Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
5ht1d_human 376 C-term A => V missense 2.659e-05 3 112824 0 nan 0.017
5ht1d_human 376 C-term A => T missense 8.852e-06 1 112966 0 nan 0.002
5ht1d_human 376 C-term A => S missense 8.852e-06 1 112966 0 nan 0.008
5ht1d_human 374 C-term R => Q missense 2.634e-05 3 113908 0 0.02 0.001
5ht1d_human 374 C-term R => W missense 0.001407 161 114454 2 0.0 0.001
5ht1d_human 372 C-term P => T missense 8.617e-06 1 116046 0 0.06 0.0
5ht1d_human 367 8.54x54 H8 F => S missense 8.457e-06 1 118248 0 0.0 0.997
5ht1d_human 366 8.53x53 H8 A => V missense 0.0001602 19 118598 0 0.0 0.997
5ht1d_human 366 8.53x53 H8 A => G missense 0.0001433 17 118598 0 0.0 0.996
5ht1d_human 366 8.53x53 H8 A => D missense 2.53e-05 3 118598 0 0.0 0.999
5ht1d_human 365 8.52x52 H8 Q => R missense 7.566e-05 9 118958 0 0.41 0.146
5ht1d_human 364 8.51x51 H8 R => Q missense 1.677e-05 2 119230 0 0.13 0.004 GP (contact)
5ht1d_human 364 8.51x51 H8 R => W missense 2.51e-05 3 119518 0 0.0 0.614 GP (contact)
5ht1d_human 363 8.50x50 H8 F => C missense 8.35e-06 1 119754 0 0.0 0.998
5ht1d_human 359 7.56x56 TM7 F => S missense 8.287e-06 1 120668 0 0.28 0.997 GP (contact)
5ht1d_human 358 7.55x55 TM7 V => M missense 8.281e-06 1 120754 0 0.71 0.019 GP (contact)
5ht1d_human 353 7.50x50 TM7 P => L missense 3.302e-05 4 121128 0 0.0 1.0 SodiumPocket MicroSwitch
5ht1d_human 346 7.43x42 TM7 Y => C missense 8.245e-06 1 121286 0 0.0 1.0
5ht1d_human 345 7.42x41 TM7 G => V missense 8.244e-06 1 121298 0 0.0 1.0
5ht1d_human 342 7.39x38 TM7 T => S missense 8.242e-06 1 121326 0 0.01 0.998
5ht1d_human 335 7.32x31 TM7 P => L missense 8.239e-06 1 121368 0 0.18 0.65
5ht1d_human 335 7.32x31 TM7 P => S missense 1.648e-05 2 121370 0 0.36 0.513
5ht1d_human 331 ECL3 C => R missense 8.238e-06 1 121386 0 0.02 0.999
5ht1d_human 328 ECL3 R => Q missense 3.295e-05 4 121392 0 0.6 0.017
5ht1d_human 328 ECL3 R => W missense 2.471e-05 3 121392 0 0.0 0.863
5ht1d_human 324 6.58x58 TM6 L => F missense 8.237e-06 1 121402 0 0.04 0.791
5ht1d_human 323 6.57x57 TM6 V => I missense 2.471e-05 3 121402 0 0.42 0.094
5ht1d_human 319 6.53x53 TM6 V => M missense 4.119e-05 5 121400 0 0.0 0.924
5ht1d_human 319 6.53x53 TM6 V => L missense 1.647e-05 2 121400 0 0.2 0.478
5ht1d_human 319 6.53x53 TM6 V => L missense 8.237e-06 1 121400 0 0.2 0.478
5ht1d_human 318 6.52x52 TM6 F => V missense 2.471e-05 3 121404 0 0.0 0.999
5ht1d_human 318 6.52x52 TM6 F => L missense 8.237e-06 1 121404 0 0.0 0.996
5ht1d_human 309 6.43x43 TM6 A => T missense 8.237e-06 1 121406 0 0.11 1.0
