GPCRdb

Ligand source activities (1 row/activity)

Potency
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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	11715531	88269	20	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	5	2	4	1.9	C=CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL236013	88269	20	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	5	2	4	1.9	C=CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	28400380	89487	4	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	5	2	3	2.0	CCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237945	89487	4	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	5	2	3	2.0	CCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11415838	135834	0	None	-1	2	Human	5.0	pEC50	=	5.0	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	316	2	1	4	2.6	Cc1sc(C2(C)OC(C(=O)O)=CC2=O)cc1Br	10.1021/jm070022x
	CHEMBL373484	135834	0	None	-1	2	Human	5.0	pEC50	=	5.0	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	316	2	1	4	2.6	Cc1sc(C2(C)OC(C(=O)O)=CC2=O)cc1Br	10.1021/jm070022x
	28400046	89380	2	None	32	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	1.8	CC(C)CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237737	89380	2	None	32	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	1.8	CC(C)CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	10198518	73190	23	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	231	2	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2C1CCCC1	10.1021/jm051099t
	CHEMBL201724	73190	23	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	231	2	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2C1CCCC1	10.1021/jm051099t
	24955646	57728	0	None	-186	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	310	5	1	4	2.9	CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	CHEMBL1672639	57728	0	None	-186	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	310	5	1	4	2.9	CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	1591	131	58	None	-33	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	6485181	131	58	None	-33	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	CHEMBL428730	131	58	None	-33	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	28400196	89821	18	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	7	1	4	2.9	CCCN(CCC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238376	89821	18	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	7	1	4	2.9	CCCN(CCC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	44433532	151877	0	None	-16	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	2	2	4	0.3	CCc1[nH]nc(-c2nnn[nH]2)c1F	10.1016/j.bmcl.2007.07.101
	CHEMBL397055	151877	0	None	-16	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	2	2	4	0.3	CCc1[nH]nc(-c2nnn[nH]2)c1F	10.1016/j.bmcl.2007.07.101
	11219885	83049	0	None	-3	2	Human	4.9	pEC50	=	4.9	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	286	2	1	3	2.5	CC1(c2cccc(C(F)(F)F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL220001	83049	0	None	-3	2	Human	4.9	pEC50	=	4.9	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	286	2	1	3	2.5	CC1(c2cccc(C(F)(F)F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	15604642	74904	0	None	-323	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	250	3	2	4	0.8	CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036948	74904	0	None	-323	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	250	3	2	4	0.8	CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	43131474	151109	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	4	2	3	2.2	CC(C)C(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL396382	151109	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	4	2	3	2.2	CC(C)C(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11961288	195035	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	313	6	2	4	3.4	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccsc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL564914	195035	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	313	6	2	4	3.4	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccsc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	15604637	74910	0	None	-70	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	4	2	4	0.9	O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036955	74910	0	None	-70	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	4	2	4	0.9	O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	11380943	83046	1	None	-20	2	Human	4.9	pEC50	=	4.9	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL219980	83046	1	None	-20	2	Human	4.9	pEC50	=	4.9	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	45269912	194236	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2ccsc2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL559204	194236	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2ccsc2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11687485	89618	4	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	254	6	2	5	1.7	COCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238164	89618	4	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	254	6	2	5	1.7	COCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11483496	126	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	1589	126	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	CHEMBL375493	126	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	11483496	126	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1589	126	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL375493	126	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	28400406	89488	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	6	2	3	2.4	CCCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237946	89488	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	6	2	3	2.4	CCCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11528819	144973	20	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	2	4	2.5	CCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL391473	144973	20	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	2	4	2.5	CCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	2829816	88319	50	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	6	2	4	2.5	CCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL236219	88319	50	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	6	2	4	2.5	CCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	17965902	89384	3	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	242	3	2	3	2.0	O=C(O)c1ccc(NC(=O)c2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237739	89384	3	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	242	3	2	3	2.0	O=C(O)c1ccc(NC(=O)c2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	11379903	83855	0	None	-6	2	Human	4.8	pEC50	=	4.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	83855	0	None	-6	2	Human	4.8	pEC50	=	4.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43271548	89825	2	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	1	3	1.6	CCCN(C)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL238387	89825	2	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	1	3	1.6	CCCN(C)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11379903	83855	0	None	-6	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	83855	0	None	-6	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11379903	83855	0	None	-6	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm800896z
