GPR119 (gp119_mouse)
FAMILY
Class A (Rhodopsin) Lipid receptors GPR18, GPR55 and GPR119 GPR119
GENE
Gpr119
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Glucose-dependent insulinotropic receptor, G-protein coupled receptor 119
SOURCE
SWISSPROT
SEQUENCE
TM1 | |||||||||
M
|
E
|
S
|
S
|
F
|
S
|
F
|
G
|
V
|
I
|
10 |
L
|
A
|
V
|
L
|
T
|
I
|
L
|
I
|
I
|
A
|
20 |
V
|
N
|
A
|
L
|
V
|
V
|
V
|
A
|
M
|
L
|
30 |
ICL1 | TM2 | ||||||||
L
|
S
|
I
|
Y
|
K
|
N
|
D
|
G
|
V
|
G
|
40 |
L
|
C
|
F
|
T
|
L
|
N
|
L
|
A
|
V
|
A
|
50 |
D
|
T
|
L
|
I
|
G
|
V
|
A
|
I
|
S
|
G
|
60 |
L
|
V
|
T
|
D
|
Q
|
L
|
S
|
S
|
S
|
A
|
70 |
TM3 | |||||||||
Q
|
H
|
T
|
Q
|
K
|
T
|
L
|
C
|
S
|
L
|
80 |
R
|
M
|
A
|
F
|
V
|
T
|
S
|
S
|
A
|
A
|
90 |
A
|
S
|
V
|
L
|
T
|
V
|
M
|
L
|
I
|
A
|
100 |
F
|
D
|
R
|
Y
|
L
|
A
|
I
|
K
|
Q
|
P
|
110 |
ICL2 | TM4 | ||||||||
L
|
R
|
Y
|
F
|
Q
|
I
|
M
|
N
|
G
|
L
|
120 |
V
|
A
|
G
|
A
|
C
|
I
|
A
|
G
|
L
|
W
|
130 |
L
|
V
|
S
|
Y
|
L
|
I
|
G
|
F
|
L
|
P
|
140 |
ECL2 | |||||||||
L
|
G
|
V
|
S
|
I
|
F
|
Q
|
Q
|
T
|
T
|
150 |
Y
|
H
|
G
|
P
|
C
|
S
|
F
|
F
|
A
|
V
|
160 |
TM5 | |||||||||
F
|
H
|
P
|
R
|
F
|
V
|
L
|
T
|
L
|
S
|
170 |
C
|
A
|
G
|
F
|
F
|
P
|
A
|
V
|
L
|
L
|
180 |
F
|
V
|
F
|
F
|
Y
|
C
|
D
|
M
|
L
|
K
|
190 |
I
|
A
|
S
|
V
|
H
|
S
|
Q
|
Q
|
I
|
R
|
200 |
ICL3 | |||||||||
K
|
M
|
E
|
H
|
A
|
G
|
A
|
M
|
A
|
G
|
210 |
TM6 | |||||||||
A
|
Y
|
R
|
P
|
P
|
R
|
S
|
V
|
N
|
D
|
220 |
F
|
K
|
A
|
V
|
R
|
T
|
I
|
A
|
V
|
L
|
230 |
I
|
G
|
S
|
F
|
T
|
L
|
S
|
W
|
S
|
P
|
240 |
F
|
L
|
I
|
T
|
S
|
I
|
V
|
Q
|
V
|
A
|
250 |
ECL3 | TM7 | ||||||||
C
|
H
|
K
|
C
|
C
|
L
|
Y
|
Q
|
V
|
L
|
260 |
E
|
K
|
Y
|
L
|
W
|
L
|
L
|
G
|
V
|
G
|
270 |
N
|
S
|
L
|
L
|
N
|
P
|
L
|
I
|
Y
|
A
|
280 |
H8 | |||||||||
Y
|
W
|
Q
|
R
|
E
|
V
|
R
|
Q
|
Q
|
L
|
290 |
Y
|
H
|
M
|
A
|
L
|
G
|
V
|
K
|
K
|
F
|
300 |
C-term | |||||||||
F
|
T
|
S
|
I
|
L
|
L
|
L
|
L
|
P
|
A
|
310 |
R
|
N
|
R
|
G
|
P
|
E
|
R
|
T
|
R
|
E
|
320 |
S
|
A
|
Y
|
H
|
I
|
V
|
T
|
I
|
S
|
H
|
330 |
P
|
E
|
L
|
D
|
G
|
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available