CXCR3 (cxcr3_rat)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors CXCR3
GENE
Cxcr3
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
C-X-C chemokine receptor type 3, CXC-R3, CXCR-3, Interferon-inducible protein 10 receptor, IP-10 receptor, CD183
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
Y
|
L
|
E
|
V
|
S
|
E
|
R
|
Q
|
V
|
10 |
L
|
D
|
A
|
S
|
D
|
I
|
A
|
F
|
L
|
L
|
20 |
E
|
N
|
S
|
T
|
S
|
P
|
Y
|
D
|
Y
|
G
|
30 |
E
|
N
|
E
|
S
|
D
|
F
|
S
|
D
|
S
|
P
|
40 |
TM1 | |||||||||
P
|
C
|
P
|
Q
|
D
|
F
|
S
|
L
|
N
|
F
|
50 |
D
|
R
|
T
|
F
|
L
|
P
|
V
|
L
|
Y
|
S
|
60 |
L
|
L
|
F
|
L
|
L
|
G
|
L
|
L
|
G
|
N
|
70 |
G
|
A
|
V
|
A
|
A
|
V
|
L
|
L
|
S
|
Q
|
80 |
ICL1 | TM2 | ||||||||
R
|
T
|
A
|
L
|
S
|
S
|
T
|
D
|
T
|
F
|
90 |
L
|
L
|
H
|
L
|
A
|
V
|
A
|
D
|
V
|
L
|
100 |
L
|
V
|
L
|
T
|
L
|
P
|
L
|
W
|
A
|
V
|
110 |
ECL1 | |||||||||
D
|
A
|
A
|
A
|
Q
|
W
|
V
|
F
|
G
|
S
|
120 |
TM3 | |||||||||
G
|
L
|
C
|
K
|
V
|
A
|
G
|
A
|
L
|
F
|
130 |
N
|
I
|
N
|
F
|
Y
|
A
|
G
|
A
|
F
|
L
|
140 |
L
|
A
|
C
|
I
|
S
|
F
|
D
|
R
|
Y
|
L
|
150 |
ICL2 | |||||||||
S
|
I
|
V
|
H
|
A
|
T
|
Q
|
I
|
Y
|
R
|
160 |
TM4 | |||||||||
R
|
D
|
P
|
W
|
V
|
R
|
V
|
A
|
L
|
T
|
170 |
C
|
I
|
V
|
V
|
W
|
G
|
L
|
C
|
V
|
L
|
180 |
F
|
A
|
L
|
P
|
D
|
F
|
I
|
F
|
L
|
S
|
190 |
ECL2 | |||||||||
A
|
S
|
H
|
D
|
Q
|
R
|
L
|
N
|
A
|
T
|
200 |
TM5 | |||||||||
H
|
C
|
Q
|
Y
|
N
|
F
|
P
|
Q
|
V
|
G
|
210 |
R
|
T
|
A
|
L
|
R
|
V
|
L
|
Q
|
L
|
V
|
220 |
A
|
G
|
F
|
L
|
M
|
P
|
L
|
L
|
V
|
M
|
230 |
A
|
Y
|
C
|
Y
|
A
|
H
|
I
|
L
|
A
|
V
|
240 |
ICL3 | TM6 | |||||||||
L
|
L
|
V
|
S
|
R
|
G
|
Q
|
R
|
R
|
F
|
|
250 |
R
|
A
|
M
|
R
|
L
|
V
|
V
|
V
|
V
|
V
|
260 |
V
|
A
|
F
|
A
|
V
|
C
|
W
|
T
|
P
|
Y
|
270 |
H
|
L
|
V
|
V
|
L
|
V
|
D
|
I
|
L
|
M
|
280 |
ECL3 | TM7 | ||||||||
D
|
V
|
G
|
V
|
L
|
A
|
R
|
N
|
C
|
G
|
290 |
R
|
E
|
S
|
H
|
V
|
D
|
V
|
A
|
K
|
S
|
300 |
V
|
T
|
S
|
G
|
M
|
G
|
Y
|
M
|
H
|
C
|
310 |
C
|
L
|
N
|
P
|
L
|
L
|
Y
|
A
|
F
|
V
|
320 |
H8 | |||||||||
G
|
V
|
K
|
F
|
K
|
E
|
Q
|
M
|
W
|
M
|
330 |
L
|
L
|
M
|
R
|
L
|
G
|
R
|
S
|
D
|
Q
|
340 |
C-term | |||||||||
R
|
G
|
P
|
Q
|
R
|
Q
|
P
|
S
|
S
|
S
|
350 |
R
|
R
|
E
|
S
|
S
|
W
|
S
|
E
|
T
|
T
|
360 |
E
|
A
|
S
|
Y
|
L
|
G
|
L
|
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available