OX2 receptor (ox2r_rat)
FAMILY
Class A (Rhodopsin) Peptide receptors Orexin receptors OX2 receptor
GENE
Hcrtr2
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
Orexin receptor type 2, Ox-2-R, Ox2-R, Ox2R, Hypocretin receptor type 2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
S
|
T
|
K
|
L
|
E
|
D
|
S
|
L
|
10 |
P
|
R
|
R
|
N
|
W
|
S
|
S
|
A
|
S
|
E
|
20 |
L
|
N
|
E
|
T
|
Q
|
E
|
P
|
F
|
L
|
N
|
30 |
P
|
T
|
D
|
Y
|
D
|
D
|
E
|
E
|
F
|
L
|
40 |
R
|
Y
|
L
|
W
|
R
|
E
|
Y
|
L
|
H
|
P
|
50 |
TM1 | |||||||||
K
|
E
|
Y
|
E
|
W
|
V
|
L
|
I
|
A
|
G
|
60 |
Y
|
I
|
I
|
V
|
F
|
V
|
V
|
A
|
L
|
I
|
70 |
G
|
N
|
V
|
L
|
V
|
C
|
V
|
A
|
V
|
W
|
80 |
ICL1 | TM2 | ||||||||
K
|
N
|
H
|
H
|
M
|
R
|
T
|
V
|
T
|
N
|
90 |
Y
|
F
|
I
|
V
|
N
|
L
|
S
|
L
|
A
|
D
|
100 |
V
|
L
|
V
|
T
|
I
|
T
|
C
|
L
|
P
|
A
|
110 |
T
|
L
|
V
|
V
|
D
|
I
|
T
|
E
|
T
|
W
|
120 |
ECL1 | TM3 | ||||||||
F
|
F
|
G
|
Q
|
S
|
L
|
C
|
K
|
V
|
I
|
130 |
P
|
Y
|
L
|
Q
|
T
|
V
|
S
|
V
|
S
|
V
|
140 |
S
|
V
|
L
|
T
|
L
|
S
|
C
|
I
|
A
|
L
|
150 |
D
|
R
|
W
|
Y
|
A
|
I
|
C
|
H
|
P
|
L
|
160 |
ICL2 | TM4 | ||||||||
M
|
F
|
K
|
S
|
T
|
A
|
K
|
R
|
A
|
R
|
170 |
N
|
S
|
I
|
V
|
V
|
I
|
W
|
I
|
V
|
S
|
180 |
C
|
I
|
I
|
M
|
I
|
P
|
Q
|
A
|
I
|
V
|
190 |
ECL2 | |||||||||
M
|
E
|
R
|
S
|
S
|
M
|
L
|
P
|
G
|
L
|
200 |
A
|
N
|
K
|
T
|
T
|
L
|
F
|
T
|
V
|
C
|
210 |
TM5 | |||||||||
D
|
E
|
R
|
W
|
G
|
G
|
E
|
V
|
Y
|
P
|
220 |
K
|
M
|
Y
|
H
|
I
|
C
|
F
|
F
|
L
|
V
|
230 |
T
|
Y
|
M
|
A
|
P
|
L
|
C
|
L
|
M
|
V
|
240 |
L
|
A
|
Y
|
L
|
Q
|
I
|
F
|
R
|
K
|
L
|
250 |
ICL3 | |||||||||
W
|
C
|
R
|
Q
|
I
|
P
|
G
|
T
|
S
|
S
|
260 |
V
|
V
|
Q
|
R
|
K
|
W
|
K
|
Q
|
P
|
Q
|
270 |
P
|
V
|
S
|
Q
|
P
|
R
|
G
|
S
|
G
|
Q
|
280 |
Q
|
S
|
K
|
A
|
R
|
I
|
S
|
A
|
V
|
A
|
290 |
TM6 | |||||||||
A
|
E
|
I
|
K
|
Q
|
I
|
R
|
A
|
R
|
R
|
300 |
K
|
T
|
A
|
R
|
M
|
L
|
M
|
V
|
V
|
L
|
310 |
L
|
V
|
F
|
A
|
I
|
C
|
Y
|
L
|
P
|
I
|
320 |
S
|
I
|
L
|
N
|
V
|
L
|
K
|
R
|
V
|
F
|
330 |
ECL3 | TM7 | ||||||||
G
|
M
|
F
|
T
|
H
|
T
|
E
|
D
|
R
|
E
|
340 |
T
|
V
|
Y
|
A
|
W
|
F
|
T
|
F
|
S
|
H
|
350 |
W
|
L
|
V
|
Y
|
A
|
N
|
S
|
A
|
A
|
N
|
360 |
H8 | |||||||||
P
|
I
|
I
|
Y
|
N
|
F
|
L
|
S
|
G
|
K
|
370 |
F
|
R
|
E
|
E
|
F
|
K
|
A
|
A
|
F
|
S
|
380 |
C-term | |||||||||
C
|
C
|
L
|
G
|
V
|
H
|
R
|
R
|
Q
|
G
|
390 |
D
|
R
|
L
|
A
|
R
|
G
|
R
|
T
|
S
|
T
|
400 |
E
|
S
|
R
|
K
|
S
|
L
|
T
|
T
|
Q
|
I
|
410 |
S
|
N
|
F
|
D
|
N
|
V
|
S
|
K
|
L
|
S
|
420 |
E
|
H
|
V
|
A
|
L
|
T
|
S
|
I
|
S
|
T
|
430 |
L
|
P
|
A
|
A
|
N
|
G
|
A
|
G
|
P
|
L
|
440 |
Q
|
N
|
W
|
Y
|
L
|
Q
|
Q
|
G
|
V
|
P
|
450 |
S
|
S
|
L
|
L
|
S
|
T
|
W
|
L
|
E
|
V
|
460 |
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available