Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
oxyr_human 389 C-term A => V missense 0.0001074 12 111722 0 0.14 0.0
oxyr_human 388 C-term T => M missense 1.761e-05 2 113582 0 0.05 0.0
oxyr_human 378 C-term S => P missense 8.407e-06 1 118942 0 0.19 0.0
oxyr_human 377 C-term S => G missense 8.384e-06 1 119280 0 0.05 0.0
oxyr_human 376 C-term R => H missense 0.0001256 15 119452 0 0.23 0.0
oxyr_human 376 C-term R => G missense 0.0003093 37 119626 0 0.03 0.0
oxyr_human 376 C-term R => C missense 2.508e-05 3 119626 0 0.01 0.0
oxyr_human 374 C-term S => N missense 0.0001167 14 120016 0 0.22 0.0
oxyr_human 373 C-term L => P missense 8.322e-06 1 120166 0 0.01 0.0
oxyr_human 371 C-term F => C missense 8.306e-06 1 120400 0 0.04 0.0
oxyr_human 368 C-term S => L missense 1.657e-05 2 120682 0 0.02 0.0
oxyr_human 367 C-term N => S missense 0.0001573 19 120762 0 0.56 0.0
oxyr_human 365 C-term K => R missense 2.481e-05 3 120896 0 0.69 0.0
oxyr_human 364 C-term K => Q missense 8.268e-06 1 120950 0 0.25 0.0
oxyr_human 360 C-term T => M missense 4.129e-05 5 121084 0 0.15 0.799
oxyr_human 358 C-term G => R missense 1.651e-05 2 121122 0 0.49 0.011
oxyr_human 357 C-term L => M missense 8.253e-06 1 121166 0 0.12 0.011
oxyr_human 356 C-term R => H missense 8.253e-06 1 121174 0 0.07 0.066
oxyr_human 356 C-term R => C missense 3.301e-05 4 121186 0 0.03 0.772
oxyr_human 353 C-term K => R missense 8.249e-06 1 121226 0 0.33 0.002
oxyr_human 351 C-term Y => H missense 2.474e-05 3 121240 0 0.53 0.002
oxyr_human 350 C-term S => G missense 8.248e-06 1 121238 0 0.41 0.002
oxyr_human 349 C-term A => T missense 3.299e-05 4 121240 0 0.52 0.004
oxyr_human 346 C-term C => R missense 8.248e-06 1 121246 0 0.02 0.168
oxyr_human 343 8.57x57 H8 R => C missense 8.247e-06 1 121254 0 0.23 0.006
oxyr_human 341 8.55x55 H8 V => M missense 1.649e-05 2 121252 0 0.34 0.012
oxyr_human 341 8.55x55 H8 V => L missense 8.247e-06 1 121252 0 1.0 0.002
oxyr_human 339 8.53x53 H8 E => K missense 0.001072 130 121250 0 0.01 0.018
oxyr_human 334 8.48x48 H8 G => D missense 3.299e-05 4 121264 0 0.0 0.411 GP (contact)
oxyr_human 333 8.47x47 H8 T => M missense 3.299e-05 4 121266 0 0.0 0.772 GP (contact)
oxyr_human 331 7.55x55 TM7 L => V missense 8.246e-06 1 121270 0 0.11 0.085 GP (contact)
oxyr_human 330 7.54x54 TM7 M => I missense 8.247e-05 10 121262 0 0.0 0.181
oxyr_human 328 7.52x52 TM7 I => L missense 1.65e-05 2 121248 0 0.02 0.867
oxyr_human 326 7.50x50 TM7 P => S missense 8.249e-06 1 121226 0 0.0 1.0 SodiumPocket MicroSwitch
oxyr_human 321 7.45x45 TM7 N => K missense 2.476e-05 3 121178 0 0.0 0.978
oxyr_human 320 7.44x43 TM7 L => F missense 8.256e-06 1 121130 0 0.02 0.982 SodiumPocket MicroSwitch
oxyr_human 314 7.38x37 TM7 V => I missense 1.654e-05 2 120884 0 0.05 0.025
oxyr_human 312 7.36x35 TM7 I => S missense 8.291e-06 1 120610 0 0.11 0.019
