Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
cnr2_human 357 C-term L => F missense 1.667e-05 2 119990 0 nan 0.0
cnr2_human 354 C-term D => H missense 2.489e-05 3 120532 0 nan 0.135
cnr2_human 352 C-term S => C missense 8.278e-06 1 120800 0 0.01 0.635 PTM (Phosphorylation)
cnr2_human 348 C-term P => L missense 8.252e-05 10 121184 0 0.41 0.0
cnr2_human 342 C-term A => T missense 8.241e-06 1 121346 0 0.11 0.004
cnr2_human 339 C-term E => K missense 8.238e-06 1 121382 0 0.09 0.04
cnr2_human 338 C-term T => I missense 4.118e-05 5 121406 0 0.27 0.031 PTM (Phosphorylation)
cnr2_human 335 C-term S => F missense 8.237e-06 1 121406 0 0.02 0.99 PTM (Phosphorylation)
cnr2_human 333 C-term P => R missense 8.237e-06 1 121404 0 0.11 0.257
cnr2_human 330 C-term E => K missense 4.942e-05 6 121404 0 0.1 0.001
cnr2_human 328 C-term A => V missense 2.471e-05 3 121406 0 0.19 0.013
cnr2_human 328 C-term A => T missense 1.647e-05 2 121406 0 0.4 0.001
cnr2_human 325 C-term G => E missense 8.237e-06 1 121404 0 0.4 0.019
cnr2_human 325 C-term G => R missense 8.237e-06 1 121406 0 0.16 0.015
cnr2_human 320 C-term C => Y missense 1.647e-05 2 121402 0 1.0 0.0
cnr2_human 320 C-term C => R missense 8.237e-06 1 121398 0 0.36 0.0
cnr2_human 316 C-term H => Y missense 0.09724 11804 121392 700 1.0 0.05
cnr2_human 316 C-term H => N missense 1.648e-05 2 121392 0 0.34 0.001
cnr2_human 315 8.59x59 H8 A => V missense 2.471e-05 3 121402 0 0.2 0.004
cnr2_human 313 8.57x57 H8 C => Y missense 8.237e-06 1 121402 0 1.0 0.032
cnr2_human 308 8.52x52 H8 S => F missense 8.237e-06 1 121402 0 0.08 0.653
cnr2_human 307 8.51x51 H8 R => H missense 1.647e-05 2 121404 0 0.05 0.063 GP (contact)
cnr2_human 307 8.51x51 H8 R => C missense 1.647e-05 2 121404 0 0.02 0.037 GP (contact)
cnr2_human 307 8.51x51 H8 R => G missense 8.237e-06 1 121404 0 0.01 0.524 GP (contact)
cnr2_human 306 8.50x50 H8 I => V missense 8.237e-06 1 121402 0 0.06 0.012
cnr2_human 302 7.56x56 TM7 R => W missense 8.237e-06 1 121402 0 0.02 1.0 GP (contact)
cnr2_human 297 7.51x51 TM7 V => I missense 8.237e-06 1 121400 0 1.0 0.004
cnr2_human 290 7.44x43 TM7 I => V missense 8.237e-06 1 121400 0 1.0 0.0 SodiumPocket MicroSwitch
cnr2_human 285 7.39x38 TM7 S => F missense 8.237e-06 1 121398 0 0.0 0.983
cnr2_human 280 7.34x33 TM7 A => V missense 0.0006096 74 121382 0 1.0 0.004
cnr2_human 275 ECL3 D => E missense 8.24e-06 1 121366 0 0.22 0.015
cnr2_human 275 ECL3 D => A missense 1.648e-05 2 121366 0 0.07 0.257
cnr2_human 272 ECL3 T => M missense 9.064e-05 11 121358 0 0.05 0.873
cnr2_human 271 6.61x61 TM6 T => A missense 8.24e-06 1 121356 0 1.0 0.001
