CXCR4 (cxcr4_mouse)

FAMILY

Class A (Rhodopsin) Protein receptors Chemokine receptors CXCR4

GENE

Cxcr4 (Cmkar4, Lestr, Sdf1r)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, Fusin, Leukocyte-derived seven transmembrane domain receptor, LESTR, Pre-B-cell-derived chemokine receptor, PB-CKR, Stromal cell-derived factor 1 receptor, SDF-1 receptor, CD184

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
E
P
I
S
V
S
I
Y
T
10
                   
S
D
N
Y
S
E
E
V
G
S
20
                   
G
D
Y
D
S
N
K
E
P
C
30
  TM1            
F
R
D
E
N
V
H
F
N
R
40
                   
I
F
L
P
T
I
Y
F
I
I
50
                   
F
L
T
G
I
V
G
N
G
L
60
                   
V
I
L
V
M
G
Y
Q
K
K
70
ICL1 TM2      
L
R
S
M
T
D
K
Y
R
L
80
                   
H
L
S
V
A
D
L
L
F
V
90
                   
I
T
L
P
F
W
A
V
D
A
100
    ECL1 TM3  
M
A
D
W
Y
F
G
K
F
L
110
                   
C
K
A
V
H
I
I
Y
T
V
120
                   
N
L
Y
S
S
V
L
I
L
A
130
                   
F
I
S
L
D
R
Y
L
A
I
140
    ICL2        
V
H
A
T
N
S
Q
R
P
R
150
TM4              
K
L
L
A
E
K
A
V
Y
V
160
                   
G
V
W
I
P
A
L
L
L
T
170
                   
I
P
D
F
I
F
A
D
V
S
180
ECL2            
Q
G
D
I
S
Q
G
D
D
R
190
                   
Y
I
C
D
R
L
Y
P
D
S
200
TM5              
L
W
M
V
V
F
Q
F
Q
H
210
                   
I
M
V
G
L
I
L
P
G
I
220
                   
V
I
L
S
C
Y
C
I
I
I
230
            ICL3
S
K
L
S
H
S
K
G
H
Q
240
TM6              
K
R
K
A
L
K
T
T
V
I
250
                   
L
I
L
A
F
F
A
C
W
L
260
                   
P
Y
Y
V
G
I
S
I
D
S
270
          ECL3  
F
I
L
L
G
V
I
K
Q
G
280
TM7              
C
D
F
E
S
I
V
H
K
W
290
                   
I
S
I
T
E
A
L
A
F
F
300
                   
H
C
C
L
N
P
I
L
Y
A
310
    H8            
F
L
G
A
K
F
K
S
S
A
320
                   
Q
H
A
L
N
S
M
S
R
G
330
C-term        
S
S
L
K
I
L
S
K
G
K
340
                   
R
G
G
H
S
S
V
S
T
E
350
                 
S
E
S
S
S
F
H
S
S

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 K K L R ICL1ECL1 D W Y F ECL1ICL2 A T N S Q R P R ICL2ECL2 D V S Q G D I S Q G D D R Y I C D R L Y P D ECL2ICL3 K G H Q ICL3ECL3 V I K Q ECL3N-term M E P I S V S I Y T S D N Y S E E V G S G D Y D S N K E P C F N-termC-term S M S R G S S L K I L S K G K R G G H S S V S T E S E S S S F H S S C-term R D E N V H F N R I F L P T I Y F I I F L T G I V G N G L V I L V M G Y Q S M T D K Y R L H L S V A D L L F V I T L P F W A V D A M A G K F L C K A V H I I Y T V N L Y S S V L I L A F I S L D R Y L A I V H K L L A E K A V Y V G V W I P A L L L T I P D F I F A S L W M V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K R K A L K T T V I L I L A F F A C W L P Y Y V G I S I D S F I L L G G C D F E S I V H K W I S I T E A L A F F H C C L N P I L Y A F L G A K A Q H F K S S A L N
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N G V I G T L F I I F Y I T P L F I R 1 L H L S V A D L L F V I T L P F W A V D 2 F A L I L V S S Y L N V T Y I I H V A K 3 E K A V Y V G V W I P A L L L T I P D 4 Y C S L I V I G P L I L G V M I H Q F Q F 5 V I L I L A F F A C W L P Y Y V G I S I 6 I P N L C C H F F A L A E T I S I W K 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

1 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available