oxyr_human 312 7.36x35 TM7 I => V missense 2.487e-05 3 120606 0 0.06 0.008
oxyr_human 309 7.33x32 TM7 S => L missense 5.014e-05 6 119674 0 0.18 0.087
oxyr_human 308 7.32x31 TM7 A => G missense 2.516e-05 3 119214 0 0.38 0.012
oxyr_human 303 ECL3 N => K missense 9.368e-06 1 106748 0 0.27 0.08
oxyr_human 303 ECL3 N => S missense 9.354e-06 1 106910 0 0.19 0.08
oxyr_human 303 ECL3 N => D missense 0.0001401 15 107068 0 0.56 0.012
oxyr_human 301 6.61x61 TM6 D => N missense 2.781e-05 3 107856 0 0.0 0.911
oxyr_human 299 6.59x59 TM6 V => A missense 9.186e-06 1 108862 0 0.18 0.245
oxyr_human 299 6.59x59 TM6 V => L missense 9.181e-06 1 108918 0 0.0 0.911
oxyr_human 295 6.55x55 TM6 Q => H missense 9.022e-06 1 110840 0 0.01 0.97
oxyr_human 281 6.41x41 TM6 V => M missense 0.0005343 62 116040 0 0.0 0.999
oxyr_human 276 6.36x36 TM6 M => L missense 8.71e-06 1 114812 0 0.0 0.714 GP (contact)
oxyr_human 274 6.34x34 TM6 V => I missense 8.762e-06 1 114128 0 0.02 0.607 SodiumPocket MicroSwitch
oxyr_human 273 6.33x33 TM6 T => R missense 3.51e-05 4 113970 0 0.0 1.0 GP (contact)
oxyr_human 273 6.33x33 TM6 T => M missense 8.774e-06 1 113970 0 0.0 0.998 GP (contact)
oxyr_human 266 6.26x26 TM6 I => T missense 9.016e-06 1 110914 0 0.0 0.981 GP (contact)
oxyr_human 265 6.25x25 TM6 L => I missense 9.117e-06 1 109686 0 0.16 0.123 GP (contact)
oxyr_human 263 ICL3 V => I missense 2.756e-05 3 108872 0 0.22 0.1
oxyr_human 259 ICL3 R => H missense 1.892e-05 2 105732 0 0.12 0.316
oxyr_human 255 ICL3 V => G missense 3.906e-05 4 102418 0 0.43 0.004
oxyr_human 255 ICL3 V => M missense 0.0001078 11 102028 0 0.13 0.028
oxyr_human 252 ICL3 G => A missense 0.0005305 52 98016 0 0.91 0.004
oxyr_human 251 ICL3 D => N missense 1.06e-05 1 94374 0 0.54 0.002
oxyr_human 242 ICL3 E => Q missense 2.321e-05 2 86170 0 0.54 0.026
oxyr_human 242 ICL3 E => K missense 1.16e-05 1 86170 0 0.79 0.004
oxyr_human 241 ICL3 A => T missense 1.137e-05 1 87966 0 0.49 0.038
oxyr_human 238 5.76x76 TM5 A => T missense 0.02325 2099 90280 29 0.53 0.073
oxyr_human 236 5.74x74 TM5 A => D missense 1.092e-05 1 91586 0 0.48 0.026 GP (contact)
oxyr_human 233 5.71x71 TM5 L => I missense 1.058e-05 1 94534 0 0.39 0.058 GP (contact)
oxyr_human 228 5.66x66 TM5 W => C missense 0.0001671 18 107716 0 0.36 0.448 GP (contact)
oxyr_human 227 5.65x65 TM5 I => M missense 9.205e-06 1 108642 0 0.0 0.97 GP (contact)
oxyr_human 224 5.62x62 TM5 S => I missense 2.701e-05 3 111054 0 0.0 0.117
oxyr_human 224 5.62x62 TM5 S => N missense 9.005e-06 1 111054 0 0.0 0.758
oxyr_human 221 5.59x59 TM5 G => S missense 0.0007651 87 113704 0 0.35 0.145
oxyr_human 218 5.56x56 TM5 A => T missense 0.149 17403 116824 1550 0.4 0.045
oxyr_human 215 5.53x53 TM5 V => L missense 8.476e-06 1 117980 0 0.03 0.101
oxyr_human 214 5.52x52 TM5 I => V missense 8.463e-06 1 118168 0 0.97 0.019
