Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
hrh1_human 14 N-term M => T missense 8.489e-06 1 117796 0 nan 0.776
hrh1_human 14 N-term M => I missense 0.001026 121 117952 0 nan 0.091
hrh1_human 18 N-term N => H missense 8.39e-06 1 119196 0 0.01 0.99
hrh1_human 19 N-term K => N missense 0.004356 522 119824 1 0.29 0.118
hrh1_human 22 N-term M => V missense 6.644e-05 8 120414 0 0.34 0.0
hrh1_human 24 N-term S => G missense 8.278e-06 1 120796 0 0.09 0.002
hrh1_human 26 N-term Q => L missense 8.258e-06 1 121090 0 0.02 0.411
hrh1_human 31 1.36x36 TM1 V => L missense 8.246e-06 1 121272 0 0.15 0.231
hrh1_human 34 1.39x39 TM1 L => P missense 8.244e-06 1 121304 0 0.0 0.994
hrh1_human 48 1.53x53 TM1 V => A missense 8.24e-06 1 121352 0 0.0 1.0
hrh1_human 50 1.55x55 TM1 Y => H missense 8.24e-06 1 121360 0 0.42 0.201
hrh1_human 52 1.57x57 TM1 V => I missense 2.472e-05 3 121348 0 0.07 0.451
hrh1_human 53 1.58x58 TM1 R => W missense 1.648e-05 2 121350 0 0.03 0.993
hrh1_human 53 1.58x58 TM1 R => Q missense 0.0002555 31 121342 0 0.02 0.382
hrh1_human 56 12.48x48 ICL1 R => W missense 3.297e-05 4 121332 0 0.0 0.999
hrh1_human 56 12.48x48 ICL1 R => Q missense 8.241e-06 1 121340 0 0.01 0.984
hrh1_human 62 2.39x39 TM2 G => E missense 8.242e-06 1 121324 0 0.0 0.999
hrh1_human 63 2.40x40 TM2 N => K missense 8.243e-06 1 121318 0 0.0 1.0
hrh1_human 66 2.43x43 TM2 I => V missense 2.473e-05 3 121312 0 0.02 1.0
hrh1_human 67 2.44x44 TM2 V => I missense 2.474e-05 3 121284 0 0.08 0.573
hrh1_human 70 2.47x47 TM2 S => L missense 8.248e-06 1 121244 0 0.0 0.997 PTM (Phosphorylation)
hrh1_human 76 2.53x53 TM2 V => M missense 2.474e-05 3 121244 0 0.0 0.999
hrh1_human 79 2.56x551 TM2 V => I missense 0.0002062 25 121252 2 0.16 0.021
hrh1_human 85 2.62x61 TM2 I => T missense 8.245e-06 1 121284 0 0.0 0.842
hrh1_human 90 2.67x66 TM2 M => T missense 8.243e-06 1 121314 0 0.48 0.008
hrh1_human 97 3.22x22 TM3 R => H missense 4.945e-05 6 121332 0 0.43 0.052
hrh1_human 99 3.24x24 TM3 L => F missense 8.242e-06 1 121334 0 0.11 0.985
hrh1_human 118 3.43x43 TM3 V => I missense 0.0003297 40 121328 0 0.05 0.068
hrh1_human 127 3.52x52 TM3 R => C missense 1.649e-05 2 121274 0 0.0 1.0
hrh1_human 127 3.52x52 TM3 R => H missense 2.474e-05 3 121266 0 0.02 0.909
hrh1_human 133 34.51x51 ICL2 L => F missense 8.245e-06 1 121284 0 0.0 1.0 GP (contact)
hrh1_human 134 34.52x52 ICL2 R => M missense 8.246e-06 1 121270 0 0.0 0.928 GP (contact)
hrh1_human 139 34.57x57 ICL2 R => C missense 8.248e-06 1 121246 0 0.0 1.0 GP (contact)
hrh1_human 139 34.57x57 ICL2 R => H missense 5.772e-05 7 121276 1 0.0 1.0 GP (contact)
