GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	57781216	125326	0	None	8	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648356	125326	0	None	8	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	24954989	1503	1	None	25	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	7774	1503	1	None	25	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	CHEMBL1802025	1503	1	None	25	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	1357	2450	133	None	1	3	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	1672	2450	133	None	1	3	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	224	2450	133	None	1	3	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	896	2450	133	None	1	3	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	CHEMBL45	2450	133	None	1	3	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	DB01065	2450	133	None	1	3	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	1357	2450	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	1672	2450	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	224	2450	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	896	2450	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	CHEMBL45	2450	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	DB01065	2450	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	1357	2450	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	1672	2450	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	224	2450	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	896	2450	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	CHEMBL45	2450	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	DB01065	2450	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	139451757	184248	0	None	3	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4852096	184248	0	None	3	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451761	184014	0	None	4	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4848885	184014	0	None	4	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451781	184275	0	None	-2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4852440	184275	0	None	-2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	139451795	184747	0	None	2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859677	184747	0	None	2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451767	184421	0	None	5	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854625	184421	0	None	5	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	139451764	185685	0	None	-2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4873903	185685	0	None	-2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	145981769	166114	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	270	3	1	3	2.4	COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4281712	166114	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	270	3	1	3	2.4	COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	139451790	184714	13	None	6	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859295	184714	13	None	6	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	1357	2450	133	None	1	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	1672	2450	133	None	1	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	224	2450	133	None	1	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	896	2450	133	None	1	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	CHEMBL45	2450	133	None	1	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	DB01065	2450	133	None	1	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	1357	2450	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1672	2450	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	224	2450	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	896	2450	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	CHEMBL45	2450	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	DB01065	2450	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1357	2450	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	1672	2450	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	224	2450	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	896	2450	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	CHEMBL45	2450	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	DB01065	2450	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	139451757	184248	0	None	3	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4852096	184248	0	None	3	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451763	185751	0	None	-1	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
	CHEMBL4874954	185751	0	None	-1	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
	9839629	99654	0	None	-1	2	Human	9.8	pEC50	=	9.8	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL287560	99654	0	None	-1	2	Human	9.8	pEC50	=	9.8	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	139451761	184014	0	None	4	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4848885	184014	0	None	4	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	198	310	120	None	-3	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	82148	310	120	None	-3	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	99	310	120	None	-3	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	CHEMBL10878	310	120	None	-3	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	DB06594	310	120	None	-3	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	145982070	165922	0	None	1	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4278248	165922	0	None	1	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	145993214	166198	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	3	2	3	2.2	CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4283539	166198	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	3	2	3	2.2	CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	139451767	184421	0	None	5	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854625	184421	0	None	5	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	139451776	184428	0	None	3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854836	184428	0	None	3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	139451799	185257	0	None	3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4867553	185257	0	None	3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	139451790	184714	13	None	6	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859295	184714	13	None	6	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	164946945	189635	1	None	-3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5174929	189635	1	None	-3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	139451781	184275	0	None	-2	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4852440	184275	0	None	-2	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	139451795	184747	0	None	2	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859677	184747	0	None	2	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451764	185685	0	None	-2	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4873903	185685	0	None	-2	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	168296374	191920	0	None	9	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	CHEMBL5209359	191920	0	None	9	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	53237951	61690	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	333	5	1	2	3.7	CC(=O)NCCC1=C(Cc2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774518	61690	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	333	5	1	2	3.7	CC(=O)NCCC1=C(Cc2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	168296374	191920	0	None	9	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	CHEMBL5209359	191920	0	None	9	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	44394435	66593	0	None	34	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity towards human Melatonin receptor type 1A was determined by its ability to inhibit forskolin stimulated cAMP accumulationAgonist activity towards human Melatonin receptor type 1A was determined by its ability to inhibit forskolin stimulated cAMP accumulation	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL186586	66593	0	None	34	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity towards human Melatonin receptor type 1A was determined by its ability to inhibit forskolin stimulated cAMP accumulationAgonist activity towards human Melatonin receptor type 1A was determined by its ability to inhibit forskolin stimulated cAMP accumulation	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	168274836	189554	0	None	17	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5173623	189554	0	None	17	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	139451780	185362	0	None	-1	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
	CHEMBL4869463	185362	0	None	-1	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
	137660333	158973	0	None	-3	2	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4102177	158973	0	None	-3	2	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
	145979585	165937	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	313	5	2	3	3.0	CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4278446	165937	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	313	5	2	3	3.0	CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	145986532	166728	0	None	-4	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4293386	166728	0	None	-4	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	122188347	122647	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	232	3	1	2	2.0	CCC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612604	122647	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	232	3	1	2	2.0	CCC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	139451766	183865	0	None	-4	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4846505	183865	0	None	-4	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451769	185560	0	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
	CHEMBL4872217	185560	0	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
	1357	2450	133	None	1	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	1672	2450	133	None	1	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	224	2450	133	None	1	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	896	2450	133	None	1	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	CHEMBL45	2450	133	None	1	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	DB01065	2450	133	None	1	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	127026427	137159	0	None	-1	2	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758679	137159	0	None	-1	2	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	127026425	137295	0	None	8	2	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759816	137295	0	None	8	2	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	168274836	189554	0	None	17	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5173623	189554	0	None	17	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	198	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	82148	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	99	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	CHEMBL10878	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	DB06594	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	198	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	198	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	82148	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	82148	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	99	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	99	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	CHEMBL10878	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	CHEMBL10878	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	DB06594	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	DB06594	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	1357	2450	133	None	1	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	1672	2450	133	None	1	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	224	2450	133	None	1	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	896	2450	133	None	1	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	CHEMBL45	2450	133	None	1	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	DB01065	2450	133	None	1	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	198	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	82148	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	99	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	CHEMBL10878	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	DB06594	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	198	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	82148	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	99	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	CHEMBL10878	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	DB06594	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	198	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	82148	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	99	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	CHEMBL10878	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	DB06594	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	122188346	122646	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	262	4	1	3	2.0	CCC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612603	122646	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	262	4	1	3	2.0	CCC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	139451776	184428	0	None	3	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854836	184428	0	None	3	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	1357	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	1672	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	224	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	896	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	CHEMBL45	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	DB01065	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	18360658	8802	0	None	10	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097497	8802	0	None	10	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	145979282	166122	0	None	-1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	166122	0	None	-1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145986700	166666	0	None	-5	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4292109	166666	0	None	-5	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	122220128	159128	0	None	-27	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
	CHEMBL4104020	159128	0	None	-27	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
	145992795	166238	0	None	-25	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4284223	166238	0	None	-25	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145991111	166359	0	None	-10	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4286494	166359	0	None	-10	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	23658143	155836	1	None	-41	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4066279	155836	1	None	-41	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	46888492	8755	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	14	2	5	6.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1096991	8755	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	14	2	5	6.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	122188231	122632	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	247	3	2	2	1.8	CCNC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612462	122632	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	247	3	2	2	1.8	CCNC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	19703063	28702	1	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
	CHEMBL137969	28702	1	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
	46888520	8556	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	538	15	2	4	6.1	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095195	8556	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	538	15	2	4	6.1	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	21581654	60428	1	None	-10	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760944	60428	1	None	-10	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	10385056	111744	0	None	-354	2	Human	6.9	pEC50	=	6.9	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL329086	111744	0	None	-354	2	Human	6.9	pEC50	=	6.9	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	164946945	189635	1	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5174929	189635	1	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	145986330	166504	0	None	-3	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4289115	166504	0	None	-3	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
	52918080	60440	0	None	-12	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
	CHEMBL1760957	60440	0	None	-12	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
	9937825	8780	0	None	2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097315	8780	0	None	2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
	71508233	86646	0	None	-676	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326201	86646	0	None	-676	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	122188230	122631	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	277	4	2	3	1.8	CCNC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612461	122631	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	277	4	2	3	1.8	CCNC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	137639112	156310	0	None	-8128	2	Human	5.8	pEC50	=	5.8	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4071572	156310	0	None	-8128	2	Human	5.8	pEC50	=	5.8	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
	4018512	42974	37	None	-2	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	308	5	2	2	3.5	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1039/d2md00156j
	CHEMBL15060	42974	37	None	-2	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	308	5	2	2	3.5	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1039/d2md00156j
	121231413	3846	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	9226	3846	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	CHEMBL3612464	3846	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	52953165	62079	0	None	-87	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779810	62079	0	None	-87	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	137647756	157401	0	None	-213	2	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4084612	157401	0	None	-213	2	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	23658146	156576	1	None	-15	2	Human	7.7	pEC50	=	7.7	Functional	Partial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4074895	156576	1	None	-15	2	Human	7.7	pEC50	=	7.7	Functional	Partial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	122188237	122638	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612469	122638	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	145981162	165944	0	None	-2	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4278575	165944	0	None	-2	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
	122188349	122649	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	246	4	1	2	2.4	CCCN1c2ccccc2CCC1CNC(C)=O	10.1021/acs.jmedchem.5b01066
	CHEMBL3612606	122649	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	246	4	1	2	2.4	CCCN1c2ccccc2CCC1CNC(C)=O	10.1021/acs.jmedchem.5b01066
	52918079	60431	0	None	-2	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	CHEMBL1760947	60431	0	None	-2	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	139451766	183865	0	None	-4	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4846505	183865	0	None	-4	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	1357	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	1672	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	224	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	896	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	CHEMBL45	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	DB01065	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	1357	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	1672	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	224	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	896	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	CHEMBL45	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	DB01065	2450	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	10163052	8436	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1094212	8436	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
	46888491	8583	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	501	13	3	4	4.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095522	8583	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	501	13	3	4	4.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	9870683	8801	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	502	13	2	5	5.2	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097496	8801	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	502	13	2	5	5.2	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	46888521	8557	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	499	12	1	5	5.6	COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095196	8557	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	499	12	1	5	5.6	COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	71508235	86647	0	None	-14	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326203	86647	0	None	-14	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	145990308	166479	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	328	5	2	2	3.8	CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4288690	166479	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	328	5	2	2	3.8	CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145987794	166567	0	None	-6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4290302	166567	0	None	-6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137637884	155705	0	None	-19	2	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4064813	155705	0	None	-19	2	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	53231366	62072	0	None	-309	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779804	62072	0	None	-309	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	86273228	120806	0	None	-18	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580910	120806	0	None	-18	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	9927219	111830	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329263	111830	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	46888522	8558	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
	CHEMBL1095197	8558	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
	168283863	190376	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	274	3	0	4	2.5	COc1cc2c(CN3CCN(C)CC3)coc2cc1C	10.1039/d2md00156j
	CHEMBL5186032	190376	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	274	3	0	4	2.5	COc1cc2c(CN3CCN(C)CC3)coc2cc1C	10.1039/d2md00156j
	46845151	8578	0	None	7	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095505	8578	0	None	7	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
	53231465	62071	0	None	-35	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779803	62071	0	None	-35	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	122188225	122627	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	218	3	2	2	1.9	CCC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612456	122627	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	218	3	2	2	1.9	CCC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	122188227	122629	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	233	3	3	2	1.7	CCNC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612458	122629	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	233	3	3	2	1.7	CCNC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	10926138	206238	0	None	-147	2	Human	7.6	pEC50	=	7.6	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL97186	206238	0	None	-147	2	Human	7.6	pEC50	=	7.6	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	23642307	158349	1	None	-39	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4095334	158349	1	None	-39	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	145	140	48	None	-144	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1832	140	48	None	-144	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	CHEMBL7257	140	48	None	-144	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	DB14010	140	48	None	-144	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	9064	104740	90	None	1	3	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate ReaderAgonist activity at human MT1R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate Reader	ChEMBL	290	1	5	6	1.5	Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2	10.1016/j.ejmech.2020.112960
	CHEMBL311498	104740	90	None	1	3	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate ReaderAgonist activity at human MT1R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate Reader	ChEMBL	290	1	5	6	1.5	Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2	10.1016/j.ejmech.2020.112960
	7778	801	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	9957516	801	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	CHEMBL1094546	801	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	86079062	180150	0	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4755860	180150	0	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	198	310	120	None	-3	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	82148	310	120	None	-3	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	99	310	120	None	-3	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	CHEMBL10878	310	120	None	-3	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	DB06594	310	120	None	-3	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	122188229	122630	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	249	3	3	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612460	122630	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	249	3	3	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	86273227	120803	0	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580907	120803	0	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	127025783	137213	0	None	-8	2	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759160	137213	0	None	-8	2	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
	145982333	166004	0	None	-2	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	166004	0	None	-2	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	53238410	61699	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	361	5	1	2	4.7	CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774529	61699	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	361	5	1	2	4.7	CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	18007928	8577	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	485	12	2	4	5.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095504	8577	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	485	12	2	4	5.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	139451784	184813	0	None	-1	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
	CHEMBL4860729	184813	0	None	-1	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
	145993566	166817	0	None	-1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4294790	166817	0	None	-1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137650826	156963	0	None	-28	2	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4079699	156963	0	None	-28	2	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	122188236	122637	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.1	CC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612468	122637	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.1	CC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	54581170	60439	0	None	-2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760956	60439	0	None	-2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	162649247	179495	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
	CHEMBL4747996	179495	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
	122178509	120814	0	None	-9	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580919	120814	0	None	-9	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	122188235	122636	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	308	5	1	2	3.5	CCC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612467	122636	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	308	5	1	2	3.5	CCC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	1353	3380	3	None	-51	2	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	9998187	3380	3	None	-51	2	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	CHEMBL33549	3380	3	None	-51	2	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	86273226	120804	0	None	-12	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580908	120804	0	None	-12	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	23658145	156921	1	None	-52	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4079214	156921	1	None	-52	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	122188232	122633	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	353	6	2	3	3.3	CCNC(=O)NCC1CCc2c(OC)cccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612463	122633	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	353	6	2	3	3.3	CCNC(=O)NCC1CCc2c(OC)cccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	145982167	166058	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4280601	166058	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	52918077	60429	2	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760945	60429	2	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	53238181	921	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	7780	921	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	CHEMBL1774519	921	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	127026423	137294	0	None	-6	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759802	137294	0	None	-6	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	127029516	137109	0	None	-3	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758225	137109	0	None	-3	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	71508234	697	0	None	-173	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	7924	697	0	None	-173	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	CHEMBL2326202	697	0	None	-173	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	162668689	182176	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4790145	182176	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	162656758	180340	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4757920	180340	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	10301190	8480	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	511	12	1	5	6.2	COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1	10.1016/j.bmc.2010.04.008
	CHEMBL1094545	8480	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	511	12	1	5	6.2	COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1	10.1016/j.bmc.2010.04.008
	23642306	158527	1	None	-17	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4097233	158527	1	None	-17	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	10925526	111842	0	None	-47	2	Human	6.3	pEC50	=	6.3	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329299	111842	0	None	-47	2	Human	6.3	pEC50	=	6.3	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	145982333	166004	0	None	-2	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	166004	0	None	-2	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145990662	166376	0	None	-16	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4286896	166376	0	None	-16	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145988741	166683	0	None	-12	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4292336	166683	0	None	-12	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	52918078	60430	0	None	-3	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	CHEMBL1760946	60430	0	None	-3	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	127026426	137275	0	None	-1	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759606	137275	0	None	-1	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	86273229	120805	1	None	-3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580909	120805	1	None	-3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	145979689	166070	0	None	-1	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4280791	166070	0	None	-1	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	122188351	122650	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.7	CCC(=O)NCC1CCc2ccccc2N1c1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612608	122650	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.7	CCC(=O)NCC1CCc2ccccc2N1c1ccccc1	10.1021/acs.jmedchem.5b01066
	137650611	156970	0	None	-91	2	Human	7.2	pEC50	=	7.2	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4079784	156970	0	None	-91	2	Human	7.2	pEC50	=	7.2	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	162649850	179558	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4748822	179558	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	127026062	137164	0	None	-7	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758717	137164	0	None	-7	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	18360631	8627	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	516	13	2	4	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095831	8627	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	516	13	2	4	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12	10.1016/j.bmc.2010.04.008
	145983175	165878	0	None	-1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4277390	165878	0	None	-1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	86273222	120809	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580913	120809	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
	44359437	29686	0	None	3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
	CHEMBL138807	29686	0	None	3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
	1355	3383	3	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	9806449	3383	3	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	CHEMBL14453	3383	3	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	127025786	137324	0	None	-12	2	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
	CHEMBL3760044	137324	0	None	-12	2	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
	23658144	157634	1	None	-100	2	Human	7.1	pEC50	=	7.1	Functional	Partial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4087633	157634	1	None	-100	2	Human	7.1	pEC50	=	7.1	Functional	Partial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	145979282	166122	0	None	-1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	166122	0	None	-1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	127025782	137206	0	None	1	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759054	137206	0	None	1	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
	71508232	86645	0	None	-75	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326200	86645	0	None	-75	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	122188352	122651	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	263	3	2	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612609	122651	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	263	3	2	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	145988269	166637	0	None	-12	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4291381	166637	0	None	-12	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	46865422	86643	0	None	-181	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326199	86643	0	None	-181	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	18007985	8628	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	538	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095832	8628	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	538	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	127025784	137208	0	None	-8	2	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759084	137208	0	None	-8	2	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
	137636213	155545	0	None	-47	2	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4062947	155545	0	None	-47	2	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	137655238	158339	0	None	-891	2	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4095210	158339	0	None	-891	2	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	122188224	122626	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	248	4	2	3	1.9	CCC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612455	122626	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	248	4	2	3	1.9	CCC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	3525815	73798	3	None	-4	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at MT1Agonist activity at MT1	ChEMBL	271	2	0	3	4.1	c1ccc(-n2cc(-c3ccnc4ccccc34)cn2)cc1	10.1016/j.bmcl.2012.03.032
	CHEMBL2022867	73798	3	None	-4	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at MT1Agonist activity at MT1	ChEMBL	271	2	0	3	4.1	c1ccc(-n2cc(-c3ccnc4ccccc34)cn2)cc1	10.1016/j.bmcl.2012.03.032
	54582195	60438	0	None	-9	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760955	60438	0	None	-9	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	81689735	120811	0	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580916	120811	0	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	86273223	120807	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	242	3	1	3	3.1	COc1ccc2[nH]cc(Cc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580911	120807	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	242	3	1	3	3.1	COc1ccc2[nH]cc(Cc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	44241665	194027	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	329	6	1	4	2.6	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	CHEMBL556908	194027	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	329	6	1	4	2.6	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	90655902	110378	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	330	5	2	4	2.5	CCOC(=O)c1[nH]c2ccc(OC)c3c2c1[C@@H](CNC(C)=O)CC3	10.1021/jm401343c
	CHEMBL3260982	110378	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	330	5	2	4	2.5	CCOC(=O)c1[nH]c2ccc(OC)c3c2c1[C@@H](CNC(C)=O)CC3	10.1021/jm401343c
	24763223	214	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1021/jm401343c
	8289	214	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1021/jm401343c
	CHEMBL3260987	214	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1021/jm401343c
	52918077	60429	2	None	-1	2	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1021/jm401343c
	CHEMBL1760945	60429	2	None	-1	2	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1021/jm401343c
	11185529	3851	3	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm401343c
	7772	3851	3	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm401343c
	CHEMBL189449	3851	3	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm401343c
	1357	2450	133	None	1	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	None	1	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	None	1	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	None	1	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	None	1	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	None	1	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	103828029	3856	0	None	-20	2	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	4	1	3	3.5	COc1ccc(c(c1)CNc1cccnc1)Br	32040955
	10667	3856	0	None	-20	2	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	4	1	3	3.5	COc1ccc(c(c1)CNc1cccnc1)Br	32040955
	10666	3857	0	None	21	2	Human	7.3	pEC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	4	2	3	4.5	Clc1ccc(c(c1)Br)CNc1cccc(c1)c1nnc[nH]1	32040955
	138993662	3857	0	None	21	2	Human	7.3	pEC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	4	2	3	4.5	Clc1ccc(c(c1)Br)CNc1cccc(c1)c1nnc[nH]1	32040955
	10665	3855	0	None	50	2	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	3	4.2	CC(c1ccc(cc1)CNc1cccc(c1)c1[nH]cnn1)C	32040955
	137977202	3855	0	None	50	2	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	3	4.2	CC(c1ccc(cc1)CNc1cccc(c1)c1[nH]cnn1)C	32040955
	23581869	548	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	354	5	2	5	3.2	CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC	None
	7712	548	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	354	5	2	5	3.2	CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC	None
	CHEMBL1783282	548	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	354	5	2	5	3.2	CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC	None
	DB13994	548	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	354	5	2	5	3.2	CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC	None

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	10440	2642	15	None	-21	3	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	139030523	2642	15	None	-21	3	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	CHEMBL4449712	2642	15	None	-21	3	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	122178509	120814	0	None	-8	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human recombinant melatonin receptor-1 expressed in CHO cells assessed as effect on impedance by cellular dielectric spectroscopyAgonist activity at human recombinant melatonin receptor-1 expressed in CHO cells assessed as effect on impedance by cellular dielectric spectroscopy	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580919	120814	0	None	-8	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human recombinant melatonin receptor-1 expressed in CHO cells assessed as effect on impedance by cellular dielectric spectroscopyAgonist activity at human recombinant melatonin receptor-1 expressed in CHO cells assessed as effect on impedance by cellular dielectric spectroscopy	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	19703003	30750	0	None	-	0	Human	10.9	pIC50	=	10.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	309	5	2	3	2.9	COc1c[nH]c2nc(-c3ccccc3)c(CCNC(C)=O)c-2c1	10.1021/jm980026p
	CHEMBL139855	30750	0	None	-	0	Human	10.9	pIC50	=	10.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	309	5	2	3	2.9	COc1c[nH]c2nc(-c3ccccc3)c(CCNC(C)=O)c-2c1	10.1021/jm980026p
	9927219	111830	0	None	-25	2	Human	10.8	pIC50	=	10.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL329263	111830	0	None	-25	2	Human	10.8	pIC50	=	10.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm980026p
	57781211	125331	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	376	8	1	3	4.9	CC(=O)NCCC1CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
	CHEMBL3648361	125331	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	376	8	1	3	4.9	CC(=O)NCCC1CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
	23634404	125329	0	None	-	0	Human	10.5	pIC50	=	10.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648359	125329	0	None	-	0	Human	10.5	pIC50	=	10.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
	23725569	125333	0	None	-	0	Human	10.4	pIC50	=	10.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)sc3c21	nan
	CHEMBL3648363	125333	0	None	-	0	Human	10.4	pIC50	=	10.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)sc3c21	nan
	57781216	125326	0	None	2	2	Human	10.2	pIC50	=	10.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648356	125326	0	None	2	2	Human	10.2	pIC50	=	10.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
	23725512	125323	0	None	-	0	Human	10.2	pIC50	=	10.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	3	1	3	2.6	CC(=O)NCCC1=CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648350	125323	0	None	-	0	Human	10.2	pIC50	=	10.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	3	1	3	2.6	CC(=O)NCCC1=CCc2ccc3nc(C)oc3c21	nan
	57781262	160289	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	374	7	1	3	4.9	CC(=O)NC/C=C1\CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
	CHEMBL4114715	160289	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	374	7	1	3	4.9	CC(=O)NC/C=C1\CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
	57781258	125339	0	None	-	0	Human	10.0	pIC50	=	10.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	312	3	1	3	3.2	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C(F)(F)F)CC3	nan
	CHEMBL3648369	125339	0	None	-	0	Human	10.0	pIC50	=	10.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	312	3	1	3	3.2	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C(F)(F)F)CC3	nan
	1357	2450	133	None	-1	8	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	1672	2450	133	None	-1	8	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	224	2450	133	None	-1	8	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	896	2450	133	None	-1	8	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	CHEMBL45	2450	133	None	-1	8	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	DB01065	2450	133	None	-1	8	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	1357	2450	133	None	-1	8	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	1672	2450	133	None	-1	8	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	224	2450	133	None	-1	8	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	896	2450	133	None	-1	8	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	CHEMBL45	2450	133	None	-1	8	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	DB01065	2450	133	None	-1	8	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	23725514	125328	0	None	1	2	Human	9.9	pIC50	=	9.9	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648358	125328	0	None	1	2	Human	9.9	pIC50	=	9.9	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
	23725565	125325	0	None	1	2	Human	9.8	pIC50	=	9.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648355	125325	0	None	1	2	Human	9.8	pIC50	=	9.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
	23725567	125332	0	None	2	2	Human	9.8	pIC50	=	9.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	nan
	CHEMBL3648362	125332	0	None	2	2	Human	9.8	pIC50	=	9.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	nan
	15340632	9682	1	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	267	3	1	2	2.9	CC(=O)NCCc1cccc2ccc3c(c12)C=CCO3	10.1021/jm980026p
	CHEMBL11356	9682	1	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	267	3	1	2	2.9	CC(=O)NCCc1cccc2ccc3c(c12)C=CCO3	10.1021/jm980026p
	72548703	161019	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysisDisplacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	CHEMBL4128926	161019	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysisDisplacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	1357	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	1672	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	224	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	896	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	CHEMBL45	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	DB01065	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	57781280	160417	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	2	1	3	3.1	CC(=O)NC/C=C1\CCc2ccc3nc(C)sc3c21	nan
	CHEMBL4115681	160417	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	2	1	3	3.1	CC(=O)NC/C=C1\CCc2ccc3nc(C)sc3c21	nan
	1357	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	1672	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	224	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	896	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	CHEMBL45	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	DB01065	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	1357	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	1672	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	224	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	896	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	CHEMBL45	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	DB01065	2450	133	None	-1	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	57781261	125338	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.1	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C1CC1)CC3	nan
	CHEMBL3648368	125338	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.1	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C1CC1)CC3	nan
