NEFLAMAPIMOD


SMILES O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl
InChIKey VEPKQEUBKLEPRA-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 435.0

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Human Adrenoceptors A pKi 4.84 4.84 4.84 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 4.89 4.89 4.89 ChEMBL
A3 AA3R Human Adenosine A pKi 5.32 5.32 5.32 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Human Adrenoceptors A pIC50 4.5 4.5 4.5 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 4.47 4.47 4.47 ChEMBL
A3 AA3R Human Adenosine A pIC50 5.07 5.07 5.07 ChEMBL