hrh1_human 143 4.41x41 TM4 R => G missense 8.246e-06 1 121278 0 0.0 0.992
hrh1_human 143 4.41x41 TM4 R => Q missense 0.0001237 15 121302 0 0.05 0.7
hrh1_human 145 4.43x43 TM4 S => L missense 2.474e-05 3 121276 0 0.18 0.055
hrh1_human 147 4.45x45 TM4 T => A missense 1.649e-05 2 121268 0 0.02 0.696
hrh1_human 151 4.49x49 TM4 A => T missense 8.242e-06 1 121336 0 0.05 0.708
hrh1_human 153 4.51x51 TM4 F => S missense 8.24e-06 1 121358 0 0.0 0.208
hrh1_human 164 4.62x63 TM4 G => A missense 8.238e-06 1 121396 0 0.05 0.802
hrh1_human 173 ECL2 S => L missense 8.237e-06 1 121398 0 0.18 0.005
hrh1_human 174 ECL2 V => M missense 1.647e-05 2 121398 0 0.11 0.094
hrh1_human 175 ECL2 R => C missense 2.471e-05 3 121392 0 0.14 0.001
hrh1_human 175 ECL2 R => H missense 3.295e-05 4 121390 0 0.41 0.0
hrh1_human 176 ECL2 R => Q missense 4.943e-05 6 121396 0 0.51 0.009
hrh1_human 177 ECL2 E => K missense 8.238e-06 1 121396 0 0.21 0.03
hrh1_human 184 ECL2 F => C missense 8.238e-06 1 121392 0 0.0 1.0
hrh1_human 188 5.36x37 TM5 T => I missense 8.238e-06 1 121388 0 0.0 0.934
hrh1_human 194 5.42x43 TM5 T => A missense 8.239e-06 1 121374 0 0.09 0.889
hrh1_human 196 5.44x45 TM5 I => V missense 0.0001236 15 121372 0 0.3 0.456
hrh1_human 205 5.53x53 TM5 L => F missense 8.241e-06 1 121348 0 0.0 0.967
hrh1_human 209 5.57x57 TM5 F => L missense 8.242e-06 1 121334 0 0.08 0.387
hrh1_human 210 5.58x58 TM5 Y => C missense 1.648e-05 2 121326 0 0.0 1.0 SodiumPocket MicroSwitch
hrh1_human 213 5.61x61 TM5 I => M missense 1.649e-05 2 121282 0 0.0 1.0 GP (contact)
hrh1_human 217 5.65x65 TM5 V => I missense 8.248e-06 1 121236 0 0.0 0.97 GP (contact)
hrh1_human 218 5.66x66 TM5 R => Q missense 8.25e-06 1 121212 0 0.11 0.379 GP (contact)
hrh1_human 220 5.68x68 TM5 H => R missense 8.251e-06 1 121202 0 0.0 0.923 GP (contact)
hrh1_human 222 5.70x70 TM5 Q => H missense 8.254e-06 1 121152 0 0.0 0.981
hrh1_human 223 5.71x71 TM5 H => R missense 8.254e-06 1 121148 0 0.03 0.71 GP (contact)
hrh1_human 224 5.72x72 TM5 R => W missense 8.255e-05 10 121136 0 0.0 0.914 GP (contact)
hrh1_human 224 5.72x72 TM5 R => Q missense 0.0002889 35 121134 0 0.0 0.959 GP (contact)
hrh1_human 229 ICL3 R => S missense 8.264e-06 1 121012 0 0.09 0.003
hrh1_human 231 ICL3 L => F missense 8.266e-06 1 120978 0 0.7 0.006
hrh1_human 238 ICL3 K => R missense 8.287e-06 1 120674 0 0.14 0.056
hrh1_human 242 ICL3 E => D missense 1.66e-05 2 120486 0 0.22 0.01
hrh1_human 243 ICL3 N => I missense 8.301e-06 1 120472 0 0.04 0.076
hrh1_human 245 ICL3 K => R missense 7.474e-05 9 120416 0 0.31 0.015
hrh1_human 246 ICL3 G => E missense 8.306e-06 1 120388 0 1.0 0.002