	57781244	160286	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	270	3	1	3	3.0	CCC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
	CHEMBL4114700	160286	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	270	3	1	3	3.0	CCC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
	15340633	97777	1	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	2	2.8	CC(=O)NCCc1cccc2ccc3c(c12)CCCO3	10.1021/jm980026p
	CHEMBL274358	97777	1	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	2	2.8	CC(=O)NCCc1cccc2ccc3c(c12)CCCO3	10.1021/jm980026p
	15289276	116287	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	347	6	1	3	3.8	COc1ccc2cc(C(=O)c3ccccc3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL337764	116287	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	347	6	1	3	3.8	COc1ccc2cc(C(=O)c3ccccc3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	57781268	160283	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	2	1	3	2.6	CC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
	CHEMBL4114658	160283	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	2	1	3	2.6	CC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
	23725515	125335	0	None	-1	2	Human	9.4	pIC50	=	9.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
	CHEMBL3648365	125335	0	None	-1	2	Human	9.4	pIC50	=	9.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
	1357	2450	133	None	-1	8	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	1672	2450	133	None	-1	8	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	224	2450	133	None	-1	8	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	896	2450	133	None	-1	8	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	CHEMBL45	2450	133	None	-1	8	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	DB01065	2450	133	None	-1	8	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	1357	2450	133	None	-1	8	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	1672	2450	133	None	-1	8	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	224	2450	133	None	-1	8	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	896	2450	133	None	-1	8	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	CHEMBL45	2450	133	None	-1	8	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	DB01065	2450	133	None	-1	8	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	23725612	125337	0	None	-2	2	Human	9.3	pIC50	=	9.3	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
	CHEMBL3648367	125337	0	None	-2	2	Human	9.3	pIC50	=	9.3	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
	10059864	109335	4	None	2	2	Human	9.2	pIC50	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL323332	109335	4	None	2	2	Human	9.2	pIC50	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	1357	2450	133	None	-1	8	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	1672	2450	133	None	-1	8	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	224	2450	133	None	-1	8	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	896	2450	133	None	-1	8	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	CHEMBL45	2450	133	None	-1	8	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	DB01065	2450	133	None	-1	8	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	57781246	125336	0	None	-2	2	Human	9.2	pIC50	=	9.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	nan
	CHEMBL3648366	125336	0	None	-2	2	Human	9.2	pIC50	=	9.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	nan
	44359126	28590	1	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	6	1	2	3.3	CCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL137878	28590	1	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	6	1	2	3.3	CCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	44359127	28729	1	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	2	2.9	CCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL137998	28729	1	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	2	2.9	CCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	594980	109203	13	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	4	2	2	2.4	COc1ccc2[nH]cc(CCNC(=O)C(F)(F)F)c2c1	10.1021/jm980026p
	CHEMBL322762	109203	13	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	4	2	2	2.4	COc1ccc2[nH]cc(CCNC(=O)C(F)(F)F)c2c1	10.1021/jm980026p
	9859969	174451	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	259	4	1	2	3.2	CSc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL456727	174451	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	259	4	1	2	3.2	CSc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	57781227	125324	0	None	-6	2	Human	9.1	pIC50	=	9.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	nan
	CHEMBL3648354	125324	0	None	-6	2	Human	9.1	pIC50	=	9.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	nan
	1357	2450	133	None	-1	8	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	1672	2450	133	None	-1	8	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	224	2450	133	None	-1	8	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	896	2450	133	None	-1	8	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	CHEMBL45	2450	133	None	-1	8	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	DB01065	2450	133	None	-1	8	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	115348	70	42	None	4	2	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm980026p
	1343	70	42	None	4	2	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm980026p
	CHEMBL289233	70	42	None	4	2	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm980026p
	DB08190	70	42	None	4	2	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm980026p
	9834952	29107	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	3	1	3	2.4	CC(=O)NCCc1coc2ccc3c(c12)CCCO3	10.1021/jm980026p
	CHEMBL138321	29107	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	3	1	3	2.4	CC(=O)NCCc1coc2ccc3c(c12)CCCO3	10.1021/jm980026p
	10265261	141430	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	272	2	1	3	2.7	COc1ccc2c(c1)c1c(n2C)CCCC1NC(C)=O	10.1021/jm980026p
	CHEMBL38728	141430	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	272	2	1	3	2.7	COc1ccc2c(c1)c1c(n2C)CCCC1NC(C)=O	10.1021/jm980026p
	34247	8166	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	4	1	3	2.6	COc1ccc2scc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL109235	8166	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	4	1	3	2.6	COc1ccc2scc(CCNC(C)=O)c2c1	10.1021/jm980026p
	9975634	9655	1	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	5	2	2	2.3	COc1ccc2[nH]cc(CCNC(=O)CI)c2c1	10.1021/jm980026p
	CHEMBL113441	9655	1	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	5	2	2	2.3	COc1ccc2[nH]cc(CCNC(=O)CI)c2c1	10.1021/jm980026p
	15340631	9749	1	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	253	3	1	2	3.3	CC(=O)NCCc1cccc2ccc3occc3c12	10.1021/jm980026p
	CHEMBL11404	9749	1	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	253	3	1	2	3.3	CC(=O)NCCc1cccc2ccc3occc3c12	10.1021/jm980026p
	164405	162201	9	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	5	1	2	2.9	COc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL417151	162201	9	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	5	1	2	2.9	COc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	10059864	109335	4	None	2	2	Human	8.8	pIC50	=	8.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL323332	109335	4	None	2	2	Human	8.8	pIC50	=	8.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	10061999	7955	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	276	5	2	2	2.4	COc1cc2c(CCNC(=O)C3CC3)c[nH]c2cc1F	10.1021/jm980026p
	CHEMBL109086	7955	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	276	5	2	2	2.4	COc1cc2c(CCNC(=O)C3CC3)c[nH]c2cc1F	10.1021/jm980026p
	44358991	29637	1	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	7	1	2	3.5	C=CCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL138766	29637	1	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	7	1	2	3.5	C=CCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	3071631	138131	6	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	2	2.9	CCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL37771	138131	6	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	2	2.9	CCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	10038961	9632	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	3	1	2	3.0	CC(=O)NCCC1CCCc2ccc3c(c21)CCCO3	10.1021/jm980026p
	CHEMBL11328	9632	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	3	1	2	3.0	CC(=O)NCCC1CCCc2ccc3c(c21)CCCO3	10.1021/jm980026p
	9993398	29074	2	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	272	5	2	2	2.7	CCNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL138288	29074	2	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	272	5	2	2	2.7	CCNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	10131203	118235	1	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	3	2.2	CNC(=O)CCCc1cccc2c1SCCO2	10.1021/jm980026p
	CHEMBL341761	118235	1	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	3	2.2	CNC(=O)CCCc1cccc2c1SCCO2	10.1021/jm980026p
	4284525	188128	38	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL504585	188128	38	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	3071635	9313	3	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	4	0	2	3.0	COc1ccc2cccc(CCN3CCCC3=O)c2c1	10.1021/jm980026p
	CHEMBL111558	9313	3	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	4	0	2	3.0	COc1ccc2cccc(CCN3CCCC3=O)c2c1	10.1021/jm980026p
	21469690	28536	1	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	262	4	2	2	2.9	CCc1ccc2scc(CCNC(=O)NC)c2c1	10.1021/jm980026p
	CHEMBL137823	28536	1	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	262	4	2	2	2.9	CCc1ccc2scc(CCNC(=O)NC)c2c1	10.1021/jm980026p
	44359466	118651	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	6	1	4	1.9	CCS(=O)(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL342949	118651	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	6	1	4	1.9	CCS(=O)(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	4284525	188128	38	None	-	0	Human	6.0	pIC50	=	6	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL504585	188128	38	None	-	0	Human	6.0	pIC50	=	6	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	18177433	29182	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	4	1	3	1.8	COc1ccc2c(c1)CC(CCNC(C)=O)CO2	10.1021/jm980026p
	CHEMBL138387	29182	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	4	1	3	1.8	COc1ccc2c(c1)CC(CCNC(C)=O)CO2	10.1021/jm980026p
	44358869	118365	1	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	229	4	1	2	2.3	COc1ccc2cccc(CCC(N)=O)c2c1	10.1021/jm980026p
	CHEMBL342207	118365	1	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	229	4	1	2	2.3	COc1ccc2cccc(CCC(N)=O)c2c1	10.1021/jm980026p
	18357874	164496	2	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	219	3	1	3	1.8	CC(=O)NCCC1=COc2ccccc2O1	10.1021/jm980026p
	CHEMBL422636	164496	2	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	219	3	1	3	1.8	CC(=O)NCCC1=COc2ccccc2O1	10.1021/jm980026p
	19703067	28704	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	203	3	1	3	1.2	CC(=O)NCCn1ccc2cccnc21	10.1021/jm980026p
	CHEMBL137970	28704	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	203	3	1	3	1.2	CC(=O)NCCn1ccc2cccnc21	10.1021/jm980026p
	12288745	29090	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	221	2	1	3	1.1	COc1ccc2c(c1)CC(NC(C)=O)CO2	10.1021/jm980026p
	CHEMBL138301	29090	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	221	2	1	3	1.1	COc1ccc2c(c1)CC(NC(C)=O)CO2	10.1021/jm980026p
	19703053	29279	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	234	4	1	4	1.5	COc1nccc2c(CCNC(C)=O)coc12	10.1021/jm980026p
	CHEMBL138468	29279	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	234	4	1	4	1.5	COc1nccc2c(CCNC(C)=O)coc12	10.1021/jm980026p
	18175018	29324	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	260	4	2	2	2.2	CC(=O)NCCC1CCc2ccc(NC(C)=O)cc21	10.1021/jm980026p
	CHEMBL138508	29324	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	260	4	2	2	2.2	CC(=O)NCCC1CCc2ccc(NC(C)=O)cc21	10.1021/jm980026p
	15838838	30036	3	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	207	2	1	3	1.1	CC(=O)NCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL139091	30036	3	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	207	2	1	3	1.1	CC(=O)NCc1cccc2c1OCCO2	10.1021/jm980026p
	15372705	30419	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	4	1	4	3.0	COc1ccc2c(c1)OC(CNC(C)=O)=C(c1ccccc1)O2	10.1021/jm980026p
	CHEMBL139418	30419	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	4	1	4	3.0	COc1ccc2c(c1)OC(CNC(C)=O)=C(c1ccccc1)O2	10.1021/jm980026p
	15391788	31490	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	1	1	4	0.9	CC(=O)NC1COc2cc3c(cc2C1)OCCO3	10.1021/jm980026p
	CHEMBL140548	31490	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	1	1	4	0.9	CC(=O)NC1COc2cc3c(cc2C1)OCCO3	10.1021/jm980026p
	44359047	118746	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	4	0.5	CNC(=O)CCc1cccc2c1S(=O)(=O)CCO2	10.1021/jm980026p
	CHEMBL343575	118746	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	4	0.5	CNC(=O)CCc1cccc2c1S(=O)(=O)CCO2	10.1021/jm980026p
	15149134	99739	1	None	-	0	Human	4.0	pIC50	=	4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL288300	99739	1	None	-	0	Human	4.0	pIC50	=	4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	44359375	118716	3	None	-	0	Human	4.0	pIC50	=	4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	211	1	1	1	2.4	O=C1CC(c2cccc3ccccc23)CN1	10.1021/jm980026p
	CHEMBL343381	118716	3	None	-	0	Human	4.0	pIC50	=	4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	211	1	1	1	2.4	O=C1CC(c2cccc3ccccc23)CN1	10.1021/jm980026p
	23725566	125330	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648360	125330	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
	44272486	69485	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
	CHEMBL19374	69485	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
	44358830	30194	2	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	5	1	4	1.5	COc1ccc2occ(CCNS(C)(=O)=O)c2c1	10.1021/jm980026p
	CHEMBL139228	30194	2	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	5	1	4	1.5	COc1ccc2occ(CCNS(C)(=O)=O)c2c1	10.1021/jm980026p
	44359427	30499	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	373	5	1	2	3.1	COc1ccc2c(c1)C(CCNC(=O)CI)CCC2	10.1021/jm980026p
	CHEMBL139516	30499	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	373	5	1	2	3.1	COc1ccc2c(c1)C(CCNC(=O)CI)CCC2	10.1021/jm980026p
	19696845	116033	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	243	4	1	2	2.5	CNC(=O)CCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL336225	116033	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	243	4	1	2	2.5	CNC(=O)CCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	44359390	118501	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	295	7	1	2	3.5	C=CCOc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL342592	118501	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	295	7	1	2	3.5	C=CCOc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	19385775	118924	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	274	4	2	2	2.9	CN/C(S)=N/CCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL344880	118924	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	274	4	2	2	2.9	CN/C(S)=N/CCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	44576404	192505	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	286	5	2	3	1.9	CNC(=O)c1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL522674	192505	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	286	5	2	3	1.9	CNC(=O)c1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1016/j.bmc.2008.03.036
	10399169	28678	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	4	1	3	1.5	CC(=O)NCCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL137948	28678	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	4	1	3	1.5	CC(=O)NCCCc1cccc2c1OCCO2	10.1021/jm980026p
	19703063	28702	1	None	2	2	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1021/jm980026p
	CHEMBL137969	28702	1	None	2	2	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1021/jm980026p
	23360853	31833	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	6	1	3	3.1	COc1ccc2cc(C(C)=O)cc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL140826	31833	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	6	1	3	3.1	COc1ccc2cc(C(C)=O)cc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	44359206	118873	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	265	5	1	3	2.6	CC(=O)NCCCCc1cccc2c1SCCO2	10.1021/jm980026p
	CHEMBL344488	118873	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	265	5	1	3	2.6	CC(=O)NCCCCc1cccc2c1SCCO2	10.1021/jm980026p
	44359079	164704	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	247	5	1	3	2.5	CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL423011	164704	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	247	5	1	3	2.5	CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	44358887	26656	1	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	215	2	1	2	2.2	CNC(=O)c1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL136346	26656	1	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	215	2	1	2	2.2	CNC(=O)c1cccc2ccc(OC)cc12	10.1021/jm980026p
	44359058	29466	3	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	203	3	2	2	1.2	CC(=O)NCCc1c[nH]c2ncccc12	10.1021/jm980026p
	CHEMBL138631	29466	3	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	203	3	2	2	1.2	CC(=O)NCCc1c[nH]c2ncccc12	10.1021/jm980026p
	23725513	125327	0	None	-3	2	Human	7.8	pIC50	=	7.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648357	125327	0	None	-3	2	Human	7.8	pIC50	=	7.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
	15340629	9773	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	3	2.1	CC(=O)NCCc1cccc2ccc3c(c12)C(=O)CO3	10.1021/jm980026p
	CHEMBL11416	9773	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	3	2.1	CC(=O)NCCc1cccc2ccc3c(c12)C(=O)CO3	10.1021/jm980026p
	44359205	28718	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	8	1	2	4.1	CCCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL137983	28718	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	8	1	2	4.1	CCCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	44358971	28776	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	3	2.1	C#CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138037	28776	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	3	2.1	C#CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	10059969	28798	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	4	1	3	1.5	CNC(=O)CCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL138053	28798	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	4	1	3	1.5	CNC(=O)CCCc1cccc2c1OCCO2	10.1021/jm980026p
	15289277	28977	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	333	6	1	2	4.1	COc1ccc2cc(Cc3ccccc3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138201	28977	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	333	6	1	2	4.1	COc1ccc2cc(Cc3ccccc3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	23360848	161122	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.5	CCc1cc(CCNC(=O)C2CC2)c2cc(OC)ccc2c1	10.1021/jm980026p
	CHEMBL413121	161122	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.5	CCc1cc(CCNC(=O)C2CC2)c2cc(OC)ccc2c1	10.1021/jm980026p
	22375366	69150	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
	CHEMBL19339	69150	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
	44358744	26503	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	5	1	3	1.9	CC(=O)NCCCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL136214	26503	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	5	1	3	1.9	CC(=O)NCCCCc1cccc2c1OCCO2	10.1021/jm980026p
	15340628	27210	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	287	6	2	3	2.0	CC(=O)NCCc1cccc2ccc(OCC(=O)O)cc12	10.1021/jm980026p
	CHEMBL136815	27210	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	287	6	2	3	2.0	CC(=O)NCCc1cccc2ccc(OCC(=O)O)cc12	10.1021/jm980026p
	10060719	169868	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	3	2.2	CC(=O)NCCCc1cccc2c1SCCO2	10.1021/jm980026p
	CHEMBL444857	169868	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	3	2.2	CC(=O)NCCCc1cccc2c1SCCO2	10.1021/jm980026p
	44359046	29648	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	265	6	1	4	1.8	CC(=O)NCCCCOc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL138774	29648	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	265	6	1	4	1.8	CC(=O)NCCCCOc1cccc2c1OCCO2	10.1021/jm980026p
	18782997	32982	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	277	6	2	4	1.6	CC(=O)NCCc1coc2ccc(OCC(=O)O)cc12	10.1021/jm980026p
	CHEMBL141785	32982	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	277	6	2	4	1.6	CC(=O)NCCc1coc2ccc(OCC(=O)O)cc12	10.1021/jm980026p
	19703028	118638	2	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	204	3	1	3	1.5	CC(=O)NCCc1coc2cnccc12	10.1021/jm980026p
	CHEMBL342836	118638	2	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	204	3	1	3	1.5	CC(=O)NCCc1coc2cnccc12	10.1021/jm980026p
	44359374	118895	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	241	2	1	2	2.5	COc1ccc2cccc(C3CNC(=O)C3)c2c1	10.1021/jm980026p
	CHEMBL344632	118895	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	241	2	1	2	2.5	COc1ccc2cccc(C3CNC(=O)C3)c2c1	10.1021/jm980026p
	21460931	167890	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	245	5	1	2	3.1	CCCc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL435032	167890	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	245	5	1	2	3.1	CCCc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	15391785	28951	1	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	3	1	3	1.6	COc1ccc2c(c1)C=C(CNC(C)=O)CO2	10.1021/jm980026p
	CHEMBL138180	28951	1	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	3	1	3	1.6	COc1ccc2c(c1)C=C(CNC(C)=O)CO2	10.1021/jm980026p
	44358928	29954	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	333	7	1	2	4.1	COc1ccc2cccc(CC(=O)NCCCc3ccccc3)c2c1	10.1021/jm980026p
	CHEMBL139016	29954	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	333	7	1	2	4.1	COc1ccc2cccc(CC(=O)NCCCc3ccccc3)c2c1	10.1021/jm980026p
	44359070	32579	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	205	3	1	3	0.6	CC(=O)NCCN1CCc2cccnc21	10.1021/jm980026p
	CHEMBL141430	32579	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	205	3	1	3	0.6	CC(=O)NCCN1CCc2cccnc21	10.1021/jm980026p
	22375372	66922	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)C(N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
	CHEMBL18808	66922	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)C(N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
	11059058	9996	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity against melatonin receptor type 1ABinding affinity against melatonin receptor type 1A	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
	CHEMBL115444	9996	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity against melatonin receptor type 1ABinding affinity against melatonin receptor type 1A	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
	44576399	188200	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	260	4	2	3	1.5	CNC(=O)c1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL505744	188200	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	260	4	2	3	1.5	CNC(=O)c1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	23725568	125334	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@H]1CCc2ccc3nc(C)sc3c21	nan
	CHEMBL3648364	125334	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@H]1CCc2ccc3nc(C)sc3c21	nan
	10039072	28679	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	6	3	2	2.4	CCCNC(=O)NCCc1c[nH]c2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL137949	28679	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	6	3	2	2.4	CCCNC(=O)NCCc1c[nH]c2ccc(OC)cc12	10.1021/jm980026p
	10377971	29312	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	3	2.4	CCCC(=O)NCC1=Cc2cc(OC)ccc2OC1	10.1021/jm980026p
	CHEMBL138496	29312	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	3	2.4	CCCC(=O)NCC1=Cc2cc(OC)ccc2OC1	10.1021/jm980026p
	44359437	29686	0	None	1	3	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138807	29686	0	None	1	3	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1021/jm980026p
	19752678	29688	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	243	5	1	2	2.7	COc1ccc2cccc(CCCC(N)=O)c2c1	10.1021/jm980026p
	CHEMBL138808	29688	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	243	5	1	2	2.7	COc1ccc2cccc(CCCC(N)=O)c2c1	10.1021/jm980026p
	10448305	29845	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138924	29845	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359018	118939	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	5	1	3	2.5	COc1ccc2occ(CCNC(=O)CBr)c2c1	10.1021/jm980026p
	CHEMBL345029	118939	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	5	1	3	2.5	COc1ccc2occ(CCNC(=O)CBr)c2c1	10.1021/jm980026p
	44358910	27211	1	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	7	1	2	3.7	CCCOc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL136816	27211	1	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	7	1	2	3.7	CCCOc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	2821758	29144	15	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	207	2	1	3	1.0	CC(=O)NCC1COc2ccccc2O1	10.1021/jm980026p
	CHEMBL138355	29144	15	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	207	2	1	3	1.0	CC(=O)NCC1COc2ccccc2O1	10.1021/jm980026p
	44358944	32683	3	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	9	2	1	4.2	CCCCCCCC(=O)NCCc1c[nH]c2ccccc12	10.1021/jm980026p
	CHEMBL141522	32683	3	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	9	2	1	4.2	CCCCCCCC(=O)NCCc1c[nH]c2ccccc12	10.1021/jm980026p
	15149133	119510	1	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	8	1	2	4.1	CCCCCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL35017	119510	1	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	8	1	2	4.1	CCCCCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	53827707	110377	3	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK293 cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	279	6	1	3	3.0	CCCNC(=O)CCCc1cccc2c1SCCO2	10.1021/jm401343c
	CHEMBL3260981	110377	3	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK293 cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	279	6	1	3	3.0	CCCNC(=O)CCCc1cccc2c1SCCO2	10.1021/jm401343c
	18360745	29700	1	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	258	4	2	2	2.3	CNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL138817	29700	1	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	258	4	2	2	2.3	CNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	3071630	137711	3	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	5	1	2	3.2	COc1ccc2cccc(CCNC(=O)C(C)C)c2c1	10.1021/jm980026p
	CHEMBL37703	137711	3	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	5	1	2	3.2	COc1ccc2cccc(CCNC(=O)C(C)C)c2c1	10.1021/jm980026p
	10266979	98562	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	303	3	1	3	2.0	CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
	CHEMBL280142	98562	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	303	3	1	3	2.0	CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
	11178762	66671	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	463	5	0	2	6.1	COc1cc2c(cc1Br)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
	CHEMBL186941	66671	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	463	5	0	2	6.1	COc1cc2c(cc1Br)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
	44340895	9329	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	219	3	1	2	1.9	COc1ccc2c(c1)C(CNC(C)=O)CC2	10.1021/jm980026p
	CHEMBL111667	9329	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	219	3	1	2	1.9	COc1ccc2c(c1)C(CNC(C)=O)CC2	10.1021/jm980026p
	44359479	29959	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	277	6	1	3	3.4	CCCOc1ccc2scc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL139021	29959	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	277	6	1	3	3.4	CCCOc1ccc2scc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359019	31383	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	6	1	3	2.7	C=CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL140427	31383	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	6	1	3	2.7	C=CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	19086015	30428	4	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	300	7	2	2	3.5	CCCNC(=O)NCCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL139428	30428	4	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	300	7	2	2	3.5	CCCNC(=O)NCCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	19703043	118821	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	5	1	4	1.7	COc1cnc2c(c1)c(CCNC(=O)C1CC1)cn2C	10.1021/jm980026p
	CHEMBL344179	118821	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	5	1	4	1.7	COc1cnc2c(c1)c(CCNC(=O)C1CC1)cn2C	10.1021/jm980026p
	3071647	135821	2	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	344	5	2	2	4.3	COc1ccc2cccc(CCNC(=O)c3cc4ccccc4[nH]3)c2c1	10.1021/jm980026p
	CHEMBL37341	135821	2	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	344	5	2	2	4.3	COc1ccc2cccc(CCNC(=O)c3cc4ccccc4[nH]3)c2c1	10.1021/jm980026p
	18175032	175023	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	358	6	2	4	2.3	CNS(=O)(=O)c1ccc2cccc(CCNC(=O)c3ccco3)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL457992	175023	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	358	6	2	4	2.3	CNS(=O)(=O)c1ccc2cccc(CCNC(=O)c3ccco3)c2c1	10.1016/j.ejmech.2011.02.010
	44593610	186789	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	302	6	2	4	2.8	C=CCC(=O)NCCc1coc2ccc(NC(=O)OC)cc12	10.1016/j.bmc.2008.03.036
	CHEMBL493424	186789	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	302	6	2	4	2.8	C=CCC(=O)NCCc1coc2ccc(NC(=O)OC)cc12	10.1016/j.bmc.2008.03.036
	44359035	31492	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	7	1	2	3.7	CCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL140549	31492	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	7	1	2	3.7	CCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	18947294	32191	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	248	4	2	3	1.9	CNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL141115	32191	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	248	4	2	3	1.9	CNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	44359270	168041	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	6	2	2	3.3	C=CCc1c(O)ccc2cccc(CCNC(=O)CC)c12	10.1021/jm980026p
	CHEMBL436006	168041	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	6	2	2	3.3	C=CCc1c(O)ccc2cccc(CCNC(=O)CC)c12	10.1021/jm980026p
	10333620	108717	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	5	1	3	3.0	COc1ccc2scc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL321612	108717	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	5	1	3	3.0	COc1ccc2scc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	44359308	114991	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	244	4	2	2	2.1	COc1ccc2cccc(CCNC(N)=O)c2c1	10.1021/jm980026p
	CHEMBL335116	114991	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	244	4	2	2	2.1	COc1ccc2cccc(CCNC(N)=O)c2c1	10.1021/jm980026p
	18783022	116256	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	3	1	3	2.5	CC(=O)NCCc1coc2ccc3c(c12)C=CCO3	10.1021/jm980026p
	CHEMBL337580	116256	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	3	1	3	2.5	CC(=O)NCCc1coc2ccc3c(c12)C=CCO3	10.1021/jm980026p
	19967248	168753	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	6	1	3	3.2	CCCC(=O)NOCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL441664	168753	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	6	1	3	3.2	CCCC(=O)NOCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	18175008	174922	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	292	4	2	3	1.2	CC(=O)NCCc1cccc2ccc(S(N)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
	CHEMBL457763	174922	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	292	4	2	3	1.2	CC(=O)NCCc1cccc2ccc(S(N)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
	44358896	30494	2	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	228	3	2	1	2.3	CNC(=O)NCCc1cccc2ccccc12	10.1021/jm980026p
	CHEMBL139510	30494	2	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	228	3	2	1	2.3	CNC(=O)NCCc1cccc2ccccc12	10.1021/jm980026p
	44358943	31181	1	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	5	1	2	4.2	CC(=O)NCCc1cccc2ccc(OC3CCCCC3)cc12	10.1021/jm980026p
	CHEMBL140244	31181	1	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	5	1	2	4.2	CC(=O)NCCc1cccc2ccc(OC3CCCCC3)cc12	10.1021/jm980026p
	10243074	9705	2	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	1	4	1.2	COc1ccc2ncn(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL113692	9705	2	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	1	4	1.2	COc1ccc2ncn(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359228	30089	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	237	4	1	4	1.0	CC(=O)NCCOc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL139133	30089	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	237	4	1	4	1.0	CC(=O)NCCOc1cccc2c1OCCO2	10.1021/jm980026p
	15372706	118922	1	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	281	3	1	3	3.0	CC(=O)NCC1=C(c2ccccc2)Oc2ccccc2O1	10.1021/jm980026p
	CHEMBL344866	118922	1	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	281	3	1	3	3.0	CC(=O)NCC1=C(c2ccccc2)Oc2ccccc2O1	10.1021/jm980026p
	9861677	186976	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	315	5	1	4	3.1	COC(=O)c1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL494566	186976	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	315	5	1	4	3.1	COC(=O)c1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
	10379422	8352	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	289	5	1	3	3.4	COc1ccc2scc(CCNC(=O)C3CCC3)c2c1	10.1021/jm980026p
	CHEMBL109361	8352	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	289	5	1	3	3.4	COc1ccc2scc(CCNC(=O)C3CCC3)c2c1	10.1021/jm980026p
	15391789	29400	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	3	1	3	1.4	COc1ccc2c(c1)CC(CNC(C)=O)CO2	10.1021/jm980026p
	CHEMBL138581	29400	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	3	1	3	1.4	COc1ccc2c(c1)CC(CNC(C)=O)CO2	10.1021/jm980026p
	23360817	30576	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	6	1	3	3.1	COc1ccc2cc(C(=O)C3CC3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL139627	30576	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	6	1	3	3.1	COc1ccc2cc(C(=O)C3CC3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359020	31389	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	337	7	1	3	4.1	CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL140433	31389	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	337	7	1	3	4.1	CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm980026p
	44358768	116294	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	6	1	3	2.8	CCCC(=O)NCCCc1cccc2c1OC=CO2	10.1021/jm980026p
	CHEMBL337802	116294	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	6	1	3	2.8	CCCC(=O)NCCCc1cccc2c1OC=CO2	10.1021/jm980026p
	44358840	118242	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	1	3	2.7	COC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL341802	118242	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	1	3	2.7	COC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	2368416	99619	5	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	242	4	2	1	2.6	O=C(NCCc1c[nH]c2ccccc12)C1CCC1	10.1021/jm980026p
	CHEMBL287310	99619	5	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	242	4	2	1	2.6	O=C(NCCc1c[nH]c2ccccc12)C1CCC1	10.1021/jm980026p
	44272591	71361	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
	CHEMBL19653	71361	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
	21916760	175126	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	291	4	1	3	1.9	CC(=O)NCCc1cccc2ccc(S(C)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
	CHEMBL458209	175126	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	291	4	1	3	1.9	CC(=O)NCCc1cccc2ccc(S(C)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
	10422677	9214	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	5	1	3	2.5	COc1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL110980	9214	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	5	1	3	2.5	COc1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	18783019	28627	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	267	5	1	2	2.5	C#CCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL137910	28627	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	267	5	1	2	2.5	C#CCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359309	29244	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	2	3	2.0	COc1ccc2cccc(C(O)CNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138440	29244	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	2	3	2.0	COc1ccc2cccc(C(O)CNC(C)=O)c2c1	10.1021/jm980026p
	9881916	29622	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	2	1	3	2.3	COc1ccc2ccc3c(c2c1)CC(NC(C)=O)CO3	10.1021/jm980026p
	CHEMBL138752	29622	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	2	1	3	2.3	COc1ccc2ccc3c(c2c1)CC(NC(C)=O)CO3	10.1021/jm980026p
	10248871	108078	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	375	5	1	3	3.0	COc1ccc2scc(CCNC(=O)CI)c2c1	10.1021/jm980026p
	CHEMBL320253	108078	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	375	5	1	3	3.0	COc1ccc2scc(CCNC(=O)CI)c2c1	10.1021/jm980026p
	44359464	29734	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	7	1	3	3.3	CCCCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138841	29734	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	7	1	3	3.3	CCCCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	18947318	118293	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	293	6	3	2	2.6	CCCNC(=O)NCCc1c[nH]c2cc(F)c(OC)cc12	10.1021/jm980026p
	CHEMBL342162	118293	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	293	6	3	2	2.6	CCCNC(=O)NCCc1c[nH]c2cc(F)c(OC)cc12	10.1021/jm980026p
	44358743	118537	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	5	1	3	1.9	CNC(=O)CCCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL342649	118537	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	5	1	3	1.9	CNC(=O)CCCCc1cccc2c1OCCO2	10.1021/jm980026p
	23360832	118778	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	6	1	3	3.1	CCC(=O)c1cc(CCNC(C)=O)c2cc(OC)ccc2c1	10.1021/jm980026p
	CHEMBL343819	118778	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	6	1	3	3.1	CCC(=O)c1cc(CCNC(C)=O)c2cc(OC)ccc2c1	10.1021/jm980026p
	22133298	118868	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	6	2	2	3.1	CCCNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL344454	118868	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	6	2	2	3.1	CCCNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	18175028	59764	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	306	5	2	3	1.4	CNS(=O)(=O)c1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL1738752	59764	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	306	5	2	3	1.4	CNS(=O)(=O)c1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	10085672	29293	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	291	7	1	3	3.8	CCCCC(=O)NCCc1csc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL138475	29293	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	291	7	1	3	3.8	CCCCC(=O)NCCc1csc2ccc(OC)cc12	10.1021/jm980026p
	21572387	29527	3	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	214	3	2	1	2.1	NC(=O)NCCc1cccc2ccccc12	10.1021/jm980026p
	CHEMBL138675	29527	3	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	214	3	2	1	2.1	NC(=O)NCCc1cccc2ccccc12	10.1021/jm980026p
	44359120	29862	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	1	2	3.4	O=C(NCCc1csc2ccccc12)C1CCC1	10.1021/jm980026p
	CHEMBL138938	29862	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	1	2	3.4	O=C(NCCc1csc2ccccc12)C1CCC1	10.1021/jm980026p
	9837777	31921	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	247	4	1	4	1.3	COc1cnc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm980026p
	CHEMBL140896	31921	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	247	4	1	4	1.3	COc1cnc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm980026p
	15838839	33000	2	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	221	3	1	3	1.1	CC(=O)NCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL141796	33000	2	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	221	3	1	3	1.1	CC(=O)NCCc1cccc2c1OCCO2	10.1021/jm980026p
	11749479	66564	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	385	5	0	2	5.4	COc1ccc2c(c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1016/j.bmcl.2004.09.024
	CHEMBL186452	66564	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	385	5	0	2	5.4	COc1ccc2c(c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1016/j.bmcl.2004.09.024
	44576406	186787	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	330	5	2	4	3.5	COC(=O)Nc1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL493414	186787	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	330	5	2	4	3.5	COC(=O)Nc1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
	17957007	192054	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	304	5	2	4	2.9	COC(=O)Nc1ccc2occ(CCNC(=O)C(C)C)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL521826	192054	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	304	5	2	4	2.9	COC(=O)Nc1ccc2occ(CCNC(=O)C(C)C)c2c1	10.1016/j.bmc.2008.03.036
	10265421	9342	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	7	1	3	3.3	CCCCC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL111718	9342	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	7	1	3	3.3	CCCCC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	44359121	29951	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL139014	29951	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	23360808	30411	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	6	1	2	3.5	CCCc1cc(CCNC(C)=O)c2cc(OC)ccc2c1	10.1021/jm980026p
	CHEMBL139410	30411	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	6	1	2	3.5	CCCc1cc(CCNC(C)=O)c2cc(OC)ccc2c1	10.1021/jm980026p
	11361621	125286	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	401	7	0	3	5.0	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C=O)CC2	10.1016/j.bmcl.2004.09.024
	CHEMBL364816	125286	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	401	7	0	3	5.0	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C=O)CC2	10.1016/j.bmcl.2004.09.024
	18177435	28954	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	3	1	3	2.5	COc1ccc2ccc3c(c2c1)CC(CNC(C)=O)CO3	10.1021/jm980026p
	CHEMBL138182	28954	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	3	1	3	2.5	COc1ccc2ccc3c(c2c1)CC(CNC(C)=O)CO3	10.1021/jm980026p
	21469691	118641	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	2	3.5	CCC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	CHEMBL342855	118641	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	2	3.5	CCC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	21469682	31559	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	289	7	1	2	4.3	CCCCC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	CHEMBL140611	31559	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	289	7	1	2	4.3	CCCCC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	44359381	32302	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	5	1	4	1.4	CC(=O)NCCCOc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL141208	32302	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	5	1	4	1.4	CC(=O)NCCCOc1cccc2c1OCCO2	10.1021/jm980026p
	44359294	116288	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	406	8	4	3	3.8	COc1ccc2[nH]cc(CCNC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1021/jm980026p
	CHEMBL337767	116288	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	406	8	4	3	3.8	COc1ccc2[nH]cc(CCNC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1021/jm980026p
	17524911	31843	5	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	256	4	2	1	3.0	O=C(NCCc1c[nH]c2ccccc12)C1CCCC1	10.1021/jm980026p
	CHEMBL140835	31843	5	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	256	4	2	1	3.0	O=C(NCCc1c[nH]c2ccccc12)C1CCCC1	10.1021/jm980026p
	588712	32877	10	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	244	6	2	1	3.0	CCCCC(=O)NCCc1c[nH]c2ccccc12	10.1021/jm980026p
	CHEMBL141694	32877	10	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	244	6	2	1	3.0	CCCCC(=O)NCCc1c[nH]c2ccccc12	10.1021/jm980026p
	11430378	167656	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	431	6	0	4	5.6	COC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
	CHEMBL433573	167656	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	431	6	0	4	5.6	COC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
	9837740	29369	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	245	4	1	3	2.4	COc1ccc2cccc(CONC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138549	29369	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	245	4	1	3	2.4	COc1ccc2cccc(CONC(C)=O)c2c1	10.1021/jm980026p
	44359113	115902	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	7	1	2	3.7	CCC(=O)NCCc1cccc2ccc(OCC3CC3)cc12	10.1021/jm980026p
	CHEMBL336010	115902	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	7	1	2	3.7	CCC(=O)NCCc1cccc2ccc(OCC3CC3)cc12	10.1021/jm980026p
	23360842	118472	1	None	-	1	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.5	COc1ccc2cc(CC3CC3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL342432	118472	1	None	-	1	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.5	COc1ccc2cc(CC3CC3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44358970	118538	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	359	5	1	3	2.5	COc1ccc2occ(CCNC(=O)CI)c2c1	10.1021/jm980026p
	CHEMBL342655	118538	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	359	5	1	3	2.5	COc1ccc2occ(CCNC(=O)CI)c2c1	10.1021/jm980026p
	18947325	118838	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	262	5	2	3	2.3	CCNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL344268	118838	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	262	5	2	3	2.3	CCNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	9817006	174412	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	275	4	1	2	2.3	CC(=O)NCCc1cccc2ccc([S+](C)[O-])cc12	10.1016/j.ejmech.2011.02.010
	CHEMBL456646	174412	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	275	4	1	2	2.3	CC(=O)NCCc1cccc2ccc([S+](C)[O-])cc12	10.1016/j.ejmech.2011.02.010
	44358879	29852	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.7	CCOc1ccc2cccc(CCNC(=O)C3CCC3)c2c1	10.1021/jm980026p
	CHEMBL138929	29852	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.7	CCOc1ccc2cccc(CCNC(=O)C3CCC3)c2c1	10.1021/jm980026p
	44359266	31493	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	316	4	0	5	2.2	COc1ccc2c(c1)c(CCN(C(C)=O)C(C)=O)cn2C(C)=O	10.1021/jm980026p
	CHEMBL140551	31493	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	316	4	0	5	2.2	COc1ccc2c(c1)c(CCN(C(C)=O)C(C)=O)cn2C(C)=O	10.1021/jm980026p
	18947270	32669	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	276	6	2	3	2.7	CCCNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL141507	32669	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	276	6	2	3	2.7	CCCNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	44359465	118273	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	3	2.9	CC(=O)NCCc1coc2ccc(OC(C)C)cc12	10.1021/jm980026p
	CHEMBL341989	118273	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	3	2.9	CC(=O)NCCc1coc2ccc(OC(C)C)cc12	10.1021/jm980026p
	21469693	30664	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	290	6	2	2	3.7	CCCNC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	CHEMBL139744	30664	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	290	6	2	2	3.7	CCCNC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	18177465	118835	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	4	1.4	COc1ccc2c(c1)OC(CCNC(C)=O)CO2	10.1021/jm980026p
	CHEMBL344242	118835	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	4	1.4	COc1ccc2c(c1)OC(CCNC(C)=O)CO2	10.1021/jm980026p
	15838841	30031	1	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	280	6	2	4	1.5	CCCNC(=O)NCCOc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL139087	30031	1	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	280	6	2	4	1.5	CCCNC(=O)NCCOc1cccc2c1OCCO2	10.1021/jm980026p