	CHEMBL221282	83855	0	None	-6	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm800896z
	11436345	143	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1599	143	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL424938	143	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	11218626	84468	0	None	1	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1csc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	CHEMBL223623	84468	0	None	1	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1csc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	13153555	93430	21	None	-42	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	5	2	2	1.8	CCCCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.07.101
	CHEMBL247921	93430	21	None	-42	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	5	2	2	1.8	CCCCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.07.101
	15605571	74885	2	None	-23	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036813	74885	2	None	-23	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	11470798	137440	1	None	-2	2	Human	4.7	pEC50	=	4.7	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)c(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL376419	137440	1	None	-2	2	Human	4.7	pEC50	=	4.7	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)c(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	283475	89375	111	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	3	2	4	1.3	CNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL237731	89375	111	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	3	2	4	1.3	CNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11528793	88274	4	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	236	4	2	4	2.3	O=C(O)c1ccc(NC2CCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL236028	88274	4	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	236	4	2	4	2.3	O=C(O)c1ccc(NC2CCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	10263467	140363	2	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	4	1	5	1.3	COCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL382096	140363	2	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	4	1	5	1.3	COCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	2776549	73044	76	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	177	1	1	4	0.7	Cn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL201513	73044	76	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	177	1	1	4	0.7	Cn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	3684804	89819	44	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	3	1	4	1.4	CN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238374	89819	44	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	3	1	4	1.4	CN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11322738	136243	1	None	-13	2	Human	4.7	pEC50	=	4.7	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	252	2	1	3	2.1	CC1(c2cccc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL374111	136243	1	None	-13	2	Human	4.7	pEC50	=	4.7	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	252	2	1	3	2.1	CC1(c2cccc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	3729086	145064	54	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	4	2	4	1.7	CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL391547	145064	54	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	4	2	4	1.7	CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	10465474	139927	20	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	203	2	1	4	1.5	O=C(O)c1ccc2c(c1)nnn2C1CC1	10.1021/jm051099t
	CHEMBL380939	139927	20	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	203	2	1	4	1.5	O=C(O)c1ccc2c(c1)nnn2C1CC1	10.1021/jm051099t
	11322761	141074	1	None	-1	2	Human	4.6	pEC50	=	4.6	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)cc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL385103	141074	1	None	-1	2	Human	4.6	pEC50	=	4.6	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)cc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	3824366	89078	52	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	258	4	2	4	3.0	O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	3953363	89078	52	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	258	4	2	4	3.0	O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL237296	89078	52	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	258	4	2	4	3.0	O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	45269046	194713	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2cccs2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL562675	194713	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2cccs2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11708383	88091	33	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	4	2	4	2.1	CC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL235144	88091	33	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	4	2	4	2.1	CC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	10421571	73877	2	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	5	1	5	1.2	CCOCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202351	73877	2	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	5	1	5	1.2	CCOCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	10398515	134768	27	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	1	1	4	1.9	CC(C)(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL372727	134768	27	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	1	1	4	1.9	CC(C)(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	28400056	151691	1	None	74	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	5	2	3	2.4	CCC(CC)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL396879	151691	1	None	74	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	5	2	3	2.4	CCC(CC)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11276453	84452	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1ccc(C2(C)OC(C(=O)O)=CC2=O)s1	10.1021/jm070022x
	CHEMBL223566	84452	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1ccc(C2(C)OC(C(=O)O)=CC2=O)s1	10.1021/jm070022x
