CHEMBL4473652


SMILES Cc1cccc(NC(=O)CN2CCN(c3cccc4ccccc34)CC2)c1
InChIKey LEQVQRFGBPYNQZ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 359.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 7.55 8.16 8.78 ChEMBL
D3 DRD3 Human Dopamine A pKi 4.94 5.42 5.9 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.83 6.27 6.7 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pIC50 5.37 5.48 5.6 ChEMBL
D4 DRD4 Human Dopamine A pEC50 5.04 6.0 6.96 ChEMBL
D2 DRD2 Human Dopamine A pIC50 4.17 4.17 4.17 ChEMBL