	25014882	187112	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	302	5	2	4	2.7	COC(=O)Nc1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL495232	187112	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	302	5	2	4	2.7	COC(=O)Nc1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1016/j.bmc.2008.03.036
	17957000	61076	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	286	4	2	3	2.7	COC(=O)Nc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL1770214	61076	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	286	4	2	3	2.7	COC(=O)Nc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	1357	2450	133	None	-1	8	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	1672	2450	133	None	-1	8	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	224	2450	133	None	-1	8	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	896	2450	133	None	-1	8	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	CHEMBL45	2450	133	None	-1	8	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	DB01065	2450	133	None	-1	8	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	10440	2642	15	None	-21	3	Human	5.2	pKd	=	5.2	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	139030523	2642	15	None	-21	3	Human	5.2	pKd	=	5.2	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	CHEMBL4449712	2642	15	None	-21	3	Human	5.2	pKd	=	5.2	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	22004862	61693	0	None	-1	2	Human	11.1	pKi	=	11.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	319	4	1	2	3.6	CC(=O)NCCC1=C(c2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200385u
	CHEMBL1774522	61693	0	None	-1	2	Human	11.1	pKi	=	11.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	319	4	1	2	3.6	CC(=O)NCCC1=C(c2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200385u
	9903515	22591	0	None	9	2	Human	11.0	pKi	=	11	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(C)=O)CC3	10.1021/jm000922c
	CHEMBL132802	22591	0	None	9	2	Human	11.0	pKi	=	11	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(C)=O)CC3	10.1021/jm000922c
	9839629	99654	0	None	1	2	Human	11.0	pKi	=	11	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL287560	99654	0	None	1	2	Human	11.0	pKi	=	11	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	10925712	112088	0	None	1	2	Human	11.0	pKi	=	11	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	4.3	C=CCC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL330137	112088	0	None	1	2	Human	11.0	pKi	=	11	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	4.3	C=CCC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	9839629	99654	0	None	1	2	Human	11.0	pKi	=	11	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
	CHEMBL287560	99654	0	None	1	2	Human	11.0	pKi	=	11	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
	9796846	115936	0	None	12	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	CCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL336054	115936	0	None	12	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	CCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	53237947	61686	0	None	-1	2	Human	10.9	pKi	=	10.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	299	5	1	2	3.5	CCC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774514	61686	0	None	-1	2	Human	10.9	pKi	=	10.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	299	5	1	2	3.5	CCC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	115348	70	42	None	4	2	Human	10.9	pKi	=	10.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
	1343	70	42	None	4	2	Human	10.9	pKi	=	10.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
	CHEMBL289233	70	42	None	4	2	Human	10.9	pKi	=	10.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
	DB08190	70	42	None	4	2	Human	10.9	pKi	=	10.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
	1356	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	208902	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	2355	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	CHEMBL1218	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	DB00980	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	1356	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	208902	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	2355	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	CHEMBL1218	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	DB00980	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	9926304	116075	0	None	9	2	Human	10.8	pKi	=	10.8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	299	4	1	3	3.0	COc1ccc2ccc(OC)c3c2c1CCC3CNC(C)=O	10.1021/jm000922c
	CHEMBL336509	116075	0	None	9	2	Human	10.8	pKi	=	10.8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	299	4	1	3	3.0	COc1ccc2ccc(OC)c3c2c1CCC3CNC(C)=O	10.1021/jm000922c
	9797460	117650	0	None	6	2	Human	10.8	pKi	=	10.8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL340832	117650	0	None	6	2	Human	10.8	pKi	=	10.8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	11723593	106395	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	3	4.0	C=CC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL314512	106395	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	3	4.0	C=CC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	53237946	61685	0	None	-1	2	Human	10.6	pKi	=	10.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	285	4	1	2	3.1	CC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774513	61685	0	None	-1	2	Human	10.6	pKi	=	10.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	285	4	1	2	3.1	CC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	9840277	23360	0	None	10	2	Human	10.6	pKi	=	10.6	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	325	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
	CHEMBL133416	23360	0	None	10	2	Human	10.6	pKi	=	10.6	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	325	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
	53310841	63466	0	None	5	2	Human	10.6	pKi	=	10.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	299	5	1	4	2.2	CCC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802028	63466	0	None	5	2	Human	10.6	pKi	=	10.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	299	5	1	4	2.2	CCC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	164621472	185313	0	None	2	2	Human	10.6	pKi	=	10.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	288	4	1	3	3.6	CCC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4868554	185313	0	None	2	2	Human	10.6	pKi	=	10.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	288	4	1	3	3.6	CCC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
	9873402	35611	0	None	1	2	Human	10.5	pKi	=	10.5	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	596	19	2	4	7.9	CC(=O)NCCc1cccc2ccc(OCCCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL14417	35611	0	None	1	2	Human	10.5	pKi	=	10.5	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	596	19	2	4	7.9	CC(=O)NCCc1cccc2ccc(OCCCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	18466111	19645	0	None	1	2	Human	10.5	pKi	=	10.5	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL130214	19645	0	None	1	2	Human	10.5	pKi	=	10.5	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	122188346	122646	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	262	4	1	3	2.0	CCC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612603	122646	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	262	4	1	3	2.0	CCC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	71533431	78	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	10.1016/j.bmcl.2012.11.069
	7775	78	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	10.1016/j.bmcl.2012.11.069
	CHEMBL2314259	78	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	10.1016/j.bmcl.2012.11.069
	57781216	125326	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648356	125326	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	53237949	61688	0	None	-3	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	4	1	2	3.7	CC(C)C1=C(CCNC(=O)C(F)(F)F)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	CHEMBL1774516	61688	0	None	-3	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	4	1	2	3.7	CC(C)C1=C(CCNC(=O)C(F)(F)F)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	23725567	125332	0	None	2	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648362	125332	0	None	2	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
	24954990	63464	0	None	5	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	287	5	1	4	1.9	CCC(=O)NCCc1c(CC)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802026	63464	0	None	5	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	287	5	1	4	1.9	CCC(=O)NCCc1c(CC)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	10925379	205831	0	None	1	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	5	2	3	3.6	CNC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL94838	205831	0	None	1	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	5	2	3	3.6	CNC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	56659223	64658	0	None	5	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	2	3	2.9	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
	CHEMBL1823015	64658	0	None	5	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	2	3	2.9	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
	127042142	137547	0	None	3	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	310	5	1	4	3.2	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3765540	137547	0	None	3	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	310	5	1	4	3.2	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	71533430	85987	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2cccc(/C=C/NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	CHEMBL2314255	85987	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2cccc(/C=C/NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	53310840	63465	0	None	6	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	285	4	1	4	1.8	CC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802027	63465	0	None	6	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	285	4	1	4	1.8	CC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	22004791	61684	0	None	-2	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	243	3	1	2	2.1	CC(=O)NCCC1=CCc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774512	61684	0	None	-2	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	243	3	1	2	2.1	CC(=O)NCCC1=CCc2ccc3c(c21)CCO3	10.1021/jm200221q
	9916005	32493	0	None	3	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	568	17	2	4	7.1	CC(=O)NCCc1cccc2ccc(OCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL14136	32493	0	None	3	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	568	17	2	4	7.1	CC(=O)NCCc1cccc2ccc(OCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	9914839	97704	0	None	34	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	526	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL273787	97704	0	None	34	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	526	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	44264903	203906	0	None	4	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	270	4	1	3	3.4	COc1cccc(N(C)c2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL8168	203906	0	None	4	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	270	4	1	3	3.4	COc1cccc(N(C)c2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	44272316	67258	0	None	4	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	392	10	2	3	5.3	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19026	67258	0	None	4	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	392	10	2	3	5.3	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
	10452167	78379	0	None	1	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	376	9	1	3	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
	CHEMBL2112690	78379	0	None	1	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	376	9	1	3	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
	9998754	78384	0	None	7	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	362	8	1	3	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
	CHEMBL2112700	78384	0	None	7	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	362	8	1	3	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
	10446712	78388	0	None	6	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	286	6	1	3	3.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
	CHEMBL2112722	78388	0	None	6	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	286	6	1	3	3.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
	10016733	78389	0	None	3	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	284	5	1	3	3.0	CCc1nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2003.12.052
	CHEMBL2112724	78389	0	None	3	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	284	5	1	3	3.0	CCc1nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2003.12.052
	10423378	78390	0	None	8	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	272	5	1	3	3.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
	CHEMBL2112727	78390	0	None	8	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	272	5	1	3	3.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
	11741001	78394	0	None	9	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	388	9	1	3	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2003.12.052
	CHEMBL2112734	78394	0	None	9	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	388	9	1	3	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2003.12.052
	57381112	1388	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	7776	1388	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	CHEMBL1946221	1388	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	57381112	1388	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	7776	1388	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	CHEMBL1946221	1388	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	9798080	19285	0	None	3	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	341	7	1	3	4.2	CCCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL129890	19285	0	None	3	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	341	7	1	3	4.2	CCCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	53238407	61696	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1cccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)c1	10.1021/jm200221q
	CHEMBL1774526	61696	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1cccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)c1	10.1021/jm200221q
	198	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	82148	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	99	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	CHEMBL10878	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	DB06594	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	198	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	82148	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	99	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	CHEMBL10878	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	DB06594	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	15453090	85985	0	None	3	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	285	4	1	3	2.8	COc1ccc2ccc(OC)c([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	CHEMBL2314253	85985	0	None	3	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	285	4	1	3	2.8	COc1ccc2ccc(OC)c([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	24954989	1503	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	7774	1503	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	CHEMBL1802025	1503	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	23725565	125325	0	None	1	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648355	125325	0	None	1	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	23725514	125328	0	None	1	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648358	125328	0	None	1	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	115348	70	42	None	4	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
	1343	70	42	None	4	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
	CHEMBL289233	70	42	None	4	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
	DB08190	70	42	None	4	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
	53238185	61694	0	None	-2	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	320	4	1	3	3.0	CC(=O)NCCC1=C(c2cccnc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774524	61694	0	None	-2	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	320	4	1	3	3.0	CC(=O)NCCC1=C(c2cccnc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	9883864	116154	0	None	7	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL337024	116154	0	None	7	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	46888521	8557	0	None	26	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	499	12	1	5	5.6	COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095196	8557	0	None	26	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	499	12	1	5	5.6	COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	1351	2363	15	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	10.1039/C4MD00149D
	219018	2363	15	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	10.1039/C4MD00149D
	CHEMBL4079759	2363	15	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	10.1039/C4MD00149D
	9893513	30745	0	None	29	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	540	15	2	4	6.4	CC(=O)NCCc1cccc2ccc(OCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL13985	30745	0	None	29	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	540	15	2	4	6.4	CC(=O)NCCc1cccc2ccc(OCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	115348	70	42	None	4	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
	1343	70	42	None	4	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
	CHEMBL289233	70	42	None	4	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
	DB08190	70	42	None	4	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
	11100761	101321	4	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	372	4	1	3	2.5	COc1ccc2c(c1)c(CCNC(C)=O)c(I)n2C	10.1021/jm011053+
	CHEMBL300056	101321	4	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	372	4	1	3	2.5	COc1ccc2c(c1)c(CCNC(C)=O)c(I)n2C	10.1021/jm011053+
	1357	2450	133	None	-1	8	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	1672	2450	133	None	-1	8	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	224	2450	133	None	-1	8	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	896	2450	133	None	-1	8	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	CHEMBL45	2450	133	None	-1	8	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	DB01065	2450	133	None	-1	8	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	24955343	63461	0	None	1	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.6	CC(=O)NCCc1c(-c2ccccc2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802022	63461	0	None	1	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.6	CC(=O)NCCc1c(-c2ccccc2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	1357	2450	133	None	-1	8	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	1672	2450	133	None	-1	8	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	224	2450	133	None	-1	8	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	896	2450	133	None	-1	8	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	CHEMBL45	2450	133	None	-1	8	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	DB01065	2450	133	None	-1	8	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	53310839	63463	0	None	2	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.6	CCC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802024	63463	0	None	2	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.6	CCC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	10163052	8436	0	None	72	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1094212	8436	0	None	72	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
	1357	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1672	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	224	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	896	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	CHEMBL45	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	DB01065	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1357	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	1672	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	224	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	896	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	CHEMBL45	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	DB01065	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	10016919	100144	1	None	3	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL291857	100144	1	None	3	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	10016919	100144	1	None	3	2	Human	10.0	pKi	=	10	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1021/jm970437q
	CHEMBL291857	100144	1	None	3	2	Human	10.0	pKi	=	10	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1021/jm970437q
	10659603	20056	0	None	-1	2	Human	10.0	pKi	=	10	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	CCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL130542	20056	0	None	-1	2	Human	10.0	pKi	=	10	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	CCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	9925797	22052	0	None	3	2	Human	10.0	pKi	=	10	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(C)=O)CC3	10.1021/jm000922c
	CHEMBL132340	22052	0	None	3	2	Human	10.0	pKi	=	10	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(C)=O)CC3	10.1021/jm000922c
	198	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	82148	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	99	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	CHEMBL10878	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	DB06594	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	145982070	165922	0	None	1	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4278248	165922	0	None	1	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	198	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	82148	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	99	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	CHEMBL10878	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	DB06594	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	198	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	82148	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	99	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	CHEMBL10878	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	DB06594	310	120	None	-1	5	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	71540389	85988	0	None	-1	2	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2ccccc2c1/C=C/NC(C)=O	10.1016/j.bmcl.2012.11.069
	CHEMBL2314257	85988	0	None	-1	2	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2ccccc2c1/C=C/NC(C)=O	10.1016/j.bmcl.2012.11.069
	9839199	21163	0	None	-1	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL131424	21163	0	None	-1	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	53237948	61687	0	None	-3	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	311	5	1	2	3.5	CC(C)C1=C(CCNC(=O)C2CC2)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	CHEMBL1774515	61687	0	None	-3	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	311	5	1	2	3.5	CC(C)C1=C(CCNC(=O)C2CC2)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	1357	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	1672	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	224	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	896	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	CHEMBL45	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	DB01065	2450	133	None	-1	8	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	10562968	19995	0	None	1	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	255	3	1	2	2.6	COc1ccc2cccc3c2c1C(CNC(C)=O)C3	10.1021/jm000922c
	CHEMBL130490	19995	0	None	1	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	255	3	1	2	2.6	COc1ccc2cccc3c2c1C(CNC(C)=O)C3	10.1021/jm000922c
	1357	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	1672	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	224	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	896	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	CHEMBL45	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	DB01065	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	198	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	82148	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	99	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	CHEMBL10878	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	DB06594	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	1357	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	1672	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	224	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	896	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	CHEMBL45	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	DB01065	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	198	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	82148	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	99	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	CHEMBL10878	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	DB06594	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	1357	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	1672	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	224	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	896	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	CHEMBL45	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	DB01065	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	198	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	82148	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	99	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	CHEMBL10878	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	DB06594	310	120	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	1357	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	1672	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	224	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	896	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	CHEMBL45	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	DB01065	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	44272305	66986	0	None	14	2	Human	9.9	pKi	=	9.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	392	9	2	3	5.1	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL18845	66986	0	None	14	2	Human	9.9	pKi	=	9.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	392	9	2	3	5.1	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
	44358146	26870	0	None	2	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136531	26870	0	None	2	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	1357	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	1672	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	224	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	896	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	CHEMBL45	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	DB01065	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	1357	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	1672	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	224	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	896	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	CHEMBL45	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	DB01065	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	1357	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	1672	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	224	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	896	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	CHEMBL45	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	DB01065	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	1357	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	1672	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	224	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	896	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	CHEMBL45	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	DB01065	2450	133	None	-1	8	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	10059864	109335	4	None	2	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL323332	109335	4	None	2	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm0005252
	56653119	171226	0	None	1	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	322	7	2	2	3.5	CC(=O)NCCc1c[nH]c2ccc(OCCc3ccccc3)cc12	10.1016/j.ejmech.2019.111847
	CHEMBL4467954	171226	0	None	1	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	322	7	2	2	3.5	CC(=O)NCCc1c[nH]c2ccc(OCCc3ccccc3)cc12	10.1016/j.ejmech.2019.111847
	10059864	109335	4	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL323332	109335	4	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.12.047
	10059864	109335	4	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.01.008
	CHEMBL323332	109335	4	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.01.008
	24954991	63462	0	None	3	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	259	3	1	4	1.3	CC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802023	63462	0	None	3	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	259	3	1	4	1.3	CC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	1357	2450	133	None	-1	8	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	1672	2450	133	None	-1	8	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	224	2450	133	None	-1	8	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	896	2450	133	None	-1	8	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	CHEMBL45	2450	133	None	-1	8	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	DB01065	2450	133	None	-1	8	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	25025104	185733	0	None	5	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.6	CCC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4874630	185733	0	None	5	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.6	CCC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
	44358196	118781	0	None	2	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL343825	118781	0	None	2	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	198	310	120	None	-1	5	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	82148	310	120	None	-1	5	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	99	310	120	None	-1	5	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	CHEMBL10878	310	120	None	-1	5	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	DB06594	310	120	None	-1	5	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	44272317	98456	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	300	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL279343	98456	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	300	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
	1357	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	1672	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	224	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	896	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	CHEMBL45	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	DB01065	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	9817262	19284	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	CCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL129889	19284	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	CCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	1357	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	1672	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	224	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	896	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	CHEMBL45	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	DB01065	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	9948714	20504	0	None	2	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
	CHEMBL130898	20504	0	None	2	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
	44272422	167316	0	None	3	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	5	2	3	3.1	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL431103	167316	0	None	3	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	5	2	3	3.1	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
	21581654	60428	1	None	1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760944	60428	1	None	1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	1357	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	1672	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	224	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	896	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	CHEMBL45	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	DB01065	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	1357	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	1672	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	224	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	896	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	CHEMBL45	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	DB01065	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	59145922	185690	0	None	7	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.2	CC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4874010	185690	0	None	7	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.2	CC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
	127042442	137385	0	None	-6	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	328	5	1	4	3.3	COc1ccc2oc(-c3ccc(F)cc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3763503	137385	0	None	-6	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	328	5	1	4	3.3	COc1ccc2oc(-c3ccc(F)cc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	127042791	137532	0	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	4	1	4	2.1	COc1ccc2oc(I)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3765401	137532	0	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	4	1	4	2.1	COc1ccc2oc(I)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	1357	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	1672	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	224	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	896	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	CHEMBL45	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	DB01065	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	71540396	85990	0	None	1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	286	4	2	3	2.8	CNC(=O)N/C=C/c1c(OC)ccc2ccc(OC)cc12	10.1016/j.bmcl.2012.11.069
	CHEMBL2314260	85990	0	None	1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	286	4	2	3	2.8	CNC(=O)N/C=C/c1c(OC)ccc2ccc(OC)cc12	10.1016/j.bmcl.2012.11.069
	1357	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1357	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	1672	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	224	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	896	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	CHEMBL45	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	DB01065	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	10540964	116128	0	None	1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL336858	116128	0	None	1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	44272320	98150	0	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)CC)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL276921	98150	0	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)CC)c2O1	10.1016/j.bmcl.2003.12.052
	1357	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	1672	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	224	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	896	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	CHEMBL45	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	DB01065	2450	133	None	-1	8	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	23725515	125335	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
	CHEMBL3648365	125335	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
	1357	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	1672	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	224	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	896	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	CHEMBL45	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	DB01065	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	1357	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	1672	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	224	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	896	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	CHEMBL45	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	DB01065	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	21581654	60428	1	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
	CHEMBL1760944	60428	1	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
	1357	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	1672	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	224	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	896	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	CHEMBL45	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	DB01065	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	1357	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	1672	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	224	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	896	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	CHEMBL45	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	DB01065	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	21581654	60428	1	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL1760944	60428	1	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	1357	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	1672	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	224	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	896	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	CHEMBL45	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	DB01065	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	1357	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	1672	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	224	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	896	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	CHEMBL45	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	DB01065	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	1357	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	1672	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	224	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	896	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	CHEMBL45	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	DB01065	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	18360631	8627	0	None	26	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	516	13	2	4	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095831	8627	0	None	26	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	516	13	2	4	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12	10.1016/j.bmc.2010.04.008
	1357	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	1672	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	224	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	896	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	CHEMBL45	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	DB01065	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	1357	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	1672	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	224	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	896	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	CHEMBL45	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	DB01065	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	1357	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	1672	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	224	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	896	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	CHEMBL45	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	DB01065	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	1357	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	1672	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	224	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	896	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	CHEMBL45	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	DB01065	2450	133	None	-1	8	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	1357	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	1672	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	224	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	896	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	CHEMBL45	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	DB01065	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	1357	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	1672	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	224	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	896	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	CHEMBL45	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	DB01065	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	1357	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	1672	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	224	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	896	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	CHEMBL45	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	DB01065	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	1357	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	1672	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	224	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	896	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	CHEMBL45	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	DB01065	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	1357	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	1672	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	224	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	896	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	CHEMBL45	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	DB01065	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	1357	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	1672	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	224	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	896	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	CHEMBL45	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	DB01065	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	1357	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	1672	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	224	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	896	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	CHEMBL45	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	DB01065	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	145981162	165944	0	None	-3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4278575	165944	0	None	-3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
	145986532	166728	0	None	-1	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4293386	166728	0	None	-1	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	137660333	158973	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4102177	158973	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
	25024912	185337	0	None	1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.5	CCC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4869029	185337	0	None	1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.5	CCC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
	15453084	85983	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2cccc([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	CHEMBL2314251	85983	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2cccc([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	11079938	192900	4	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1cc2c(CCNC(C)=O)c(I)[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL52755	192900	4	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1cc2c(CCNC(C)=O)c(I)[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
	1357	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	1672	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	224	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	896	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	CHEMBL45	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	DB01065	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	1357	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	1672	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	224	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	896	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	CHEMBL45	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	DB01065	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	53310987	63468	0	None	1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	327	4	1	4	2.4	CCC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802030	63468	0	None	1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	327	4	1	4	2.4	CCC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	1357	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	1672	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	224	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	896	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	CHEMBL45	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	DB01065	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	1357	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	1672	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	224	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	896	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	CHEMBL45	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	DB01065	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	139451781	184275	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4852440	184275	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	1357	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	1672	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	224	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	896	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	CHEMBL45	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	DB01065	2450	133	None	-1	8	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	44272440	67186	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	260	4	2	3	2.5	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL18960	67186	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	260	4	2	3	2.5	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
	59145872	185594	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.1	CC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4872592	185594	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.1	CC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
	18466111	19645	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL130214	19645	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	10661735	167761	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	6	1	2	3.8	CCCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL434226	167761	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	6	1	2	3.8	CCCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	46888522	8558	0	None	11	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
	CHEMBL1095197	8558	0	None	11	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
