GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	145985766	165141	0	None	-1862	3	Human	4.8	pIC50	=	4.8	Functional	Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay	ChEMBL	504	6	2	6	4.5	NC(=O)c1ccc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)cn1	10.1016/j.bmcl.2018.07.042
	CHEMBL4245355	165141	0	None	-1862	3	Human	4.8	pIC50	=	4.8	Functional	Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay	ChEMBL	504	6	2	6	4.5	NC(=O)c1ccc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)cn1	10.1016/j.bmcl.2018.07.042
	134817249	165274	12	None	-20892	3	Human	5.0	pIC50	=	5.0	Functional	Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay	ChEMBL	504	6	2	6	4.5	NC(=O)c1cc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)ccn1	10.1016/j.bmcl.2018.07.042
	CHEMBL4248604	165274	12	None	-20892	3	Human	5.0	pIC50	=	5.0	Functional	Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay	ChEMBL	504	6	2	6	4.5	NC(=O)c1cc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)ccn1	10.1016/j.bmcl.2018.07.042
	8652	832	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16904643
	810	821	0	None	-2	3	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16904643
	810	821	0	None	-2	3	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9153236
	810	821	0	None	-2	3	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9507024
	811	830	0	None	12	2	Human	9.3	pIC50	=	9.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9507024

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	183790	3685	8	None	-	2	Human	8.9	pIC50	=	8.9	Binding	Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin)	ChEMBL	495	6	1	2	6.8	Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C	10.1021/acs.jmedchem.9b01701
	783	3685	8	None	-	2	Human	8.9	pIC50	=	8.9	Binding	Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin)	ChEMBL	495	6	1	2	6.8	Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C	10.1021/acs.jmedchem.9b01701
	CHEMBL1178786	3685	8	None	-	2	Human	8.9	pIC50	=	8.9	Binding	Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin)	ChEMBL	495	6	1	2	6.8	Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C	10.1021/acs.jmedchem.9b01701
	11285792	866	30	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin)	ChEMBL	696	17	1	7	8.7	CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC	10.1021/acs.jmedchem.9b01701
	801	866	30	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin)	ChEMBL	696	17	1	7	8.7	CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC	10.1021/acs.jmedchem.9b01701
	CHEMBL2110727	866	30	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin)	ChEMBL	696	17	1	7	8.7	CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC	10.1021/acs.jmedchem.9b01701
	DB11758	866	30	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin)	ChEMBL	696	17	1	7	8.7	CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC	10.1021/acs.jmedchem.9b01701
	810	821	0	None	39	3	Human	10.0	pKd	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10512740
	8652	832	0	None	-	1	Human	9.9	pKd	=	9.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10512740