hrh1_human 248 ICL3 A => T missense 8.309e-06 1 120358 0 0.53 0.002
hrh1_human 258 ICL3 E => D missense 8.303e-06 1 120434 0 0.54 0.015
hrh1_human 264 ICL3 P => A missense 8.289e-06 1 120648 0 0.58 0.002
hrh1_human 270 ICL3 G => R missense 8.272e-06 1 120884 0 0.54 0.015
hrh1_human 270 ICL3 G => E missense 0.004516 546 120904 17 0.96 0.006
hrh1_human 276 ICL3 P => L missense 1.653e-05 2 121010 0 0.32 0.006
hrh1_human 286 ICL3 P => S missense 8.254e-06 1 121154 0 0.47 0.088
hrh1_human 286 ICL3 P => A missense 8.254e-06 1 121154 0 0.28 0.076
hrh1_human 288 ICL3 V => F missense 8.252e-06 1 121186 0 0.7 0.006
hrh1_human 294 ICL3 D => V missense 8.247e-06 1 121260 0 0.08 0.025
hrh1_human 294 ICL3 D => G missense 8.247e-06 1 121260 0 0.33 0.01
hrh1_human 295 ICL3 R => K missense 4.123e-05 5 121266 0 0.92 0.004
hrh1_human 302 ICL3 C => F missense 8.241e-06 1 121346 0 0.08 0.202
hrh1_human 307 ICL3 I => V missense 8.239e-06 1 121372 0 0.67 0.01
hrh1_human 310 ICL3 M => V missense 8.239e-06 1 121370 0 0.28 0.002
hrh1_human 310 ICL3 M => I missense 8.239e-06 1 121374 0 0.2 0.002
hrh1_human 313 ICL3 A => V missense 0.0002307 28 121376 0 0.37 0.002
hrh1_human 317 ICL3 S => C missense 0.000313 38 121392 0 0.05 0.025
hrh1_human 319 ICL3 R => G missense 2.471e-05 3 121390 0 0.32 0.01
hrh1_human 320 ICL3 D => V missense 8.238e-06 1 121394 0 0.2 0.079
hrh1_human 321 ICL3 Y => N missense 8.238e-06 1 121394 0 0.28 0.078 PTM (Phosphorylation)
hrh1_human 321 ICL3 Y => C missense 2.471e-05 3 121390 0 0.21 0.01 PTM (Phosphorylation)
hrh1_human 323 ICL3 A => S missense 8.238e-06 1 121392 0 0.74 0.009
hrh1_human 324 ICL3 V => I missense 0.0004036 49 121396 0 0.36 0.01
hrh1_human 325 ICL3 N => S missense 8.237e-06 1 121400 0 0.58 0.005
hrh1_human 326 ICL3 R => W missense 4.943e-05 6 121392 0 0.0 0.018
hrh1_human 326 ICL3 R => Q missense 0.001969 239 121396 4 0.66 0.003
hrh1_human 334 ICL3 D => N missense 1.648e-05 2 121392 0 0.28 0.017
hrh1_human 334 ICL3 D => Y missense 8.238e-06 1 121392 0 0.01 0.827
hrh1_human 334 ICL3 D => G missense 3.295e-05 4 121392 0 0.24 0.005
hrh1_human 337 ICL3 G => S missense 2.471e-05 3 121386 0 0.79 0.003
hrh1_human 337 ICL3 G => D missense 8.239e-06 1 121380 0 0.63 0.007
hrh1_human 340 ICL3 T => S missense 8.239e-06 1 121376 0 0.7 0.079
hrh1_human 345 ICL3 E => K missense 6.593e-05 8 121350 0 0.42 0.027
hrh1_human 345 ICL3 E => V missense 8.24e-06 1 121352 0 0.13 0.17
hrh1_human 346 ICL3 I => K missense 8.24e-06 1 121352 0 0.91 0.004
hrh1_human 349 ICL3 D => H missense 0.001558 189 121320 2 0.13 0.764