5ht1d_human 307 6.41x41 TM6 L => P missense 8.237e-06 1 121406 0 0.0 1.0
5ht1d_human 297 6.31x31 TM6 R => S missense 8.237e-06 1 121406 0 0.0 0.742
5ht1d_human 297 6.31x31 TM6 R => G missense 8.237e-06 1 121402 0 0.01 0.848
5ht1d_human 296 6.30x30 TM6 E => A missense 8.237e-06 1 121402 0 0.0 0.999 SodiumPocket MicroSwitch
5ht1d_human 295 6.29x29 TM6 R => Q missense 8.237e-06 1 121402 0 0.0 0.999 GP (contact)
5ht1d_human 294 6.28x28 TM6 A => V missense 1.648e-05 2 121396 0 0.05 0.999 GP (contact)
5ht1d_human 293 6.27x27 TM6 A => V missense 0.0001071 13 121396 0 0.02 0.549
5ht1d_human 289 ICL3 K => N missense 4.943e-05 6 121394 0 0.1 0.825
5ht1d_human 289 ICL3 K => N missense 8.238e-06 1 121394 0 0.1 0.825
5ht1d_human 288 ICL3 R => H missense 3.295e-05 4 121392 0 0.01 1.0
5ht1d_human 288 ICL3 R => C missense 0.0002307 28 121390 0 0.0 1.0
5ht1d_human 285 ICL3 A => T missense 8.238e-06 1 121390 0 0.58 0.077
5ht1d_human 268 ICL3 A => S missense 8.24e-06 1 121356 0 0.85 0.01
5ht1d_human 267 ICL3 S => L missense 6.593e-05 8 121346 0 0.28 0.006
5ht1d_human 267 ICL3 S => P missense 1.648e-05 2 121352 0 0.18 0.006
5ht1d_human 266 ICL3 H => L missense 1.648e-05 2 121354 0 0.74 0.309
5ht1d_human 266 ICL3 H => R missense 8.24e-06 1 121354 0 0.6 0.309
5ht1d_human 266 ICL3 H => Y missense 8.24e-06 1 121358 0 1.0 0.664
5ht1d_human 265 ICL3 S => L missense 0.002571 312 121342 4 0.51 0.002
5ht1d_human 261 ICL3 H => Q missense 4.945e-05 6 121342 0 0.57 0.016
5ht1d_human 261 ICL3 H => R missense 8.241e-06 1 121344 0 0.57 0.243
5ht1d_human 257 ICL3 N => H missense 1.648e-05 2 121336 0 0.07 0.035
5ht1d_human 255 ICL3 S => W missense 1.649e-05 2 121318 0 0.01 1.0
5ht1d_human 255 ICL3 S => L missense 3.297e-05 4 121318 0 0.1 0.999
5ht1d_human 253 ICL3 L => F missense 8.244e-06 1 121302 0 0.36 0.186
5ht1d_human 252 ICL3 S => L missense 1.649e-05 2 121314 0 0.02 0.999
5ht1d_human 250 ICL3 G => V missense 1.649e-05 2 121310 0 0.01 0.788
5ht1d_human 250 ICL3 G => R missense 3.298e-05 4 121304 0 0.04 0.089
5ht1d_human 246 ICL3 T => I missense 8.244e-06 1 121304 0 0.06 0.112
5ht1d_human 246 ICL3 T => P missense 8.244e-06 1 121300 0 0.3 0.004
5ht1d_human 243 ICL3 H => N missense 8.245e-06 1 121288 0 0.07 0.111
5ht1d_human 242 ICL3 A => S missense 8.245e-06 1 121286 0 0.16 0.999
5ht1d_human 241 ICL3 T => M missense 0.0003216 39 121270 0 0.03 0.99
5ht1d_human 238 ICL3 R => H missense 4.948e-05 6 121262 0 0.01 0.141
5ht1d_human 238 ICL3 R => C missense 8.248e-06 1 121244 0 0.0 0.976
