Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
pe2r4_human 8 N-term S => L missense 8.621e-06 1 115996 0 0.14 0.002
pe2r4_human 10 N-term A => V missense 1.705e-05 2 117318 0 0.19 0.013
pe2r4_human 11 N-term S => F missense 8.485e-05 10 117850 0 0.02 0.035
pe2r4_human 13 N-term S => G missense 8.439e-06 1 118500 0 0.44 0.001
pe2r4_human 14 N-term P => A missense 8.425e-06 1 118690 0 0.18 0.001
pe2r4_human 15 N-term D => H missense 8.404e-06 1 118996 0 0.12 0.002
pe2r4_human 26 1.41x41 TM1 V => L missense 8.317e-06 1 120238 0 0.22 0.004
pe2r4_human 29 1.44x44 TM1 I => V missense 8.302e-06 1 120446 0 0.2 0.04
pe2r4_human 29 1.44x44 TM1 I => L missense 8.302e-06 1 120446 0 0.07 0.008
pe2r4_human 32 1.47x47 TM1 V => A missense 8.295e-06 1 120558 0 0.09 0.573
pe2r4_human 39 1.54x54 TM1 I => M missense 8.272e-06 1 120886 0 0.0 0.987
pe2r4_human 74 2.59x58 TM2 P => S missense 8.254e-06 1 121148 0 0.0 0.88
pe2r4_human 79 2.64x63 TM2 T => R missense 8.258e-06 1 121094 0 0.0 0.038
pe2r4_human 81 2.66x65 TM2 M => L missense 8.259e-06 1 121078 0 0.6 0.001
pe2r4_human 96 3.29x29 TM3 T => S missense 8.253e-06 1 121166 0 1.0 0.01
pe2r4_human 101 3.34x34 TM3 F => L missense 8.253e-06 1 121172 0 0.0 0.74
pe2r4_human 109 3.42x42 TM3 I => F missense 1.651e-05 2 121168 0 0.03 0.809
pe2r4_human 112 3.45x45 TM3 A => T missense 8.254e-06 1 121160 0 0.07 0.753
pe2r4_human 126 34.52x52 ICL2 F => L missense 1.652e-05 2 121070 0 0.09 0.062 GP (contact)
pe2r4_human 129 34.55x55 ICL2 H => Q missense 3.303e-05 4 121090 0 0.59 0.009 GP (contact)
pe2r4_human 135 4.41x41 TM4 L => W missense 1.653e-05 2 120994 0 0.01 0.222
pe2r4_human 143 4.49x49 TM4 V => A missense 1.655e-05 2 120840 0 0.03 0.217
pe2r4_human 144 4.50x50 TM4 Y => C missense 1.655e-05 2 120810 0 0.0 0.766
pe2r4_human 147 4.53x53 TM4 N => S missense 2.484e-05 3 120758 0 0.02 0.137
pe2r4_human 149 4.55x55 TM4 L => I missense 8.285e-06 1 120696 0 0.06 0.021
pe2r4_human 156 4.62x62 TM4 M => L missense 8.3e-06 1 120484 0 0.27 0.028
pe2r4_human 156 4.62x62 TM4 M => V missense 8.3e-06 1 120484 0 0.14 0.173
pe2r4_human 180 ECL2 A => T missense 8.39e-06 1 119190 0 1.0 0.004
pe2r4_human 180 ECL2 A => E missense 8.393e-06 1 119150 0 0.17 0.125
pe2r4_human 186 5.39x39 TM5 Y => C missense 8.433e-06 1 118582 0 0.0 0.984
pe2r4_human 187 5.40x40 TM5 M => T missense 1.689e-05 2 118446 0 0.13 0.115
pe2r4_human 193 5.46x46 TM5 S => C missense 2.567e-05 3 116878 0 0.04 0.976
pe2r4_human 194 5.47x47 TM5 F => L missense 8.584e-06 1 116496 0 1.0 0.01 SodiumPocket MicroSwitch
pe2r4_human 196 5.49x49 TM5 I => V missense 8.642e-06 1 115720 0 0.27 0.326
pe2r4_human 199 5.52x52 TM5 T => S missense 8.782e-06 1 113874 0 0.0 0.857
pe2r4_human 205 5.58x58 TM5 L => R missense 9.311e-06 1 107404 0 0.01 0.309 SodiumPocket MicroSwitch
pe2r4_human 208 5.61x61 TM5 G => A missense 9.759e-06 1 102468 0 0.64 0.009 GP (contact)
pe2r4_human 212 5.65x65 TM5 R => H missense 5.357e-05 5 93340 0 0.02 0.435 GP (contact)
pe2r4_human 215 5.68x68 TM5 R => C missense 1.117e-05 1 89548 0 0.0 0.973 GP (contact)
pe2r4_human 216 5.69x69 TM5 Q => R missense 1.154e-05 1 86662 0 1.0 0.007 GP (contact)
pe2r4_human 224 ICL3 G => A missense 1.557e-05 1 64216 0 0.08 0.241
pe2r4_human 225 ICL3 T => N missense 3.114e-05 2 64222 0 0.05 0.014