oxyr_human 212 5.50x50 TM5 P => Q missense 1.689e-05 2 118420 0 0.0 1.0 SodiumPocket MicroSwitch
oxyr_human 211 5.49x49 TM5 V => L missense 1.686e-05 2 118592 0 0.83 0.048
oxyr_human 211 5.49x49 TM5 V => L missense 8.432e-06 1 118592 0 0.83 0.048
oxyr_human 210 5.48x48 TM5 I => V missense 8.423e-06 1 118726 0 0.89 0.018
oxyr_human 209 5.47x47 TM5 Y => F missense 8.422e-06 1 118736 0 1.0 0.189 SodiumPocket MicroSwitch
oxyr_human 208 5.46x461 TM5 V => I missense 8.416e-06 1 118822 0 1.0 0.245
oxyr_human 206 5.44x45 TM5 L => V missense 0.001791 213 118932 4 0.45 0.219
oxyr_human 204 5.42x43 TM5 I => F missense 8.403e-06 1 119000 0 0.02 0.065
oxyr_human 203 5.41x42 TM5 W => R missense 8.401e-06 1 119032 0 0.0 0.999
oxyr_human 194 5.32x33 TM5 P => T missense 8.416e-06 1 118824 0 0.01 0.913
oxyr_human 192 ECL2 I => L missense 8.424e-06 1 118714 0 0.13 0.112
oxyr_human 188 45.51x51 ECL2 W => C missense 8.443e-06 1 118444 0 0.0 0.999
oxyr_human 188 45.51x51 ECL2 W => R missense 8.442e-06 1 118460 0 0.01 0.809
oxyr_human 187 45.50x50 ECL2 C => F missense 2.535e-05 3 118348 0 0.0 1.0
oxyr_human 187 45.50x50 ECL2 C => G missense 8.448e-06 1 118376 0 0.0 1.0
oxyr_human 186 ECL2 D => N missense 8.456e-06 1 118254 0 0.0 0.964
oxyr_human 186 ECL2 D => Y missense 8.456e-06 1 118254 0 0.0 0.999
oxyr_human 180 ECL2 V => L missense 8.506e-06 1 117560 0 0.02 0.45
oxyr_human 172 4.61x62 TM4 V => A missense 0.005501 633 115070 26 0.3 0.095
oxyr_human 164 4.53x53 TM4 C => G missense 9.119e-06 1 109656 0 0.02 0.058
oxyr_human 160 4.49x49 TM4 T => M missense 9.077e-06 1 110172 0 0.0 0.979
oxyr_human 154 4.43x43 TM4 R => S missense 2.829e-05 3 106042 0 0.1 0.264
oxyr_human 151 4.40x40 TM4 R => C missense 9.633e-06 1 103806 0 0.01 0.943
oxyr_human 150 4.39x39 TM4 R => S missense 2.925e-05 3 102550 0 0.01 0.304
oxyr_human 147 ICL2 S => L missense 2.04e-05 2 98052 0 0.01 0.152
oxyr_human 146 ICL2 R => H missense 1.027e-05 1 97340 0 0.05 0.062
oxyr_human 138 3.51x51 TM3 C => Y missense 1.069e-05 1 93510 0 1.0 0.024
oxyr_human 133 3.46x46 TM3 M => I missense 2.095e-05 2 95462 0 0.01 0.911
oxyr_human 122 3.35x35 TM3 G => D missense 9.559e-06 1 104618 0 0.0 0.994
oxyr_human 121 3.34x34 TM3 V => L missense 9.403e-06 1 106348 0 1.0 0.244
oxyr_human 117 3.30x30 TM3 Y => C missense 9.087e-06 1 110052 0 0.0 1.0
oxyr_human 116 3.29x29 TM3 K => E missense 9.02e-06 1 110868 0 0.0 0.996
oxyr_human 115 3.28x28 TM3 V => I missense 8.978e-06 1 111384 0 0.13 0.478
oxyr_human 110 3.23x23 TM3 L => V missense 8.812e-06 1 113478 0 0.42 0.054
oxyr_human 108 3.21x21 TM3 P => A missense 0.0002546 29 113894 0 0.0 0.984
oxyr_human 106 3.19x19 TM3 Y => C missense 8.753e-06 1 114250 0 0.06 0.981
oxyr_human 106 3.19x19 TM3 Y => D missense 8.752e-06 1 114266 0 0.07 0.793
oxyr_human 101 2.66x66 TM2 I => V missense 8.732e-06 1 114524 0 0.36 0.714