5ht1d_human 235 ICL3 Y => C missense 8.247e-06 1 121256 0 0.15 0.006 PTM (Phosphorylation)
5ht1d_human 234 ICL3 L => R missense 2.474e-05 3 121256 0 0.66 0.588
5ht1d_human 227 5.68x68 TM5 R => H missense 0.001279 155 121194 3 0.03 0.056 GP (contact)
5ht1d_human 225 5.66x66 TM5 R => Q missense 7.426e-05 9 121200 0 0.13 0.104 GP (contact)
5ht1d_human 225 5.66x66 TM5 R => W missense 9.077e-05 11 121188 0 0.0 0.961 GP (contact)
5ht1d_human 224 5.65x65 TM5 A => S missense 6.6e-05 8 121220 0 0.03 0.999 GP (contact)
5ht1d_human 222 5.63x63 TM5 R => Q missense 1.65e-05 2 121194 0 0.64 0.096
5ht1d_human 222 5.63x63 TM5 R => W missense 8.251e-05 10 121198 0 0.15 0.533
5ht1d_human 219 5.60x60 TM5 R => Q missense 2.475e-05 3 121222 0 0.0 0.036
5ht1d_human 219 5.60x60 TM5 R => W missense 4.95e-05 6 121202 0 0.0 0.888
5ht1d_human 217 5.58x58 TM5 Y => C missense 2.475e-05 3 121222 0 0.01 0.086 SodiumPocket MicroSwitch
5ht1d_human 214 5.55x55 TM5 I => V missense 8.25e-06 1 121210 0 0.2 0.009
5ht1d_human 210 5.51x51 TM5 S => L missense 8.253e-06 1 121172 0 1.0 0.269
5ht1d_human 208 5.49x49 TM5 I => V missense 0.0001403 17 121200 0 0.13 0.033
5ht1d_human 201 5.42x43 TM5 S => Y missense 0.0006937 84 121084 1 0.0 0.959
5ht1d_human 199 5.40x41 TM5 I => T missense 1.652e-05 2 121066 1 0.0 0.486
5ht1d_human 198 5.39x40 TM5 T => I missense 8.261e-06 1 121056 0 0.0 0.999
5ht1d_human 192 ECL2 T => I missense 8.268e-06 1 120942 0 0.07 0.999
5ht1d_human 190 45.52x52 ECL2 V => A missense 8.277e-06 1 120814 0 0.0 0.876
5ht1d_human 190 45.52x52 ECL2 V => M missense 1.655e-05 2 120854 1 0.02 0.978
5ht1d_human 186 ECL2 S => L missense 3.311e-05 4 120796 0 0.2 0.006
5ht1d_human 186 ECL2 S => A missense 1.655e-05 2 120832 0 0.63 0.003
5ht1d_human 177 ECL2 R => Q missense 3.311e-05 4 120804 0 0.04 0.99
5ht1d_human 177 ECL2 R => W missense 6.62e-05 8 120838 0 0.0 0.998
5ht1d_human 173 4.60x60 TM4 P => L missense 4.135e-05 5 120920 0 0.0 0.733
5ht1d_human 169 4.56x56 TM4 I => L missense 8.26e-06 1 121062 0 0.0 0.994
5ht1d_human 168 4.55x55 TM4 C => Y missense 3.304e-05 4 121062 0 0.06 0.819
5ht1d_human 166 4.53x53 TM4 S => F missense 1.651e-05 2 121114 0 0.0 0.999
5ht1d_human 166 4.53x53 TM4 S => P missense 8.257e-06 1 121110 0 0.01 0.999
5ht1d_human 165 4.52x52 TM4 I => T missense 8.256e-06 1 121124 0 0.0 0.646
5ht1d_human 161 4.48x48 TM4 I => T missense 8.256e-06 1 121128 0 0.54 0.004
5ht1d_human 160 4.47x47 TM4 A => V missense 8.255e-06 1 121136 0 0.06 0.055
5ht1d_human 160 4.47x47 TM4 A => T missense 1.651e-05 2 121116 0 0.18 0.035
