Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
drd1_human 446 C-term T => I missense 3.586e-05 4 111542 0 nan 0.46
drd1_human 446 C-term T => A missense 0.0001613 18 111570 0 nan 0.069
drd1_human 443 C-term Q => R missense 2.674e-05 3 112200 0 nan 0.801
drd1_human 441 C-term N => D missense 8.858e-06 1 112894 0 0.03 0.16
drd1_human 437 C-term P => H missense 8.79e-06 1 113762 0 0.0 0.866
drd1_human 430 C-term V => A missense 8.546e-06 1 117020 0 nan 0.174
drd1_human 429 C-term D => E missense 8.502e-06 1 117620 0 1.0 0.041
drd1_human 425 C-term D => Y missense 8.361e-06 1 119600 0 nan 0.959
drd1_human 421 C-term S => L missense 8.243e-06 1 121308 0 nan 0.894
drd1_human 410 C-term A => T missense 8.244e-06 1 121300 0 nan 0.014
drd1_human 410 C-term A => S missense 8.244e-06 1 121300 0 1.0 0.001
drd1_human 409 C-term I => T missense 8.243e-06 1 121310 0 nan 0.0
drd1_human 405 C-term E => G missense 8.243e-06 1 121314 0 nan 0.055
drd1_human 403 C-term K => N missense 8.243e-06 1 121320 0 0.49 0.013
drd1_human 400 C-term D => N missense 1.649e-05 2 121320 0 nan 0.195
drd1_human 395 C-term V => M missense 2.473e-05 3 121334 0 0.0 0.703
drd1_human 393 C-term H => R missense 0.0001401 17 121350 0 0.03 0.147
drd1_human 388 C-term V => I missense 8.238e-06 1 121382 0 nan 0.033
drd1_human 385 C-term C => Y missense 1.648e-05 2 121392 0 0.66 0.17
drd1_human 379 C-term G => V missense 8.237e-06 1 121400 0 0.51 0.883
drd1_human 378 C-term R => Q missense 8.237e-06 1 121402 0 0.55 0.012
drd1_human 374 C-term H => R missense 1.647e-05 2 121404 0 0.04 0.071
drd1_human 372 C-term S => P missense 8.237e-06 1 121404 0 0.01 0.616
drd1_human 369 C-term A => V missense 0.0001153 14 121406 0 0.33 0.0
drd1_human 369 C-term A => S missense 8.237e-06 1 121404 0 1.0 0.003
drd1_human 369 C-term A => T missense 1.647e-05 2 121404 1 0.34 0.011
drd1_human 366 C-term N => K missense 8.237e-06 1 121406 0 0.06 0.014
drd1_human 363 C-term I => M missense 8.237e-06 1 121402 0 0.02 0.825
drd1_human 363 C-term I => V missense 8.237e-06 1 121400 0 0.1 0.083
drd1_human 362 C-term S => N missense 1.647e-05 2 121402 0 1.0 0.082
drd1_human 360 C-term T => M missense 8.237e-06 1 121398 0 0.02 0.84 PTM (Phosphorylation)
drd1_human 354 C-term T => M missense 8.238e-06 1 121386 0 0.03 0.459
drd1_human 353 C-term A => V missense 0.0005272 64 121388 1 0.23 0.001
drd1_human 353 C-term A => G missense 1.648e-05 2 121388 0 0.76 0.001
drd1_human 349 C-term R => S missense 8.239e-06 1 121380 0 0.09 0.119
drd1_human 349 C-term R => T missense 8.239e-06 1 121380 0 0.09 0.011
drd1_human 349 C-term R => G missense 8.239e-06 1 121378 0 0.12 0.119
drd1_human 348 C-term Y => H missense 8.239e-06 1 121368 0 0.56 0.008
drd1_human 310 7.32x31 TM7 S => P missense 8.257e-06 1 121108 0 0.17 0.002
drd1_human 306 7.28x27 TM7 F => C missense 8.26e-06 1 121066 0 0.18 0.95
drd1_human 306 7.28x27 TM7 F => V missense 7.434e-05 9 121064 0 0.5 0.403
drd1_human 306 7.28x27 TM7 F => L missense 1.652e-05 2 121064 0 0.66 0.029
drd1_human 303 ECL3 T => M missense 1.652e-05 2 121036 0 0.1 0.767
drd1_human 301 ECL3 G => R missense 8.265e-06 1 120992 0 0.43 0.018
drd1_human 288 6.51x51 TM6 F => L missense 8.269e-06 1 120928 0 0.01 0.999
drd1_human 270 6.33x33 TM6 V => L missense 1.654e-05 2 120938 0 0.06 0.999 GP (contact)
drd1_human 261 6.24x24 TM6 K => N missense 8.264e-06 1 121006 0 0.0 0.99
drd1_human 259 ICL3 S => Y missense 0.003709 449 121050 6 0.0 0.981
drd1_human 256 ICL3 P => L missense 4.128e-05 5 121112 0 0.08 0.005
drd1_human 252 ICL3 E => K missense 3.3e-05 4 121230 0 0.31 0.69
drd1_human 250 ICL3 P => S missense 0.0001566 19 121290 0 0.42 0.006
drd1_human 241 ICL3 C => R missense 8.239e-06 1 121378 0 0.18 0.013
drd1_human 238 ICL3 A => T missense 8.239e-06 1 121378 0 0.03 1.0
drd1_human 237 ICL3 H => Q missense 8.238e-06 1 121384 0 0.14 0.838
drd1_human 229 5.73x73 TM5 A => V missense 3.295e-05 4 121406 0 0.0 0.226
drd1_human 228 5.72x72 TM5 I => V missense 8.237e-06 1 121408 0 0.01 0.998 GP (contact)