pe2r4_human 229 ICL3 H => Q missense 1.96e-05 1 51022 0 0.23 0.023
pe2r4_human 230 ICL3 A => E missense 1.926e-05 1 51920 0 0.53 0.206
pe2r4_human 230 ICL3 A => V missense 1.926e-05 1 51920 0 0.36 0.021
pe2r4_human 238 ICL3 S => T missense 1.687e-05 1 59284 0 0.42 0.001
pe2r4_human 243 ICL3 A => T missense 4.46e-05 3 67258 0 0.53 0.001
pe2r4_human 247 ICL3 A => G missense 2.521e-05 2 79330 0 nan 0.004
pe2r4_human 249 ICL3 P => Q missense 6.992e-05 6 85818 0 0.25 0.013
pe2r4_human 249 ICL3 P => R missense 1.165e-05 1 85818 0 0.1 0.039
pe2r4_human 253 ICL3 D => G missense 1.031e-05 1 96982 0 0.09 0.446
pe2r4_human 258 ICL3 R => G missense 9.574e-06 1 104446 0 0.01 0.899
pe2r4_human 258 ICL3 R => P missense 9.496e-06 1 105312 0 0.04 0.249
pe2r4_human 265 6.28x28 TM6 G => V missense 1.84e-05 2 108692 0 0.0 0.616 GP (contact)
pe2r4_human 272 6.35x35 TM6 I => F missense 1.836e-05 2 108944 0 0.08 0.111
pe2r4_human 289 6.52x52 TM6 V => M missense 1.88e-05 2 106408 0 0.0 0.2
pe2r4_human 294 6.57x57 TM6 V => I missense 0.01695 2017 118990 17 0.4 0.002
pe2r4_human 300 ECL3 P => S missense 4.973e-05 6 120658 0 0.19 0.026
pe2r4_human 301 ECL3 S => R missense 8.278e-06 1 120798 0 0.36 0.005
pe2r4_human 304 7.28x27 TM7 R => Q missense 9.08e-05 11 121142 0 0.57 0.009
pe2r4_human 313 7.37x36 TM7 Q => K missense 0.001187 144 121360 0 1.0 0.036
pe2r4_human 335 8.49x49 H8 T => A missense 8.239e-06 1 121372 0 0.32 0.003 PTM (Phosphorylation) GP (contact)
pe2r4_human 335 8.49x49 H8 T => R missense 1.648e-05 2 121374 0 0.0 0.197 PTM (Phosphorylation) GP (contact)
pe2r4_human 341 8.55x55 H8 I => V missense 8.239e-06 1 121370 0 0.37 0.003
pe2r4_human 345 8.59x59 H8 K => N missense 8.24e-06 1 121354 0 0.01 0.762
pe2r4_human 346 8.60x60 H8 C => S missense 8.241e-06 1 121346 0 0.14 0.392
pe2r4_human 348 C-term F => S missense 1.648e-05 2 121328 0 0.0 0.933
pe2r4_human 350 C-term R => H missense 3.312e-05 4 120756 0 0.0 0.696
pe2r4_human 351 C-term I => T missense 8.282e-06 1 120742 0 0.14 0.313
pe2r4_human 355 C-term R => C missense 0.0001986 24 120830 0 0.01 0.556
pe2r4_human 355 C-term R => H missense 6.619e-05 8 120868 0 0.14 0.005
pe2r4_human 356 C-term R => G missense 8.271e-06 1 120904 0 0.18 0.002
pe2r4_human 357 C-term E => D missense 3.307e-05 4 120958 0 0.8 0.001
pe2r4_human 358 C-term R => C missense 0.0002397 29 120960 0 0.07 0.368
pe2r4_human 358 C-term R => H missense 1.653e-05 2 120966 0 0.33 0.001
pe2r4_human 360 C-term G => R missense 1.652e-05 2 121064 0 0.09 0.003
pe2r4_human 362 C-term H => R missense 8.255e-06 1 121144 0 0.33 0.002
pe2r4_human 382 C-term S => C missense 4.948e-05 6 121258 0 0.0 0.728 PTM (Phosphorylation)
pe2r4_human 383 C-term R => W missense 8.248e-06 1 121246 0 0.04 0.01
pe2r4_human 383 C-term R => Q missense 4.949e-05 6 121242 0 0.11 0.347
pe2r4_human 386 C-term K => R missense 8.247e-06 1 121262 0 1.0 0.001
pe2r4_human 386 C-term K => N missense 8.246e-06 1 121268 0 0.01 0.138
pe2r4_human 391 C-term T => I missense 8.245e-06 1 121280 0 0.03 0.614
pe2r4_human 395 C-term L => F missense 8.245e-06 1 121284 0 0.5 0.015
pe2r4_human 401 C-term L => Q missense 8.246e-06 1 121278 0 0.05 0.079
pe2r4_human 403 C-term D => N missense 1.649e-05 2 121284 0 0.11 0.047