cnr2_human 270 6.60x60 TM6 A => D missense 8.24e-06 1 121358 0 0.06 0.295
cnr2_human 266 6.56x56 TM6 A => S missense 1.648e-05 2 121350 0 0.02 0.077
cnr2_human 265 6.55x55 TM6 M => R missense 1.648e-05 2 121352 0 0.0 0.912
cnr2_human 254 6.44x44 TM6 L => F missense 0.0001648 20 121346 0 0.0 0.969 SodiumPocket MicroSwitch
cnr2_human 250 6.40x40 TM6 V => L missense 8.246e-06 1 121274 0 0.2 0.09 GP (contact)
cnr2_human 248 6.38x38 TM6 G => V missense 8.247e-06 1 121250 0 0.3 0.487
cnr2_human 248 6.38x38 TM6 G => R missense 1.65e-05 2 121246 0 0.07 0.993
cnr2_human 244 6.34x34 TM6 A => D missense 8.252e-06 1 121176 0 0.0 1.0 SodiumPocket MicroSwitch
cnr2_human 244 6.34x34 TM6 A => V missense 0.000132 16 121176 0 0.0 1.0 SodiumPocket MicroSwitch
cnr2_human 242 6.32x32 TM6 R => S missense 8.259e-06 1 121084 0 0.01 0.345 GP (contact)
cnr2_human 242 6.32x32 TM6 R => M missense 8.26e-06 1 121062 0 0.21 0.078 GP (contact)
cnr2_human 236 6.26x26 TM6 R => Q missense 4.141e-05 5 120742 0 0.23 0.908 GP (contact)
cnr2_human 236 6.26x26 TM6 R => G missense 8.283e-06 1 120734 0 0.02 0.945 GP (contact)
cnr2_human 233 6.23x23 TM6 G => E missense 8.291e-06 1 120610 0 0.46 0.825
cnr2_human 229 ICL3 R => K missense 8.304e-06 1 120426 0 0.35 0.01
cnr2_human 228 ICL3 D => N missense 2.492e-05 3 120370 0 0.51 0.01
cnr2_human 218 5.67x67 TM5 Q => H missense 8.434e-06 1 118570 0 0.25 0.946 GP (contact)
cnr2_human 218 5.67x67 TM5 Q => R missense 8.428e-06 1 118654 0 0.4 0.065 GP (contact)
cnr2_human 216 5.65x65 TM5 A => V missense 5.066e-05 6 118440 0 0.0 1.0 GP (contact)
cnr2_human 211 5.60x60 TM5 H => Q missense 8.461e-06 1 118196 0 0.11 0.422
cnr2_human 211 5.60x60 TM5 H => L missense 8.464e-06 1 118142 0 0.31 0.608
cnr2_human 210 5.59x59 TM5 G => R missense 8.476e-06 1 117986 0 0.14 0.882
cnr2_human 204 5.53x53 TM5 G => R missense 3.4e-05 4 117650 0 0.37 0.921
cnr2_human 203 5.52x52 TM5 S => C missense 8.503e-06 1 117608 0 0.2 0.017
cnr2_human 199 5.48x48 TM5 A => G missense 8.517e-06 1 117408 0 0.23 0.532
cnr2_human 199 5.48x48 TM5 A => T missense 9.378e-05 11 117298 0 0.44 0.025
cnr2_human 190 5.39x39 TM5 Y => C missense 8.573e-06 1 116644 0 0.0 0.999
cnr2_human 186 ECL2 I => N missense 8.608e-06 1 116166 0 0.0 0.939
cnr2_human 178 ECL2 P => T missense 2.594e-05 3 115670 0 1.0 0.026
cnr2_human 174 ECL2 C => Y missense 8.648e-06 1 115638 0 0.0 1.0
cnr2_human 164 4.56x56 TM4 V => I missense 8.547e-06 1 116994 0 1.0 0.023
cnr2_human 159 4.51x51 TM4 V => F missense 8.459e-06 1 118216 0 0.07 0.089
cnr2_human 158 4.50x50 TM4 W => C missense 8.449e-06 1 118354 0 0.0 1.0
cnr2_human 155 4.47x47 TM4 G => S missense 8.264e-06 1 121006 0 0.56 0.08
