Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ada2c_human 28 N-term S => T missense 0.004587 1 218 0 0.61 0.0
ada2c_human 57 1.38x38 TM1 V => L missense 0.0001038 1 9634 0 1.0 0.004
ada2c_human 59 1.40x40 TM1 G => S missense 0.000168 2 11906 0 0.74 0.056
ada2c_human 59 1.40x40 TM1 G => D missense 8.15e-05 1 12270 0 0.09 0.737
ada2c_human 62 1.43x43 TM1 I => V missense 6.447e-05 1 15512 0 0.16 0.688
ada2c_human 66 1.47x47 TM1 V => M missense 9.887e-05 2 20228 0 0.0 0.96
ada2c_human 67 1.48x48 TM1 V => A missense 4.666e-05 1 21432 0 0.02 0.823
ada2c_human 70 1.51x51 TM1 V => L missense 0.0001231 3 24370 0 0.02 0.963
ada2c_human 80 12.48x48 ICL1 R => Q missense 5.252e-05 2 38084 0 0.0 0.997
ada2c_human 84 2.37x37 TM2 A => V missense 1.978e-05 1 50564 0 0.0 0.998
ada2c_human 87 2.40x40 TM2 N => K missense 1.627e-05 1 61460 0 0.01 1.0
ada2c_human 105 2.58x57 TM2 M => L missense 9.531e-06 1 104918 0 0.02 0.475
ada2c_human 110 2.63x62 TM2 A => V missense 9.021e-06 1 110848 0 0.02 0.951
ada2c_human 115 2.68x67 TM2 A => S missense 8.662e-06 1 115442 0 0.0 0.439
ada2c_human 115 2.68x67 TM2 A => T missense 1.732e-05 2 115442 0 0.0 0.636
ada2c_human 118 23.51x51 ECL1 Y => F missense 8.559e-06 1 116834 0 0.07 0.449
ada2c_human 121 3.22x22 TM3 Q => R missense 8.492e-06 1 117758 0 0.54 0.03
ada2c_human 135 3.36x36 TM3 C => R missense 8.355e-06 1 119690 0 0.0 1.0
ada2c_human 157 34.51x51 ICL2 V => I missense 0.0001174 14 119218 0 0.61 0.472 GP (contact)
ada2c_human 158 34.52x52 ICL2 E => K missense 0.0001175 14 119138 0 0.02 0.692 GP (contact)
ada2c_human 169 4.43x43 TM4 K => Q missense 8.528e-06 1 117266 0 0.0 1.0
ada2c_human 172 4.46x46 TM4 I => V missense 8.602e-06 1 116254 0 0.02 0.863
ada2c_human 173 4.47x47 TM4 V => L missense 8.638e-06 1 115768 0 0.86 0.243
ada2c_human 174 4.48x48 TM4 A => V missense 8.657e-06 1 115508 0 1.0 0.055
ada2c_human 181 4.55x55 TM4 V => I missense 3.603e-05 4 111004 0 0.33 0.416
ada2c_human 181 4.55x55 TM4 V => F missense 1.802e-05 2 111004 0 0.11 0.63
ada2c_human 191 ECL2 Y => F missense 2.813e-05 3 106666 0 0.11 0.707
ada2c_human 192 ECL2 R => H missense 9.425e-06 1 106096 0 0.04 0.183
ada2c_human 195 ECL2 D => E missense 2.878e-05 3 104242 0 0.97 0.055
ada2c_human 198 ECL2 A => D missense 0.0001067 11 103092 0 0.42 0.066
ada2c_human 200 ECL2 P => L missense 9.871e-06 1 101306 0 0.01 0.362
ada2c_human 213 5.41x42 TM5 S => Y missense 2.23e-05 2 89680 0 0.34 0.53
ada2c_human 224 5.52x52 TM5 L => V missense 1.359e-05 1 73560 0 0.3 0.557
ada2c_human 227 5.55x55 TM5 G => V missense 7.789e-05 5 64196 0 0.25 0.086
ada2c_human 229 5.57x57 TM5 V => L missense 1.623e-05 1 61630 0 0.0 0.919
ada2c_human 232 5.60x60 TM5 R => L missense 3.634e-05 2 55036 0 0.0 0.998
ada2c_human 234 5.62x62 TM5 Y => H missense 1.887e-05 1 53000 0 0.0 0.999
ada2c_human 240 5.68x68 TM5 R => H missense 2.841e-05 1 35200 0 0.11 0.998 GP (contact)
ada2c_human 243 5.71x71 TM5 T => R missense 3.349e-05 1 29858 0 0.34 0.852 GP (contact)
ada2c_human 244 5.72x72 TM5 L => R missense 3.588e-05 1 27868 0 0.53 0.666 GP (contact)
ada2c_human 254 ICL3 D => H missense 7.082e-05 1 14120 0 0.03 0.972
ada2c_human 256 ICL3 A => V missense 0.0004595 6 13058 0 0.19 0.183
ada2c_human 277 ICL3 A => V missense 0.0004806 3 6242 0 0.31 0.013
ada2c_human 332 ICL3 A => P missense 0.01563 1 64 0 0.31 0.238
ada2c_human 339 ICL3 P => S missense 0.007895 3 380 0 0.24 0.003
ada2c_human 342 ICL3 G => V missense 0.001109 1 902 0 0.25 0.248
ada2c_human 351 ICL3 R => C missense 0.0003255 3 9216 0 0.01 0.791
ada2c_human 357 ICL3 L => R missense 3.506e-05 1 28524 0 0.58 0.013
ada2c_human 360 ICL3 R => W missense 2.363e-05 1 42322 0 0.01 0.948
ada2c_human 360 ICL3 R => G missense 2.363e-05 1 42322 0 0.46 0.498
ada2c_human 360 ICL3 R => P missense 2.179e-05 1 45896 0 0.19 0.037
ada2c_human 361 ICL3 R => S missense 0.0002561 12 46864 0 0.67 0.6
ada2c_human 366 ICL3 S => C missense 1.159e-05 1 86248 0 0.02 0.199
ada2c_human 366 ICL3 S => R missense 3.408e-05 3 88016 0 0.34 0.259
ada2c_human 369 ICL3 R => C missense 1.036e-05 1 96552 0 0.0 0.991
ada2c_human 370 ICL3 R => L missense 9.914e-06 1 100864 0 0.06 0.162
ada2c_human 371 6.24x24 TM6 K => R missense 1.926e-05 2 103852 0 0.43 0.279
ada2c_human 372 6.25x25 TM6 V => L missense 9.531e-06 1 104920 0 0.26 0.018 GP (contact)
ada2c_human 392 6.45x45 TM6 V => M missense 8.46e-05 10 118200 0 0.02 1.0
ada2c_human 401 6.54x54 TM6 S => I missense 8.415e-06 1 118840 0 0.0 0.903
ada2c_human 404 6.57x57 TM6 L => M missense 8.407e-06 1 118942 0 0.01 1.0
ada2c_human 406 6.59x59 TM6 G => R missense 8.407e-06 1 118948 0 0.0 0.978
ada2c_human 409 ECL3 R => H missense 8.403e-06 1 119004 0 0.11 0.971
ada2c_human 414 ECL3 V => L missense 8.398e-06 1 119076 0 0.1 0.164
ada2c_human 416 7.32x31 TM7 G => D missense 2.521e-05 3 119024 0 0.82 0.003
ada2c_human 421 7.37x36 TM7 F => V missense 8.399e-06 1 119056 0 0.0 0.934
ada2c_human 423 7.39x38 TM7 F => L missense 8.4e-06 1 119044 0 0.0 0.999
ada2c_human 432 7.48x48 TM7 L => V missense 8.44e-06 1 118486 0 0.12 0.841
ada2c_human 438 7.54x54 TM7 T => M missense 8.469e-06 1 118074 0 0.0 0.995
ada2c_human 447 8.53x53 H8 S => F missense 8.566e-06 1 116734 0 0.0 0.0
ada2c_human 452 8.58x58 H8 L => F missense 8.718e-06 1 114708 0 0.0 0.0
ada2c_human 455 C-term R => W missense 8.805e-06 1 113566 0 0.02 0.0
ada2c_human 455 C-term R => Q missense 8.84e-06 1 113120 0 0.67 0.0
ada2c_human 458 C-term R => K missense 0.0004368 49 112168 0 0.98 0.0
ada2c_human 202 45.50x50 ECL2 C => Ter stop gained 2.029e-05 2 98564 0 None None