	1357	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	1672	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	224	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	896	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	CHEMBL45	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	DB01065	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	1357	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	1672	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	224	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	896	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	CHEMBL45	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	DB01065	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	139451763	185751	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
	CHEMBL4874954	185751	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
	44317845	203795	0	None	3	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	301	7	1	3	3.3	CCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	CHEMBL80736	203795	0	None	3	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	301	7	1	3	3.3	CCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	1357	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	1672	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	224	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	896	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	CHEMBL45	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	DB01065	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	57781246	125336	0	None	-2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648366	125336	0	None	-2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	10.1021/acs.jmedchem.0c01836
	1357	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	1672	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	224	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	896	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	CHEMBL45	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	DB01065	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	1357	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	1672	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	224	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	896	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	CHEMBL45	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	DB01065	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	1357	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	1672	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	224	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	896	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	CHEMBL45	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	DB01065	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	145982333	166004	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	166004	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145981769	166114	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	1	3	2.4	COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4281712	166114	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	1	3	2.4	COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	10778397	19635	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	COc1ccc2cccc3c2c1C(CCNC(C)=O)C3	10.1021/jm000922c
	CHEMBL130203	19635	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	COc1ccc2cccc3c2c1C(CCNC(C)=O)C3	10.1021/jm000922c
	139451795	184747	0	None	2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859677	184747	0	None	2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	9839199	21163	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL131424	21163	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	57781227	125324	0	None	-6	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648354	125324	0	None	-6	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	10.1021/acs.jmedchem.0c01836
	23725612	125337	0	None	-2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
	CHEMBL3648367	125337	0	None	-2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
	1357	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	1672	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	224	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	896	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	CHEMBL45	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	DB01065	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	1357	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	1672	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	224	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	896	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	CHEMBL45	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	DB01065	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	1357	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	1672	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	224	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	896	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	CHEMBL45	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	DB01065	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	1357	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	1672	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	224	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	896	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	CHEMBL45	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	DB01065	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	1357	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	24954992	63467	0	None	1	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	313	3	1	4	2.0	CC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802029	63467	0	None	1	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	313	3	1	4	2.0	CC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	1362	3382	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	9870523	3382	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	CHEMBL429392	3382	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	1362	3382	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	9870523	3382	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	CHEMBL429392	3382	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	1362	3382	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	9870523	3382	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	CHEMBL429392	3382	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	1357	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	1672	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	224	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	896	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	CHEMBL45	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	DB01065	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	1357	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	1672	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	224	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	896	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	CHEMBL45	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	DB01065	2450	133	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	7778	801	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	9957516	801	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	CHEMBL1094546	801	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	1355	3383	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	9806449	3383	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	CHEMBL14453	3383	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	1355	3383	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	9806449	3383	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	CHEMBL14453	3383	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	44272425	66990	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	300	5	2	3	3.1	CC(C)C1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL18846	66990	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	300	5	2	3	3.1	CC(C)C1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
	1355	3383	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	9806449	3383	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	CHEMBL14453	3383	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	145982333	166004	0	None	1	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	166004	0	None	1	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145993188	166469	0	None	-3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	4	1	3	2.6	COc1ccc2ccc3c(c2c1)C(C)(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4288497	166469	0	None	-3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	4	1	3	2.6	COc1ccc2ccc3c(c2c1)C(C)(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	145988741	166683	0	None	-6	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4292336	166683	0	None	-6	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	1355	3383	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	9806449	3383	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	CHEMBL14453	3383	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	137647756	157401	0	None	-6	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4084612	157401	0	None	-6	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	139451764	185685	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4873903	185685	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	44349100	114313	0	None	34	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
	CHEMBL334079	114313	0	None	34	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
	44349100	114313	0	None	34	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1021/jm401343c
	CHEMBL334079	114313	0	None	34	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1021/jm401343c
	46888492	8755	0	None	18	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	14	2	5	6.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1096991	8755	0	None	18	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	14	2	5	6.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	10468642	26911	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136564	26911	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	10640828	21282	0	None	2	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	339	6	1	3	3.8	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
	CHEMBL131575	21282	0	None	2	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	339	6	1	3	3.8	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
	1357	2450	133	None	-1	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	1672	2450	133	None	-1	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	224	2450	133	None	-1	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	896	2450	133	None	-1	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	CHEMBL45	2450	133	None	-1	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	DB01065	2450	133	None	-1	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	1357	2450	133	None	-1	8	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	2450	133	None	-1	8	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	2450	133	None	-1	8	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	2450	133	None	-1	8	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	2450	133	None	-1	8	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	2450	133	None	-1	8	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	10400294	18363	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	258	5	1	3	2.6	Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL127570	18363	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	258	5	1	3	2.6	Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	122188347	122647	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	232	3	1	2	2.0	CCC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612604	122647	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	232	3	1	2	2.0	CCC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	139451780	185362	0	None	5	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
	CHEMBL4869463	185362	0	None	5	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
	46935150	15703	0	None	6	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223130	15703	0	None	6	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	9884406	205892	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	341	6	1	3	3.9	COc1ccc2oc(Cc3cccc(F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL95166	205892	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	341	6	1	3	3.9	COc1ccc2oc(Cc3cccc(F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	10361427	112373	0	None	18	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	364	10	1	3	4.9	CCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL330969	112373	0	None	18	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	364	10	1	3	4.9	CCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	12324	3848	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	10.1021/acs.jmedchem.8b00893
	145966622	3848	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	10.1021/acs.jmedchem.8b00893
	CHEMBL4210086	3848	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	10.1021/acs.jmedchem.8b00893
	10515048	116311	0	None	-8	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL337882	116311	0	None	-8	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	46888520	8556	0	None	10	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	538	15	2	4	6.1	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095195	8556	0	None	10	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	538	15	2	4	6.1	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	10199282	116093	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1CCC3CNC(C)=O	10.1021/jm000922c
	CHEMBL336647	116093	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1CCC3CNC(C)=O	10.1021/jm000922c
	145982167	166058	0	None	-7	3	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4280601	166058	0	None	-7	3	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	145990662	166376	0	None	-2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4286896	166376	0	None	-2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137636213	155545	0	None	-8	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4062947	155545	0	None	-8	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	24750192	3854	10	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	10.1021/jm700957j
	7777	3854	10	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	10.1021/jm700957j
	CHEMBL237236	3854	10	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	10.1021/jm700957j
	24750193	88125	1	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	236	6	1	3	1.7	COc1cccc(N(C)CCCNC(C)=O)c1	10.1021/jm700957j
	CHEMBL235329	88125	1	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	236	6	1	3	1.7	COc1cccc(N(C)CCCNC(C)=O)c1	10.1021/jm700957j
	1357	2450	133	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	2450	133	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	2450	133	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	2450	133	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	2450	133	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	2450	133	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	139451757	184248	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4852096	184248	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	1357	2450	133	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	2450	133	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	2450	133	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	2450	133	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	2450	133	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	2450	133	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	53238182	61691	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	3	3.8	CC(=O)NCCC1=C(Cc2ccsc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774520	61691	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	3	3.8	CC(=O)NCCC1=C(Cc2ccsc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	44358274	28740	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL138012	28740	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	9937825	8780	0	None	12	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097315	8780	0	None	12	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
	49865268	15701	0	None	13	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(OC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223128	15701	0	None	13	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(OC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	44272335	68334	0	None	-23	2	Human	9.0	pKi	=	9.0	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	7	2	3	3.6	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCC)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19211	68334	0	None	-23	2	Human	9.0	pKi	=	9.0	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	7	2	3	3.6	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCC)N2	10.1016/j.bmcl.2003.12.052
	9817636	20475	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
	CHEMBL130876	20475	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
	44272410	67674	0	None	-7	2	Human	9.0	pKi	=	9.0	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	274	5	2	3	2.9	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL19128	67674	0	None	-7	2	Human	9.0	pKi	=	9.0	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	274	5	2	3	2.9	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
	44389812	62673	0	None	19	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	365	10	1	2	4.9	CCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL178678	62673	0	None	19	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	365	10	1	2	4.9	CCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	11581340	121827	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	363	8	1	2	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL359921	121827	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	363	8	1	2	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	20590653	122759	0	None	5	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	389	9	1	2	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
	CHEMBL361410	122759	0	None	5	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	389	9	1	2	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
	20590654	129648	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	9	1	2	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL367797	129648	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	9	1	2	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	44264892	203469	0	None	-5	2	Human	9.0	pKi	=	9	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	284	5	1	3	3.8	CCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7832	203469	0	None	-5	2	Human	9.0	pKi	=	9	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	284	5	1	3	3.8	CCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	139451799	185257	0	None	3	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4867553	185257	0	None	3	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	145979689	166070	0	None	-5	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4280791	166070	0	None	-5	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145993214	166198	0	None	-5	3	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	2	3	2.2	CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4283539	166198	0	None	-5	3	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	2	3	2.2	CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	11110447	206054	0	None	-4	2	Human	9.0	pKi	=	9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	6	1	3	4.3	C/C=C/C(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL96104	206054	0	None	-4	2	Human	9.0	pKi	=	9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	6	1	3	4.3	C/C=C/C(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	9850873	8779	0	None	13	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	15	2	4	6.4	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1	10.1016/j.bmc.2010.04.008
	CHEMBL1097314	8779	0	None	13	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	15	2	4	6.4	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1	10.1016/j.bmc.2010.04.008
	10753255	117987	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	251	3	1	1	3.0	O=C(NCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
	CHEMBL341439	117987	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	251	3	1	1	3.0	O=C(NCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
	18007985	8628	0	None	10	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	538	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095832	8628	0	None	10	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	538	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	44264769	96549	0	None	-10	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	298	6	1	3	4.2	CCCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL266549	96549	0	None	-10	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	298	6	1	3	4.2	CCCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	139451761	184014	0	None	4	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4848885	184014	0	None	4	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451769	185560	0	None	1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
	CHEMBL4872217	185560	0	None	1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
	53237950	61689	0	None	-13	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	314	5	2	2	3.3	CCNC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774517	61689	0	None	-13	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	314	5	2	2	3.3	CCNC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	53238186	61695	0	None	-54	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccccc1C1=C(CCNC(C)=O)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	CHEMBL1774525	61695	0	None	-54	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccccc1C1=C(CCNC(C)=O)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	10873443	193554	4	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1cc2c(CCNC(C)=O)c(I)n(C)c2cc1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL55084	193554	4	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1cc2c(CCNC(C)=O)c(I)n(C)c2cc1[N+](=O)[O-]	10.1021/jm011053+
	11536239	76349	1	None	2	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	2	2	2.6	COc1ccc2[nH]cc(C(C)(C)CNC(C)=O)c2c1	10.1021/jm0512544
	CHEMBL206472	76349	1	None	2	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	2	2	2.6	COc1ccc2[nH]cc(C(C)(C)CNC(C)=O)c2c1	10.1021/jm0512544
	24763223	214	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 mins	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1039/C5MD00190K
	8289	214	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 mins	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1039/C5MD00190K
	CHEMBL3260987	214	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 mins	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1039/C5MD00190K
	20642483	30437	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	272	3	1	3	1.7	O=C(N[C@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
	CHEMBL139439	30437	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	272	3	1	3	1.7	O=C(N[C@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
	10752506	19786	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	2	1	1	3.0	CC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL130319	19786	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	2	1	1	3.0	CC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
	85880795	110379	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
	CHEMBL3260984	110379	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
	139451767	184421	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854625	184421	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	127041169	136325	0	None	6	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3741890	136325	0	None	6	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	57781248	183980	0	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	2	4	1.9	CC(=O)NCCC1CCc2ccc3nc(CO)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4848381	183980	0	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	2	4	1.9	CC(=O)NCCC1CCc2ccc3nc(CO)oc3c21	10.1021/acs.jmedchem.0c01836
	11644612	77895	0	None	-9	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	CHEMBL210791	77895	0	None	-9	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	127041169	136325	0	None	6	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3741890	136325	0	None	6	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	164946945	189635	1	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5174929	189635	1	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	9927219	111830	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329263	111830	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	9927219	111830	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
	CHEMBL329263	111830	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
	9927219	111830	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm401343c
	CHEMBL329263	111830	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm401343c
	10019103	67153	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	323	5	1	2	3.8	CCCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
	CHEMBL189395	67153	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	323	5	1	2	3.8	CCCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
	10089253	116584	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	350	9	1	3	4.5	CC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL339265	116584	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	350	9	1	3	4.5	CC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	10022570	167982	0	None	13	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	10	1	3	5.1	CC(C)C(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL435586	167982	0	None	13	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	10	1	3	5.1	CC(C)C(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	44353165	116414	0	None	-7	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	4	1	1	3.8	CCCC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL338425	116414	0	None	-7	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	4	1	1	3.8	CCCC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
	44272438	69966	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	5	2	3	3.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19441	69966	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	5	2	3	3.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	52918079	60431	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	CHEMBL1760947	60431	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	57781208	185039	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	320	4	1	3	4.1	CC(=O)NCCC1CCc2ccc3nc(-c4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4864102	185039	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	320	4	1	3	4.1	CC(=O)NCCC1CCc2ccc3nc(-c4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
	53238412	61701	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	375	4	1	3	4.8	CC(=O)NCCC1=C(c2csc3ccccc23)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774531	61701	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	375	4	1	3	4.8	CC(=O)NCCC1=C(c2csc3ccccc23)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	10763177	24533	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	393	7	1	4	3.2	CCC(=O)NCCc1c(OC(=O)CBr)ccc2ccc(OC)cc12	10.1021/jm970437q
	CHEMBL134416	24533	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	393	7	1	4	3.2	CCC(=O)NCCc1c(OC(=O)CBr)ccc2ccc(OC)cc12	10.1021/jm970437q
	10850411	114858	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	281	4	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(=O)C1CC1)C3	10.1021/jm000922c
	CHEMBL334962	114858	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	281	4	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(=O)C1CC1)C3	10.1021/jm000922c
	20355585	110376	5	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	280	4	2	2	2.8	COc1cc2c(CCNC(C)=O)c(C)[nH]c2cc1Cl	10.1021/jm401343c
	CHEMBL3260979	110376	5	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	280	4	2	2	2.8	COc1cc2c(CCNC(C)=O)c(C)[nH]c2cc1Cl	10.1021/jm401343c
	10244841	67155	1	None	-8	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
	CHEMBL189414	67155	1	None	-8	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
	23642306	158527	1	None	2	3	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4097233	158527	1	None	2	3	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	9870683	8801	0	None	9	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	502	13	2	5	5.2	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097496	8801	0	None	9	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	502	13	2	5	5.2	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	52918077	60429	2	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760945	60429	2	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	10244841	67155	1	None	-8	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm800974d
	CHEMBL189414	67155	1	None	-8	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm800974d
	53238411	61700	0	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	375	4	1	2	4.9	CC(=O)NCCC1=C(c2ccc(C(C)(C)C)cc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774530	61700	0	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	375	4	1	2	4.9	CC(=O)NCCC1=C(c2ccc(C(C)(C)C)cc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	12004056	173650	0	None	13	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	340	6	3	3	2.0	CC(=O)NCCc1c(Br)[nH]c2ccc(OCCO)cc12	10.1016/j.ejmech.2019.111847
	CHEMBL4548591	173650	0	None	13	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	340	6	3	3	2.0	CC(=O)NCCc1c(Br)[nH]c2ccc(OCCO)cc12	10.1016/j.ejmech.2019.111847
	44358184	116040	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL336268	116040	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	46845151	8578	0	None	38	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095505	8578	0	None	38	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
	137641357	156537	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4074273	156537	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	122188351	122650	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.7	CCC(=O)NCC1CCc2ccccc2N1c1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612608	122650	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.7	CCC(=O)NCC1CCc2ccccc2N1c1ccccc1	10.1021/acs.jmedchem.5b01066
	19703015	137372	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1ccc2occ(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3763281	137372	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1ccc2occ(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	11630146	77731	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.4	COc1ccc2[nH]cc(C(C)CNC(C)=O)c2c1	10.1021/jm0512544
	CHEMBL210147	77731	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.4	COc1ccc2[nH]cc(C(C)CNC(C)=O)c2c1	10.1021/jm0512544
	49865204	15674	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223050	15674	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	44429442	149690	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	5	2	2	2.6	CCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL395221	149690	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	5	2	2	2.6	CCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	44272443	193815	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	6	2	3	3.5	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL553105	193815	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	6	2	3	3.5	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	9858255	206337	0	None	-30	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	320	4	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL9772	206337	0	None	-30	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	320	4	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
	168296374	191920	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	CHEMBL5209359	191920	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	10542922	116092	0	None	6	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	309	5	1	2	3.8	COc1ccc2cccc3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
	CHEMBL336633	116092	0	None	6	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	309	5	1	2	3.8	COc1ccc2cccc3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
	127026427	137159	0	None	-3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758679	137159	0	None	-3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	122220128	159128	0	None	-5	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
	CHEMBL4104020	159128	0	None	-5	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
	10637638	20401	0	None	4	2	Human	8.0	pKi	=	8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	5	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(=O)C1CC1)C3	10.1021/jm000922c
	CHEMBL130813	20401	0	None	4	2	Human	8.0	pKi	=	8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	5	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(=O)C1CC1)C3	10.1021/jm000922c
	127026424	137167	0	None	-5	2	Human	8.0	pKi	=	8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3oc(CCNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758720	137167	0	None	-5	2	Human	8.0	pKi	=	8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3oc(CCNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	44394415	123888	0	None	1	2	Human	8.0	pKi	=	8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	389	10	1	2	6.0	CCCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL363947	123888	0	None	1	2	Human	8.0	pKi	=	8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	389	10	1	2	6.0	CCCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44429449	86935	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	324	4	1	3	2.6	COc1cc(Br)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	CHEMBL233309	86935	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	324	4	1	3	2.6	COc1cc(Br)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	11536939	76761	0	None	-12	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	6	1	3	3.5	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	CHEMBL207625	76761	0	None	-12	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	6	1	3	3.5	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	44264818	203514	0	None	-91	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	6	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7867	203514	0	None	-91	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	6	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	44359437	29686	0	None	1	3	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
	CHEMBL138807	29686	0	None	1	3	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
	10526493	203583	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	427	8	1	3	3.7	CCC(=O)NCCc1c(OCCI)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL79224	203583	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	427	8	1	3	3.7	CCC(=O)NCCc1c(OCCI)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	24750188	148712	0	None	-114	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1ccc(N(CCNC(C)=O)c2cccc(OC)c2)cc1	10.1021/jm700957j
	CHEMBL394430	148712	0	None	-114	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1ccc(N(CCNC(C)=O)c2cccc(OC)c2)cc1	10.1021/jm700957j
	16105169	174105	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2009.04.068
	CHEMBL455909	174105	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2009.04.068
	45268309	194597	0	None	-4	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	303	7	2	3	2.3	CCN(C)Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2009.04.068
	CHEMBL561928	194597	0	None	-4	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	303	7	2	3	2.3	CCN(C)Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2009.04.068
	16105169	174105	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2008.07.012
	CHEMBL455909	174105	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2008.07.012
	25210130	69	0	None	-91	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	7782	69	0	None	-91	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	CHEMBL514415	69	0	None	-91	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	1358	124	35	None	-870	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm048956y
	3976006	124	35	None	-870	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm048956y
	CHEMBL285718	124	35	None	-870	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm048956y
	54584155	60432	0	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	366	8	1	5	2.8	COc1ccc2c(CN(C)Cc3ccccc3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760949	60432	0	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	366	8	1	5	2.8	COc1ccc2c(CN(C)Cc3ccccc3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	49865148	15655	2	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccccc1OC(C)CNC(C)=O	10.1016/j.bmc.2010.06.100
	CHEMBL1222984	15655	2	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccccc1OC(C)CNC(C)=O	10.1016/j.bmc.2010.06.100
	44394478	65957	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	404	8	1	3	5.3	CC(C)C(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL184762	65957	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	404	8	1	3	5.3	CC(C)C(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	44264849	203661	0	None	-19	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	298	5	1	3	4.1	COc1cccc(N(C)c2ccc(NC(=O)C(C)C)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL7990	203661	0	None	-19	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	298	5	1	3	4.1	COc1cccc(N(C)c2ccc(NC(=O)C(C)C)cc2)c1	10.1016/j.bmcl.2003.11.030
	10956792	101341	7	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1ccc2[nH]cc(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL300195	101341	7	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1ccc2[nH]cc(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
	25210135	174352	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL456505	174352	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	25210135	174352	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL456505	174352	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	45268310	194888	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL563847	194888	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	46935149	15675	2	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223051	15675	2	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	44394508	65814	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	404	9	1	3	5.5	CCCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL184144	65814	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	404	9	1	3	5.5	CCCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	10831675	21580	0	None	-6	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	349	7	1	4	3.1	CCC(=O)NCCc1c(OC(=O)CCl)ccc2ccc(OC)cc12	10.1021/jm970437q
	CHEMBL131919	21580	0	None	-6	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	349	7	1	4	3.1	CCC(=O)NCCc1c(OC(=O)CCl)ccc2ccc(OC)cc12	10.1021/jm970437q
	1346	160	42	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1016/j.ejmech.2019.111847
	1858	160	42	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1016/j.ejmech.2019.111847
	CHEMBL34730	160	42	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1016/j.ejmech.2019.111847
	1346	160	42	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1021/jm401343c
	1858	160	42	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1021/jm401343c
	CHEMBL34730	160	42	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1021/jm401343c
	11587169	76964	0	None	-8	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	4	1	3	2.6	COc1ccc2c(c1)c(C(C)(C)CNC(C)=O)cn2C	10.1021/jm0512544
	CHEMBL208307	76964	0	None	-8	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	4	1	3	2.6	COc1ccc2c(c1)c(C(C)(C)CNC(C)=O)cn2C	10.1021/jm0512544
	127041170	136166	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3740377	136166	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	45268303	195070	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	301	4	1	4	1.8	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCN(C)C1	10.1016/j.bmc.2009.04.068
	CHEMBL565176	195070	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	301	4	1	4	1.8	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCN(C)C1	10.1016/j.bmc.2009.04.068
	44272424	68733	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	289	4	3	3	2.5	CNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19237	68733	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	289	4	3	3	2.5	CNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	11666721	64659	0	None	-18	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	CNC(=O)CCc1c(-c2ccccc2)nc2ccc(OC)cn12	10.1016/j.ejmech.2011.06.030
	CHEMBL1823016	64659	0	None	-18	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	CNC(=O)CCc1c(-c2ccccc2)nc2ccc(OC)cn12	10.1016/j.ejmech.2011.06.030
	45268310	194888	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL563847	194888	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	1362	3382	18	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	9870523	3382	18	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	CHEMBL429392	3382	18	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	11403195	123162	1	None	1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	278	3	1	2	3.4	CC(=O)NCCN1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
	CHEMBL362133	123162	1	None	1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	278	3	1	2	3.4	CC(=O)NCCN1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
	90666309	108898	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
	CHEMBL3219330	108898	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
	1362	3382	18	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	9870523	3382	18	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	CHEMBL429392	3382	18	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	25210130	69	0	None	-91	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	7782	69	0	None	-91	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	CHEMBL514415	69	0	None	-91	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	16743124	91777	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	282	5	1	2	3.0	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CC1	10.1016/j.ejmech.2007.01.005
	CHEMBL242573	91777	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	282	5	1	2	3.0	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CC1	10.1016/j.ejmech.2007.01.005
	162661094	180861	2	None	-10	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4764211	180861	2	None	-10	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	12436516	15680	6	None	-2	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	179	4	1	2	1.2	CC(=O)NCCOc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223056	15680	6	None	-2	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	179	4	1	2	1.2	CC(=O)NCCOc1ccccc1	10.1016/j.bmc.2010.06.100
	49865377	15758	0	None	1	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223280	15758	0	None	1	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	10664333	206442	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	4	1	2	4.3	CCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9838	206442	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	4	1	2	4.3	CCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	122188227	122629	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	233	3	3	2	1.7	CCNC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612458	122629	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	233	3	3	2	1.7	CCNC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	22718579	16345	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	3.0	CC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123690	16345	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	3.0	CC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	11543959	76771	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	6	2	2	3.5	CCCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	CHEMBL207676	76771	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	6	2	2	3.5	CCCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	11791741	206370	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CC1	10.1021/jm980684+
	CHEMBL9791	206370	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CC1	10.1021/jm980684+
	46885228	7624	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	341	10	1	3	4.1	CCCC(=O)NCCCc1cc(OC)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	CHEMBL1088825	7624	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	341	10	1	3	4.1	CCCC(=O)NCCCc1cc(OC)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	22718619	16595	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.8	CCCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124445	16595	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.8	CCCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	44264844	203154	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	296	5	1	3	3.8	COc1cccc(N(C)c2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL7567	203154	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	296	5	1	3	3.8	COc1cccc(N(C)c2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	127041170	136166	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3740377	136166	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	145964105	163666	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	475	12	2	5	4.9	CC(=O)NCCN(C)c1cccc(OCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4211018	163666	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	475	12	2	5	4.9	CC(=O)NCCN(C)c1cccc(OCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	11068422	206109	0	None	-7	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	361	6	1	4	4.7	COc1ccc2oc(-c3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
	CHEMBL96420	206109	0	None	-7	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	361	6	1	4	4.7	COc1ccc2oc(-c3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
	127038225	137461	0	None	-13	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	338	5	1	4	3.8	COc1ccc2oc(-c3c(C)cccc3C)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3764421	137461	0	None	-13	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	338	5	1	4	3.8	COc1ccc2oc(-c3c(C)cccc3C)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	25210134	189032	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL514904	189032	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	49865317	15718	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223191	15718	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	10544425	206596	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	330	4	1	2	4.1	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CCC1	10.1021/jm980684+
	CHEMBL9934	206596	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	330	4	1	2	4.1	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CCC1	10.1021/jm980684+
	16094578	82859	1	None	-8	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C\c1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL218808	82859	1	None	-8	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C\c1ccccc1)c1ccccc1	10.1021/jm060850a
	12436514	15751	6	None	-3	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NC(C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223273	15751	6	None	-3	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NC(C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	49865376	15757	2	None	-9	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223279	15757	2	None	-9	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	25210134	189032	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL514904	189032	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	46865422	86643	0	None	-575	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326199	86643	0	None	-575	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	54586061	60435	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	441	7	1	6	3.2	COc1ccc2c(CN3CCN(c4cccc(Cl)c4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760952	60435	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	441	7	1	6	3.2	COc1ccc2c(CN3CCN(c4cccc(Cl)c4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	122188238	122639	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612470	122639	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	10656443	206634	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	218	3	2	2	1.8	COc1cccc2[nH]c(CNC(C)=O)cc12	10.1021/jm001125h
