Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
adrb3_human 406 C-term G => E missense 8.496e-06 1 117708 0 nan 0.028
adrb3_human 403 C-term A => V missense 1.707e-05 2 117192 0 nan 0.003
adrb3_human 403 C-term A => P missense 4.269e-05 5 117110 0 nan 0.277
adrb3_human 375 C-term A => T missense 0.001795 21 11702 0 0.16 0.004
adrb3_human 374 C-term A => S missense 8.538e-05 1 11712 0 0.45 0.199
adrb3_human 374 C-term A => T missense 8.538e-05 1 11712 0 0.45 0.006
adrb3_human 355 8.53x53 H8 A => T missense 6.745e-05 1 14826 0 0.02 0.979
adrb3_human 353 8.51x51 H8 R => C missense 0.004538 69 15204 1 0.0 0.932 GP (contact)
adrb3_human 353 8.51x51 H8 R => G missense 6.577e-05 1 15204 0 0.0 0.719 GP (contact)
adrb3_human 352 8.50x50 H8 F => L missense 6.552e-05 1 15262 0 0.0 0.989
adrb3_human 345 7.52x52 TM7 I => V missense 0.0001858 3 16148 0 0.0 0.996
adrb3_human 338 7.45x45 TM7 N => S missense 0.0001191 2 16794 0 0.0 0.999
adrb3_human 329 7.36x35 TM7 L => F missense 5.955e-05 1 16794 0 0.05 0.956
adrb3_human 320 ECL3 P => A missense 0.0001255 2 15936 0 0.49 0.999
adrb3_human 317 6.60x60 TM6 L => V missense 6.31e-05 1 15848 0 0.12 0.075
adrb3_human 311 6.54x54 TM6 A => S missense 6.428e-05 1 15558 0 0.02 0.88
adrb3_human 295 6.38x38 TM6 G => A missense 0.000227 3 13218 0 0.0 1.0
adrb3_human 294 6.37x37 TM6 L => W missense 7.649e-05 1 13074 0 0.0 0.987 GP (contact)
adrb3_human 276 ICL3 G => D missense 9.05e-05 1 11050 0 0.06 0.47
adrb3_human 270 ICL3 E => K missense 0.000281 3 10678 0 0.89 0.129
adrb3_human 268 ICL3 P => L missense 9.395e-05 1 10644 0 0.33 0.108
adrb3_human 267 ICL3 A => V missense 9.397e-05 1 10642 0 0.15 0.515
adrb3_human 265 ICL3 T => M missense 0.001242 13 10470 0 0.13 0.028
adrb3_human 265 ICL3 T => R missense 9.551e-05 1 10470 0 0.6 0.009
adrb3_human 262 ICL3 P => R missense 9.275e-05 1 10782 0 0.6 0.009
adrb3_human 252 ICL3 P => L missense 7.026e-05 1 14232 0 0.12 0.426
adrb3_human 248 ICL3 E => Q missense 0.0005619 9 16018 0 0.63 0.146
adrb3_human 244 ICL3 R => L missense 5.861e-05 1 17062 0 0.01 1.0
adrb3_human 241 5.75x75 TM5 E => V missense 5.587e-05 1 17900 0 0.28 1.0 GP (contact)
adrb3_human 239 5.73x73 TM5 R => H missense 5.491e-05 1 18212 0 0.05 0.988
adrb3_human 231 5.65x65 TM5 A => V missense 0.0001034 2 19350 0 0.0 0.999 GP (contact)
adrb3_human 228 5.62x62 TM5 F => L missense 5.079e-05 1 19690 0 0.01 0.107
adrb3_human 225 5.59x59 TM5 A => T missense 0.0004018 8 19912 0 0.15 1.0
adrb3_human 197 45.51x51 ECL2 A => T missense 4.822e-05 1 20740 0 0.08 0.026
adrb3_human 194 ECL2 R => P missense 4.834e-05 1 20686 0 0.11 0.778
adrb3_human 193 ECL2 P => L missense 0.0001457 3 20588 0 0.03 1.0
adrb3_human 186 ECL2 A => E missense 0.0002539 5 19690 0 0.02 1.0
adrb3_human 171 4.59x59 TM4 A => G missense 0.000679 14 20618 0 0.0 0.957
adrb3_human 169 4.57x57 TM4 S => L missense 4.721e-05 1 21180 0 0.0 0.999
adrb3_human 169 4.57x57 TM4 S => W missense 4.721e-05 1 21180 0 0.0 1.0
adrb3_human 155 4.43x43 TM4 R => Q missense 3.808e-05 1 26262 0 0.01 0.935
adrb3_human 155 4.43x43 TM4 R => G missense 7.498e-05 2 26674 0 0.01 0.075
adrb3_human 154 4.42x42 TM4 A => D missense 0.0004417 12 27166 0 0.0 0.978
adrb3_human 154 4.42x42 TM4 A => S missense 3.668e-05 1 27260 0 0.0 0.924
adrb3_human 153 4.41x41 TM4 C => F missense 7.183e-05 2 27844 0 0.0 0.166
adrb3_human 152 4.40x40 TM4 R => L missense 3.543e-05 1 28228 0 0.68 0.075
adrb3_human 151 4.39x39 TM4 K => R missense 0.0002761 8 28980 0 0.18 0.999
adrb3_human 142 34.50x50 ICL2 P => T missense 2.585e-05 1 38690 0 0.0 0.997 GP (contact)
adrb3_human 137 3.52x52 TM3 L => P missense 2.13e-05 1 46946 0 0.0 0.988
adrb3_human 130 3.45x45 TM3 A => S missense 1.386e-05 1 72154 0 0.0 0.959
adrb3_human 130 3.45x45 TM3 A => T missense 1.386e-05 1 72154 0 0.02 0.933
adrb3_human 129 3.44x44 TM3 C => Y missense 1.323e-05 1 75580 0 0.0 1.0
adrb3_human 126 3.41x41 TM3 E => K missense 2.422e-05 2 82568 0 0.0 0.908
adrb3_human 125 3.40x40 TM3 I => T missense 1.196e-05 1 83578 0 0.0 0.917 SodiumPocket MicroSwitch
adrb3_human 122 3.37x37 TM3 T => I missense 2.31e-05 2 86588 0 0.0 1.0
adrb3_human 110 3.25x25 TM3 C => Y missense 2.168e-05 2 92252 0 0.0 1.0
adrb3_human 100 2.67x66 TM2 T => I missense 1.073e-05 1 93174 0 0.44 0.2
adrb3_human 96 2.63x62 TM2 T => I missense 1.048e-05 1 95446 0 0.04 0.984
adrb3_human 92 2.59x58 TM2 P => L missense 1.002e-05 1 99816 0 0.0 1.0
adrb3_human 83 2.50x50 TM2 D => N missense 9.133e-06 1 109496 0 0.0 1.0
adrb3_human 82 2.49x49 TM2 A => S missense 9.095e-06 1 109956 0 0.0 0.999
adrb3_human 81 2.48x48 TM2 A => T missense 9.035e-06 1 110678 0 0.25 0.012
adrb3_human 76 2.43x43 TM2 V => L missense 8.788e-06 1 113794 0 0.0 0.999
adrb3_human 74 2.41x41 TM2 V => M missense 8.726e-06 1 114598 0 0.03 1.0
adrb3_human 66 12.48x48 ICL1 P => L missense 8.656e-06 1 115524 0 0.01 1.0
adrb3_human 64 1.59x59 TM1 W => R missense 0.1057 12257 115984 797 1.0 0.0
adrb3_human 63 1.58x58 TM1 A => V missense 1.73e-05 2 115638 0 0.02 0.617
adrb3_human 60 1.55x55 TM1 V => L missense 1.737e-05 2 115162 0 0.11 0.61
adrb3_human 47 1.42x42 TM1 A => E missense 9.275e-06 1 107818 0 0.05 0.025
adrb3_human 43 1.38x38 TM1 L => P missense 9.585e-06 1 104332 0 0.0 0.999
adrb3_human 42 1.37x37 TM1 A => S missense 6.83e-05 7 102492 0 0.02 0.529
adrb3_human 35 1.30x30 TM1 W => C missense 1.059e-05 1 94386 0 0.01 0.806
adrb3_human 27 N-term T => I missense 1.138e-05 1 87850 0 0.02 0.101
adrb3_human 25 N-term A => T missense 1.178e-05 1 84870 0 0.13 0.103
adrb3_human 17 N-term L => F missense 0.0001251 10 79956 0 0.38 0.019
adrb3_human 14 N-term W => R missense 0.0001046 8 76452 0 nan 0.01
adrb3_human 12 N-term A => V missense 2.681e-05 2 74604 0 nan 0.001
adrb3_human 7 N-term E => D missense 4.452e-05 3 67382 0 0.17 0.013
adrb3_human 4 N-term W => C missense 6.486e-05 4 61670 0 nan 0.885
adrb3_human 405 C-term W => Ter stop gained 8.496e-06 1 117706 0 None None
adrb3_human 38 1.33x33 TM1 A => ProfsTer2 frameshift 4.087e-05 4 97870 0 None None