hrh1_human 353 ICL3 G => S missense 8.244e-06 1 121300 0 0.56 0.032
hrh1_human 354 ICL3 D => E missense 8.245e-06 1 121284 0 0.27 0.01
hrh1_human 356 ICL3 Q => R missense 2.474e-05 3 121270 0 0.49 0.071
hrh1_human 360 ICL3 R => Q missense 1.65e-05 2 121204 0 0.35 0.007
hrh1_human 361 ICL3 T => M missense 2.475e-05 3 121210 0 0.08 0.126
hrh1_human 363 ICL3 S => P missense 0.0006849 83 121194 0 0.11 0.015
hrh1_human 364 ICL3 D => G missense 8.252e-06 1 121190 0 0.19 0.257
hrh1_human 368 ICL3 E => G missense 1.65e-05 2 121176 0 0.14 0.015
hrh1_human 371 ICL3 P => S missense 8.254e-06 1 121148 0 0.77 0.003
hrh1_human 377 ICL3 R => S missense 8.255e-06 1 121132 0 0.36 0.124
hrh1_human 378 ICL3 S => N missense 8.255e-06 1 121136 0 0.69 0.004 PTM (Phosphorylation)
hrh1_human 379 ICL3 G => R missense 0.0001733 21 121144 0 0.57 0.002
hrh1_human 379 ICL3 G => E missense 2.477e-05 3 121128 0 1.0 0.002
hrh1_human 386 ICL3 Y => H missense 8.255e-06 1 121136 0 0.09 0.986 PTM (Phosphorylation)
hrh1_human 388 ICL3 K => E missense 8.255e-06 1 121140 0 0.0 0.886
hrh1_human 395 ICL3 R => C missense 4.127e-05 5 121154 0 0.12 0.212
hrh1_human 395 ICL3 R => S missense 8.254e-06 1 121154 0 0.16 0.927
hrh1_human 395 ICL3 R => H missense 1.651e-05 2 121152 0 0.37 0.212
hrh1_human 396 ICL3 S => P missense 8.254e-06 1 121160 0 0.02 0.702 PTM (Phosphorylation)
hrh1_human 396 ICL3 S => W missense 8.254e-06 1 121160 0 0.0 0.948 PTM (Phosphorylation)
hrh1_human 401 ICL3 Y => C missense 1.65e-05 2 121198 0 0.13 0.06 PTM (Phosphorylation)
hrh1_human 409 6.29x29 TM6 R => C missense 8.249e-06 1 121230 0 0.0 0.996 GP (contact)
hrh1_human 409 6.29x29 TM6 R => H missense 1.65e-05 2 121228 0 0.0 0.996 GP (contact)
hrh1_human 410 6.30x30 TM6 E => K missense 3.299e-05 4 121242 0 0.0 0.996 SodiumPocket MicroSwitch
hrh1_human 412 6.32x32 TM6 K => N missense 8.246e-06 1 121276 0 0.0 1.0 GP (contact)
hrh1_human 414 6.34x34 TM6 A => T missense 8.246e-06 1 121266 0 0.0 1.0 SodiumPocket MicroSwitch
hrh1_human 415 6.35x35 TM6 K => R missense 8.244e-06 1 121300 0 0.13 0.434
hrh1_human 416 6.36x36 TM6 Q => L missense 8.243e-06 1 121310 0 0.0 1.0 GP (contact)
hrh1_human 417 6.37x37 TM6 L => F missense 8.244e-06 1 121306 0 0.0 1.0 GP (contact)
hrh1_human 422 6.42x42 TM6 A => V missense 4.946e-05 6 121302 0 0.06 0.169
hrh1_human 433 6.53x53 TM6 I => V missense 8.241e-06 1 121338 0 1.0 0.022
hrh1_human 437 6.57x57 TM6 V => F missense 0.0001154 14 121348 0 0.0 0.999
hrh1_human 438 6.58x58 TM6 I => V missense 1.648e-05 2 121348 0 0.1 0.042
hrh1_human 438 6.58x58 TM6 I => T missense 8.241e-06 1 121348 0 0.1 0.189