	11492560	88090	5	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	7	2	4	2.9	CCCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL235141	88090	5	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	7	2	4	2.9	CCCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	10014206	72694	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	5	1	4	2.3	CCCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL201048	72694	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	5	1	4	2.3	CCCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	11715556	120	36	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	10.1016/j.bmcl.2007.09.058
	5801	120	36	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	10.1016/j.bmcl.2007.09.058
	CHEMBL236011	120	36	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	10.1016/j.bmcl.2007.09.058
	44250176	1111	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	5800	1111	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	CHEMBL564300	1111	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	51346919	57538	5	None	-100	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	296	5	1	4	2.5	O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1671877	57538	5	None	-100	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	296	5	1	4	2.5	O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	1595	257	43	None	-4	2	Human	5.5	pEC50	=	5.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	51576	257	43	None	-4	2	Human	5.5	pEC50	=	5.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	CHEMBL278488	257	43	None	-4	2	Human	5.5	pEC50	=	5.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	10353934	132640	2	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	4	1	4	2.5	CCC(CC)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL370386	132640	2	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	4	1	4	2.5	CCC(CC)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	10422270	73025	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	251	5	1	5	1.9	CCSCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL201409	73025	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	251	5	1	5	1.9	CCSCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	4992776	89809	25	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.9	O=C(O)c1ccc(NC2CC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL238358	89809	25	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.9	O=C(O)c1ccc(NC2CC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	11565047	146685	24	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	250	4	2	4	2.6	O=C(O)c1ccc(NC2CCCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL392830	146685	24	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	250	4	2	4	2.6	O=C(O)c1ccc(NC2CCCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	2942936	149332	18	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	5	2	5	1.9	O=C(O)c1ccc(NCC2CCCO2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL394906	149332	18	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	5	2	5	1.9	O=C(O)c1ccc(NCC2CCCO2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	44434363	168405	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	286	4	2	4	2.5	O=C(O)c1ccc(NC(=O)c2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL439028	168405	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	286	4	2	4	2.5	O=C(O)c1ccc(NC(=O)c2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	10330955	168539	3	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	217	2	1	4	1.9	O=C(O)c1ccc2c(c1)nnn2C1CCC1	10.1021/jm051099t
	CHEMBL440041	168539	3	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	217	2	1	4	1.9	O=C(O)c1ccc2c(c1)nnn2C1CCC1	10.1021/jm051099t
	10398583	73621	12	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	221	4	1	5	0.8	COCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202157	73621	12	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	221	4	1	5	0.8	COCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	28400038	88181	31	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	3	2	3	1.4	O=C(O)c1ccc(NC2CC2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL235615	88181	31	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	3	2	3	1.4	O=C(O)c1ccc(NC2CC2)nc1	10.1016/j.bmcl.2007.09.058
	44433529	88108	0	None	5	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	CHEMBL235230	88108	0	None	5	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	2771812	89381	46	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	214	3	2	3	2.5	O=C(O)c1ccc(Nc2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237738	89381	46	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	214	3	2	3	2.5	O=C(O)c1ccc(Nc2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	43187344	89823	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	5	2	4	1.2	COCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL238385	89823	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	5	2	4	1.2	COCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11817645	84482	1	None	-12	2	Human	4.5	pEC50	=	4.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2cc(F)cc(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223700	84482	1	None	-12	2	Human	4.5	pEC50	=	4.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2cc(F)cc(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	10013684	73681	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	3	1	4	2.1	CCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202206	73681	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	3	1	4	2.1	CCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	4712703	140691	36	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	204	2	1	3	2.3	CC(C)n1cnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL382863	140691	36	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	204	2	1	3	2.3	CC(C)n1cnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	44433529	88108	0	None	5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	CHEMBL235230	88108	0	None	5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	11322762	137077	1	None	-5	2	Human	4.4	pEC50	=	4.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2c(F)cccc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375625	137077	1	None	-5	2	Human	4.4	pEC50	=	4.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2c(F)cccc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43085192	89001	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	5	2	4	2.7	CC(C)C(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL237077	89001	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	5	2	4	2.7	CC(C)C(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11483496	126	0	None	-14	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1589	126	0	None	-14	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL375493	126	0	None	-14	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	11311474	165229	0	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2ccc(Cl)s2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL424750	165229	0	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2ccc(Cl)s2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43187332	151688	2	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	2.0	CCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL396878	151688	2	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	2.0	CCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	1447952	89379	7	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	206	3	2	3	2.1	O=C(O)c1ccc(NC2CCCC2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237735	89379	7	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	206	3	2	3	2.1	O=C(O)c1ccc(NC2CCCC2)nc1	10.1016/j.bmcl.2007.09.058
