CHEMBL179429


SMILES COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@@H](c3ccccc3)N(C)C)c2=O)c1F
InChIKey NAKAWVWXVKWSQY-DEOSSOPVSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 8
Molecular weight (Da) 523.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GnRH1 GNRHR Rat Gonadotrophin-releasing hormone A pKi 4.96 4.96 4.96 ChEMBL
GnRH1 GNRHR Human Gonadotrophin-releasing hormone A pKi 6.92 7.55 8.19 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GnRH1 GNRHR Human Gonadotrophin-releasing hormone A pIC50 7.31 7.31 7.31 ChEMBL