Residue

Diagrams

P R L Q ICL1ECL1 G H W P L ECL1 P L R Y G A L V ICL2ECL2 W W R V G A D A E A Q R C H S N P R C C A F A S ECL2ICL3 G R F P P E E S P P A P S R S L A P A P V G T C A P P E G V P A C G R R P A ICL3ECL3 G P S L V ECL3N-term M A P W P H E N S S L A P W P D L P T L A P N T A N T S G N-termC-term R C G R R L P P E P C A A A R P A L F P S G V P A A R S S P A Q P R L C Q R L D G A S W G V S C-term L P G V P W E A A L A G A L L A L A V L A T V G G N L L V I V A I A W T T M T N V F V T S L A A A D L V M G L L V V P P A A T L A L T G A T G C E L W T S V D V L C V T A S I E T L C A L A V D R Y L A V T N T K R C A R T A V V L V W V V S A A V S F A P I M S Q N M P Y V L L S S S V S F Y L P L L V M L F V Y A R V F V V A T R Q L R L L R G E L R L L P L R E H R A L C T L G L I M G T F T L C W L P F F L A N V L R A L G P G P A F L A L N W L G Y A N S A F N P L I Y C R S P D F R R F R S A L L C
SnakePlot Download: PNG | SVG L N G G V T A L V A L A L L A G A L A A 1 T S L A A A D L V M G L L V V P P A A T L 2 A C L T E I S A T V C L V D V S T W L E 3 A R T A V V L V W V V S A A V S F A P I 4 Y V F L M V L L P L Y F S V S S S L L V Y 5 G L I M G T F T L C W L P F F L A N V L 6 L P N F A S N A Y G L W N L A L F A P 7
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