	11744994	89376	23	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	166	3	2	3	1.2	CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237732	89376	23	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	166	3	2	3	1.2	CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	1597	1934	73	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm051099t
	2736690	1934	73	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm051099t
	CHEMBL381638	1934	73	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm051099t
	45268162	194565	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	235	6	2	3	1.7	O=C(O)c1cc(N(CC2CC2)CC2CC2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL561720	194565	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	235	6	2	3	1.7	O=C(O)c1cc(N(CC2CC2)CC2CC2)[nH]n1	10.1016/j.bmcl.2009.05.108
	28399894	148755	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2009.05.108
	CHEMBL394468	148755	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2009.05.108
	11324121	84243	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	CC1(c2cc(Br)cs2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL222472	84243	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	CC1(c2cc(Br)cs2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	776421	89498	100	None	-30	2	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL238002	89498	100	None	-30	2	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.07.101
	1595	257	43	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	51576	257	43	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	CHEMBL278488	257	43	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	1595	257	43	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	51576	257	43	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	CHEMBL278488	257	43	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	11183678	84348	1	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	224	2	1	4	1.5	CC1(c2ccsc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223140	84348	1	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	224	2	1	4	1.5	CC1(c2ccsc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	1595	257	43	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	51576	257	43	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	CHEMBL278488	257	43	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	11992587	193826	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	183	4	3	3	1.3	CCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	CHEMBL553415	193826	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	183	4	3	3	1.3	CCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	11148966	1102	4	None	4	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	1598	1102	4	None	4	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	CHEMBL436301	1102	4	None	4	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	11380943	83046	1	None	-20	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL219980	83046	1	None	-20	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11436345	143	0	None	-1	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1599	143	0	None	-1	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL424938	143	0	None	-1	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	9971057	73954	4	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	283	4	1	5	2.2	COc1cccc(Cn2nnc3cc(C(=O)O)ccc32)c1	10.1021/jm051099t
	CHEMBL202427	73954	4	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	283	4	1	5	2.2	COc1cccc(Cn2nnc3cc(C(=O)O)ccc32)c1	10.1021/jm051099t
	28399946	89377	7	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	4	2	3	1.6	CCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237733	89377	7	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	4	2	3	1.6	CCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11739420	84333	0	None	-12	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	344	2	1	3	2.1	CC1(c2cccc(I)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223013	84333	0	None	-12	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	344	2	1	3	2.1	CC1(c2cccc(I)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11413114	137094	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	208	2	1	3	1.4	CC1(C2=CCCC2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375754	137094	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	208	2	1	3	1.4	CC1(C2=CCCC2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43271417	89820	1	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCCN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238375	89820	1	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCCN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11992688	194066	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	335	8	2	3	3.4	O=C(O)c1cc(N(CCc2ccccc2)CCc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL557298	194066	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	335	8	2	3	3.4	O=C(O)c1cc(N(CCc2ccccc2)CCc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11514348	152555	5	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	6	2	4	2.9	CCC(CC)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL397616	152555	5	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	6	2	4	2.9	CCC(CC)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	4738197	150773	36	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	240	6	2	5	1.4	COCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL396073	150773	36	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	240	6	2	5	1.4	COCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	653819	140730	45	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	245	2	1	4	2.6	O=C(O)c1ccc2c(c1)nnn2C1CCCCC1	10.1021/jm051099t
	CHEMBL383099	140730	45	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	245	2	1	4	2.6	O=C(O)c1ccc2c(c1)nnn2C1CCCCC1	10.1021/jm051099t
