GPR62 (d4a2b1_rat)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans GPR62

GENE

Gpr62 ()

ORGANISM

Rat (Rattus norvegicus)

ALT. NAMES

G protein-coupled receptor 62

SOURCE

TREMBL

SEQUENCE

N-term        
M
A
S
S
S
G
L
S
V
T
10
TM1              
E
L
A
G
S
V
G
F
I
L
20
                   
A
V
L
V
E
V
G
A
V
L
30
                   
G
N
G
T
L
L
V
V
V
L
40
    ICL1 TM2  
R
T
P
D
L
Q
D
A
F
Y
50
                   
L
A
H
L
C
V
V
D
L
L
60
                   
A
A
A
S
I
M
P
L
G
L
70
        ECL1    
L
A
A
P
P
G
L
G
S
V
80
TM3              
P
L
D
P
S
S
C
R
A
A
90
                   
R
F
L
S
A
A
L
L
P
A
100
                   
C
T
L
G
V
A
A
L
G
L
110
                   
A
R
Y
R
L
I
V
H
P
L
120
ICL2     TM4  
R
P
G
A
R
P
A
P
A
L
130
                   
V
L
T
A
V
W
S
A
A
A
140
                   
L
L
G
A
L
S
L
L
G
P
150
ECL2            
P
P
A
P
P
P
A
P
A
R
160
              TM5
C
S
V
L
A
G
G
L
G
P
170
                   
F
R
P
L
W
A
M
L
A
F
180
                   
A
L
P
A
L
L
L
L
A
A
190
                   
Y
G
S
I
F
L
V
A
R
R
200
                   
A
A
L
R
P
P
R
G
T
R
210
ICL3            
P
R
S
D
S
L
D
S
R
L
220
          TM6    
S
F
L
P
S
L
R
P
R
L
230
                   
P
G
G
K
A
A
L
A
P
A
240
                   
L
A
V
G
Q
F
A
A
C
W
250
                   
L
P
Y
A
C
A
C
L
A
P
260
ECL3       TM7
A
A
R
A
A
A
A
E
A
A
270
                   
V
T
W
V
A
Y
S
A
F
A
280
                   
A
H
P
F
L
Y
G
L
L
Q
290
H8                
R
P
V
R
L
A
L
G
R
L
300
        C-term
T
R
G
V
L
P
R
A
P
K
310
                   
A
C
T
P
Q
A
W
D
L
R
320
                   
T
L
L
Q
R
L
Q
G
L
C
330
                   
K
D
P
A
L
G
P
S
E
A
340
                   
P
E
Q
N
R
E
L
A
G
Q
350
               
S
P
R
V
S
E
A
T

LINKS

DIAGRAMS

7TM

ICL1 P D ICL1ECL1 P G L G S ECL1ICL2 P L R P G A R P ICL2ECL2 P P A P P P A P A R C S V L A G G ECL2ICL3 R P R S D S L D S R L S F L P S ICL3ECL3 A A R A A A A ECL3N-term M A S S S G L S V T N-termC-term L P R A P K A C T P Q A W D L R T L L Q R L Q G L C K D P A L G P S E A P E Q N R E L A G Q S P R V S E A T C-term E L A G S V G F I L A V L V E V G A V L G N G T L L V V V L R T L Q D A F Y L A H L C V V D L L A A A S I M P L G L L A A P V P L D P S S C R A A R F L S A A L L P A C T L G V A A L G L A R Y R L I V H A P A L V L T A V W S A A A L L G A L S L L G P L G P F R P L W A M L A F A L P A L L L L A A Y G S I F L V A R R A A L R P P R G T L R P R L P G G K A A L A P A L A V G Q F A A C W L P Y A C A C L A P E A A V T W V A Y S A F A A H P F L Y G L L Q R P L G R V V R L A L T R G
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N G L V A G V E V L V A L I F G V S G 1 A H L C V V D L L A A S A I M P L G L L A 2 A A V G L T C A P L L A A S L F R A A R 3 P A L V L T A V W S A A A L L G A L S L 4 Y A A L L L L A P L A F A L M A W L P R F 5 A L A V G Q F A A C W L P Y A C A C L A 6 F P H A A F A S Y A V W T V A A E 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available