (face-to-edge)
apelin receptor early endogenous ligand I109 3.32x32 TM3 hydrophobic
apelin receptor early endogenous ligand R168 ECL2 polar (charge-assisted hydrogen bond)
apelin receptor early endogenous ligand Q180 ECL2 Van der Waals
apelin receptor early endogenous ligand C181 45.50x50 ECL2 polar (hydrogen bond with backbone)
apelin receptor early endogenous ligand C181 45.50x50 ECL2 Van der Waals
apelin receptor early endogenous ligand Y182 45.51x51 ECL2 hydrophobic
apelin receptor early endogenous ligand Y182 45.51x51 ECL2 Van der Waals
apelin receptor early endogenous ligand M183 45.52x52 ECL2 polar (hydrogen bond with backbone)
apelin receptor early endogenous ligand M183 45.52x52 ECL2 Van der Waals
apelin receptor early endogenous ligand Y264 6.51x51 TM6 polar (hydrogen bond)
apelin receptor early endogenous ligand Y264 6.51x51 TM6 polar (hydrogen bond)
apelin receptor early endogenous ligand M288 7.32x31 TM7 Van der Waals

Ligands

apelin receptor early endogenous ligand

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Residue Diagrams

G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7
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ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x60 2.60x60 W85
TM3
3x32 3.32x32 I109
ECL2
45x50 45.50x50 C181
45x51 45.51x51 Y182
45x52 45.52x52 M183
TM6
6x51 6.51x51 Y264
TM7
7x31 7.32x31 M288