Residue

Diagrams

R A L R ICL1ECL1 Y W Y F ECL1 A V E Y N L K R ICL2ECL2 S L Y R Q P D G A A Y P Q C G L N D ECL2ICL3 R A P V G P D G A S P T T E N G L G A A A G A G E N G H C A P P P A D V E P D E S S A A A E R R R R R G A L R R G G R R R A G A E G G A G G A D G Q G A G P G A A E S G A L T A S R S P G P G G R L S R A S S R S V E F F L S R R R R A R S S V C R R ICL3ECL3 R E A C Q V ECL3N-term M A S P A L A A A L A V A A A A G P N A S G A G E R G S G G V A N A S G A S W G P P R G Q Y S N-termC-term R R R R R G F R Q C-term A G A V A G L A A V V G F L I V F T V V G N V L V V I A V L T S A P Q N L F L V S L A S A D I L V A T L V M P F S L A N E L M A G Q V W C G V Y L A L D V L F C T S S I V H L C A I S L D R Y W S V T Q T P R R V K A T I V A V W L I S A V I S F P P L V E T W Y I L S S C I G S F F A P C L I M G L V Y A R I Y R V A K L R T R T L S E K K V A Q A R E K R F T F V L A V V M G V F V L C W F P F F F S Y S L Y G I C P G P L F K F F F W I G Y C N S S L N P V I Y T V F N Q D F K H F R R S I L F
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