5ht1d_human 158 4.45x45 TM4 M => V missense 8.255e-06 1 121144 0 0.02 0.989
5ht1d_human 157 4.44x44 TM4 T => I missense 2.477e-05 3 121122 0 1.0 0.001
5ht1d_human 157 4.44x44 TM4 T => N missense 7.431e-05 9 121122 0 0.06 0.131
5ht1d_human 156 4.43x43 TM4 A => G missense 8.256e-06 1 121126 0 0.51 0.002
5ht1d_human 155 4.42x42 TM4 A => V missense 8.256e-06 1 121124 0 0.02 0.208
5ht1d_human 155 4.42x42 TM4 A => T missense 3.303e-05 4 121106 0 0.0 0.913
5ht1d_human 154 4.41x41 TM4 H => Y missense 3.302e-05 4 121126 0 0.0 0.545
5ht1d_human 152 4.39x39 TM4 A => S missense 0.0004211 51 121122 0 0.19 0.226
5ht1d_human 152 4.39x39 TM4 A => T missense 8.256e-06 1 121122 0 0.15 0.014
5ht1d_human 151 4.38x38 TM4 T => M missense 0.0001156 14 121130 0 0.0 1.0
5ht1d_human 149 34.56x56 ICL2 R => H missense 1.651e-05 2 121104 0 0.07 0.061 GP (contact)
5ht1d_human 149 34.56x56 ICL2 R => C missense 4.953e-05 6 121142 0 0.03 0.976 GP (contact)
5ht1d_human 147 34.54x54 ICL2 S => G missense 1.651e-05 2 121158 0 0.02 0.345 PTM (Phosphorylation) GP (contact)
5ht1d_human 143 34.50x50 ICL2 A => V missense 8.252e-06 1 121184 0 0.0 0.999 GP (contact)
5ht1d_human 138 3.52x52 TM3 W => R missense 8.247e-06 1 121254 0 0.38 1.0
5ht1d_human 136 3.50x50 TM3 R => T missense 8.247e-06 1 121252 0 0.0 0.999 SodiumPocket MicroSwitch GP (contact)
5ht1d_human 134 3.48x48 TM3 L => V missense 1.649e-05 2 121284 0 0.02 0.999
5ht1d_human 133 3.47x47 TM3 A => V missense 8.244e-06 1 121302 0 0.0 0.999
5ht1d_human 130 3.44x44 TM3 C => Y missense 8.243e-06 1 121312 0 0.0 0.661
5ht1d_human 125 3.39x39 TM3 S => F missense 7.416e-05 9 121358 0 0.0 0.999
5ht1d_human 125 3.39x39 TM3 S => A missense 8.24e-06 1 121352 0 0.0 0.996
5ht1d_human 116 3.30x30 TM3 S => P missense 8.237e-06 1 121404 0 0.01 0.966
5ht1d_human 105 23.51x51 ECL1 N => K missense 8.236e-06 1 121412 0 0.15 0.002
5ht1d_human 105 23.51x51 ECL1 N => S missense 0.000173 21 121412 0 0.41 0.001
5ht1d_human 97 2.63x62 TM2 A => T missense 2.471e-05 3 121412 0 0.18 0.3
5ht1d_human 84 2.50x50 TM2 D => N missense 1.647e-05 2 121412 0 0.0 1.0
5ht1d_human 83 2.49x49 TM2 T => S missense 8.236e-06 1 121412 0 0.0 0.998
5ht1d_human 72 2.38x38 TM2 P => A missense 1.647e-05 2 121412 0 0.01 0.999
5ht1d_human 63 1.57x57 TM1 I => F missense 4.118e-05 5 121412 0 0.0 0.999
5ht1d_human 63 1.57x57 TM1 I => V missense 9.884e-05 12 121412 0 0.16 0.994
5ht1d_human 57 1.51x51 TM1 A => T missense 1.647e-05 2 121412 0 0.12 0.009
5ht1d_human 56 1.50x50 TM1 N => S missense 3.295e-05 4 121412 0 0.0 0.998