drd1_human 227 5.71x71 TM5 R => H missense 8.237e-06 1 121408 0 0.0 1.0 GP (contact)
drd1_human 227 5.71x71 TM5 R => C missense 2.471e-05 3 121410 0 0.0 1.0 GP (contact)
drd1_human 227 5.71x71 TM5 R => S missense 8.237e-06 1 121410 0 0.03 1.0 GP (contact)
drd1_human 226 5.70x70 TM5 R => Q missense 1.647e-05 2 121412 0 0.04 0.999
drd1_human 226 5.70x70 TM5 R => W missense 8.236e-06 1 121412 0 0.0 1.0
drd1_human 226 5.70x70 TM5 R => G missense 8.236e-06 1 121412 0 0.0 1.0
drd1_human 217 5.61x61 TM5 I => V missense 4.118e-05 5 121412 0 0.0 0.998 GP (contact)
drd1_human 208 5.52x52 TM5 A => V missense 8.236e-06 1 121412 0 0.18 0.074
drd1_human 200 5.44x45 TM5 V => A missense 8.236e-06 1 121412 0 0.0 0.033
drd1_human 191 5.35x36 TM5 S => G missense 1.647e-05 2 121412 0 0.0 0.219
drd1_human 185 ECL2 N => K missense 7.413e-05 9 121412 0 0.1 0.788
drd1_human 185 ECL2 N => D missense 8.236e-06 1 121412 0 0.21 0.074
drd1_human 183 ECL2 I => V missense 8.236e-06 1 121412 0 0.29 0.001
drd1_human 182 ECL2 T => A missense 4.942e-05 6 121412 0 0.77 0.001
drd1_human 181 ECL2 E => D missense 8.237e-06 1 121410 0 0.61 0.002
drd1_human 174 ECL2 G => R missense 8.236e-06 1 121412 0 0.67 0.005
drd1_human 164 ECL2 H => Q missense 8.236e-06 1 121412 0 0.0 1.0
drd1_human 148 4.50x50 TM4 W => R missense 8.236e-06 1 121412 0 0.0 1.0
drd1_human 147 4.49x49 TM4 A => T missense 8.236e-06 1 121412 0 0.18 0.458
drd1_human 145 4.47x47 TM4 S => G missense 2.471e-05 3 121412 0 1.0 0.002
drd1_human 138 4.40x40 TM4 K => T missense 8.236e-06 1 121412 0 0.05 0.078
drd1_human 137 4.39x39 TM4 P => L missense 2.471e-05 3 121412 0 0.06 0.981
drd1_human 137 4.39x39 TM4 P => S missense 2.471e-05 3 121412 0 0.08 0.974
drd1_human 134 34.56x56 ICL2 K => N missense 8.236e-06 1 121412 0 0.01 1.0 GP (contact)
drd1_human 130 34.52x52 ICL2 R => Q missense 8.237e-06 1 121408 0 0.08 0.05 GP (contact)
drd1_human 130 34.52x52 ICL2 R => W missense 8.237e-06 1 121410 0 0.0 0.952 GP (contact)
drd1_human 119 3.48x48 TM3 V => M missense 8.237e-06 1 121406 0 0.12 0.981
drd1_human 96 3.25x25 TM3 C => Y missense 8.239e-06 1 121374 0 0.0 0.999
drd1_human 75 2.55x55 TM2 V => I missense 5.771e-05 7 121300 0 0.37 0.007
drd1_human 72 2.52x52 TM2 L => S missense 8.244e-06 1 121302 0 0.11 0.988
drd1_human 56 2.36x36 TM2 S => A missense 8.244e-06 1 121294 0 0.47 0.669 PTM (Phosphorylation)
drd1_human 50 1.59x59 TM1 R => K missense 8.245e-06 1 121290 0 0.69 0.015
drd1_human 48 1.57x57 TM1 V => I missense 1.649e-05 2 121274 0 0.24 0.997
drd1_human 42 1.51x51 TM1 T => M missense 2.474e-05 3 121280 0 0.08 1.0
drd1_human 29 1.38x38 TM1 F => L missense 8.248e-06 1 121236 0 1.0 0.039
drd1_human 27 1.36x36 TM1 A => G missense 8.249e-06 1 121220 0 1.0 0.0
drd1_human 23 1.32x32 TM1 R => H missense 9.901e-05 12 121194 0 0.0 0.998
drd1_human 23 1.32x32 TM1 R => L missense 8.251e-06 1 121194 0 0.0 0.998
drd1_human 23 1.32x32 TM1 R => P missense 8.251e-06 1 121194 0 0.0 0.999
drd1_human 23 1.32x32 TM1 R => S missense 1.65e-05 2 121182 0 0.01 0.998
drd1_human 19 1.28x28 TM1 D => E missense 8.253e-06 1 121164 0 0.65 0.001
drd1_human 18 1.27x27 TM1 R => S missense 4.127e-05 5 121140 1 nan 0.012
drd1_human 17 1.26x26 TM1 E => V missense 1.651e-05 2 121104 0 nan 0.087
drd1_human 11 N-term G => R missense 0.0004558 55 120672 1 nan 0.003
drd1_human 2 N-term R => K missense 8.424e-06 1 118702 0 nan 0.0
drd1_human 394 C-term A => LeufsTer3 frameshift 8.242e-06 1 121326 0 None None
drd1_human 361 C-term V => GlufsTer4 frameshift 8.237e-06 1 121402 0 None None


Residue

Diagrams

R H L R ICL1ECL1 A G F W P F ECL1 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 R A A V H A K N C Q T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P ECL3N-term M R T L N T S A M D G T G L V N-termC-term Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term V E R D F S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F S K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C F C I D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T L R K A F L G C
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