	59343664	74906	0	None	-29	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	272	4	2	4	0.8	O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036951	74906	0	None	-29	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	272	4	2	4	0.8	O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	43187366	89824	3	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.4	O=C(O)c1ccc(NCC2CCCO2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL238386	89824	3	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.4	O=C(O)c1ccc(NCC2CCCO2)nc1	10.1016/j.bmcl.2007.09.058
	28400003	148757	31	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	3	2	3	1.6	CC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL394469	148757	31	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	3	2	3	1.6	CC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11184165	83041	0	None	-5	2	Human	5.2	pEC50	=	5.2	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	246	3	1	3	2.0	CCc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	CHEMBL219950	83041	0	None	-5	2	Human	5.2	pEC50	=	5.2	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	246	3	1	3	2.0	CCc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	2833647	149335	23	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCN(CC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL394907	149335	23	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCN(CC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	16775596	89181	3	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	6	1	3	2.4	CCCN(CCC)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237525	89181	3	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	6	1	3	2.4	CCCN(CCC)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	59304608	74909	0	None	-67	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	3	2	4	0.9	O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036954	74909	0	None	-67	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	3	2	4	0.9	O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	11992588	193778	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	197	5	3	3	1.7	CCCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	CHEMBL552399	193778	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	197	5	3	3	1.7	CCCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	11379903	83855	0	None	-6	2	Human	6.2	pEC50	=	6.2	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	83855	0	None	-6	2	Human	6.2	pEC50	=	6.2	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	10331019	74064	24	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	4	1	4	1.9	CCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202586	74064	24	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	4	1	4	1.9	CCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	28399894	148755	2	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL394468	148755	2	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	44434380	89180	18	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	192	3	2	3	1.7	O=C(O)c1ccc(NC2CCC2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237524	89180	18	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	192	3	2	3	1.7	O=C(O)c1ccc(NC2CCC2)nc1	10.1016/j.bmcl.2007.09.058
	44433528	146989	0	None	10	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	178	3	2	4	0.5	CCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL393064	146989	0	None	10	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	178	3	2	4	0.5	CCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	22271415	88096	46	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	152	2	2	3	0.8	CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL235168	88096	46	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	152	2	2	3	0.8	CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	10058774	74068	22	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	3	1	4	1.5	CCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202614	74068	22	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	3	1	4	1.5	CCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	44433530	146991	0	None	2	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	192	4	2	4	0.9	CCCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL393065	146991	0	None	2	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	192	4	2	4	0.9	CCCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	117629482	2781	133	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	1588	2781	133	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	1594	2781	133	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	2835	2781	133	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	938	2781	133	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	CHEMBL573	2781	133	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	DB00627	2781	133	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	11992592	194357	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	211	6	2	3	1.7	CCCN(CCC)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	CHEMBL560254	194357	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	211	6	2	3	1.7	CCCN(CCC)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	11992591	194596	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	307	6	2	3	3.3	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL561920	194596	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	307	6	2	3	3.3	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11992790	193522	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	343	6	2	3	3.6	O=C(O)c1cc(N(Cc2ccccc2F)Cc2ccccc2F)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL550563	193522	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	343	6	2	3	3.6	O=C(O)c1cc(N(Cc2ccccc2F)Cc2ccccc2F)[nH]n1	10.1016/j.bmcl.2009.05.108
	2103992	168560	38	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	191	2	1	4	1.1	CCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL440217	168560	38	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	191	2	1	4	1.1	CCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	45269904	195057	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	287	6	2	5	2.5	O=C(O)c1cc(N(Cc2ccoc2)Cc2ccoc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL565055	195057	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	287	6	2	5	2.5	O=C(O)c1cc(N(Cc2ccoc2)Cc2ccoc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11608532	72947	24	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	253	3	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2Cc1ccccc1	10.1021/jm051099t
	CHEMBL201278	72947	24	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	253	3	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2Cc1ccccc1	10.1021/jm051099t
