Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
aa1r_human 3 N-term P => S missense 1.773e-05 2 112828 0 nan 0.002
aa1r_human 11 1.34x34 TM1 A => S missense 8.547e-06 1 117004 0 0.36 0.209
aa1r_human 14 1.37x37 TM1 G => S missense 2.524e-05 3 118836 0 0.59 0.002
aa1r_human 31 1.54x54 TM1 I => M missense 8.245e-06 1 121282 0 0.02 0.936
aa1r_human 39 12.49x49 ICL1 A => V missense 0.000239 29 121342 0 0.01 0.442
aa1r_human 46 2.41x41 TM2 C => R missense 8.24e-06 1 121366 0 0.04 0.654
aa1r_human 46 2.41x41 TM2 C => Y missense 1.648e-05 2 121366 0 1.0 0.011
aa1r_human 53 2.48x48 TM2 V => M missense 0.0006426 78 121382 0 0.03 0.588
aa1r_human 65 2.60x59 TM2 L => F missense 8.238e-06 1 121388 0 0.2 0.991
aa1r_human 71 2.66x65 TM2 I => T missense 8.238e-06 1 121392 0 0.03 0.355
aa1r_human 72 2.67x66 TM2 G => E missense 8.238e-06 1 121390 0 0.06 0.988
aa1r_human 74 23.51x51 ECL1 Q => H missense 3.295e-05 4 121394 0 0.21 0.008
aa1r_human 79 3.24x24 TM3 T => A missense 8.238e-06 1 121392 0 0.14 0.411
aa1r_human 85 3.30x30 TM3 C => G missense 4.12e-05 5 121372 0 0.0 0.996
aa1r_human 86 3.31x31 TM3 P => L missense 8.24e-06 1 121366 0 1.0 0.009
aa1r_human 93 3.38x38 TM3 S => I missense 8.249e-06 1 121228 0 0.0 0.994
aa1r_human 100 3.45x45 TM3 A => V missense 8.278e-06 1 120806 0 0.0 1.0
aa1r_human 110 3.55x55 TM3 K => R missense 8.52e-06 1 117374 0 0.02 0.246 GP (contact)
aa1r_human 113 34.51x51 ICL2 L => F missense 8.582e-06 1 116518 0 0.06 0.227 GP (contact)
aa1r_human 117 34.55x55 ICL2 M => I missense 8.896e-06 1 112404 0 0.22 0.0 GP (contact)
aa1r_human 118 34.56x56 ICL2 V => L missense 9.784e-05 11 112428 0 0.38 0.03 GP (contact)
aa1r_human 118 34.56x56 ICL2 V => M missense 8.895e-06 1 112428 0 0.01 0.292 GP (contact)
aa1r_human 122 4.40x40 TM4 R => W missense 8.998e-06 1 111130 0 0.0 0.883
aa1r_human 122 4.40x40 TM4 R => Q missense 8.983e-06 1 111326 0 0.06 0.02
aa1r_human 125 4.43x43 TM4 A => V missense 8.1e-05 9 111116 0 0.49 0.0
aa1r_human 130 4.48x48 TM4 G => S missense 1.796e-05 2 111350 0 0.02 0.313
aa1r_human 137 4.55x55 TM4 V => M missense 2.694e-05 3 111358 0 0.0 0.482
aa1r_human 137 4.55x55 TM4 V => L missense 8.98e-06 1 111358 0 1.0 0.006
aa1r_human 143 4.61x61 TM4 M => V missense 8.946e-06 1 111780 0 0.03 0.004
aa1r_human 143 4.61x61 TM4 M => I missense 8.944e-06 1 111806 0 0.01 0.029
aa1r_human 151 ECL2 A => V missense 6.226e-05 7 112426 0 0.21 0.002
aa1r_human 152 ECL2 V => M missense 1.771e-05 2 112938 0 0.2 0.004
aa1r_human 154 ECL2 R => W missense 8.842e-06 1 113094 0 0.01 0.512