5ht1d_human 51 1.45x45 TM1 A => V missense 2.471e-05 3 121412 0 0.23 0.098
5ht1d_human 47 1.41x41 TM1 V => I missense 2.471e-05 3 121412 0 0.85 0.001
5ht1d_human 44 1.38x38 TM1 V => I missense 8.236e-06 1 121412 0 0.5 0.001
5ht1d_human 43 1.37x37 TM1 V => M missense 1.647e-05 2 121412 0 0.06 0.387
5ht1d_human 40 1.34x34 TM1 S => F missense 2.471e-05 3 121412 0 0.71 0.299
5ht1d_human 38 1.32x32 TM1 K => R missense 8.236e-06 1 121412 0 0.12 0.002
5ht1d_human 37 1.31x31 TM1 L => F missense 2.471e-05 3 121408 0 0.47 0.016
5ht1d_human 36 1.30x30 TM1 A => V missense 8.237e-06 1 121410 0 0.17 0.004
5ht1d_human 34 1.28x28 TM1 L => V missense 8.237e-06 1 121408 0 0.24 0.098
5ht1d_human 31 N-term P => S missense 3.295e-05 4 121406 0 0.48 0.05
5ht1d_human 28 N-term A => T missense 1.648e-05 2 121396 0 0.56 0.001
5ht1d_human 21 N-term N => K missense 8.239e-06 1 121372 0 0.03 0.309
5ht1d_human 17 N-term N => S missense 1.649e-05 2 121308 0 0.1 0.043
5ht1d_human 17 N-term N => T missense 8.243e-06 1 121308 0 0.03 0.345
5ht1d_human 17 N-term N => D missense 1.649e-05 2 121298 0 0.05 0.345
5ht1d_human 12 N-term P => L missense 8.265e-06 1 120994 0 nan 0.0
5ht1d_human 10 N-term G => S missense 8.291e-06 1 120612 0 nan 0.001
5ht1d_human 7 N-term S => P missense 8.322e-06 1 120160 0 0.04 0.765
5ht1d_human 376 C-term A => ProfsTer7 frameshift 8.863e-06 1 112824 0 None None
5ht1d_human 368 8.55x55 H8 Q => ArgfsTer15 frameshift 2.544e-05 3 117930 0 None None
5ht1d_human 274 ICL3 F => SerfsTer4 frameshift 8.24e-06 1 121352 0 None None
5ht1d_human 74 2.40x40 TM2 N => ThrfsTer3 frameshift 8.236e-06 1 121412 0 None None


Residue

Diagrams

R K L H ICL1ECL1 T W N F ECL1 A L E Y S K R R ICL2ECL2 R Q A K A Q E E M S D C L V N T S ECL2ICL3 L Y G K R F T T A H L I T G S A G S S L C S L N S S L H E G H S H S A G S P L F F N H V K I K L A D S A L E R K ICL3ECL3 C R D S C W I ECL3N-term M S P L N Q S A E G L P Q E A S N R S L N A T E T S E A W D P R T N-termC-term P F R K A S C-term L Q A L K I S L A V V L S V I T L A T V L S N A F V L T T I L L T T P A N Y L I G S L A T T D L L V S I L V M P I S I A Y T I T H G Q I L C D I W L S S D I T C C T A S I L H L C V I A L D R Y W A I T D T A G H A A T M I A I V W A I S I C I S I P P L F W Q I S Y T I Y S T C G A F Y I P S V L L I I L Y G R I Y R A A R N R I L N P P S R I S A A R E R K A T K I L G I I L G A F I I C W L P F F V V S L V L P I H P A L F D F F T W L G Y L N S L I N P I I Y T V F N E E F Q K F R Q A I V
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