	CHEMBL99534	206634	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	218	3	2	2	1.8	COc1cccc2[nH]c(CNC(C)=O)cc12	10.1021/jm001125h
	10656443	206634	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	218	3	2	2	1.8	COc1cccc2[nH]c(CNC(C)=O)cc12	10.1021/jm970721h
	CHEMBL99534	206634	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	218	3	2	2	1.8	COc1cccc2[nH]c(CNC(C)=O)cc12	10.1021/jm970721h
	137660180	158576	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.3	COc1cnc2cccc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2016.12.013
	CHEMBL4097817	158576	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.3	COc1cnc2cccc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2016.12.013
	44579164	181548	0	None	-14	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	406	7	2	4	4.8	CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	CHEMBL478218	181548	0	None	-14	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	406	7	2	4	4.8	CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	12985494	190035	0	None	-239	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	7	2	3	4.1	CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	CHEMBL518113	190035	0	None	-239	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	7	2	3	4.1	CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	24750190	89455	2	None	-32	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	254	5	1	2	3.0	CC(=O)NCCN(c1ccccc1)c1ccccc1	10.1021/jm700957j
	CHEMBL237840	89455	2	None	-32	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	254	5	1	2	3.0	CC(=O)NCCN(c1ccccc1)c1ccccc1	10.1021/jm700957j
	44429455	87320	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.5	COc1cc(-c2ccccc2)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	CHEMBL233740	87320	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.5	COc1cc(-c2ccccc2)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	12985492	181249	0	None	-177	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	459	6	1	2	5.1	COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL477833	181249	0	None	-177	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	459	6	1	2	5.1	COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	46885283	8171	0	None	-48	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	237	6	1	3	1.8	COc1ccc(OC)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092400	8171	0	None	-48	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	237	6	1	3	1.8	COc1ccc(OC)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	10428383	3850	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm001125h
	7783	3850	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm001125h
	CHEMBL33185	3850	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm001125h
	10903368	206364	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2ccc(OC)cc2n1Cc1ccccc1	10.1021/jm001125h
	CHEMBL97885	206364	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2ccc(OC)cc2n1Cc1ccccc1	10.1021/jm001125h
	45267465	193099	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	365	8	2	3	3.5	COc1ccc2[nH]c(CN(C)Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL538129	193099	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	365	8	2	3	3.5	COc1ccc2[nH]c(CN(C)Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	24750195	88126	0	None	-24	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	298	6	0	3	3.3	COc1cccc(N(CCN(C)C(C)=O)c2ccccc2)c1	10.1021/jm700957j
	CHEMBL235334	88126	0	None	-24	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	298	6	0	3	3.3	COc1cccc(N(CCN(C)C(C)=O)c2ccccc2)c1	10.1021/jm700957j
	10428383	3850	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm048956y
	7783	3850	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm048956y
	CHEMBL33185	3850	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm048956y
	44429452	86937	0	None	-4	2	Human	4.9	pKi	=	4.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	308	5	2	2	3.5	COc1cc(-c2ccccc2)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	CHEMBL233311	86937	0	None	-4	2	Human	4.9	pKi	=	4.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	308	5	2	2	3.5	COc1cc(-c2ccccc2)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	44358087	115913	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL336024	115913	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	10428383	3850	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at human MT1 receptorAntagonist activity at human MT1 receptor	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm401343c
	7783	3850	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at human MT1 receptorAntagonist activity at human MT1 receptor	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm401343c
	CHEMBL33185	3850	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at human MT1 receptorAntagonist activity at human MT1 receptor	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm401343c
	10428383	3850	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm800974d
	7783	3850	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm800974d
	CHEMBL33185	3850	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm800974d
	139451766	183865	0	None	-8	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4846505	183865	0	None	-8	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	122188225	122627	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	218	3	2	2	1.9	CCC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612456	122627	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	218	3	2	2	1.9	CCC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	122193492	123424	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	261	4	1	4	1.5	COc1ccc2oc(=O)cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.09.003
	CHEMBL3628489	123424	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	261	4	1	4	1.5	COc1ccc2oc(=O)cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.09.003
	53238410	61699	0	None	-1174	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	361	5	1	2	4.7	CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774529	61699	0	None	-1174	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	361	5	1	2	4.7	CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	22718610	16708	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	308	6	1	3	4.0	CCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL125033	16708	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	308	6	1	3	4.0	CCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	22718602	96097	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.1	CCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL262890	96097	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.1	CCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	24750189	89050	0	None	-1174	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	334	6	1	3	4.1	COc1cccc(N(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm700957j
	CHEMBL237234	89050	0	None	-1174	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	334	6	1	3	4.1	COc1cccc(N(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm700957j
	122188232	122633	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	353	6	2	3	3.3	CCNC(=O)NCC1CCc2c(OC)cccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612463	122633	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	353	6	2	3	3.3	CCNC(=O)NCC1CCc2c(OC)cccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	44581851	174639	0	None	-1202	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	333	6	1	2	4.5	COc1cccc(C(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm800974d
	CHEMBL457128	174639	0	None	-1202	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	333	6	1	2	4.5	COc1cccc(C(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm800974d
	10610443	206566	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	5	2	2	2.2	CCC(=O)NCCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
	CHEMBL99084	206566	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	5	2	2	2.2	CCC(=O)NCCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
	10610443	206566	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	5	2	2	2.2	CCC(=O)NCCc1cc2c(OC)cccc2[nH]1	10.1021/jm970721h
	CHEMBL99084	206566	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	5	2	2	2.2	CCC(=O)NCCc1cc2c(OC)cccc2[nH]1	10.1021/jm970721h
	46865422	86643	0	None	-575	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1039/C1MD00149C
	CHEMBL2326199	86643	0	None	-575	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1039/C1MD00149C
	46865422	86643	0	None	-575	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.ejmech.2016.01.008
	CHEMBL2326199	86643	0	None	-575	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.ejmech.2016.01.008
	44579259	186531	0	None	-331	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	347	6	1	3	4.0	COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL491604	186531	0	None	-331	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	347	6	1	3	4.0	COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	12436515	15656	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NCC(C)Oc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1222985	15656	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NCC(C)Oc1ccccc1	10.1016/j.bmc.2010.06.100
	10427851	181251	0	None	-407	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	348	6	2	3	3.7	COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL477834	181251	0	None	-407	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	348	6	2	3	3.7	COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	86273227	120803	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580907	120803	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	44429450	86936	0	None	-6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	338	5	1	3	3.0	CCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233310	86936	0	None	-6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	338	5	1	3	3.0	CCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	11824364	112060	0	None	-42	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329960	112060	0	None	-42	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	56671857	64122	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	384	13	1	4	4.3	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2ccccc2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813324	64122	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	384	13	1	4	4.3	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2ccccc2)c1	10.1016/j.bmc.2011.06.063
	10617720	206084	0	None	-56	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL9630	206084	0	None	-56	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2Cc2ccccc2-1	10.1021/jm980684+
	3956219	101077	11	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc2c(CCNC(C)=O)c[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL298335	101077	11	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc2c(CCNC(C)=O)c[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
	127027022	137284	0	None	-19	3	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	314	4	2	3	3.6	CCNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759677	137284	0	None	-19	3	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	314	4	2	3	3.6	CCNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	25210132	170310	0	None	-9	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1021/jm800974d
	CHEMBL445427	170310	0	None	-9	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1021/jm800974d
	10829695	118700	0	None	-21	2	Human	6.9	pKi	=	6.9	Binding	Binding Affinity (pKi) towards Melatonin receptor type 1ABinding Affinity (pKi) towards Melatonin receptor type 1A	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm020982d
	CHEMBL34327	118700	0	None	-21	2	Human	6.9	pKi	=	6.9	Binding	Binding Affinity (pKi) towards Melatonin receptor type 1ABinding Affinity (pKi) towards Melatonin receptor type 1A	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm020982d
	10829695	118700	0	None	-21	2	Human	6.9	pKi	=	6.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm048956y
	CHEMBL34327	118700	0	None	-21	2	Human	6.9	pKi	=	6.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm048956y
	25210132	170310	0	None	-9	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1021/jm800974d
	CHEMBL445427	170310	0	None	-9	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1021/jm800974d
	22718585	16329	0	None	-9	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.4	CCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123634	16329	0	None	-9	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.4	CCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	46884599	8334	0	None	-13	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1cccc(COc2ccc(CCCNC(C)=O)cc2OC)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1093457	8334	0	None	-13	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1cccc(COc2ccc(CCCNC(C)=O)cc2OC)c1	10.1016/j.bmcl.2010.02.084
	25209860	188396	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL508552	188396	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	168274836	189554	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5173623	189554	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	162647716	179307	0	None	-3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4745789	179307	0	None	-3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	10853020	97714	0	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	4	1	2	3.9	CCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL273897	97714	0	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	4	1	2	3.9	CCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	25209860	188396	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL508552	188396	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	11536746	138921	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	4	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(C)=O)CCCC1)cn2C	10.1021/jm0512544
	CHEMBL379403	138921	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	4	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(C)=O)CCCC1)cn2C	10.1021/jm0512544
	44241666	194422	0	None	-6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	351	7	2	3	3.5	COc1ccc2[nH]c(CN(C)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL560865	194422	0	None	-6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	351	7	2	3	3.5	COc1ccc2[nH]c(CN(C)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	44429445	87104	0	None	-6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.6	CCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233516	87104	0	None	-6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.6	CCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	12985496	181749	0	None	-31	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	389	7	2	3	4.5	COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL478438	181749	0	None	-31	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	389	7	2	3	4.5	COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1	10.1016/j.bmc.2008.08.052
	44412079	165704	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	4	2	3	2.8	CCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	CHEMBL426861	165704	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	4	2	3	2.8	CCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	11098363	168550	1	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	293	5	1	2	3.7	CC(=O)NCCc1c(Cc2ccccc2)oc2ccccc12	10.1021/jm0005252
	CHEMBL440144	168550	1	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	293	5	1	2	3.7	CC(=O)NCCc1c(Cc2ccccc2)oc2ccccc12	10.1021/jm0005252
	127025786	137324	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
	CHEMBL3760044	137324	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
	127025782	137206	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759054	137206	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
	122162	2355	67	None	-18	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm401343c
	1363	2355	67	None	-18	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm401343c
	CHEMBL286615	2355	67	None	-18	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm401343c
	54581170	60439	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760956	60439	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	137660726	158785	0	None	-15	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	322	6	1	5	1.6	CCS(=O)(=O)NC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4100108	158785	0	None	-15	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	322	6	1	5	1.6	CCS(=O)(=O)NC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	18522267	65993	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	377	11	1	2	5.8	CCCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL184990	65993	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	377	11	1	2	5.8	CCCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44394394	122195	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	387	9	1	2	5.6	O=C(NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
	CHEMBL360428	122195	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	387	9	1	2	5.6	O=C(NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
	145971624	164061	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	517	15	2	5	6.0	CCC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4215980	164061	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	517	15	2	5	6.0	CCC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	10849065	137	8	None	4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1345	137	8	None	4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL126809	137	8	None	4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	24750191	88124	0	None	-85	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	332	5	1	2	3.7	CC(=O)NCCN(c1ccccc1)c1cccc(Br)c1	10.1021/jm700957j
	CHEMBL235328	88124	0	None	-85	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	332	5	1	2	3.7	CC(=O)NCCN(c1ccccc1)c1cccc(Br)c1	10.1021/jm700957j
	11392720	66716	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	COc1ccc2c(c1)C(CCNC(C)=O)Cc1ccccc1C2	10.1021/jm040768k
	CHEMBL187160	66716	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	COc1ccc2c(c1)C(CCNC(C)=O)Cc1ccccc1C2	10.1021/jm040768k
	10513752	108014	3	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2[nH]c(CCNC(C)=O)cc2c1	10.1021/jm001125h
	CHEMBL319970	108014	3	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2[nH]c(CCNC(C)=O)cc2c1	10.1021/jm001125h
	10513752	108014	3	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2[nH]c(CCNC(C)=O)cc2c1	10.1021/jm970721h
	CHEMBL319970	108014	3	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2[nH]c(CCNC(C)=O)cc2c1	10.1021/jm970721h
	22718571	16659	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	8	1	3	3.6	CCCC(=O)NCCCc1cccc2nc(CCC)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124782	16659	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	8	1	3	3.6	CCCC(=O)NCCCc1cccc2nc(CCC)oc12	10.1016/j.bmcl.2004.04.082
	121231413	3846	1	None	-16982	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	9226	3846	1	None	-16982	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	CHEMBL3612464	3846	1	None	-16982	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	86273229	120805	1	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580909	120805	1	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	127025787	137207	0	None	-4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	298	4	2	3	3.4	CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759080	137207	0	None	-4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	298	4	2	3	3.4	CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	44587357	187567	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4CC3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
	CHEMBL498494	187567	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4CC3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
	44358218	27309	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136895	27309	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	86273222	120809	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580913	120809	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
	11515177	140529	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.4	COc1ccc2c(c1)c(C(C)(C)CNC(=O)C1CCC1)cn2C	10.1021/jm0512544
	CHEMBL382439	140529	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.4	COc1ccc2c(c1)c(C(C)(C)CNC(=O)C1CCC1)cn2C	10.1021/jm0512544
	122188348	122648	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	308	5	1	2	3.2	CC(=O)NCC1CCc2ccccc2N1CCc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612605	122648	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	308	5	1	2	3.2	CC(=O)NCC1CCc2ccccc2N1CCc1ccccc1	10.1021/acs.jmedchem.5b01066
	10591657	4608	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	5	1	2	4.1	CCCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL10328	4608	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	5	1	2	4.1	CCCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	11616029	77640	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	4	1	3	2.4	COc1ccc2c(c1)c(C1(CNC(C)=O)CC1)cn2C	10.1021/jm0512544
	CHEMBL209711	77640	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	4	1	3	2.4	COc1ccc2c(c1)c(C1(CNC(C)=O)CC1)cn2C	10.1021/jm0512544
	16105170	189135	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
	CHEMBL515696	189135	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
	44264871	203321	0	None	-26	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	297	5	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7700	203321	0	None	-26	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	297	5	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	10854190	97861	0	None	-87	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL274896	97861	0	None	-87	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
	15453819	203275	0	None	-30	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	287	6	1	4	3.1	COCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7659	203275	0	None	-30	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	287	6	1	4	3.1	COCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	16105170	189135	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm401343c
	CHEMBL515696	189135	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm401343c
	16105170	189135	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
	CHEMBL515696	189135	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
	16105170	189135	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2008.07.012
	CHEMBL515696	189135	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2008.07.012
	10447987	116468	1	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	308	5	1	3	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2-c1ccccc1	10.1021/jm020982d
	CHEMBL33869	116468	1	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	308	5	1	3	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2-c1ccccc1	10.1021/jm020982d
	90666303	108892	0	None	-31	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	361	6	2	3	3.9	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	CHEMBL3219324	108892	0	None	-31	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	361	6	2	3	3.9	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	23658145	156921	1	None	-33	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4079214	156921	1	None	-33	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	10705590	206466	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	4	1	3	1.9	COc1ccc2cc(CCNC(C)=O)n(C)c2c1	10.1021/jm001125h
	CHEMBL98484	206466	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	4	1	3	1.9	COc1ccc2cc(CCNC(C)=O)n(C)c2c1	10.1021/jm001125h
	10705590	206466	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	4	1	3	1.9	COc1ccc2cc(CCNC(C)=O)n(C)c2c1	10.1021/jm970721h
	CHEMBL98484	206466	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	4	1	3	1.9	COc1ccc2cc(CCNC(C)=O)n(C)c2c1	10.1021/jm970721h
	16105170	189135	0	None	-4	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2009.04.068
	CHEMBL515696	189135	0	None	-4	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2009.04.068
	22718521	16474	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL124216	16474	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
	46885284	8021	0	None	-114	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	251	7	1	3	2.2	CCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
	CHEMBL1091561	8021	0	None	-114	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	251	7	1	3	2.2	CCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
	46884552	8043	0	None	-1122	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	314	8	1	4	2.7	COc1ccc(OCc2ccccn2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1091716	8043	0	None	-1122	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	314	8	1	4	2.7	COc1ccc(OCc2ccccn2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	122188233	122634	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2cc(OC)ccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612465	122634	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2cc(OC)ccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	145977894	163297	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	372	11	2	5	3.2	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4206516	163297	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	372	11	2	5	3.2	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
	10454621	101410	4	None	-47	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1ccc2c(c(CCNC(C)=O)c(I)n2C)c1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL300728	101410	4	None	-47	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1ccc2c(c(CCNC(C)=O)c(I)n2C)c1[N+](=O)[O-]	10.1021/jm011053+
	137636173	155460	0	None	-63	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	276	6	1	3	2.3	COc1ccc2cccc(CCC(=O)NCCF)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4061905	155460	0	None	-63	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	276	6	1	3	2.3	COc1ccc2cccc(CCC(=O)NCCF)c2n1	10.1016/j.ejmech.2016.12.013
	71540275	85982	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	225	2	1	1	2.8	CC(=O)N[C@@H]1C[C@H]1c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	CHEMBL2314250	85982	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	225	2	1	1	2.8	CC(=O)N[C@@H]1C[C@H]1c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	18522208	126764	0	None	6	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	349	9	1	2	5.1	CC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL365852	126764	0	None	6	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	349	9	1	2	5.1	CC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	24750077	148512	0	None	-691	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1cccc(N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm700957j
	CHEMBL394273	148512	0	None	-691	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1cccc(N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm700957j
	10069719	192795	4	None	1	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL52559	192795	4	None	1	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
	44429446	146199	0	None	-14	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.0	CCCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL392422	146199	0	None	-14	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.0	CCCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	56671856	64120	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	19	2	6	4.6	CC(=O)NCCN(C)c1cccc(OCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813322	64120	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	19	2	6	4.6	CC(=O)NCCN(C)c1cccc(OCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	16743294	91649	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	256	4	1	2	2.7	CC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	CHEMBL241928	91649	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	256	4	1	2	2.7	CC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	1550607	102594	64	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	298	6	0	3	4.9	CC(C)=CCC/C(C)=C/COc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	CHEMBL307341	102594	64	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	298	6	0	3	4.9	CC(C)=CCC/C(C)=C/COc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	44349269	16411	1	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	6	2	3	3.2	CCNC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123972	16411	1	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	6	2	3	3.2	CCNC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	10517621	206324	0	None	-11	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	290	3	1	2	3.3	CC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL9765	206324	0	None	-11	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	290	3	1	2	3.3	CC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	127039212	137500	0	None	-154	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3cccc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3764879	137500	0	None	-154	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3cccc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	10245336	38983	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	318	5	2	1	4.3	O=C(NCCc1c(-c2ccccc2)[nH]c2ccccc12)C1CCC1	10.1021/jm970721h
	CHEMBL14701	38983	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	318	5	2	1	4.3	O=C(NCCc1c(-c2ccccc2)[nH]c2ccccc12)C1CCC1	10.1021/jm970721h
	44389845	64501	0	None	15	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	10	1	2	4.9	O=C(NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
	CHEMBL181974	64501	0	None	15	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	10	1	2	4.9	O=C(NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
	20590652	129456	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	10	1	2	5.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL367604	129456	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	10	1	2	5.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	44389813	130852	0	None	15	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	11	1	2	5.3	CCCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL368886	130852	0	None	15	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	11	1	2	5.3	CCCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	145991966	166283	0	None	-5	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	1	3	3.2	COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4285145	166283	0	None	-5	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	1	3	3.2	COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145987794	166567	0	None	-19	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4290302	166567	0	None	-19	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145988269	166637	0	None	-10	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4291381	166637	0	None	-10	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137639112	156310	0	None	-10	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4071572	156310	0	None	-10	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
	137655238	158339	0	None	-19	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4095210	158339	0	None	-19	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	9805364	36732	0	None	89	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	484	11	2	4	4.8	CC(=O)NCCc1cccc2ccc(OCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL14514	36732	0	None	89	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	484	11	2	4	4.8	CC(=O)NCCc1cccc2ccc(OCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	9796251	117607	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL340745	117607	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	139451790	184714	13	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859295	184714	13	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	127026062	137164	0	None	-5	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758717	137164	0	None	-5	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	44394438	66630	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	375	9	1	2	5.6	CCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL186736	66630	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	375	9	1	2	5.6	CCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44358238	118867	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL344449	118867	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	10333442	202188	0	None	-5	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	272	6	1	3	2.7	CCCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
	CHEMBL68864	202188	0	None	-5	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	272	6	1	3	2.7	CCCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
	139451776	184428	0	None	5	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854836	184428	0	None	5	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	10754723	168632	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	273	5	2	3	2.6	CCC(=O)NCCc1c(O)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL440692	168632	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	273	5	2	3	2.6	CCC(=O)NCCc1c(O)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	127040021	137492	0	None	-24	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3ccc4ccccc4c3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3764765	137492	0	None	-24	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3ccc4ccccc4c3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	11776674	116149	1	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm020982d
	CHEMBL33700	116149	1	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm020982d
	10038243	116461	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	3.0	CCCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL338659	116461	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	3.0	CCCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	168274836	189554	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5173623	189554	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	10301190	8480	0	None	7	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	511	12	1	5	6.2	COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1	10.1016/j.bmc.2010.04.008
	CHEMBL1094545	8480	0	None	7	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	511	12	1	5	6.2	COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1	10.1016/j.bmc.2010.04.008
	137641357	156537	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4074273	156537	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	44394535	66678	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	390	8	1	3	5.1	CCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL186977	66678	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	390	8	1	3	5.1	CCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	86273228	120806	0	None	-5	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580910	120806	0	None	-5	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	11776674	116149	1	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm011053+
	CHEMBL33700	116149	1	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm011053+
	44394435	66593	0	None	3	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL186586	66593	0	None	3	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	10561982	22820	0	None	-12	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL133001	22820	0	None	-12	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	16094584	82832	0	None	-33	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL218708	82832	0	None	-33	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	44429441	86299	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.2	COc1cc(C)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	CHEMBL231872	86299	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.2	COc1cc(C)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	53237951	61690	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	333	5	1	2	3.7	CC(=O)NCCC1=C(Cc2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774518	61690	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	333	5	1	2	3.7	CC(=O)NCCC1=C(Cc2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	10332159	16615	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.6	CCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124577	16615	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.6	CCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	127026423	137294	0	None	-31	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759802	137294	0	None	-31	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	44429443	144812	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	6	2	2	2.9	CCCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL391350	144812	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	6	2	2	2.9	CCCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	9839199	21163	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL131424	21163	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	137636079	155686	0	None	-19	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	232	3	1	2	1.8	CCN1CC(CNC(C)=O)Cc2ccccc21	10.1021/acs.jmedchem.8b00359
	CHEMBL4064626	155686	0	None	-19	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	232	3	1	2	1.8	CCN1CC(CNC(C)=O)Cc2ccccc21	10.1021/acs.jmedchem.8b00359
	127026425	137295	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759816	137295	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	53310838	63460	0	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.8	CC(=O)NCCn1c(-c2ccccc2)nc2ccc3c(c21)CCO3	10.1021/jm200385u
	CHEMBL1802021	63460	0	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.8	CC(=O)NCCn1c(-c2ccccc2)nc2ccc3c(c21)CCO3	10.1021/jm200385u
	44424018	84934	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	620	16	4	8	4.2	COc1ccc2[nH]c(C(=O)OCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL226162	84934	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	620	16	4	8	4.2	COc1ccc2[nH]c(C(=O)OCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	56661499	64093	0	None	102	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	456	14	2	6	2.7	CC(=O)NCCN(C)c1cccc(OCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813174	64093	0	None	102	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	456	14	2	6	2.7	CC(=O)NCCN(C)c1cccc(OCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	46884555	8258	0	None	-16	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.7	CCC(=O)NCCCc1ccc(OCc2ccccc2)c(OC)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092911	8258	0	None	-16	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.7	CCC(=O)NCCCc1ccc(OCc2ccccc2)c(OC)c1	10.1016/j.bmcl.2010.02.084
	44358088	26576	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136273	26576	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	10518621	96866	0	None	-11	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	4	1	2	3.7	CCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL269175	96866	0	None	-11	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	4	1	2	3.7	CCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	12985493	186509	0	None	-213	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	7	1	3	4.3	COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	CHEMBL491403	186509	0	None	-213	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	7	1	3	4.3	COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	10736247	206622	0	None	-5	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCc1ccccc1-2)C1CCC1	10.1021/jm980684+
	CHEMBL9950	206622	0	None	-5	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCc1ccccc1-2)C1CCC1	10.1021/jm980684+
	11208578	125368	0	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	292	2	1	2	3.0	CC(=O)NCC(=O)N1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
	CHEMBL364845	125368	0	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	292	2	1	2	3.0	CC(=O)NCC(=O)N1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
	189748	16637	6	None	-60	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	262	5	2	3	1.9	COc1cc2[nH]cc(CCNC(C)=O)c2cc1OC	10.1021/jm401343c
	CHEMBL124699	16637	6	None	-60	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	262	5	2	3	1.9	COc1cc2[nH]cc(CCNC(C)=O)c2cc1OC	10.1021/jm401343c
	11287002	15753	2	None	-4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223275	15753	2	None	-4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	44358217	27305	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136894	27305	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	44394456	65785	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	378	10	2	2	5.3	CCNC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL183962	65785	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	378	10	2	2	5.3	CCNC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	145963877	163704	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	503	14	2	5	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4211530	163704	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	503	14	2	5	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	10385056	111744	0	None	-194	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL329086	111744	0	None	-194	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	10385056	111744	0	None	-194	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm401343c
	CHEMBL329086	111744	0	None	-194	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm401343c
	145	140	48	None	-40	29	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1832	140	48	None	-40	29	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	CHEMBL7257	140	48	None	-40	29	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	DB14010	140	48	None	-40	29	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	122178507	120810	0	None	-13	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580915	120810	0	None	-13	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	127025170	137217	0	None	-4	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759180	137217	0	None	-4	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	162656758	180340	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4757920	180340	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	162658247	180436	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2cnnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4759137	180436	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2cnnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	11688043	77641	0	None	-28	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	6	1	3	3.1	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
	CHEMBL209712	77641	0	None	-28	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	6	1	3	3.1	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
	122188234	122635	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2ccc(OC)cc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612466	122635	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2ccc(OC)cc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	44424019	84935	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	648	18	4	8	5.0	COc1ccc2[nH]c(C(=O)OCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL226163	84935	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	648	18	4	8	5.0	COc1ccc2[nH]c(C(=O)OCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	16094595	82848	4	None	-407	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.4	COc1cccc(C(CCNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL218773	82848	4	None	-407	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.4	COc1cccc(C(CCNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	44412078	138987	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	3	2	3	2.4	CC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	CHEMBL379504	138987	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	3	2	3	2.4	CC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	137637884	155705	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4064813	155705	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	122188352	122651	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	263	3	2	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612609	122651	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	263	3	2	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	44394532	66910	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	376	7	1	3	4.7	CC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL188016	66910	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	376	7	1	3	4.7	CC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	11351216	62075	0	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	1	3	5.4	O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779807	62075	0	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	1	3	5.4	O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	162668689	182176	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4790145	182176	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	71508233	86646	0	None	-40	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326201	86646	0	None	-40	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	11066802	99625	0	None	-21	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	308	5	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	CHEMBL287343	99625	0	None	-21	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	308	5	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	11463056	62073	0	None	-51	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	1	3	5.4	CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779805	62073	0	None	-51	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	1	3	5.4	CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	11131123	170066	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1cccc(Cc2oc3ccccc3c2CCNC(C)=O)c1	10.1021/jm0005252
	CHEMBL445117	170066	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1cccc(Cc2oc3ccccc3c2CCNC(C)=O)c1	10.1021/jm0005252
	16094593	165491	0	None	-91	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C\CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL425644	165491	0	None	-91	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C\CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	44349305	170570	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	320	6	1	3	4.0	O=C(NCCCc1cccc2nc(-c3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
	CHEMBL445840	170570	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	320	6	1	3	4.0	O=C(NCCCc1cccc2nc(-c3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
	23725513	125327	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648357	125327	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	44394416	65906	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	389	9	1	2	5.9	CC(C)C(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL184562	65906	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	389	9	1	2	5.9	CC(C)C(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	10750842	188097	3	None	-30	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	207	5	1	2	1.8	COc1cccc(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL50398	188097	3	None	-30	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	207	5	1	2	1.8	COc1cccc(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	127026426	137275	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759606	137275	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	90666307	108896	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	8	2	3	3.9	C=CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
	CHEMBL3219328	108896	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	8	2	3	3.9	C=CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
	16094584	82832	0	None	-33	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm800974d
