triprolidine


SMILES Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1
InChIKey CBEQULMOCCWAQT-WOJGMQOQSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 278.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations H1

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Guinea pig Histamine A pKd 9.9 9.9 9.9 ChEMBL
H1 HRH1 Guinea pig Histamine A pKi 8.78 8.78 8.78 ChEMBL
H1 HRH1 Human Histamine A pKi 8.8 8.8 8.8 ChEMBL
H1 HRH1 Human Histamine A pKi 5.0 8.39 9.34 PDSP Ki database
H1 HRH1 Human Histamine A pKi 8.0 8.0 8.0 Drug Central
H1 HRH1 Human Histamine A pKi 8.5 8.75 9.0 Guide to Pharmacology
H1 HRH1 Guinea pig Histamine A pKd 8.0 8.0 8.0 Drug Central
H1 HRH1 Guinea pig Histamine A pKi 8.94 9.15 9.51 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 8.25 8.25 8.25 PDSP Ki database
H1 HRH1 Mouse Histamine A pKi 8.04 8.04 8.04 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NPS NPSR1 Human Neuropeptide S A Potency 7.3 7.3 7.3 ChEMBL