cnr2_human 154 4.46x46 TM4 L => V missense 8.262e-06 1 121036 0 0.01 0.982
cnr2_human 148 4.40x40 TM4 G => R missense 8.252e-06 1 121188 0 0.74 0.023
cnr2_human 147 4.39x39 TM4 R => H missense 6.602e-05 8 121178 0 0.09 0.04
cnr2_human 144 34.56x56 ICL2 L => Q missense 8.249e-06 1 121228 0 0.0 0.993 GP (contact)
cnr2_human 142 34.54x54 ICL2 K => R missense 8.248e-06 1 121242 0 0.12 0.255 GP (contact)
cnr2_human 139 34.51x51 ICL2 P => T missense 8.247e-06 1 121256 0 0.98 0.018 GP (contact)
cnr2_human 137 3.56x56 TM3 Y => C missense 8.246e-06 1 121264 0 0.01 0.866 PTM (Phosphorylation) GP (contact)
cnr2_human 136 3.55x55 TM3 R => H missense 5.773e-05 7 121258 0 1.0 0.002 GP (contact)
cnr2_human 136 3.55x55 TM3 R => C missense 6.597e-05 8 121272 0 0.24 0.0 GP (contact)
cnr2_human 134 3.53x53 TM3 C => Y missense 8.246e-06 1 121270 0 0.0 0.995 GP (contact)
cnr2_human 133 3.52x52 TM3 L => I missense 0.003636 441 121284 3 0.9 0.721
cnr2_human 131 3.50x50 TM3 R => Q missense 2.474e-05 3 121278 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
cnr2_human 128 3.47x47 TM3 A => S missense 8.245e-06 1 121292 0 0.0 1.0
cnr2_human 119 3.38x38 TM3 A => D missense 8.242e-06 1 121336 0 0.0 0.991
cnr2_human 117 3.36x36 TM3 F => S missense 8.241e-06 1 121342 0 0.0 1.0
cnr2_human 114 3.33x33 TM3 T => P missense 8.241e-06 1 121346 0 0.01 0.996 PTM (Phosphorylation)
cnr2_human 113 3.32x32 TM3 V => M missense 8.241e-06 1 121350 0 0.0 1.0
cnr2_human 111 3.30x30 TM3 G => S missense 1.648e-05 2 121348 0 0.02 0.975
cnr2_human 110 3.29x29 TM3 I => M missense 1.648e-05 2 121350 0 0.01 0.794
cnr2_human 110 3.29x29 TM3 I => T missense 0.0002555 31 121352 0 0.0 0.751
cnr2_human 101 ECL1 D => A missense 8.24e-06 1 121352 0 0.0 0.92
cnr2_human 95 2.65x65 TM2 H => R missense 8.24e-06 1 121354 0 0.0 1.0
cnr2_human 92 2.62x62 TM2 V => M missense 8.24e-06 1 121354 0 0.0 0.968
cnr2_human 90 2.60x60 TM2 S => N missense 8.24e-06 1 121356 0 0.2 0.036
cnr2_human 89 2.59x59 TM2 C => Y missense 1.648e-05 2 121356 0 1.0 0.024
cnr2_human 89 2.59x59 TM2 C => R missense 8.24e-06 1 121358 0 0.18 0.039
cnr2_human 84 2.54x54 TM2 S => C missense 4.12e-05 5 121350 0 0.02 0.729
cnr2_human 74 2.44x44 TM2 G => C missense 8.24e-06 1 121358 0 0.0 0.975
cnr2_human 70 2.40x40 TM2 Y => H missense 4.944e-05 6 121354 0 0.01 0.995
cnr2_human 66 2.36x36 TM2 R => Q missense 0.003504 424 121004 9 0.17 0.319
cnr2_human 66 2.36x36 TM2 R => W missense 4.128e-05 5 121114 0 0.01 0.991
cnr2_human 65 12.51x51 ICL1 R => H missense 1.651e-05 2 121124 0 0.01 0.265
cnr2_human 65 12.51x51 ICL1 R => C missense 0.0001237 15 121238 0 0.01 0.993