oxyr_human 95 2.60x60 TM2 P => L missense 8.802e-06 1 113610 0 0.0 1.0
oxyr_human 87 2.52x52 TM2 V => E missense 8.931e-06 1 111964 0 0.0 0.858
oxyr_human 77 2.42x42 TM2 F => L missense 9.153e-06 1 109254 0 0.01 0.799
oxyr_human 68 12.48x48 ICL1 R => H missense 1.872e-05 2 106836 0 0.05 0.721
oxyr_human 68 12.48x48 ICL1 R => P missense 9.36e-06 1 106836 0 0.34 0.63
oxyr_human 68 12.48x48 ICL1 R => C missense 9.351e-06 1 106938 0 0.0 0.993
oxyr_human 65 1.58x58 TM1 R => H missense 9.414e-06 1 106220 0 1.0 0.006
oxyr_human 63 1.56x56 TM1 A => T missense 2.839e-05 3 105676 0 0.0 0.546
oxyr_human 56 1.49x49 TM1 G => W missense 6.602e-05 5 75732 0 0.0 1.0
oxyr_human 51 1.44x44 TM1 L => F missense 2.909e-05 2 68742 1 0.49 0.005
oxyr_human 47 1.40x40 TM1 C => Y missense 1.627e-05 1 61468 0 0.0 0.648
oxyr_human 46 1.39x39 TM1 L => P missense 3.324e-05 2 60174 0 0.0 0.999
oxyr_human 45 1.38x38 TM1 V => L missense 0.0005131 29 56516 0 0.02 0.661
oxyr_human 44 1.37x37 TM1 A => V missense 3.646e-05 2 54848 0 0.01 0.546
oxyr_human 40 1.33x33 TM1 R => S missense 2.301e-05 1 43468 0 nan 0.405
oxyr_human 38 N-term L => V missense 2.825e-05 1 35400 0 nan 0.64
oxyr_human 30 N-term G => E missense 0.0001145 1 8736 0 nan 0.01
oxyr_human 27 N-term R => P missense 0.0002762 1 3620 0 nan 0.005
oxyr_human 324 7.48x48 TM7 C => Ter stop gained 8.25e-06 1 121212 0 None None
oxyr_human 323 7.47x47 TM7 C => AlafsTer30 frameshift 8.251e-06 1 121198 0 None None
oxyr_human 307 7.31x30 TM7 E => Ter stop gained 9.543e-06 1 104788 0 None None
oxyr_human 187 45.50x50 ECL2 C => AlafsTer20 frameshift 8.45e-06 1 118348 0 None None
oxyr_human 161 4.50x50 TM4 W => Ter stop gained 9.056e-06 1 110430 0 None None
oxyr_human 128 3.41x41 TM3 Y => Ter stop gained 5.073e-05 5 98556 0 None None
oxyr_human 119 3.32x32 TM3 Q => Ter stop gained 9.216e-06 1 108510 0 None None
oxyr_human 22 N-term G => AspfsTer25 frameshift 0.0001783 1 5608 0 None None


Residue

Diagrams

R Q K H ICL1ECL1 T F R F ECL1ICL2 P L R S L ICL2ECL2 S L R E V A D G V F D C W A V F I Q ECL2ICL3 A A A E A P E G A A A G D G G R V A L A R V S S V ICL3ECL3 A N A P K ECL3N-term M E G A L A A N W S A E A A N A S A A P P G A E G N R T A G P P R R N E A L N-termC-term L C C S A S Y L K G R R L G E T S A S K K S N S S S F V L S H R S S S Q R S C S Q P S T A C-term A R V E V A V L C L I L L L A L S G N A C V L L A L R T T S R L F F F M K H L S I A D L V V A V F Q V L P Q L L W D I Y G P D L L C R L V K Y L Q V V G M F A S T Y L L L L M S L D R C L A I C Q R R R T D R L A V L A T W L G C L V A S A P Q V H I F P W G P K A Y I T W I T L A V Y I V P V I V L A A C Y G L I S F K I W Q N L R L K T A A A K L I S K A K I R T V K M T F I I V L A F I V C W T P F F F V Q M W S V W D E A S A F I I V M L L A S L N S C C N P W I Y M L F T G H L V Q L F H E R F
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