CHEMBL4476394


SMILES CCc1cc(Cl)c(OC)c(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4[nH]3)CC2)c1
InChIKey NRSBRNRWCATXOT-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 9
Molecular weight (Da) 484.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 4.86 4.86 4.86 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.66 5.66 5.66 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.73 6.73 6.73 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.12 8.14 8.16 ChEMBL
D2 DRD2 Human Dopamine A pKi 4.88 4.91 4.94 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Human Dopamine A pIC50 6.44 6.44 6.44 ChEMBL