hrh1_human 441 6.61x61 TM6 C => Y missense 8.24e-06 1 121354 0 0.08 0.995
hrh1_human 442 ECL3 K => E missense 2.472e-05 3 121352 0 0.84 0.004
hrh1_human 446 7.31x30 TM7 N => D missense 8.241e-06 1 121348 0 0.2 0.142
hrh1_human 446 7.31x30 TM7 N => S missense 8.241e-05 10 121346 0 0.42 0.034
hrh1_human 448 7.33x32 TM7 H => R missense 8.241e-06 1 121342 0 0.43 0.002
hrh1_human 453 7.38x37 TM7 T => S missense 8.243e-06 1 121310 0 0.0 0.996
hrh1_human 455 7.40x39 TM7 W => C missense 8.246e-06 1 121266 0 0.0 1.0
hrh1_human 468 7.53x53 TM7 Y => D missense 8.353e-06 1 119716 0 0.0 1.0 SodiumPocket MicroSwitch
hrh1_human 469 7.54x54 TM7 P => R missense 8.374e-06 1 119412 0 0.0 0.998
hrh1_human 475 8.50x50 H8 F => S missense 8.504e-06 1 117592 0 0.0 1.0
hrh1_human 477 8.52x52 H8 K => T missense 1.712e-05 2 116822 0 0.02 0.566
hrh1_human 479 8.54x54 H8 F => S missense 1.719e-05 2 116320 0 0.0 1.0
hrh1_human 486 C-term R => G missense 2.634e-05 3 113892 0 0.08 0.012
hrh1_human 486 C-term R => H missense 8.804e-06 1 113588 0 0.39 0.004
hrh1_human 10 N-term L => Ter stop gained 8.588e-06 1 116438 0 None None
hrh1_human 176 ECL2 R => Ter stop gained 8.238e-06 1 121394 0 None None
hrh1_human 281 ICL3 K => Ter stop gained 8.258e-06 1 121096 0 None None
hrh1_human 363 ICL3 S => Ter stop gained 8.252e-06 1 121190 0 None None
hrh1_human 445 ECL3 C => Ter stop gained 8.241e-06 1 121350 0 None None
hrh1_human 455 7.40x39 TM7 W => Ter stop gained 8.245e-06 1 121280 0 None None


Residue

Diagrams

R K L H ICL1ECL1 S K W S L ECL1 P L R Y L K Y R ICL2ECL2 W N H F M Q Q T S V R R E D K C E T D F Y D ECL2ICL3 R S L P S F S E I K L R P E N P K G D A K K P G K E S P W E V L K R K P K D A G G G S V L K S P S Q T P K E M K S P V V F S Q E D D R E V D K L Y C F P L D I V H M Q A A A E G S S R D Y V A V N R S H G Q L K T D E Q G L N T H G A S E I S E D Q M L G D S Q S F S R T D S D T T T E T A P G K G K L R S G S N T G L D Y I K F T W K R L R S H S R Q Y V S ICL3ECL3 K N C C ECL3N-term M S L P N S S C L L E D K M C E G N K T T M A S P Q L M N-termC-term I R S C-term P L V V V L S T I C L V T V G L N L L V L Y A V R S E T V G N L Y I V S L S V A D L I V G A V V M P M N I L Y L L M G R P L C L F W L S M D Y V A S T A S I F S V F I L C I D R Y R S V Q Q T K T R A S A T I L G A W F L S F L W V I P I L G V T W F K V M T A I I N F Y L P T L L M L W F Y A K I Y K A V R Q H C Q H R E L I N G L H M N R E R K A A K Q L G F I M A A F I L C W I P Y F I F F M V I A F C N E H L H M F T I W L G Y I N S T L N P L I Y P L C N E N F K R F K K T I L H
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