compound 27 [PMID: 20346665]


SMILES Cc1ccc(cc1)n1cnc2c(c1=O)sc1c2c(N)nc(n1)C
InChIKey RIMQNIZNDUNPQK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 323.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 8.1 8.1 8.1 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 6.94 6.94 6.94 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 7.57 7.57 7.57 Guide to Pharmacology
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 7.57 7.57 7.57 ChEMBL