	CHEMBL218708	82832	0	None	-33	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm800974d
	86079062	180150	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4755860	180150	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	10808489	206040	0	None	-42	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	360	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL9600	206040	0	None	-42	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	360	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
	53231464	62077	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	6	1	3	5.2	C=CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779809	62077	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	6	1	3	5.2	C=CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	11173131	123579	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	265	2	1	1	3.1	CC(=O)NCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	CHEMBL363321	123579	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	265	2	1	1	3.1	CC(=O)NCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	11014883	206387	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	400	6	1	3	4.1	COc1ccc2c(Br)c(CCNC(C)=O)n(Cc3ccccc3)c2c1	10.1021/jm001125h
	CHEMBL98028	206387	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	400	6	1	3	4.1	COc1ccc2c(Br)c(CCNC(C)=O)n(Cc3ccccc3)c2c1	10.1021/jm001125h
	22718576	114107	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	1	3	2.2	CC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL333810	114107	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	1	3	2.2	CC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	11824365	106883	0	None	-47	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc(Cc2oc3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1021/jm0005252
	CHEMBL317742	106883	0	None	-47	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc(Cc2oc3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1021/jm0005252
	44424021	141559	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	690	21	4	8	6.2	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL388141	141559	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	690	21	4	8	6.2	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	53231465	62071	0	None	-5	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779803	62071	0	None	-5	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	44579260	186532	0	None	-38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	377	6	1	4	4.0	COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	CHEMBL491605	186532	0	None	-38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	377	6	1	4	4.0	COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	10853021	97685	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	3	1	2	3.9	CC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL273623	97685	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	3	1	2	3.9	CC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	10465460	206565	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	202	3	2	1	1.8	CC(=O)NCCc1cc2ccccc2[nH]1	10.1021/jm001125h
	CHEMBL99083	206565	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	202	3	2	1	1.8	CC(=O)NCCc1cc2ccccc2[nH]1	10.1021/jm001125h
	10465460	206565	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	202	3	2	1	1.8	CC(=O)NCCc1cc2ccccc2[nH]1	10.1021/jm970721h
	CHEMBL99083	206565	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	202	3	2	1	1.8	CC(=O)NCCc1cc2ccccc2[nH]1	10.1021/jm970721h
	137656715	159000	0	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	5	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4102517	159000	0	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	5	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	71540393	85986	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	226	2	2	1	2.7	CNC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	CHEMBL2314254	85986	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	226	2	2	1	2.7	CNC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	127038130	136100	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3739824	136100	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
	44424022	83059	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	718	23	4	8	6.9	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL220091	83059	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	718	23	4	8	6.9	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	10737123	96931	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	358	4	1	2	4.7	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CCC1	10.1021/jm980684+
	CHEMBL269670	96931	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	358	4	1	2	4.7	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CCC1	10.1021/jm980684+
	90666302	108891	0	None	-11	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.4	COc1ccc2[nH]c(CN3CCc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	CHEMBL3219323	108891	0	None	-11	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.4	COc1ccc2[nH]c(CN3CCc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	CHEMBL3109562	209344	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		CCC1=C(C)C2=Cc3c(CCNC(C)=O)c4cc(OC)ccc4n3[B-](F)(F)[N+]2=C1C	10.1021/ml4004155
	10596576	4109	0	None	-39	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	390	7	1	3	5.1	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL10007	4109	0	None	-39	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	390	7	1	3	5.1	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	46884598	8106	0	None	-20	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1cc(CCCNC(C)=O)ccc1O	10.1016/j.bmcl.2010.02.084
	CHEMBL1092047	8106	0	None	-20	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1cc(CCCNC(C)=O)ccc1O	10.1016/j.bmcl.2010.02.084
	45269177	193196	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	299	5	1	3	2.5	CCCC(=O)NCCc1c2n(c3ccccc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	CHEMBL540182	193196	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	299	5	1	3	2.5	CCCC(=O)NCCc1c2n(c3ccccc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	45269183	194351	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	385	7	2	3	4.1	COc1ccc2[nH]c(CN(C)c3ccc(Cl)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL560186	194351	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	385	7	2	3	4.1	COc1ccc2[nH]c(CN(C)c3ccc(Cl)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	16094594	82833	0	None	-165	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C\CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL218709	82833	0	None	-165	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C\CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
	162674581	182730	0	None	-51	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	268	3	1	4	2.7	COc1ccc2cccc(/C=C/c3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	CHEMBL4797226	182730	0	None	-51	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	268	3	1	4	2.7	COc1ccc2cccc(/C=C/c3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	46885227	7990	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	CHEMBL1091161	7990	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	16743464	91894	0	None	-11	2	Human	5.6	pKi	=	5.6	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	310	3	1	2	3.9	CC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
	CHEMBL243002	91894	0	None	-11	2	Human	5.6	pKi	=	5.6	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	310	3	1	2	3.9	CC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
	10714573	98041	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL276005	98041	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	1353	3380	3	None	-112	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm800974d
	9998187	3380	3	None	-112	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm800974d
	CHEMBL33549	3380	3	None	-112	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm800974d
	145976375	163245	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	525	15	2	6	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4206000	163245	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	525	15	2	6	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
	46885288	8245	0	None	-95	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1ccc(COc2ccc(OC)cc2CCCNC(C)=O)cc1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092839	8245	0	None	-95	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1ccc(COc2ccc(OC)cc2CCCNC(C)=O)cc1	10.1016/j.bmcl.2010.02.084
	10760155	97967	0	None	-43	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	4	1	3	3.9	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL275529	97967	0	None	-43	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	4	1	3	3.9	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	7922	1925	0	None	-741	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
	9798456	1925	0	None	-741	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
	CHEMBL476131	1925	0	None	-741	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
	11045144	206541	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	310	4	2	2	3.0	CCC(=O)NCc1[nH]c2cc(OC)ccc2c1Br	10.1021/jm001125h
	CHEMBL98956	206541	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	310	4	2	2	3.0	CCC(=O)NCc1[nH]c2cc(OC)ccc2c1Br	10.1021/jm001125h
	49865205	15676	0	None	-4	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223052	15676	0	None	-4	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	137644121	157604	0	None	-7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	291	4	1	1	4.0	CCC(=O)NCC1=C(c2ccccc2)c2ccccc2CC1	10.1021/acs.jmedchem.8b00359
	CHEMBL4087265	157604	0	None	-7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	291	4	1	1	4.0	CCC(=O)NCC1=C(c2ccccc2)c2ccccc2CC1	10.1021/acs.jmedchem.8b00359
	11702296	64660	4	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	COc1ccc2nc(-c3ccccc3)c(CCNC(C)=O)n2c1	10.1016/j.ejmech.2011.06.030
	CHEMBL1823017	64660	4	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	COc1ccc2nc(-c3ccccc3)c(CCNC(C)=O)n2c1	10.1016/j.ejmech.2011.06.030
	86273223	120807	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	242	3	1	3	3.1	COc1ccc2[nH]cc(Cc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580911	120807	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	242	3	1	3	3.1	COc1ccc2[nH]cc(Cc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	90666305	108894	0	None	-125	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	CHEMBL3219326	108894	0	None	-125	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	49865266	15699	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccc(SCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223126	15699	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccc(SCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	10520058	97686	0	None	-8	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	324	3	1	2	4.0	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL273624	97686	0	None	-8	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	324	3	1	2	4.0	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)Cc1ccccc1-2	10.1021/jm980684+
	53231367	62076	0	None	-117	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	425	8	1	3	6.0	O=C(CCCCl)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779808	62076	0	None	-117	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	425	8	1	3	6.0	O=C(CCCCl)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	11078652	206181	0	None	-16	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	7	1	3	4.3	CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL96778	206181	0	None	-16	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	7	1	3	4.3	CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	10641756	97826	0	None	-57	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	352	3	1	2	4.6	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL274630	97826	0	None	-57	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	352	3	1	2	4.6	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	56662799	64125	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	15	2	6	2.9	COc1cccc(N(CCNC(C)=O)C(=O)CCCCC(=O)N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813327	64125	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	15	2	6	2.9	COc1cccc(N(CCNC(C)=O)C(=O)CCCCC(=O)N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1016/j.bmc.2011.06.063
	11088627	205811	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	6	1	4	3.1	COc1ccc2oc(Cc3cccnc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL94745	205811	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	6	1	4	3.1	COc1ccc2oc(Cc3cccnc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	15453821	203395	0	None	-151	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	301	6	1	3	4.6	CCCC(=O)Nc1ccc(Sc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7771	203395	0	None	-151	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	301	6	1	3	4.6	CCCC(=O)Nc1ccc(Sc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	145983175	165878	0	None	-14	3	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4277390	165878	0	None	-14	3	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137661786	158569	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	262	5	1	3	1.9	COc1cnc2cccc(CCNC(=O)CF)c2c1	10.1016/j.ejmech.2016.12.013
	CHEMBL4097693	158569	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	262	5	1	3	1.9	COc1cnc2cccc(CCNC(=O)CF)c2c1	10.1016/j.ejmech.2016.12.013
	145975938	163347	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	519	14	3	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4207166	163347	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	519	14	3	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
	122188239	122640	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	320	5	1	2	3.5	O=C(NCC1CCc2ccccc2N1Cc1ccccc1)C1CC1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612471	122640	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	320	5	1	2	3.5	O=C(NCC1CCc2ccccc2N1Cc1ccccc1)C1CC1	10.1021/acs.jmedchem.5b01066
	46885286	8084	0	None	-218	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.4	COc1ccc(OCCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1091895	8084	0	None	-218	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.4	COc1ccc(OCCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	10620323	206599	0	None	-34	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL9935	206599	0	None	-34	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	10658090	206553	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	5	2	2	2.2	COc1ccc2[nH]c(CCCNC(C)=O)cc2c1	10.1021/jm001125h
	CHEMBL99000	206553	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	5	2	2	2.2	COc1ccc2[nH]c(CCCNC(C)=O)cc2c1	10.1021/jm001125h
	10658090	206553	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	5	2	2	2.2	COc1ccc2[nH]c(CCCNC(C)=O)cc2c1	10.1021/jm970721h
	CHEMBL99000	206553	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	5	2	2	2.2	COc1ccc2[nH]c(CCCNC(C)=O)cc2c1	10.1021/jm970721h
	12985490	180638	0	None	-12	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL476132	180638	0	None	-12	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	10015474	18373	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	2.8	Cc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL127596	18373	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	2.8	Cc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	145979282	166122	0	None	-16	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	166122	0	None	-16	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	53238408	61697	0	None	-81	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)cc1	10.1021/jm200221q
	CHEMBL1774527	61697	0	None	-81	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)cc1	10.1021/jm200221q
	11426853	165815	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	3	1	3	2.7	COc1ccc2c(c1)C(CNC(C)=O)Cc1ccccc1C2=O	10.1021/jm040768k
	CHEMBL427516	165815	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	3	1	3	2.7	COc1ccc2c(c1)C(CNC(C)=O)Cc1ccccc1C2=O	10.1021/jm040768k
	137641357	156537	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4074273	156537	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	49865321	15722	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223195	15722	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	44272406	68840	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	289	5	3	3	2.7	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CC)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19260	68840	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	289	5	3	3	2.7	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CC)N2	10.1016/j.bmcl.2003.12.052
	1355	3383	3	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	9806449	3383	3	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	CHEMBL14453	3383	3	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	71540395	85989	0	None	2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	256	3	2	2	2.7	CNC(=O)N/C=C/c1c(OC)ccc2ccccc12	10.1016/j.bmcl.2012.11.069
	CHEMBL2314258	85989	0	None	2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	256	3	2	2	2.7	CNC(=O)N/C=C/c1c(OC)ccc2ccccc12	10.1016/j.bmcl.2012.11.069
	11810280	206193	0	None	-16	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.5	CCCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL96859	206193	0	None	-16	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.5	CCCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	10091075	17099	0	None	8	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	11	1	3	5.2	CCCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL125705	17099	0	None	8	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	11	1	3	5.2	CCCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	52918078	60430	0	None	-11	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	CHEMBL1760946	60430	0	None	-11	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	23658146	156576	1	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4074895	156576	1	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	56664925	64119	0	None	53	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813321	64119	0	None	53	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	137631636	156067	0	None	-7	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	4	1	2	3.4	CCC(=O)NC[C@@H]1CN(C)c2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	CHEMBL4068887	156067	0	None	-7	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	4	1	2	3.4	CCC(=O)NC[C@@H]1CN(C)c2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	85880795	110379	0	None	12	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
	CHEMBL3260984	110379	0	None	12	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
	18360658	8802	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097497	8802	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	10015475	16584	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124362	16584	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	44272444	67604	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	303	6	3	3	3.0	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)NCC)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL19109	67604	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	303	6	3	3	3.0	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)NCC)c2O1	10.1016/j.bmcl.2003.12.052
	137648419	157297	0	None	-15	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	CHEMBL4083618	157297	0	None	-15	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	10926138	206238	0	None	-57	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL97186	206238	0	None	-57	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	44429447	87318	0	None	-5	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	310	4	2	2	2.6	COc1cc(Br)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	CHEMBL233728	87318	0	None	-5	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	310	4	2	2	2.6	COc1cc(Br)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	139451784	184813	0	None	6	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
	CHEMBL4860729	184813	0	None	6	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
	49865149	15657	2	None	2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1222986	15657	2	None	2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	25270146	30478	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	262	5	1	3	2.2	CCCC(=O)N[C@H]1CCN(c2cccc(OC)c2)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL139497	30478	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	262	5	1	3	2.2	CCCC(=O)N[C@H]1CCN(c2cccc(OC)c2)C1	10.1016/j.bmcl.2003.09.030
	15453093	85984	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2ccccc2c1[C@@H]1C[C@H]1NC(C)=O	10.1016/j.bmcl.2012.11.069
	CHEMBL2314252	85984	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2ccccc2c1[C@@H]1C[C@H]1NC(C)=O	10.1016/j.bmcl.2012.11.069
	10022490	66722	0	None	22	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	377	10	1	2	5.7	CC(C)C(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL187186	66722	0	None	22	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	377	10	1	2	5.7	CC(C)C(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	49865324	15725	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223198	15725	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	9860296	29004	0	None	8	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	272	3	1	3	1.7	O=C(N[C@@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
	CHEMBL138228	29004	0	None	8	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	272	3	1	3	1.7	O=C(N[C@@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
	18466111	19645	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL130214	19645	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	1362	3382	18	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	9870523	3382	18	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	CHEMBL429392	3382	18	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	56653120	110380	0	None	12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	336	8	2	2	3.9	CC(=O)NCCc1c[nH]c2ccc(OCCCc3ccccc3)cc12	10.1021/jm401343c
	CHEMBL3260985	110380	0	None	12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	336	8	2	2	3.9	CC(=O)NCCc1c[nH]c2ccc(OCCCc3ccccc3)cc12	10.1021/jm401343c
	56681902	64121	0	None	10	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813323	64121	0	None	10	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	22718532	16604	0	None	-7	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	218	4	1	3	1.9	CC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124488	16604	0	None	-7	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	218	4	1	3	1.9	CC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	9881917	96594	0	None	-44	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	271	5	1	3	3.8	CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL266970	96594	0	None	-44	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	271	5	1	3	3.8	CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	25210000	188904	0	None	-11	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL513933	188904	0	None	-11	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	25022442	188968	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
	CHEMBL514413	188968	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
	11681201	140545	0	None	-2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.5	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
	CHEMBL382555	140545	0	None	-2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.5	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
	162663385	181416	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4780509	181416	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
	122188229	122630	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	249	3	3	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612460	122630	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	249	3	3	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	11573203	140547	0	None	-2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	312	5	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCC1)cn2C	10.1021/jm0512544
	CHEMBL382579	140547	0	None	-2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	312	5	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCC1)cn2C	10.1021/jm0512544
	10991315	206554	0	None	-23	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	336	7	1	3	4.1	CCC(=O)NCCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	CHEMBL99001	206554	0	None	-23	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	336	7	1	3	4.1	CCC(=O)NCCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	25210000	188904	0	None	-11	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL513933	188904	0	None	-11	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	145974583	163938	0	None	4	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	279	9	2	4	1.4	CC(=O)NCCN(C)c1cccc(OCCCCN)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4214348	163938	0	None	4	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	279	9	2	4	1.4	CC(=O)NCCN(C)c1cccc(OCCCCN)c1	10.1021/acs.jmedchem.8b00893
	44264705	202756	1	None	-79	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	284	6	2	3	4.2	CCCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7229	202756	1	None	-79	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	284	6	2	3	4.2	CCCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	127040022	137424	0	None	-6	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3c4ccccc4cc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3764063	137424	0	None	-6	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3c4ccccc4cc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	9819843	206397	0	None	-20	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.3	COc1ccc2oc(CCCc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL98074	206397	0	None	-20	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.3	COc1ccc2oc(CCCc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	145978811	163308	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	531	16	2	5	6.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4206642	163308	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	531	16	2	5	6.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	137655489	158429	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1cnc2cccc(CCNC(N)=O)c2c1	10.1016/j.ejmech.2016.12.013
	CHEMBL4096197	158429	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1cnc2cccc(CCNC(N)=O)c2c1	10.1016/j.ejmech.2016.12.013
	25022442	188968	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2009.04.068
	CHEMBL514413	188968	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2009.04.068
	11058163	206473	0	None	-22	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	386	5	1	3	4.1	COc1cccc2c1c(Br)c(CNC(C)=O)n2Cc1ccccc1	10.1021/jm001125h
	CHEMBL98520	206473	0	None	-22	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	386	5	1	3	4.1	COc1cccc2c1c(Br)c(CNC(C)=O)n2Cc1ccccc1	10.1021/jm001125h
	49865423	15782	2	None	-4	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)NC(C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223345	15782	2	None	-4	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)NC(C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	25022442	188968	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2008.07.012
	CHEMBL514413	188968	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2008.07.012
	145982333	166004	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	166004	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL3109563	209345	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		COc1ccc2c(c1)c(CCNC(C)=O)c1n2[B-](F)(F)[N+]2=C(C)C=C(C)C2=C1	10.1021/ml4004155
	129776	142	5	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1016/j.ejmech.2019.111847
	1364	142	5	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1016/j.ejmech.2019.111847
	CHEMBL339105	142	5	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1016/j.ejmech.2019.111847
	129776	142	5	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1021/jm401343c
	1364	142	5	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1021/jm401343c
	CHEMBL339105	142	5	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1021/jm401343c
	71508235	86647	0	None	-95	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326203	86647	0	None	-95	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	25022442	188968	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
	CHEMBL514413	188968	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
	162649850	179558	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4748822	179558	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	24750194	89518	0	None	-87	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	324	7	1	3	3.8	COc1cccc(N(CCNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm700957j
	CHEMBL238049	89518	0	None	-87	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	324	7	1	3	3.8	COc1cccc(N(CCNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm700957j
	122188353	122652	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	322	6	1	2	3.9	CCC(=O)NCCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612610	122652	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	322	6	1	2	3.9	CCC(=O)NCCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	20590664	123155	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	390	9	2	2	5.4	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL362097	123155	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	390	9	2	2	5.4	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44429451	148680	0	None	-15	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	352	6	1	3	3.4	CCCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL394406	148680	0	None	-15	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	352	6	1	3	3.4	CCCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	11002150	107067	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	334	6	1	3	3.7	COc1cccc2c1cc(CCNC(=O)C1CC1)n2-c1ccccc1	10.1021/jm001125h
	CHEMBL318871	107067	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	334	6	1	3	3.7	COc1cccc2c1cc(CCNC(=O)C1CC1)n2-c1ccccc1	10.1021/jm001125h
	44349270	112593	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	6	1	3	3.4	CC(C)c1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL331317	112593	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	6	1	3	3.4	CC(C)c1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	44264843	203139	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	300	5	1	4	4.0	CCOC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7556	203139	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	300	5	1	4	4.0	CCOC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	137640407	156202	0	None	-67	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.5	COc1ccc2cccc(CCC(=O)NC3CC3)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4070527	156202	0	None	-67	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.5	COc1ccc2cccc(CCC(=O)NC3CC3)c2n1	10.1016/j.ejmech.2016.12.013
	11638009	165210	0	None	-7	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	5	1	3	3.1	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	CHEMBL424693	165210	0	None	-7	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	5	1	3	3.1	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	44587356	192781	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	423	8	3	5	2.8	COc1ccc2c(c1)CC(CO)N2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2008.07.012
	CHEMBL525374	192781	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	423	8	3	5	2.8	COc1ccc2c(c1)CC(CO)N2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2008.07.012
	168296374	191920	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	CHEMBL5209359	191920	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	145966403	163656	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	497	13	2	6	4.9	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4210884	163656	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	497	13	2	6	4.9	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
	44349294	18367	1	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	323	6	2	3	3.7	CCNC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL127576	18367	1	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	323	6	2	3	3.7	CCNC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	23658143	155836	1	None	-6	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4066279	155836	1	None	-6	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	49865375	15756	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223278	15756	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	127038131	136128	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3740052	136128	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	122178509	120814	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580919	120814	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	122178509	120814	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	CHEMBL3580919	120814	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	127038131	136128	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3740052	136128	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	49865373	15754	2	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223276	15754	2	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	44264861	203434	0	None	-74	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	310	5	1	3	4.1	CCCC(=O)Nc1ccc(N(C)c2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7807	203434	0	None	-74	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	310	5	1	3	4.1	CCCC(=O)Nc1ccc(N(C)c2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	16094587	82849	3	None	-72	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.7	CCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	CHEMBL218774	82849	3	None	-72	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.7	CCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	16094592	82872	1	None	-6	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C/c1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL218926	82872	1	None	-6	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C/c1ccccc1)c1ccccc1	10.1021/jm060850a
	49865267	15700	2	None	-7	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccccc1SCCNC(C)=O	10.1016/j.bmc.2010.06.100
	CHEMBL1223127	15700	2	None	-7	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccccc1SCCNC(C)=O	10.1016/j.bmc.2010.06.100
	49865374	15755	0	None	-7	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223277	15755	0	None	-7	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	122188235	122636	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	308	5	1	2	3.5	CCC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612467	122636	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	308	5	1	2	3.5	CCC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	145971692	162470	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	264	3	0	3	3.8	O=c1ccc2ccc(O/C=C/c3ccccc3)cc2o1	10.1021/acs.jnatprod.7b00853
	CHEMBL4175759	162470	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	264	3	0	3	3.8	O=c1ccc2ccc(O/C=C/c3ccccc3)cc2o1	10.1021/acs.jnatprod.7b00853
	16743125	91871	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	296	5	1	2	3.4	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CCC1	10.1016/j.ejmech.2007.01.005
	CHEMBL242786	91871	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	296	5	1	2	3.4	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CCC1	10.1016/j.ejmech.2007.01.005
	49865425	15784	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223347	15784	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	4207624	15679	35	None	-5	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccccc1OCCNC(C)=O	10.1016/j.bmc.2010.06.100
	CHEMBL1223055	15679	35	None	-5	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccccc1OCCNC(C)=O	10.1016/j.bmc.2010.06.100
	46885230	8109	0	None	-8	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1ccc(O)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092062	8109	0	None	-8	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1ccc(O)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	25210131	174743	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	CHEMBL457352	174743	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	25210131	174743	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	CHEMBL457352	174743	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	71508232	86645	0	None	-524	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326200	86645	0	None	-524	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	44579296	186212	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	376	6	2	3	4.2	COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL489170	186212	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	376	6	2	3	4.2	COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	145969866	164289	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	546	15	3	6	4.8	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4218897	164289	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	546	15	3	6	4.8	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
	56662798	64124	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	COc1cccc(N(CCCCCCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813326	64124	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	COc1cccc(N(CCCCCCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
	10704742	106777	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1cccc2cc(CCNC(C)=O)[nH]c12	10.1021/jm001125h
	CHEMBL316952	106777	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1cccc2cc(CCNC(C)=O)[nH]c12	10.1021/jm001125h
	10704742	106777	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1cccc2cc(CCNC(C)=O)[nH]c12	10.1021/jm970721h
	CHEMBL316952	106777	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1cccc2cc(CCNC(C)=O)[nH]c12	10.1021/jm970721h
	13250272	15698	14	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	195	4	1	2	1.9	CC(=O)NCCSc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223125	15698	14	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	195	4	1	2	1.9	CC(=O)NCCSc1ccccc1	10.1016/j.bmc.2010.06.100
	44579261	186396	0	None	-87	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	6	2	3	3.9	COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL490594	186396	0	None	-87	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	6	2	3	3.9	COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	44424026	141804	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	546	17	4	4	5.8	COc1ccc2[nH]cc(CCNC(=O)CCCCCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL388591	141804	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	546	17	4	4	5.8	COc1ccc2[nH]cc(CCNC(=O)CCCCCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
	10709646	206098	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	3	1	2	3.5	CC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9634	206098	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	3	1	2	3.5	CC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	11219713	125322	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	279	3	1	1	3.4	CC(=O)NCCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	CHEMBL364835	125322	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	279	3	1	1	3.4	CC(=O)NCCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	16094579	80430	5	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	267	6	1	1	3.3	CCC(=O)NCCc1cccc(Cc2ccccc2)c1	10.1021/jm060850a
	CHEMBL215252	80430	5	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	267	6	1	1	3.3	CCC(=O)NCCc1cccc(Cc2ccccc2)c1	10.1021/jm060850a
	44394338	121529	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	405	8	2	3	4.9	CCNC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL359561	121529	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	405	8	2	3	4.9	CCNC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	71508234	697	0	None	-38	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	7924	697	0	None	-38	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	CHEMBL2326202	697	0	None	-38	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	10638747	206626	0	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	310	4	2	2	2.6	COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
	CHEMBL99512	206626	0	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	310	4	2	2	2.6	COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
	10638747	206626	0	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	310	4	2	2	2.6	COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1	10.1021/jm970721h
	CHEMBL99512	206626	0	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	310	4	2	2	2.6	COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1	10.1021/jm970721h
	44389839	64270	0	None	10	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	10	1	2	5.1	CC(C)C(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL181687	64270	0	None	10	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	10	1	2	5.1	CC(C)C(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	12071674	123425	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	351	9	1	2	4.5	CC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL362849	123425	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	351	9	1	2	4.5	CC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	145979282	166122	0	None	-16	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	166122	0	None	-16	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145988801	166493	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	4	1	2	3.4	COc1ccc2ccc3c(c2c1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4288925	166493	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	4	1	2	3.4	COc1ccc2ccc3c(c2c1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	145986700	166666	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4292109	166666	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137650826	156963	0	None	-10	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4079699	156963	0	None	-10	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	46888491	8583	0	None	20	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	501	13	3	4	4.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095522	8583	0	None	20	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	501	13	3	4	4.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	10522675	4272	0	None	-20	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL10099	4272	0	None	-20	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
	10522675	4272	0	None	-20	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1016/j.ejmech.2019.111847
	CHEMBL10099	4272	0	None	-20	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1016/j.ejmech.2019.111847
	16656789	88123	0	None	-63	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1cccc(N(CCNC(C)=O)c2ccccc2)c1	10.1021/jm700957j
	CHEMBL235327	88123	0	None	-63	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1cccc(N(CCNC(C)=O)c2ccccc2)c1	10.1021/jm700957j
	24750071	98463	0	None	-39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	312	8	1	3	3.8	CCCC(=O)NCCN(c1ccccc1)c1cccc(OC)c1	10.1021/jm700957j
	CHEMBL279401	98463	0	None	-39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	312	8	1	3	3.8	CCCC(=O)NCCN(c1ccccc1)c1cccc(OC)c1	10.1021/jm700957j
	44429448	87319	0	None	-7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233729	87319	0	None	-7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	49865319	15720	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NCC(C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223193	15720	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NCC(C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	10704399	21307	0	None	-8	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	225	2	1	1	2.6	CC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL131602	21307	0	None	-8	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	225	2	1	1	2.6	CC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	11652196	137785	0	None	-9	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.2	CCCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	CHEMBL377101	137785	0	None	-9	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.2	CCCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	10495702	203524	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	317	8	2	4	2.3	CCC(=O)NCCc1c(OCCO)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL78751	203524	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	317	8	2	4	2.3	CCC(=O)NCCc1c(OCCO)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	10729569	116056	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL336333	116056	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	9840647	97769	0	None	-25	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL274317	97769	0	None	-25	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)Cc1ccccc1-2	10.1021/jm980684+
	44358276	118467	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL342393	118467	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	57781240	185406	0	None	-36	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	334	5	1	3	4.0	CC(=O)NCCC1CCc2ccc3nc(Cc4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4870108	185406	0	None	-36	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	334	5	1	3	4.0	CC(=O)NCCC1CCc2ccc3nc(Cc4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
	1350	1959	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm980684+
	4172142	1959	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm980684+
	CHEMBL10009	1959	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm980684+
	1350	1959	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm401343c
	4172142	1959	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm401343c
	CHEMBL10009	1959	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm401343c
	44348996	17025	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	272	6	1	3	2.8	CCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL125642	17025	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	272	6	1	3	2.8	CCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	127029516	137109	0	None	-6	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758225	137109	0	None	-6	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	23642307	158349	1	None	-8	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4095334	158349	1	None	-8	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	145976009	162980	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	541	15	3	4	7.0	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
	CHEMBL4202816	162980	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	541	15	3	4	7.0	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
	44272334	67293	0	None	-17	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	6	2	3	3.5	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL19050	67293	0	None	-17	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	6	2	3	3.5	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
	44272430	166379	0	None	-15	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	5	2	3	3.1	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL428692	166379	0	None	-15	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	5	2	3	3.1	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	11550834	139014	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.8	CCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	CHEMBL379616	139014	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.8	CCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	22718555	16412	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	6	1	3	3.7	CC(C)C(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123973	16412	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	6	1	3	3.7	CC(C)C(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	22718530	17765	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	294	5	1	3	3.6	CC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL126005	17765	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	294	5	1	3	3.6	CC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	19703063	28702	1	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
