α2C-adrenoceptor (ada2c_mouse)
FAMILY
Class A (Rhodopsin) Aminergic receptors Adrenoceptors α2C-adrenoceptor
GENE
Adra2c
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Alpha-2C adrenergic receptor, Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2C adrenoceptor, Alpha-2CAR
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
S
|
P
|
A
|
L
|
A
|
A
|
A
|
L
|
10 |
A
|
A
|
A
|
A
|
A
|
E
|
G
|
P
|
N
|
G
|
20 |
S
|
D
|
A
|
G
|
E
|
W
|
G
|
S
|
G
|
G
|
30 |
G
|
A
|
N
|
A
|
S
|
G
|
T
|
D
|
W
|
V
|
40 |
TM1 | |||||||||
P
|
P
|
P
|
G
|
Q
|
Y
|
S
|
A
|
G
|
A
|
50 |
V
|
A
|
G
|
L
|
A
|
A
|
V
|
V
|
G
|
F
|
60 |
L
|
I
|
V
|
F
|
T
|
V
|
V
|
G
|
N
|
V
|
70 |
L
|
V
|
V
|
I
|
A
|
V
|
L
|
T
|
S
|
R
|
80 |
ICL1 | TM2 | ||||||||
A
|
L
|
R
|
A
|
P
|
Q
|
N
|
L
|
F
|
L
|
90 |
V
|
S
|
L
|
A
|
S
|
A
|
D
|
I
|
L
|
V
|
100 |
A
|
T
|
L
|
V
|
M
|
P
|
F
|
S
|
L
|
A
|
110 |
ECL1 | |||||||||
N
|
E
|
L
|
M
|
A
|
Y
|
W
|
Y
|
F
|
G
|
120 |
TM3 | |||||||||
Q
|
V
|
W
|
C
|
G
|
V
|
Y
|
L
|
A
|
L
|
130 |
D
|
V
|
L
|
F
|
C
|
T
|
S
|
S
|
I
|
V
|
140 |
H
|
L
|
C
|
A
|
I
|
S
|
L
|
D
|
R
|
Y
|
150 |
ICL2 | |||||||||
W
|
S
|
V
|
T
|
Q
|
A
|
V
|
E
|
Y
|
N
|
160 |
TM4 | |||||||||
L
|
K
|
R
|
T
|
P
|
R
|
R
|
V
|
K
|
A
|
170 |
T
|
I
|
V
|
A
|
V
|
W
|
L
|
I
|
S
|
A
|
180 |
V
|
I
|
S
|
F
|
P
|
P
|
L
|
V
|
S
|
F
|
190 |
ECL2 | |||||||||
Y
|
R
|
R
|
P
|
D
|
G
|
A
|
A
|
Y
|
P
|
200 |
TM5 | |||||||||
Q
|
C
|
G
|
L
|
N
|
D
|
E
|
T
|
W
|
Y
|
210 |
I
|
L
|
S
|
S
|
C
|
I
|
G
|
S
|
F
|
F
|
220 |
A
|
P
|
C
|
L
|
I
|
M
|
G
|
L
|
V
|
Y
|
230 |
A
|
R
|
I
|
Y
|
R
|
V
|
A
|
K
|
L
|
R
|
240 |
T
|
R
|
T
|
L
|
S
|
E
|
K
|
R
|
G
|
P
|
250 |
ICL3 | |||||||||
A
|
G
|
P
|
D
|
G
|
A
|
S
|
P
|
T
|
T
|
260 |
E
|
N
|
G
|
L
|
G
|
K
|
A
|
A
|
G
|
E
|
270 |
N
|
G
|
H
|
C
|
A
|
P
|
P
|
R
|
T
|
E
|
280 |
V
|
E
|
P
|
D
|
E
|
S
|
S
|
A
|
A
|
E
|
290 |
R
|
R
|
R
|
R
|
R
|
G
|
A
|
L
|
R
|
R
|
300 |
G
|
G
|
R
|
R
|
R
|
E
|
G
|
A
|
E
|
G
|
310 |
D
|
T
|
G
|
S
|
A
|
D
|
G
|
P
|
G
|
P
|
320 |
G
|
L
|
A
|
A
|
E
|
Q
|
G
|
A
|
R
|
T
|
330 |
A
|
S
|
R
|
S
|
P
|
G
|
P
|
G
|
G
|
R
|
340 |
L
|
S
|
R
|
A
|
S
|
S
|
R
|
S
|
V
|
E
|
350 |
F
|
F
|
L
|
S
|
R
|
R
|
R
|
R
|
A
|
R
|
360 |
TM6 | |||||||||
S
|
S
|
V
|
C
|
R
|
R
|
K
|
V
|
A
|
Q
|
370 |
A
|
R
|
E
|
K
|
R
|
F
|
T
|
F
|
V
|
L
|
380 |
A
|
V
|
V
|
M
|
G
|
V
|
F
|
V
|
L
|
C
|
390 |
W
|
F
|
P
|
F
|
F
|
F
|
S
|
Y
|
S
|
L
|
400 |
ECL3 | |||||||||
Y
|
G
|
I
|
C
|
R
|
E
|
A
|
C
|
Q
|
L
|
410 |
TM7 | |||||||||
P
|
E
|
P
|
L
|
F
|
K
|
F
|
F
|
F
|
W
|
420 |
I
|
G
|
Y
|
C
|
N
|
S
|
S
|
L
|
N
|
P
|
430 |
H8 | |||||||||
V
|
I
|
Y
|
T
|
V
|
F
|
N
|
Q
|
D
|
F
|
440 |
R
|
R
|
S
|
F
|
K
|
H
|
I
|
L
|
F
|
R
|
450 |
C-term | |||||||
R
|
R
|
R
|
R
|
G
|
F
|
R
|
Q
|
LINKS
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available