aa1r_human 154 ECL2 R => Q missense 3.526e-05 4 113458 0 0.47 0.001
aa1r_human 156 ECL2 W => S missense 8.766e-06 1 114076 0 0.41 0.129
aa1r_human 158 ECL2 A => S missense 6.986e-05 8 114508 0 0.8 0.056
aa1r_human 159 ECL2 N => S missense 8.689e-06 1 115092 0 0.24 0.93
aa1r_human 159 ECL2 N => K missense 8.686e-06 1 115122 0 0.27 0.988
aa1r_human 160 ECL2 G => S missense 8.666e-06 1 115398 0 0.51 0.028
aa1r_human 161 ECL2 S => T missense 6.042e-05 7 115850 0 0.49 0.037
aa1r_human 161 ECL2 S => N missense 8.632e-06 1 115850 0 0.17 0.599
aa1r_human 162 ECL2 M => V missense 3.443e-05 4 116182 0 0.51 0.0
aa1r_human 163 ECL2 G => V missense 8.578e-06 1 116584 0 0.17 0.003
aa1r_human 166 ECL2 V => M missense 0.000136 16 117660 1 0.2 0.019
aa1r_human 166 ECL2 V => L missense 8.499e-06 1 117660 0 0.67 0.005
aa1r_human 168 ECL2 K => T missense 1.688e-05 2 118496 0 0.62 0.001
aa1r_human 168 ECL2 K => N missense 8.435e-06 1 118560 0 0.48 0.034
aa1r_human 169 45.50x50 ECL2 C => Y missense 8.423e-06 1 118720 0 0.0 0.994
aa1r_human 170 45.51x51 ECL2 E => D missense 8.396e-06 1 119100 0 0.18 0.079
aa1r_human 173 ECL2 K => T missense 8.355e-06 1 119686 0 0.47 0.001
aa1r_human 182 5.40x411 TM5 Y => C missense 8.314e-06 1 120286 0 0.0 1.0
aa1r_human 191 5.49x49 TM5 P => S missense 1.66e-05 2 120508 0 0.03 0.862
aa1r_human 192 5.50x50 TM5 P => Q missense 8.293e-06 1 120590 0 0.0 0.997 SodiumPocket MicroSwitch
aa1r_human 197 5.55x55 TM5 V => A missense 1.656e-05 2 120794 0 0.14 0.003
aa1r_human 208 5.66x66 TM5 R => C missense 0.0001404 17 121078 0 0.06 0.071 GP (contact)
aa1r_human 208 5.66x66 TM5 R => H missense 1.651e-05 2 121104 0 0.19 0.008 GP (contact)
aa1r_human 212 5.70x70 TM5 N => S missense 0.001271 154 121168 0 1.0 0.005
aa1r_human 220 ICL3 G => S missense 1.651e-05 2 121158 0 0.59 0.003
aa1r_human 221 6.22x22 TM6 D => N missense 2.476e-05 3 121152 0 0.28 0.986
aa1r_human 222 6.23x23 TM6 P => L missense 8.255e-06 1 121138 0 0.09 0.977
aa1r_human 234 6.35x35 TM6 K => Q missense 8.287e-06 1 120678 0 0.0 0.999
aa1r_human 235 6.36x36 TM6 S => L missense 2.488e-05 3 120568 0 0.0 1.0 GP (contact)
aa1r_human 237 6.38x38 TM6 A => T missense 8.297e-06 1 120520 0 0.02 0.953
aa1r_human 252 6.53x53 TM6 I => T missense 8.349e-06 1 119770 0 0.09 0.057
aa1r_human 252 6.53x53 TM6 I => M missense 2.505e-05 3 119746 0 0.0 0.825
aa1r_human 256 6.57x57 TM6 I => V missense 8.35e-06 1 119754 0 0.48 0.015
aa1r_human 259 6.60x60 TM6 F => L missense 8.353e-06 1 119722 0 0.0 0.998
aa1r_human 261 ECL3 P => L missense 2.506e-05 3 119712 0 0.04 0.944