cnr2_human 63 12.49x49 ICL1 Q => R missense 0.6182 74778 120970 23628 1.0 0.0
cnr2_human 63 12.49x49 ICL1 Q => K missense 8.244e-06 1 121298 0 0.86 0.0
cnr2_human 62 12.48x48 ICL1 H => R missense 8.243e-06 1 121310 0 0.8 0.002
cnr2_human 61 1.60x60 TM1 S => F missense 1.648e-05 2 121324 0 0.0 0.984
cnr2_human 52 1.51x51 TM1 V => M missense 5.772e-05 7 121270 0 0.19 0.013
cnr2_human 47 1.46x46 TM1 S => R missense 8.248e-06 1 121242 0 0.03 0.73
cnr2_human 40 1.39x39 TM1 C => Y missense 3.303e-05 4 121094 0 0.0 0.999
cnr2_human 30 1.29x29 TM1 G => D missense 9.938e-05 12 120750 0 0.68 0.002
cnr2_human 29 1.28x28 TM1 S => R missense 8.284e-06 1 120716 0 0.01 0.478 PTM (Phosphorylation)
cnr2_human 22 N-term M => I missense 8.331e-06 1 120038 0 0.08 0.004
cnr2_human 22 N-term M => V missense 2.501e-05 3 119954 0 0.03 0.049
cnr2_human 22 N-term M => L missense 8.337e-06 1 119954 0 0.24 0.004
cnr2_human 20 N-term N => S missense 2.507e-05 3 119646 0 0.57 0.007
cnr2_human 18 N-term D => V missense 8.414e-06 1 118848 0 0.03 0.059
cnr2_human 16 N-term G => V missense 8.457e-06 1 118244 0 0.03 0.157
cnr2_human 15 N-term D => Y missense 4.245e-05 5 117788 0 0.04 0.428
cnr2_human 11 N-term N => S missense 1.718e-05 2 116444 0 0.05 0.091
cnr2_human 9 N-term I => M missense 8.64e-06 1 115736 0 0.18 0.029
cnr2_human 9 N-term I => T missense 1.73e-05 2 115616 0 0.67 0.0
cnr2_human 4 N-term C => Y missense 8.846e-06 1 113046 0 0.0 0.938
cnr2_human 341 C-term E => GlyfsTer2 frameshift 8.241e-06 1 121346 0 None None
cnr2_human 257 6.47x47 TM6 C => GlyfsTer20 frameshift 8.24e-06 1 121354 0 None None
cnr2_human 255 6.45x45 TM6 L => SerfsTer66 frameshift 8.24e-06 1 121356 0 None None
cnr2_human 236 6.26x26 TM6 R => Ter stop gained 0.0001822 22 120734 0 None None GP (contact)
cnr2_human 194 5.43x43 TM5 W => Ter stop gained 8.549e-06 1 116970 0 None None
cnr2_human 132 3.51x51 TM3 Y => Ter stop gained 2.473e-05 3 121288 0 None None
cnr2_human 131 3.50x50 TM3 R => Ter stop gained 0.0002144 26 121294 0 None None SodiumPocket MicroSwitch GP (contact)
cnr2_human 63 12.49x49 ICL1 Q => Ter stop gained 8.244e-06 1 121298 0 None None
cnr2_human 5 N-term W => Ter stop gained 1.759e-05 2 113718 0 None None


Residue

Diagrams

H Q L R ICL1ECL1 F H G V D ECL1 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q ICL3ECL3 T L S D Q ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term H W K K C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S R K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G V P G M A R M R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H I R S S C L A
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