pe2r4_human 407 C-term N => S missense 8.245e-06 1 121290 0 0.8 0.0
pe2r4_human 409 C-term L => P missense 8.245e-06 1 121290 0 0.09 0.248
pe2r4_human 413 C-term N => D missense 8.245e-06 1 121292 0 0.41 0.021
pe2r4_human 417 C-term G => R missense 8.245e-06 1 121288 0 nan 0.927
pe2r4_human 418 C-term V => M missense 8.245e-06 1 121280 0 nan 0.332
pe2r4_human 420 C-term G => D missense 0.0001319 16 121286 0 nan 0.003
pe2r4_human 423 C-term L => Q missense 8.246e-06 1 121276 0 nan 0.01
pe2r4_human 425 C-term Q => R missense 8.247e-06 1 121260 0 nan 0.031
pe2r4_human 426 C-term E => D missense 8.248e-06 1 121244 0 nan 0.008
pe2r4_human 427 C-term D => H missense 2.474e-05 3 121240 0 nan 0.503
pe2r4_human 428 C-term T => P missense 6.599e-05 8 121234 0 nan 0.265
pe2r4_human 430 C-term S => L missense 5.775e-05 7 121208 0 nan 0.002 PTM (Phosphorylation)
pe2r4_human 434 C-term L => W missense 8.254e-06 1 121158 0 nan 0.002
pe2r4_human 434 C-term L => S missense 8.254e-06 1 121158 0 nan 0.135
pe2r4_human 435 C-term R => Q missense 0.0001238 15 121116 0 nan 0.033
pe2r4_human 441 C-term D => V missense 8.26e-06 1 121060 0 nan 0.007
pe2r4_human 444 C-term Q => E missense 8.263e-06 1 121018 0 nan 0.012
pe2r4_human 446 C-term Q => R missense 7.439e-05 9 120990 0 nan 0.021
pe2r4_human 447 C-term D => Y missense 4.132e-05 5 121002 0 nan 0.804
pe2r4_human 455 C-term D => G missense 8.273e-06 1 120876 0 nan 0.114
pe2r4_human 459 C-term G => E missense 8.516e-06 1 117430 0 nan 0.007
pe2r4_human 461 C-term G => S missense 6.782e-05 8 117968 0 1.0 0.001
pe2r4_human 467 C-term P => L missense 8.39e-06 1 119190 0 nan 0.034
pe2r4_human 472 C-term L => V missense 8.41e-06 1 118904 0 nan 0.718
pe2r4_human 473 C-term Q => K missense 8.418e-06 1 118798 0 nan 0.03
pe2r4_human 475 C-term T => A missense 8.449e-06 1 118362 0 nan 0.02
pe2r4_human 476 C-term F => V missense 8.472e-06 1 118040 0 nan 0.78
pe2r4_human 483 C-term L => S missense 2.616e-05 3 114682 0 nan 0.005
pe2r4_human 488 C-term I => M missense 2.675e-05 3 112156 0 nan 0.996
pe2r4_human 305 7.29x28 TM7 E => Ter stop gained 8.252e-06 1 121190 0 None None


Residue

Diagrams

ICL1 R K E Q K E ICL1ECL1 Q W P G ECL1 A Y F Y S H Y V ICL2ECL2 R L Q Y P D T W C F I D W T T N V T A H ECL2ICL3 G T E Q H H A A A A A S V A S R G H P A A S P A L P R L S D F R R R R S F ICL3ECL3 Q P S L E ECL3N-term M S T P G V N S S A S L S P D R L N-termC-term L F C R I G G S R R E R S G Q H C S D S Q R T S S A M S G H S R S F I S R E L K E I S S T S Q T L L P D L S L P D L S E N G L G G R N L L P G V P G M G L A Q E D T T S L R T L R I S E T S D S S Q G Q D S E S V L L V D E A G G S G R A G P A P K G S S L Q V T F P S E T L N L S E K C I C-term N S P V T I P A V M F I F G V V G N L V A I V V L C K S T T F Y T L V C G L A V T D L L G T L L V S P V T I A T Y M K G G Q P L C E Y S T F I L L F F S L S G L S I I C A M S V E R Y L A I N H D K R L A G L T L F A V Y A S N V L F C A L P N M G L G S S A A Y S Y M Y A G F S S F L I L A T V L C N V L V C G A L L R M H R Q F M R R T S L R R I A G A E I Q M V I L L I A T S L V V L I C S I P L V V R V F V N Q L Y R E V S K N P D L Q A I R I A S V N P I L D P W I Y I L L R K T A I E V L S K K I K C
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