aa1r_human 270 7.35x34 TM7 T => I missense 8.319e-06 1 120208 0 0.51 0.001
aa1r_human 279 7.44x43 TM7 G => S missense 8.292e-06 1 120592 0 0.1 0.993 SodiumPocket MicroSwitch
aa1r_human 282 7.47x47 TM7 A => S missense 8.292e-06 1 120602 0 0.01 0.994
aa1r_human 283 7.48x48 TM7 M => K missense 8.292e-06 1 120600 0 0.0 0.646
aa1r_human 286 7.51x51 TM7 I => T missense 8.3e-06 1 120484 0 0.0 0.672
aa1r_human 291 7.56x56 TM7 R => H missense 8.338e-06 1 119928 0 0.0 0.465 GP (contact)
aa1r_human 296 8.51x51 H8 R => H missense 1.685e-05 2 118678 0 0.03 0.033 GP (contact)
aa1r_human 297 8.52x52 H8 V => I missense 8.442e-06 1 118462 0 0.38 0.003
aa1r_human 308 8.63x63 H8 R => C missense 1.75e-05 2 114286 0 0.23 0.001
aa1r_human 308 8.63x63 H8 R => H missense 2.627e-05 3 114194 0 0.07 0.315
aa1r_human 308 8.63x63 H8 R => L missense 8.757e-06 1 114194 0 1.0 0.002
aa1r_human 309 8.64x64 H8 C => Y missense 8.791e-06 1 113750 0 0.01 0.976 PTM (Palmitoylation)
aa1r_human 312 8.67x67 H8 A => V missense 1.775e-05 2 112672 0 0.18 0.0
aa1r_human 315 C-term I => T missense 2.694e-05 3 111376 0 0.35 0.0
aa1r_human 322 C-term E => D missense 7.278e-05 8 109926 0 0.49 0.001
aa1r_human 8 1.31x31 TM1 F => SerfsTer23 frameshift 8.701e-06 1 114930 0 None None
aa1r_human 100 3.45x45 TM3 A => GlufsTer20 frameshift 8.274e-06 1 120854 0 None None
aa1r_human 146 ECL2 W => Ter stop gained 8.925e-06 1 112046 0 None None
aa1r_human 178 5.36x38 TM5 E => Ter stop gained 8.327e-06 1 120096 0 None None
aa1r_human 216 ICL3 S => Ter stop gained 8.254e-06 1 121158 0 None None
aa1r_human 265 ECL3 K => SerfsTer19 frameshift 8.341e-06 1 119894 0 None None
aa1r_human 323 C-term R => SerfsTer36 frameshift 9.097e-06 1 109926 0 None None


Residue

Diagrams

Q A L R ICL1ECL1 P Q T ECL1 P L R Y K M V V ICL2ECL2 W N N L S A V E R A W A A N G S M G E P V I K C E F E K V I ECL2ICL3 S A S S G ICL3ECL3 P S C H K ECL3N-term M P P S I N-termC-term I D E D L P E E R P D D C-term S A F Q A A Y I G I E V L I A L V S V P G N V L V I W A V K V N D A T F C F I V S L A V A D V A V G A L V I P L A I L I N I G Y F H T C L M V A C P V L I L T Q S S I L A L L A I A V D R Y L R V K I T P R R A A V A I A G C W I L S F V V G L T P M F G S M E Y M V Y F N F F V W V L P P L L L M V L I Y L E V F Y L I R K Q L N K K V D P Q K Y Y G K E L K I A K S L A L I L F L F A L S W L P L H I L N C I T L F C P S I L T Y I A I F L T H G N S A M N P I V Y A F R I Q K F L K H F R P P F R V T I W N D C Q P A
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