	CHEMBL137969	28702	1	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
	19703063	28702	1	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.ejmech.2016.01.008
	CHEMBL137969	28702	1	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.ejmech.2016.01.008
	1347	162	51	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10.1016/j.ejmech.2019.111847
	1864	162	51	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10.1016/j.ejmech.2019.111847
	CHEMBL127421	162	51	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10.1016/j.ejmech.2019.111847
	1353	3380	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	9998187	3380	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	CHEMBL33549	3380	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	1353	3380	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm401343c
	9998187	3380	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm401343c
	CHEMBL33549	3380	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm401343c
	25209861	174647	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	CHEMBL457138	174647	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	25210133	188970	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL514427	188970	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	44436051	150831	6	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL396132	150831	6	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	1353	3380	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm048956y
	9998187	3380	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm048956y
	CHEMBL33549	3380	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm048956y
	46885285	8083	0	None	-186	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	265	8	1	3	2.6	CCCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
	CHEMBL1091894	8083	0	None	-186	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	265	8	1	3	2.6	CCCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
	10657206	119184	2	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	2.2	CCC(=O)NCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
	CHEMBL34728	119184	2	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	2.2	CCC(=O)NCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
	10657206	119184	2	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	2.2	CCC(=O)NCc1cc2c(OC)cccc2[nH]1	10.1021/jm970721h
	CHEMBL34728	119184	2	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	2.2	CCC(=O)NCc1cc2c(OC)cccc2[nH]1	10.1021/jm970721h
	44264904	203909	0	None	-57	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	295	5	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL8169	203909	0	None	-57	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	295	5	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	25209861	174647	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	CHEMBL457138	174647	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	25210133	188970	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL514427	188970	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	16743295	92757	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	284	6	1	2	3.4	CCCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	CHEMBL244472	92757	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	284	6	1	2	3.4	CCCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	5151463	82920	12	None	-29	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.3	CC(=O)NCCC(c1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL219177	82920	12	None	-29	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.3	CC(=O)NCCC(c1ccccc1)c1ccccc1	10.1021/jm060850a
	10545399	203801	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	344	9	1	4	2.9	CCC(=O)NCCc1c(OCCN(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL80792	203801	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	344	9	1	4	2.9	CCC(=O)NCCc1c(OCCN(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	44394556	123706	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	402	8	1	3	5.1	O=C(N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1)C1CC1	10.1016/j.bmcl.2004.07.055
	CHEMBL363441	123706	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	402	8	1	3	5.1	O=C(N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1)C1CC1	10.1016/j.bmcl.2004.07.055
	56661512	64116	0	None	23	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	470	15	2	6	3.1	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813319	64116	0	None	23	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	470	15	2	6	3.1	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	10959837	205844	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	10	1	3	5.3	CCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL94919	205844	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	10	1	3	5.3	CCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	49865147	15654	2	None	-3	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccc(OC(C)CNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	CHEMBL1222983	15654	2	None	-3	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccc(OC(C)CNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	127025788	137242	0	None	-53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	300	3	2	3	3.2	CNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759372	137242	0	None	-53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	300	3	2	3	3.2	CNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	130400672	156454	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	204	2	2	2	1.4	CC(=O)NCC1CNc2ccccc2C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4073210	156454	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	204	2	2	2	1.4	CC(=O)NCC1CNc2ccccc2C1	10.1021/acs.jmedchem.8b00359
	10595585	98094	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCc2ccccc2-1	10.1021/jm980684+
	CHEMBL276490	98094	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCc2ccccc2-1	10.1021/jm980684+
	44349362	16397	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL123899	16397	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	46884553	8213	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1cccc(COc2ccc(OC)cc2CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092646	8213	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1cccc(COc2ccc(OC)cc2CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	910172	37496	23	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	252	3	0	3	3.4	O=c1ccc2ccc(OCc3ccccc3)cc2o1	10.1021/acs.jnatprod.7b00853
	CHEMBL145781	37496	23	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	252	3	0	3	3.4	O=c1ccc2ccc(OCc3ccccc3)cc2o1	10.1021/acs.jnatprod.7b00853
	145965883	163530	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	307	11	2	4	2.2	CC(=O)NCCN(C)c1cccc(OCCCCCCN)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4209446	163530	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	307	11	2	4	2.2	CC(=O)NCCN(C)c1cccc(OCCCCCCN)c1	10.1021/acs.jmedchem.8b00893
	122188236	122637	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612468	122637	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	122188237	122638	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612469	122638	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	10712600	4292	0	None	-48	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL10110	4292	0	None	-48	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
	11602301	76348	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCCC1)cn2C	10.1021/jm0512544
	CHEMBL206471	76348	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCCC1)cn2C	10.1021/jm0512544
	10950593	111033	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	459	6	1	3	5.7	COc1ccc2oc(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL327864	111033	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	459	6	1	3	5.7	COc1ccc2oc(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	164946945	189635	1	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5174929	189635	1	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	49865378	15759	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223281	15759	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	11501012	76889	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	340	5	1	3	3.9	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCCC1)cn2C	10.1021/jm0512544
	CHEMBL207959	76889	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	340	5	1	3	3.9	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCCC1)cn2C	10.1021/jm0512544
	49865203	15673	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223049	15673	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	122188226	122628	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	263	4	3	3	1.7	CCNC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612457	122628	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	263	4	3	3	1.7	CCNC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	11616210	138928	0	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	4	1	3	2.7	COc1ccc2c(c1)c(C1(CNC(C)=O)CCC1)cn2C	10.1021/jm0512544
	CHEMBL379413	138928	0	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	4	1	3	2.7	COc1ccc2c(c1)c(C1(CNC(C)=O)CCC1)cn2C	10.1021/jm0512544
	44347098	16239	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	344	5	1	4	2.7	CCCCC(=O)n1c(OC)cc2c1=C(CN)C1CCCCC(C)C1C=2	10.1021/jm970721h
	CHEMBL123119	16239	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	344	5	1	4	2.7	CCCCC(=O)n1c(OC)cc2c1=C(CN)C1CCCCC(C)C1C=2	10.1021/jm970721h
	CHEMBL3109561	209343	0	None	6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		COc1ccc(C2=[N+]3C(=Cc4c(CCNC(C)=O)c5cc(OC)ccc5n4[B-]3(F)F)C=C2)cc1	10.1021/ml4004155
	11065731	101411	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc([N+](=O)[O-])c2[nH]cc(CCNC(C)=O)c2c1	10.1021/jm011053+
	CHEMBL300729	101411	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc([N+](=O)[O-])c2[nH]cc(CCNC(C)=O)c2c1	10.1021/jm011053+
	44358035	29750	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL138848	29750	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	44579163	181547	0	None	-53	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	362	6	1	3	4.3	COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL478217	181547	0	None	-53	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	362	6	1	3	4.3	COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	44349329	18362	1	None	-13	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	7	2	3	3.0	CCCc1nc2cccc(CCCNC(=O)NCC)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL127565	18362	1	None	-13	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	7	2	3	3.0	CCCc1nc2cccc(CCCNC(=O)NCC)c2o1	10.1016/j.bmcl.2004.04.082
	11500596	138150	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	312	5	2	2	3.5	COc1ccc2[nH]cc(C3(CNC(=O)C4CCC4)CCC3)c2c1	10.1021/jm0512544
	CHEMBL377809	138150	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	312	5	2	2	3.5	COc1ccc2[nH]cc(C3(CNC(=O)C4CCC4)CCC3)c2c1	10.1021/jm0512544
	122188230	122631	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	277	4	2	3	1.8	CCNC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612461	122631	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	277	4	2	3	1.8	CCNC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	10424693	109155	1	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
	CHEMBL322339	109155	1	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
	127038129	136349	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
	CHEMBL3742090	136349	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
	86273226	120804	0	None	-5	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580908	120804	0	None	-5	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	145983929	165868	0	None	-6	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	4	1	3	2.8	COc1ccc2ccc3c(c2n1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4277185	165868	0	None	-6	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	4	1	3	2.8	COc1ccc2ccc3c(c2n1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	145993566	166817	0	None	-25	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4294790	166817	0	None	-25	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137642160	157847	0	None	-165	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	308	5	1	5	1.3	COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4089965	157847	0	None	-165	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	308	5	1	5	1.3	COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1	10.1016/j.ejmech.2016.12.013
	127038129	136349	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
	CHEMBL3742090	136349	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
	44272431	98401	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	274	4	2	3	2.7	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL278922	98401	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	274	4	2	3	2.7	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	16750569	86934	0	None	-14	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	338	6	2	2	3.4	CCCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233308	86934	0	None	-14	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	338	6	2	2	3.4	CCCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	9888609	8804	0	None	46	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO-K1 cells after 2 hrsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO-K1 cells after 2 hrs	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1039/C5MD00190K
	CHEMBL1097525	8804	0	None	46	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO-K1 cells after 2 hrsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO-K1 cells after 2 hrs	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1039/C5MD00190K
	9888609	8804	0	None	46	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm401343c
	CHEMBL1097525	8804	0	None	46	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm401343c
	24750070	153019	4	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	208	5	2	3	1.2	COc1cccc(NCCNC(C)=O)c1	10.1021/jm700957j
	CHEMBL398017	153019	4	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	208	5	2	3	1.2	COc1cccc(NCCNC(C)=O)c1	10.1021/jm700957j
	122188231	122632	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	247	3	2	2	1.8	CCNC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612462	122632	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	247	3	2	2	1.8	CCNC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	10882307	205741	0	None	-15	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	338	6	2	3	3.5	CNC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL94301	205741	0	None	-15	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	338	6	2	3	3.5	CNC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	49865318	15719	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223192	15719	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	11644612	77895	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	CHEMBL210791	77895	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	90666306	108895	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
	CHEMBL3219327	108895	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
	127025784	137208	0	None	-8	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759084	137208	0	None	-8	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
	10424693	109155	1	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
	CHEMBL322339	109155	1	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
	25209998	189150	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
	CHEMBL515856	189150	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
	49865206	15677	1	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223053	15677	1	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	122188349	122649	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	246	4	1	2	2.4	CCCN1c2ccccc2CCC1CNC(C)=O	10.1021/acs.jmedchem.5b01066
	CHEMBL3612606	122649	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	246	4	1	2	2.4	CCCN1c2ccccc2CCC1CNC(C)=O	10.1021/acs.jmedchem.5b01066
	25209998	189150	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
	CHEMBL515856	189150	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
	23658144	157634	1	None	-6	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4087633	157634	1	None	-6	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	10712733	206700	0	None	-48	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	5	1	3	3.9	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9997	206700	0	None	-48	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	5	1	3	3.9	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
	10399579	202285	0	None	-4	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	244	4	1	3	1.9	COc1ccc2nccc(CCNC(C)=O)c2c1	10.1016/S0960-894X(97)00392-2
	CHEMBL69521	202285	0	None	-4	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	244	4	1	3	1.9	COc1ccc2nccc(CCNC(C)=O)c2c1	10.1016/S0960-894X(97)00392-2
	12985489	189642	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL517502	189642	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	44349258	16736	1	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	261	5	2	3	2.4	CCNC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL125226	16736	1	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	261	5	2	3	2.4	CCNC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	10903463	206623	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1[nH]c2cccc(OC)c2c1Br	10.1021/jm001125h
	CHEMBL99502	206623	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1[nH]c2cccc(OC)c2c1Br	10.1021/jm001125h
	24750069	149950	0	None	-66	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	298	7	1	3	2.8	COc1cccc(N(CCNC(C)=O)Cc2ccccc2)c1	10.1021/jm700957j
	CHEMBL395437	149950	0	None	-66	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	298	7	1	3	2.8	COc1cccc(N(CCNC(C)=O)Cc2ccccc2)c1	10.1021/jm700957j
	12985491	186397	0	None	-91	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	411	6	1	2	5.1	COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL490595	186397	0	None	-91	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	411	6	1	2	5.1	COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	118712359	113651	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	350	3	1	4	3.4	O=C(CN1CCCC2Cc3cc4c(cc3C21)OCO4)Nc1ccccc1	10.1016/j.ejmech.2014.09.038
	CHEMBL3329376	113651	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	350	3	1	4	3.4	O=C(CN1CCCC2Cc3cc4c(cc3C21)OCO4)Nc1ccccc1	10.1016/j.ejmech.2014.09.038
	162649247	179495	0	None	-10	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
	CHEMBL4747996	179495	0	None	-10	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
	10738183	4311	0	None	-41	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL10124	4311	0	None	-41	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	1358	124	35	None	-870	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm401343c
	3976006	124	35	None	-870	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm401343c
	CHEMBL285718	124	35	None	-870	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm401343c
	22718661	16660	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)CC)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL124783	16660	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)CC)c2o1	10.1016/j.bmcl.2004.04.082
	168288029	191025	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5195595	191025	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	54582194	60433	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	330	6	1	5	2.2	COc1ccc2c(CN3CCCCC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760950	60433	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	330	6	1	5	2.2	COc1ccc2c(CN3CCCCC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	16094582	82901	5	None	-44	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.3	CC(=O)NCC=C(c1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL219076	82901	5	None	-44	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.3	CC(=O)NCC=C(c1ccccc1)c1ccccc1	10.1021/jm060850a
	10666373	97869	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL274995	97869	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	10737372	4564	0	None	-37	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL10293	4564	0	None	-37	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	52953165	62079	0	None	-218	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779810	62079	0	None	-218	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	320362	49459	42	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	230	3	0	3	3.1	CC(C)=CCOc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	CHEMBL156692	49459	42	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	230	3	0	3	3.1	CC(C)=CCOc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	10563168	119187	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	258	4	2	2	2.6	COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12	10.1021/jm001125h
	CHEMBL34729	119187	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	258	4	2	2	2.6	COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12	10.1021/jm001125h
	10563168	119187	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	258	4	2	2	2.6	COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12	10.1021/jm970721h
	CHEMBL34729	119187	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	258	4	2	2	2.6	COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12	10.1021/jm970721h
	16094577	83065	4	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.5	CCC(=O)NCC(Cc1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	CHEMBL220136	83065	4	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.5	CCC(=O)NCC(Cc1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	9818487	172961	0	None	-141	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	319	5	1	2	4.2	COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL453138	172961	0	None	-141	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	319	5	1	2	4.2	COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	9884156	206140	0	None	-77	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	3.9	C=CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL96548	206140	0	None	-77	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	3.9	C=CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	44429457	168785	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	350	7	1	3	4.3	CCCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL441916	168785	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	350	7	1	3	4.3	CCCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	49865265	15697	2	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1cccc(SCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223124	15697	2	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1cccc(SCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	162643514	181105	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2ncnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4776540	181105	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2ncnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
	11208632	122390	1	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	294	4	1	2	3.5	CCC(=O)NCCN1c2ccccc2CCc2ccccc21	10.1021/jm040768k
	CHEMBL360600	122390	1	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	294	4	1	2	3.5	CCC(=O)NCCN1c2ccccc2CCc2ccccc21	10.1021/jm040768k
	11277044	126081	1	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	263	2	1	1	3.3	CC(=O)NCC1=Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	CHEMBL365249	126081	1	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	263	2	1	1	3.3	CC(=O)NCC1=Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	16094588	136199	4	None	-208	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	311	8	1	2	4.1	CCCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	CHEMBL374075	136199	4	None	-208	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	311	8	1	2	4.1	CCCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	11046748	206199	0	None	-19	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	365	8	1	4	3.9	C=CC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL96916	206199	0	None	-19	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	365	8	1	4	3.9	C=CC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	162673916	182452	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	327	6	1	5	2.9	COc1ccc2[nH]cc(CCc3nn(CC4CCC4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	CHEMBL4793947	182452	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	327	6	1	5	2.9	COc1ccc2[nH]cc(CCc3nn(CC4CCC4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	162673578	182536	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	272	5	2	5	2.4	CNc1nnc(CCc2c[nH]c3ccc(OC)cc23)o1	10.1016/j.ejmech.2020.112090
	CHEMBL4794879	182536	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	272	5	2	5	2.4	CNc1nnc(CCc2c[nH]c3ccc(OC)cc23)o1	10.1016/j.ejmech.2020.112090
	45268318	194652	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	315	4	1	4	2.2	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCN(C)C1	10.1016/j.bmc.2009.04.068
	CHEMBL562328	194652	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	315	4	1	4	2.2	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCN(C)C1	10.1016/j.bmc.2009.04.068
	11109646	205343	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	2	3	3.4	CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(O)cc12	10.1021/jm0005252
	CHEMBL91813	205343	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	2	3	3.4	CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(O)cc12	10.1021/jm0005252
	122188224	122626	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	248	4	2	3	1.9	CCC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612455	122626	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	248	4	2	3	1.9	CCC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	53231366	62072	0	None	-66	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779804	62072	0	None	-66	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	11393103	125283	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.8	CCC(=O)NCCN1c2ccccc2C=Cc2ccc(OC)cc21	10.1021/jm040768k
	CHEMBL364806	125283	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.8	CCC(=O)NCCN1c2ccccc2C=Cc2ccc(OC)cc21	10.1021/jm040768k
	90666304	108893	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	401	7	2	3	4.6	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
	CHEMBL3219325	108893	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	401	7	2	3	4.6	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
	56678563	64118	0	None	14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	484	16	2	6	3.5	CC(=O)NCCN(C)c1cccc(OCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813320	64118	0	None	14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	484	16	2	6	3.5	CC(=O)NCCN(C)c1cccc(OCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	11529521	76406	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	298	5	2	2	3.1	COc1ccc2[nH]cc(C3(CNC(=O)C4CC4)CCC3)c2c1	10.1021/jm0512544
	CHEMBL206790	76406	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	298	5	2	2	3.1	COc1ccc2[nH]cc(C3(CNC(=O)C4CC4)CCC3)c2c1	10.1021/jm0512544
	122178508	120812	0	None	-8	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	4	1	4	2.3	COc1ccc2[nH]cc(CCc3nnco3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580917	120812	0	None	-8	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	4	1	4	2.3	COc1ccc2[nH]cc(CCc3nnco3)c2c1	10.1021/acs.jmedchem.5b00245
	137633839	156069	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4068922	156069	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
	137640743	156503	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2ccc(CCNC(C)=O)cc2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4073867	156503	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2ccc(CCNC(C)=O)cc2n1	10.1016/j.ejmech.2016.12.013
	16094586	82735	4	None	-213	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	311	6	1	3	3.3	COc1cccc(C(=CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm060850a
	CHEMBL218225	82735	4	None	-213	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	311	6	1	3	3.3	COc1cccc(C(=CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm060850a
	145968467	164237	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	400	13	2	5	4.0	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4218247	164237	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	400	13	2	5	4.0	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
	44429456	87501	0	None	-8	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	336	6	1	3	3.9	CCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233945	87501	0	None	-8	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	336	6	1	3	3.9	CCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	16743288	91895	0	None	-14	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	338	5	1	2	4.7	CCCC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
	CHEMBL243003	91895	0	None	-14	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	338	5	1	2	4.7	CCCC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
	11595087	76314	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	328	6	1	3	3.9	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
	CHEMBL206419	76314	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	328	6	1	3	3.9	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
	137645887	157397	0	None	-58	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4084568	157397	0	None	-58	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	1358	124	35	None	-870	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm800974d
	3976006	124	35	None	-870	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm800974d
	CHEMBL285718	124	35	None	-870	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm800974d
	44424020	84938	0	None	-7	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	676	20	4	8	5.8	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL226171	84938	0	None	-7	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	676	20	4	8	5.8	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	39847023	83981	1	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	330	9	1	3	4.9	COc1cc(/C=C/C(=O)O)ccc1OC/C=C(\C)CCC=C(C)C	10.1021/acs.jnatprod.7b00853
	CHEMBL221960	83981	1	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	330	9	1	3	4.9	COc1cc(/C=C/C(=O)O)ccc1OC/C=C(\C)CCC=C(C)C	10.1021/acs.jnatprod.7b00853
	20590665	123112	0	None	14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	9	1	2	5.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL361854	123112	0	None	14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	9	1	2	5.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	44358312	29608	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL138744	29608	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	145986330	166504	0	None	-15	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4289115	166504	0	None	-15	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
	18522272	65758	0	None	15	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	375	10	1	2	5.5	O=C(NCCCc1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
	CHEMBL183846	65758	0	None	15	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	375	10	1	2	5.5	O=C(NCCCc1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
	145972981	163943	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	513	13	3	4	6.2	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
	CHEMBL4214478	163943	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	513	13	3	4	6.2	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
	11507534	165580	0	None	-5	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	5	1	3	3.0	CCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	CHEMBL426127	165580	0	None	-5	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	5	1	3	3.0	CCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	11185529	3851	3	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm040768k
	7772	3851	3	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm040768k
	CHEMBL189449	3851	3	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm040768k
	127041168	136081	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3739674	136081	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
	11185529	3851	3	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm048956y
	7772	3851	3	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm048956y
	CHEMBL189449	3851	3	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm048956y
	127041168	136081	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3739674	136081	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
	10611901	23373	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	5	1	1	3.8	CCCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL133426	23373	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	5	1	1	3.8	CCCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	10801655	21175	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	265	4	1	1	3.4	O=C(NCCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
	CHEMBL131431	21175	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	265	4	1	1	3.4	O=C(NCCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
	10800029	116210	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL337295	116210	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	44358275	167888	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL435023	167888	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	22718564	16601	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	5	1	3	2.3	CCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124476	16601	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	5	1	3	2.3	CCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	44241665	194027	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	329	6	1	4	2.6	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	CHEMBL556908	194027	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	329	6	1	4	2.6	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	44426096	85309	0	None	-4	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	211	2	1	1	2.9	CC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	CHEMBL229015	85309	0	None	-4	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	211	2	1	1	2.9	CC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	10061064	102495	0	None	-7	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	258	5	1	3	2.3	CCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
	CHEMBL306468	102495	0	None	-7	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	258	5	1	3	2.3	CCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
	44389768	64212	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	426	9	2	2	5.5	CCNC(=O)NC[C@@H]1C[C@H]1c1c(Cl)ccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL181457	64212	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	426	9	2	2	5.5	CCNC(=O)NC[C@@H]1C[C@H]1c1c(Cl)ccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	22718654	112833	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.5	CCCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL331636	112833	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.5	CCCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	22718596	116870	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	7	1	3	4.3	CCCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL339784	116870	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	7	1	3	4.3	CCCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	137655435	158264	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1cnc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.12.013
	CHEMBL4094436	158264	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1cnc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.12.013
	12985495	180804	0	None	-213	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	377	8	2	3	4.5	CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	CHEMBL476341	180804	0	None	-213	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	377	8	2	3	4.5	CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	122162	2355	67	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm980684+
	1363	2355	67	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm980684+
	CHEMBL286615	2355	67	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm980684+
	44264706	202725	1	None	-33	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	270	5	2	3	3.8	CCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7215	202725	1	None	-33	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	270	5	2	3	3.8	CCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	44264689	203342	1	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	282	5	2	3	3.8	COc1cccc(Nc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL7713	203342	1	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	282	5	2	3	3.8	COc1cccc(Nc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	90666308	108897	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	7	2	3	3.8	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CC3)c2c1	10.1039/C1MD00149C
	CHEMBL3219329	108897	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	7	2	3	3.8	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CC3)c2c1	10.1039/C1MD00149C
	44429453	87113	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	322	6	2	2	3.9	CCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233517	87113	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	322	6	2	2	3.9	CCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	3964826	15678	30	None	-1	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccc(OCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223054	15678	30	None	-1	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccc(OCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	44412063	77235	0	None	2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	298	4	2	3	2.8	Cn1cc(C2(CNC(=O)C3CC3)CCC2)c2cc(O)ccc21	10.1021/jm0512544
	CHEMBL208802	77235	0	None	2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	298	4	2	3	2.8	Cn1cc(C2(CNC(=O)C3CC3)CCC2)c2cc(O)ccc21	10.1021/jm0512544
	137637541	155457	0	None	-269	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	CHEMBL4061850	155457	0	None	-269	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	9947753	203192	0	None	-83	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	285	6	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7599	203192	0	None	-83	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	285	6	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	44264949	203260	0	None	-83	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	299	7	1	3	4.6	CCCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7650	203260	0	None	-83	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	299	7	1	3	4.6	CCCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	145990308	166479	0	None	-20	3	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	5	2	2	3.8	CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4288690	166479	0	None	-20	3	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	5	2	2	3.8	CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	10567865	4114	0	None	-38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	CHEMBL100104	4114	0	None	-38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	10567865	4114	0	None	-38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	322	6	1	3	3.7	CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm970721h
	CHEMBL100104	4114	0	None	-38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	322	6	1	3	3.7	CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm970721h
	10639585	113965	0	None	-83	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
	CHEMBL33346	113965	0	None	-83	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
	10513751	162743	1	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1cccc2[nH]c(CCNC(C)=O)cc12	10.1021/jm001125h
	CHEMBL418789	162743	1	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1cccc2[nH]c(CCNC(C)=O)cc12	10.1021/jm001125h
	10639585	113965	0	None	-83	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm970721h
	CHEMBL33346	113965	0	None	-83	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm970721h
	10513751	162743	1	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1cccc2[nH]c(CCNC(C)=O)cc12	10.1021/jm970721h
	CHEMBL418789	162743	1	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1cccc2[nH]c(CCNC(C)=O)cc12	10.1021/jm970721h
	11310062	15752	2	None	-1	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223274	15752	2	None	-1	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	122188345	122645	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	334	5	1	2	3.9	O=C(NCC1CCc2ccccc2N1Cc1ccccc1)C1CCC1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612602	122645	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	334	5	1	2	3.9	O=C(NCC1CCc2ccccc2N1Cc1ccccc1)C1CCC1	10.1021/acs.jmedchem.5b01066
	10969292	206097	0	None	-7	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	2	4.3	CCc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL96333	206097	0	None	-7	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	2	4.3	CCc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	44424025	84750	0	None	1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	504	14	4	4	4.6	COc1ccc2[nH]cc(CCNC(=O)CCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL225302	84750	0	None	1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	504	14	4	4	4.6	COc1ccc2[nH]cc(CCNC(=O)CCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
	11680808	76726	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	5	2	2	3.1	CCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	CHEMBL207420	76726	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	5	2	2	3.1	CCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	1359	2139	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm800974d
	5311198	2139	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm800974d
	CHEMBL274438	2139	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm800974d
	1359	2139	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm048956y
	5311198	2139	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm048956y
	CHEMBL274438	2139	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm048956y
	1359	2139	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm980684+
	5311198	2139	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm980684+
	CHEMBL274438	2139	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm980684+
	1359	2139	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm401343c
	5311198	2139	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm401343c
	CHEMBL274438	2139	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm401343c
	10925526	111842	0	None	-26	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329299	111842	0	None	-26	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	44357899	118176	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL341705	118176	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	118712372	113653	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	308	2	1	2	3.4	CCNC(=O)N1CCCC2Cc3cc(Cl)c(OC)cc3C21	10.1016/j.ejmech.2014.09.038
	CHEMBL3329390	113653	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	308	2	1	2	3.4	CCNC(=O)N1CCCC2Cc3cc(Cl)c(OC)cc3C21	10.1016/j.ejmech.2014.09.038
	127040355	137387	0	None	-13	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3cc4ccccc4c4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3763537	137387	0	None	-13	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3cc4ccccc4c4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	16094580	81146	4	None	-11	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.0	COc1ccc(Cc2ccccc2)c(CCNC(C)=O)c1	10.1021/jm060850a
	CHEMBL216158	81146	4	None	-11	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.0	COc1ccc(Cc2ccccc2)c(CCNC(C)=O)c1	10.1021/jm060850a
	137657824	159250	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4105511	159250	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
	162668486	181992	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	377	8	1	5	3.7	COc1ccc2[nH]cc(CCc3nn(CCCc4ccccc4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	CHEMBL4787877	181992	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	377	8	1	5	3.7	COc1ccc2[nH]cc(CCc3nn(CCCc4ccccc4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	10893437	206707	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	348	6	1	3	4.1	COc1cccc2c1cc(CCNC(=O)C1CCC1)n2-c1ccccc1	10.1021/jm001125h
	CHEMBL99987	206707	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	348	6	1	3	4.1	COc1cccc2c1cc(CCNC(=O)C1CCC1)n2-c1ccccc1	10.1021/jm001125h
	16094591	82910	4	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.2	COc1cccc(C(CNC(C)=O)Cc2ccccc2)c1	10.1021/jm060850a
	CHEMBL219127	82910	4	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.2	COc1cccc(C(CNC(C)=O)Cc2ccccc2)c1	10.1021/jm060850a
	10948786	206065	0	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	375	7	1	4	4.6	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
	CHEMBL96173	206065	0	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	375	7	1	4	4.6	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
	44358231	26742	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136431	26742	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	145979585	165937	0	None	-17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	313	5	2	3	3.0	CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4278446	165937	0	None	-17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	313	5	2	3	3.0	CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	145991111	166359	0	None	-17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4286494	166359	0	None	-17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137645530	157181	0	None	-23	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	260	4	1	4	2.1	COC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4082097	157181	0	None	-23	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	260	4	1	4	2.1	COC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	11002840	205794	0	None	-33	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	357	6	1	3	4.4	COc1ccc2oc(Cc3cccc(Cl)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL94607	205794	0	None	-33	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	357	6	1	3	4.4	COc1ccc2oc(Cc3cccc(Cl)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	10616723	97853	0	None	-14	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	4	1	3	3.6	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCc2ccccc2-1	10.1021/jm980684+
	CHEMBL274842	97853	0	None	-14	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	4	1	3	3.6	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCc2ccccc2-1	10.1021/jm980684+
	44436051	150831	6	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1021/jm700957j
	CHEMBL396132	150831	6	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1021/jm700957j
	10384120	123872	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	363	10	1	2	5.5	CCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL363936	123872	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	363	10	1	2	5.5	CCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44317725	203958	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	329	9	1	3	4.1	CCCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	CHEMBL82135	203958	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	329	9	1	3	4.1	CCCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	11644612	77895	0	None	-9	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	CHEMBL210791	77895	0	None	-9	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	168288029	191025	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5195595	191025	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	49865269	15702	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223129	15702	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	56653479	110381	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3260986	110381	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	56653479	110381	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1021/jm401343c