	28400019	88138	7	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	5	2	4	0.8	COCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL235394	88138	7	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	5	2	4	0.8	COCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	56950369	3503	4	None	-47	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	8469	3503	4	None	-47	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	CHEMBL2036958	3503	4	None	-47	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	DB12433	3503	4	None	-47	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	11264843	137095	1	None	-1	2	Human	5.0	pEC50	=	5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	236	2	1	3	1.6	CC1(c2ccc(F)cc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375762	137095	1	None	-1	2	Human	5.0	pEC50	=	5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	236	2	1	3	1.6	CC1(c2ccc(F)cc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	1595	257	43	None	-4	2	Human	5.5	pIC50	=	5.5	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	51576	257	43	None	-4	2	Human	5.5	pIC50	=	5.5	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	CHEMBL278488	257	43	None	-4	2	Human	5.5	pIC50	=	5.5	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	117629482	2781	133	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	1588	2781	133	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	1594	2781	133	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	2835	2781	133	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	938	2781	133	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	CHEMBL573	2781	133	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	DB00627	2781	133	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	5798	1474	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	6923517	1474	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	9060	1474	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	CHEMBL292303	1474	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	DB03225	1474	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	5797	1447	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	6919011	1447	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	71567	1447	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	CHEMBL379630	1447	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	DB02556	1447	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	11367166	101	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCC[C@@H](CC(=O)O)O	19561068
	2933	101	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCC[C@@H](CC(=O)O)O	19561068
	117629482	2781	133	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	1588	2781	133	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	1594	2781	133	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	2835	2781	133	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	938	2781	133	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	CHEMBL573	2781	133	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	DB00627	2781	133	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	5796	67	70	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCCCC(C(=O)O)O	19561068
	94180	67	70	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCCCC(C(=O)O)O	19561068
	CHEMBL4447980	67	70	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCCCC(C(=O)O)O	19561068
	1152206	1412	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	5799	1412	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	6971244	1412	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	CHEMBL1233899	1412	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	1597	1934	73	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	16480258
	2736690	1934	73	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	16480258
	CHEMBL381638	1934	73	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	16480258
	12418	1448	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	166	3	2	2	0.7	C1=CC=C(C=C1)C[C@@H](C(=O)O)O	31120900
	444718	1448	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	166	3	2	2	0.7	C1=CC=C(C=C1)C[C@@H](C(=O)O)O	31120900
	DB02494	1448	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	166	3	2	2	0.7	C1=CC=C(C=C1)C[C@@H](C(=O)O)O	31120900
	11715556	120	36	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	17931863
	5801	120	36	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	17931863
	CHEMBL236011	120	36	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	17931863
	44250176	1111	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	19524438
	5800	1111	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	19524438
	CHEMBL564300	1111	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	19524438
	1595	257	43	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	1595	257	43	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	1595	257	43	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	1595	257	43	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	51576	257	43	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	51576	257	43	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	51576	257	43	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	51576	257	43	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	CHEMBL278488	257	43	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	CHEMBL278488	257	43	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	CHEMBL278488	257	43	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	CHEMBL278488	257	43	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	11148966	1102	4	None	4	2	Human	5.3	pEC50	None	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	17358052
	1598	1102	4	None	4	2	Human	5.3	pEC50	None	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	17358052
	CHEMBL436301	1102	4	None	4	2	Human	5.3	pEC50	None	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	17358052
	11436345	143	0	None	-1	2	Human	6.7	pEC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	1599	143	0	None	-1	2	Human	6.7	pEC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	CHEMBL424938	143	0	None	-1	2	Human	6.7	pEC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	53232	188040	92	None	1	5	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	None
	CHEMBL503	188040	92	None	1	5	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	None

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1595	257	43	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
	51576	257	43	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
	CHEMBL278488	257	43	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
	135899171	15994	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of radioligand from human GPR109BDisplacement of radioligand from human GPR109B	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	CHEMBL1224070	15994	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of radioligand from human GPR109BDisplacement of radioligand from human GPR109B	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108

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Main reference

Ligand source activities (1 row/activity)