CHEMBL4459533


SMILES CCc1cc(Cl)c(OC)c(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1
InChIKey NIENYVQCIJZKMD-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 9
Molecular weight (Da) 469.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 6.15 6.15 6.15 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.26 7.26 7.26 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.25 6.25 6.25 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.6 7.6 7.6 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.5 8.5 8.5 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.86 6.86 6.86 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Human Dopamine A pIC50 6.38 6.38 6.38 ChEMBL