	CHEMBL3260986	110381	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1021/jm401343c
	16750566	141500	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	662	19	4	8	5.4	COc1ccc2[nH]c(C(=O)OCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL387655	141500	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	662	19	4	8	5.4	COc1ccc2[nH]c(C(=O)OCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	56653479	110381	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3260986	110381	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	44424023	144281	0	None	-14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	346	9	2	4	3.2	CCCCCOC(=O)c1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2007.03.080
	CHEMBL390944	144281	0	None	-14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	346	9	2	4	3.2	CCCCCOC(=O)c1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2007.03.080
	49865323	15724	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223197	15724	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	10711649	206049	0	None	-19	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	5	1	2	4.3	CCCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9605	206049	0	None	-19	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	5	1	2	4.3	CCCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	16094576	137604	6	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.1	CC(=O)NCC(Cc1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL376693	137604	6	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.1	CC(=O)NCC(Cc1ccccc1)c1ccccc1	10.1021/jm060850a
	81689735	120811	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580916	120811	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3109560	209342	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		COc1ccc(/C=C/C2=[N+]3C(=Cc4c(CCNC(C)=O)c5cc(OC)ccc5n4[B-]3(F)F)C=C2)cc1	10.1021/ml4004155
	681	1437	65	None	-38	38	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	940	1437	65	None	-38	38	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	947	1437	65	None	-38	38	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	CHEMBL59	1437	65	None	-38	38	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	DB00988	1437	65	None	-38	38	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	11624018	140357	0	None	5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCC1)cn2C	10.1021/jm0512544
	CHEMBL382050	140357	0	None	5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCC1)cn2C	10.1021/jm0512544
	44412082	138749	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	5	2	3	3.2	CCCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	CHEMBL379096	138749	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	5	2	3	3.2	CCCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	127025781	137299	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759859	137299	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	127039218	137370	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1cc2c(CCNC(C)=O)coc2cn1	10.1016/j.ejmech.2016.01.008
	CHEMBL3763247	137370	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1cc2c(CCNC(C)=O)coc2cn1	10.1016/j.ejmech.2016.01.008
	56671858	64123	0	None	-20	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	COc1cccc(N(CCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813325	64123	0	None	-20	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	COc1cccc(N(CCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
	49865424	15783	0	None	-1	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223346	15783	0	None	-1	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	44349171	16476	1	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	275	6	2	3	2.6	CCNC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124217	16476	1	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	275	6	2	3	2.6	CCNC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	16743123	92644	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	270	5	1	2	3.0	CCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	CHEMBL244263	92644	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	270	5	1	2	3.0	CCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	11794657	206580	0	None	-23	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	5	1	3	4.7	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL9917	206580	0	None	-23	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	5	1	3	4.7	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	10567427	4175	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	316	4	1	2	3.7	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CC1	10.1021/jm980684+
	CHEMBL10043	4175	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	316	4	1	2	3.7	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CC1	10.1021/jm980684+
	24749950	3853	6	None	-588	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	10.1021/jm700957j
	7923	3853	6	None	-588	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	10.1021/jm700957j
	CHEMBL394676	3853	6	None	-588	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	10.1021/jm700957j
	9859693	73777	1	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	246	6	0	3	3.3	COc1cc(/C=C/C=O)ccc1OCC=C(C)C	10.1021/acs.jnatprod.7b00853
	CHEMBL2022666	73777	1	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	246	6	0	3	3.3	COc1cc(/C=C/C=O)ccc1OCC=C(C)C	10.1021/acs.jnatprod.7b00853
	10807560	206406	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	2	4.7	CCCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9815	206406	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	2	4.7	CCCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	122162	2355	67	None	-18	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1016/j.ejmech.2007.01.005
	1363	2355	67	None	-18	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1016/j.ejmech.2007.01.005
	CHEMBL286615	2355	67	None	-18	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1016/j.ejmech.2007.01.005
	10044270	188953	0	None	-891	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	1	2	4.8	COc1ccc2c(c1)[C@@H](CCNC(=O)C1CCC1)C[C@@H](c1ccccc1)C2	10.1021/jm800974d
	CHEMBL514280	188953	0	None	-891	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	1	2	4.8	COc1ccc2c(c1)[C@@H](CCNC(=O)C1CCC1)C[C@@H](c1ccccc1)C2	10.1021/jm800974d
	45270052	193722	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
	CHEMBL552002	193722	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
	137650611	156970	0	None	-26	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4079784	156970	0	None	-26	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	9970584	16592	0	None	-8	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124422	16592	0	None	-8	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	44317822	104397	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	315	8	1	3	3.7	CCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	CHEMBL311106	104397	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	315	8	1	3	3.7	CCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	45270052	193722	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
	CHEMBL552002	193722	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
	10938056	106575	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	393	11	1	3	5.7	CCCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL315653	106575	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	393	11	1	3	5.7	CCCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	11637615	76894	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	4	2	2	2.7	COc1ccc2[nH]cc(C3(CNC(C)=O)CCC3)c2c1	10.1021/jm0512544
	CHEMBL207960	76894	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	4	2	2	2.7	COc1ccc2[nH]cc(C3(CNC(C)=O)CCC3)c2c1	10.1021/jm0512544
	11681026	76787	0	None	-11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	302	6	1	3	3.4	CCCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	CHEMBL207745	76787	0	None	-11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	302	6	1	3	3.4	CCCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	49865270	15704	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(SC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223131	15704	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(SC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	11733059	111163	0	None	-21	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	449	7	1	3	4.1	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)CI)c2c1	10.1021/jm0005252
	CHEMBL328617	111163	0	None	-21	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	449	7	1	3	4.1	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)CI)c2c1	10.1021/jm0005252
	44429444	146198	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.2	COc1cc(C)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	CHEMBL392421	146198	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.2	COc1cc(C)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	9860588	19746	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
	CHEMBL130286	19746	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
	10522674	206026	0	None	-56	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	7	1	3	4.5	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL9590	206026	0	None	-56	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	7	1	3	4.5	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)Cc1ccccc1-2	10.1021/jm980684+
	11784134	106466	0	None	-67	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	4.7	COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL314947	106466	0	None	-67	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	4.7	COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	49865320	15721	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223194	15721	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	1354	3381	10	None	-275	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
	22133318	3381	10	None	-275	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
	CHEMBL490188	3381	10	None	-275	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
	44579115	181253	0	None	-162	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	348	6	2	3	4.2	CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	CHEMBL477835	181253	0	None	-162	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	348	6	2	3	4.2	CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	54583162	60437	0	None	-7	2	Human	5.1	pKi	=	5.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	276	6	2	5	0.9	CNCc1cn(CCNC(C)=O)c2nc(OC)ccc12	10.1016/j.bmcl.2011.02.097
	CHEMBL1760954	60437	0	None	-7	2	Human	5.1	pKi	=	5.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	276	6	2	5	0.9	CNCc1cn(CCNC(C)=O)c2nc(OC)ccc12	10.1016/j.bmcl.2011.02.097
	137653199	158077	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	218	2	1	2	1.4	CC(=O)NCC1Cc2ccccc2N(C)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4092308	158077	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	218	2	1	2	1.4	CC(=O)NCC1Cc2ccccc2N(C)C1	10.1021/acs.jmedchem.8b00359
	44424024	84749	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	522	16	2	6	5.6	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL225301	84749	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	522	16	2	6	5.6	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	10640625	206555	0	None	-46	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	336	7	1	3	3.8	CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
	CHEMBL99002	206555	0	None	-46	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	336	7	1	3	3.8	CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
	10640625	206555	0	None	-46	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	336	7	1	3	3.8	CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm970721h
	CHEMBL99002	206555	0	None	-46	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	336	7	1	3	3.8	CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm970721h
	44264707	96723	1	None	-19	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	256	4	2	3	3.4	COc1cccc(Nc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL268165	96723	1	None	-19	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	256	4	2	3	3.4	COc1cccc(Nc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	9859913	203819	0	None	-20	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	257	4	1	3	3.4	COc1cccc(Oc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL8094	203819	0	None	-20	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	257	4	1	3	3.4	COc1cccc(Oc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	9930390	206144	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	5.0	COc1ccc2oc(Cc3c(Cl)cccc3Cl)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL96562	206144	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	5.0	COc1ccc2oc(Cc3c(Cl)cccc3Cl)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	25209999	174945	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL457807	174945	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	25209999	174945	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL457807	174945	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	10104923	101030	2	None	-12	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	221	6	1	2	2.2	CCC(=O)NCCCc1cccc(OC)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL297947	101030	2	None	-12	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	221	6	1	2	2.2	CCC(=O)NCCCc1cccc(OC)c1	10.1016/j.bmcl.2010.02.084
	10609620	206568	1	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2cc(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
	CHEMBL99091	206568	1	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2cc(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
	10609620	206568	1	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2cc(CCNC(C)=O)[nH]c2c1	10.1021/jm970721h
	CHEMBL99091	206568	1	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2cc(CCNC(C)=O)[nH]c2c1	10.1021/jm970721h
	10946222	193073	0	None	-43	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	291	5	1	5	1.8	COc1ccc2c(c(CCNC(C)=O)cn2C)c1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL53622	193073	0	None	-43	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	291	5	1	5	1.8	COc1ccc2c(c(CCNC(C)=O)cn2C)c1[N+](=O)[O-]	10.1021/jm011053+
	11623375	138163	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	5	1	3	2.7	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
	CHEMBL377871	138163	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	5	1	3	2.7	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
	22718548	16324	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	6	1	3	4.2	CC(C)C(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123612	16324	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	6	1	3	4.2	CC(C)C(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	71540390	85991	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	235	4	1	3	1.7	COc1ccc(OC)c([C@@H]2C[C@H]2NC(C)=O)c1	10.1016/j.bmcl.2012.11.069
	CHEMBL2314263	85991	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	235	4	1	3	1.7	COc1ccc(OC)c([C@@H]2C[C@H]2NC(C)=O)c1	10.1016/j.bmcl.2012.11.069
	10518884	112062	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	308	5	1	3	3.3	COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1	10.1021/jm001125h
	CHEMBL329979	112062	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	308	5	1	3	3.3	COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1	10.1021/jm001125h
	10518884	112062	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	308	5	1	3	3.3	COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1	10.1021/jm970721h
	CHEMBL329979	112062	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	308	5	1	3	3.3	COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1	10.1021/jm970721h
	46885226	7989	0	None	-18620	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1ccc(OCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1091160	7989	0	None	-18620	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1ccc(OCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	76319554	85058	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	228	2	0	3	2.6	CCC#CCOc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	CHEMBL2268532	85058	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	228	2	0	3	2.6	CCC#CCOc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	137656978	159216	0	None	-147	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.1	CCC(=O)NC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4105125	159216	0	None	-147	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.1	CCC(=O)NC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	162644724	178814	0	None	-57	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	321	5	1	4	3.0	COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4739898	178814	0	None	-57	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	321	5	1	4	3.0	COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	46884554	8214	0	None	-128	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1cc(CCCNC(C)=O)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092647	8214	0	None	-128	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1cc(CCCNC(C)=O)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	44389864	64005	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	380	10	2	2	4.7	CCNC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL181192	64005	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	380	10	2	2	4.7	CCNC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	11165283	122616	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	392	9	2	2	4.8	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL361206	122616	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	392	9	2	2	4.8	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	22718561	17073	0	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.5	CCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL125665	17073	0	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.5	CCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
	52918080	60440	0	None	-13	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
	CHEMBL1760957	60440	0	None	-13	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
	127038130	136100	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3739824	136100	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
	127038132	136291	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3741561	136291	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
	145992795	166238	0	None	-29	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4284223	166238	0	None	-29	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	18007928	8577	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	485	12	2	4	5.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095504	8577	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	485	12	2	4	5.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	49865322	15723	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NCC(C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223196	15723	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NCC(C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	53238181	921	0	None	-741	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	7780	921	0	None	-741	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	CHEMBL1774519	921	0	None	-741	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	59145848	185485	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	3	1	3	2.5	CC(=O)NCCC1CCc2ccn3nc(C)c(C)c3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4871181	185485	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	3	1	3	2.5	CC(=O)NCCC1CCc2ccn3nc(C)c(C)c3c21	10.1021/acs.jmedchem.0c01836
	127038132	136291	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3741561	136291	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
	44424017	84899	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	592	14	4	8	3.4	COc1ccc2[nH]c(C(=O)OCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL226112	84899	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	592	14	4	8	3.4	COc1ccc2[nH]c(C(=O)OCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	21581653	137515	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1cc2c(CCNC(C)=O)c[nH]c2cn1	10.1016/j.ejmech.2016.01.008
	CHEMBL3765249	137515	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1cc2c(CCNC(C)=O)c[nH]c2cn1	10.1016/j.ejmech.2016.01.008
	25022429	187566	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4C[C@H]3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
	CHEMBL498493	187566	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4C[C@H]3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
	44349108	16685	0	None	-2	2	Human	8.0	pKi	=	8	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	6	1	3	2.7	CCCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124914	16685	0	None	-2	2	Human	8.0	pKi	=	8	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	6	1	3	2.7	CCCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	127025783	137213	0	None	-4	2	Human	8.0	pKi	=	8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759160	137213	0	None	-4	2	Human	8.0	pKi	=	8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
	137633385	155872	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human melatonin MT1 assessed as inhibition constantBinding affinity to human melatonin MT1 assessed as inhibition constant	ChEMBL	311	4	0	1	4.8	O=C(c1ccc(F)cc1)N(Cc1ccccc1)C1CCCCC1	10.1021/acs.jmedchem.1c01571
	CHEMBL4066660	155872	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human melatonin MT1 assessed as inhibition constantBinding affinity to human melatonin MT1 assessed as inhibition constant	ChEMBL	311	4	0	1	4.8	O=C(c1ccc(F)cc1)N(Cc1ccccc1)C1CCCCC1	10.1021/acs.jmedchem.1c01571
	CHEMBL5200484	155872	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human melatonin MT1 assessed as inhibition constantBinding affinity to human melatonin MT1 assessed as inhibition constant	ChEMBL	311	4	0	1	4.8	O=C(c1ccc(F)cc1)N(Cc1ccccc1)C1CCCCC1	10.1021/acs.jmedchem.1c01571
	1348	1815	1	None	-100	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10.1021/jm401343c
	44208891	1815	1	None	-100	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10.1021/jm401343c
	CHEMBL3260983	1815	1	None	-100	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10.1021/jm401343c
	54582195	60438	0	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760955	60438	0	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	16094583	165587	3	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	291	5	1	1	4.0	O=C(NCC=C(c1ccccc1)c1ccccc1)C1CCC1	10.1021/jm060850a
	CHEMBL426168	165587	3	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	291	5	1	1	4.0	O=C(NCC=C(c1ccccc1)c1ccccc1)C1CCC1	10.1021/jm060850a
	11418246	62074	0	None	-4	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	6	1	3	5.8	O=C(NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12)C1CCC1	10.1016/j.ejmech.2011.02.044
	CHEMBL1779806	62074	0	None	-4	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	6	1	3	5.8	O=C(NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12)C1CCC1	10.1016/j.ejmech.2011.02.044
	44264909	203523	0	None	-117	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	293	5	1	2	4.8	CCCC(=O)Nc1ccc(Cc2cccc3occc23)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7875	203523	0	None	-117	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	293	5	1	2	4.8	CCCC(=O)Nc1ccc(Cc2cccc3occc23)cc1	10.1016/j.bmcl.2003.11.030
	44264942	203733	0	None	-19	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	313	5	1	4	4.0	CCCC(=O)Nc1ccc(Oc2cccc3c2OCCO3)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL8032	203733	0	None	-19	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	313	5	1	4	4.0	CCCC(=O)Nc1ccc(Oc2cccc3c2OCCO3)cc1	10.1016/j.bmcl.2003.11.030
	10390684	11225	0	None	-4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	359	9	1	3	3.0	CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL1179488	11225	0	None	-4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	359	9	1	3	3.0	CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL78338	11225	0	None	-4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	359	9	1	3	3.0	CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	16094585	82477	0	None	-204	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL218065	82477	0	None	-204	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
	54583161	60436	0	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	452	8	1	6	3.4	COc1ccc2c(CN3CCC(C(=O)c4ccc(F)cc4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760953	60436	0	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	452	8	1	6	3.4	COc1ccc2c(CN3CCC(C(=O)c4ccc(F)cc4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	44429454	148683	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	336	7	2	2	4.3	CCCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL394408	148683	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	336	7	2	2	4.3	CCCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	44264962	203142	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	5	1	3	4.0	C/C=C/C(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7559	203142	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	5	1	3	4.0	C/C=C/C(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	18702059	203288	3	None	-7	2	Human	7.0	pKi	=	7	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	5	1	3	3.8	COc1cccc(Oc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL7673	203288	3	None	-7	2	Human	7.0	pKi	=	7	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	5	1	3	3.8	COc1cccc(Oc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	145979282	166122	0	None	-16	3	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	166122	0	None	-16	3	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	1357	2450	133	None	-1	8	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	1672	2450	133	None	-1	8	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	224	2450	133	None	-1	8	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	896	2450	133	None	-1	8	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	CHEMBL45	2450	133	None	-1	8	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	DB01065	2450	133	None	-1	8	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	198	310	120	125I-Iodomelatonin	-1	5	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	310	120	125I-Iodomelatonin	-1	5	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	310	120	125I-Iodomelatonin	-1	5	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	310	120	125I-Iodomelatonin	-1	5	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	310	120	125I-Iodomelatonin	-1	5	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Mel	-1	8	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Mel	-1	8	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Mel	-1	8	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Mel	-1	8	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Mel	-1	8	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Mel	-1	8	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1349	1819	0	125I-Iodomelatonin	-1	2	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
	5311134	1819	0	125I-Iodomelatonin	-1	2	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Mel	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Mel	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Mel	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Mel	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Mel	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Mel	-1	8	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	4004	214329	0	35S-GTPGammaS	-	1	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	330	9	0	8	2.1	CCOC(=O)CC(C(=O)OCC)SP(=S)(OC)OC	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	198	310	120	125I-Mel	-1	5	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	310	120	125I-Mel	-1	5	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	310	120	125I-Mel	-1	5	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	310	120	125I-Mel	-1	5	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	310	120	125I-Mel	-1	5	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	198	310	120	125I-Iodomelatonin	-1	5	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	310	120	125I-Iodomelatonin	-1	5	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	310	120	125I-Iodomelatonin	-1	5	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	310	120	125I-Iodomelatonin	-1	5	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	310	120	125I-Iodomelatonin	-1	5	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Mel	-1	8	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Mel	-1	8	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Mel	-1	8	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Mel	-1	8	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Mel	-1	8	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Mel	-1	8	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	198	310	120	None	-1	5	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	310	120	None	-1	5	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	310	120	None	-1	5	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	310	120	None	-1	5	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	310	120	None	-1	5	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	1356	3236	98	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	208902	3236	98	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	2355	3236	98	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	CHEMBL1218	3236	98	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	DB00980	3236	98	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	5	139	66	125I-Mel	-23442	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	125I-Mel	-23442	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	125I-Mel	-23442	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	125I-Mel	-23442	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	141	116	125I-Iodomelatonin	-14791	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	125I-Iodomelatonin	-14791	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	125I-Iodomelatonin	-14791	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	4209	3114	71	125I-Mel	-63095	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	4893	3114	71	125I-Mel	-63095	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	503	3114	71	125I-Mel	-63095	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	5385	3114	71	125I-Mel	-63095	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	CHEMBL2	3114	71	125I-Mel	-63095	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	DB00457	3114	71	125I-Mel	-63095	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	122162	2355	67	125I-Iodomelatonin	-18	2	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1363	2355	67	125I-Iodomelatonin	-18	2	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	CHEMBL286615	2355	67	125I-Iodomelatonin	-18	2	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	70547	112844	72	125I-Iodomelatonin	-10	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
	CHEMBL33171	112844	72	125I-Iodomelatonin	-10	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
	1349	1819	0	125I-Iodomelatonin	-1	2	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
	5311134	1819	0	125I-Iodomelatonin	-1	2	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
	164157684	214332	0	125I-Iodomelatonin	-60	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	1094	24	4	18	8.7	CC(C)(C)OC(=O)N(C)CC(CN(C)C(=O)OC(C)(C)C)CSP(=O)(O)O.CNCC(CNC)CSP(=O)(OCOC(=O)C1=CC=CC=C1)OCOC(=O)C2=CC=CC=C2.C1=CC=C(C=C1)C(=O)OCCl	None
	903	112402	83	125I-Iodomelatonin	1	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
	CHEMBL33103	112402	83	125I-Iodomelatonin	1	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
	122162	2355	67	125I-Iodomelatonin	-18	2	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1363	2355	67	125I-Iodomelatonin	-18	2	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	CHEMBL286615	2355	67	125I-Iodomelatonin	-18	2	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2450	133	125I-Iodomelatonin	-1	8	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Iodomelatonin	-1	8	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Iodomelatonin	-1	8	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Iodomelatonin	-1	8	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Iodomelatonin	-1	8	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Iodomelatonin	-1	8	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1358	124	35	125I-Iodomelatonin	-870	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
	3976006	124	35	125I-Iodomelatonin	-870	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
	CHEMBL285718	124	35	125I-Iodomelatonin	-870	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
	None	214328	0	125I-Iodomelatonin	-1	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	218	2	2	4	1.5	CC(=O)N1C=C(C2=C1C=CC(=C2)O)CCN	None
	None	214328	0	35S-GTPGammaS	-1	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	218	2	2	4	1.5	CC(=O)N1C=C(C2=C1C=CC(=C2)O)CCN	None
	681	1437	65	None	-38	38	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1437	65	None	-38	38	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1437	65	None	-38	38	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1437	65	None	-38	38	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1437	65	None	-38	38	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	12835	214333	0	125I-Iodomelatonin	-6	2	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	191	3	2	2	1.7	COC1=CC2=C(C=C1)NC=C2CCO	None
	122162	2355	67	125I-Iodomelatonin	-18	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1363	2355	67	125I-Iodomelatonin	-18	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	CHEMBL286615	2355	67	125I-Iodomelatonin	-18	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1357	2450	133	125I-Mel	-1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	125I-Mel	-1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	125I-Mel	-1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	125I-Mel	-1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	125I-Mel	-1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	125I-Mel	-1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	903	112402	83	125I-Iodomelatonin	1	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
	CHEMBL33103	112402	83	125I-Iodomelatonin	1	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
	70547	112844	72	125I-Iodomelatonin	-10	2	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
	CHEMBL33171	112844	72	125I-Iodomelatonin	-10	2	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
	10220503	3699	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	4820	3699	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	7393	3699	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	CHEMBL2103822	3699	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	DB09071	3699	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	None	214328	0	125I-Mel	-1	2	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	218	2	2	4	1.5	CC(=O)N1C=C(C2=C1C=CC(=C2)O)CCN	None
	198	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	198	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	82148	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	82148	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	99	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	99	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	CHEMBL10878	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	CHEMBL10878	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	DB06594	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	DB06594	310	120	None	-1	5	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	24954989	1503	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	21568291
	7774	1503	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	21568291
	CHEMBL1802025	1503	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	21568291
	71533431	78	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	23265885
	7775	78	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	23265885
	CHEMBL2314259	78	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	23265885
	57381112	1388	0	None	20	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	22301214
	7776	1388	0	None	20	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	22301214
	CHEMBL1946221	1388	0	None	20	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	22301214
	115348	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
	115348	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
	1343	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
	1343	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
	CHEMBL289233	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
	CHEMBL289233	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
	DB08190	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
	DB08190	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
	1356	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	208902	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	2355	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	CHEMBL1218	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	DB00980	3236	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	11196	1955	0	None	-3	2	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	888	18	3	11	5.9	COc1ccc2c(n1)c(CCNC(=O)C)cn2CCNC(=O)CCCCCN1c2ccc(cc2C(/C/1=C\C=C\C1=[N+](CC)c2c(C1(C)C)cc(cc2)S(=O)(=O)O)(C)C)S(=O)(=O)[O-]	28493341
	154699456	1955	0	None	-3	2	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	888	18	3	11	5.9	COc1ccc2c(n1)c(CCNC(=O)C)cn2CCNC(=O)CCCCCN1c2ccc(cc2C(/C/1=C\C=C\C1=[N+](CC)c2c(C1(C)C)cc(cc2)S(=O)(=O)O)(C)C)S(=O)(=O)[O-]	28493341
	122162	2355	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10696085
	122162	2355	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	12764576
	122162	2355	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	2843633
	122162	2355	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9089668
	1363	2355	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10696085
	1363	2355	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	12764576
	1363	2355	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	2843633
	1363	2355	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9089668
	CHEMBL286615	2355	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10696085
	CHEMBL286615	2355	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	12764576
	CHEMBL286615	2355	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	2843633
	CHEMBL286615	2355	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9089668
	7773	3852	0	None	-12	2	Human	6.9	pKi	=	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	296	3	2	2	2.6	COc1ccc2c(c1)C(CNC(=O)N)Cc1c(C2)cccc1	17907131
	86277838	3852	0	None	-12	2	Human	6.9	pKi	=	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	296	3	2	2	2.6	COc1ccc2c(c1)C(CNC(=O)N)Cc1c(C2)cccc1	17907131
	11185529	3851	3	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	15293992
	11185529	3851	3	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	17907131
	7772	3851	3	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	15293992
	7772	3851	3	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	17907131
	CHEMBL189449	3851	3	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	15293992
	CHEMBL189449	3851	3	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	17907131
	1346	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	12764576
	1346	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	2991499
	1346	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9089668
	1346	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9618428
	1858	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	12764576
	1858	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	2991499
	1858	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9089668
	1858	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9618428
	CHEMBL34730	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	12764576
	CHEMBL34730	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	2991499
	CHEMBL34730	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9089668
	CHEMBL34730	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9618428
	24763223	214	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	22927210
	8289	214	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	22927210
	CHEMBL3260987	214	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	22927210
	1347	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10696085
	1347	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	2991499
	1347	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9089668
	1347	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9618428
	1864	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10696085
	1864	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	2991499
	1864	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9089668
	1864	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9618428
	CHEMBL127421	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10696085
	CHEMBL127421	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	2991499
	CHEMBL127421	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9089668
	CHEMBL127421	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9618428
	24750192	3854	10	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	18052314
	7777	3854	10	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	18052314
	CHEMBL237236	3854	10	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	18052314
	12324	3848	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	30126274
	145966622	3848	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	30126274
	CHEMBL4210086	3848	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	30126274
	7778	801	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	20444610
	9957516	801	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	20444610
	CHEMBL1094546	801	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	20444610
	1357	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	1357	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	1357	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	1672	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	1672	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	1672	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	224	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	224	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	224	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	896	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	896	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	896	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	CHEMBL45	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	CHEMBL45	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	CHEMBL45	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	DB01065	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	DB01065	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	DB01065	2450	133	None	-1	8	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	10220503	3699	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	4820	3699	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	7393	3699	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	CHEMBL2103822	3699	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	DB09071	3699	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	4004	214329	0	None	-	1	Human	8.0	pKi	None	8.0	Binding	NoneNone	Drug Central	330	9	0	8	2.1	CCOC(=O)CC(C(=O)OCC)SP(=S)(OC)OC	None
	1351	2363	15	None	-1	2	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	15302228
	219018	2363	15	None	-1	2	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	15302228
	CHEMBL4079759	2363	15	None	-1	2	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	15302228
	127856	3378	0	None	-3	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	4	1	1	3.3	O=C(C1CCC1)NCCc1cccc2c1cccc2	12764576
	1360	3378	0	None	-3	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	4	1	1	3.3	O=C(C1CCC1)NCCc1cccc2c1cccc2	12764576
	CHEMBL12296	3378	0	None	-3	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	4	1	1	3.3	O=C(C1CCC1)NCCc1cccc2c1cccc2	12764576
	1358	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	12764576
	1358	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9089668
	1358	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9737724
	3976006	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	12764576
	3976006	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9089668
	3976006	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9737724
	CHEMBL285718	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	12764576
	CHEMBL285718	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9089668
	CHEMBL285718	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9737724
	1348	1815	1	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10205014
	1348	1815	1	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	9089668
	44208891	1815	1	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10205014
	44208891	1815	1	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	9089668
	CHEMBL3260983	1815	1	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10205014
	CHEMBL3260983	1815	1	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	9089668
	1354	3381	10	None	-275	2	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	12764576
	22133318	3381	10	None	-275	2	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	12764576
	CHEMBL490188	3381	10	None	-275	2	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	12764576
	1359	2139	20	None	-125	2	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10737738
	5311198	2139	20	None	-125	2	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10737738
	CHEMBL274438	2139	20	None	-125	2	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10737738
	1353	3380	3	None	-112	2	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	12764576
	9998187	3380	3	None	-112	2	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	12764576
	CHEMBL33549	3380	3	None	-112	2	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	12764576
	10849065	137	8	None	4	2	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	11068946
	1345	137	8	None	4	2	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	11068946
	CHEMBL126809	137	8	None	4	2	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	11068946
	1361	3379	0	None	-1	2	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	4	1	2	3.1	CCc1ccc2c(c1)c(CCNC(=O)C)cs2	12764576
	9816339	3379	0	None	-1	2	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	4	1	2	3.1	CCc1ccc2c(c1)c(CCNC(=O)C)cs2	12764576
	1350	1959	0	None	-95	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10737738
	4172142	1959	0	None	-95	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10737738
	CHEMBL10009	1959	0	None	-95	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10737738
	1362	3382	18	None	39	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	9870523	3382	18	None	39	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	CHEMBL429392	3382	18	None	39	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	1355	3383	3	None	70	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	9806449	3383	3	None	70	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	CHEMBL14453	3383	3	None	70	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	1349	1819	0	None	-1	2	Human	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	10696085
	1349	1819	0	None	-1	2	Human	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	9618428
	5311134	1819	0	None	-1	2	Human	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	10696085
	5311134	1819	0	None	-1	2	Human	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	9618428

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)