AT1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7F6G

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

March 29, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

68 interactions (Click to see)

LIGANDS

SAR1-AngII - Agonist

ENDOGENOUS LIGANDS

angiotensin A, angiotensin III, angiotensin IV, angiotensin II



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 134 - G.H5 K 345 G.H5.12
Polar ICL2 L 138 - G.hns1 R 37 G.hns1.02
Hydrophobic TM6 I 238 6x33 G.H5 L 358 G.H5.25
Polar TM3 A 129 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 129 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 129 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 R 137 - G.S1 L 40 G.S1.02
Van-der-waals ICL2 R 137 - G.S1 L 40 G.S1.02
Hydrophobic ICL2 M 134 - G.S3 V 199 G.S3.01
Hydrophobic ICL2 P 133 - G.H5 K 345 G.H5.12
Hydrophobic ICL2 L 138 - G.hns1 R 38 G.hns1.03
Hydrophobic TM5 L 222 5x65 G.H5 L 353 G.H5.20
Polar ICL2 R 140 - G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 140 - G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 130 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 130 3x54 G.H5 L 349 G.H5.16
Hydrophobic TM6 I 238 6x33 G.H5 L 353 G.H5.20
Hydrophobic ICL4 G 306 - G.H5 V 359 G.H5.26
Hydrophobic ICL2 M 134 - G.H5 F 341 G.H5.08
Van-der-waals ICL2 M 134 - G.H5 F 341 G.H5.08
Hydrophobic TM3 I 130 3x54 G.H5 L 358 G.H5.25
Polar ICL2 R 137 - G.S1 E 39 G.S1.01
Hydrophobic TM2 A 63 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 A 63 2x39 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 133 - G.H5 I 348 G.H5.15
Hydrophobic TM6 I 238 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM3 R 126 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 126 3x50 G.H5 L 358 G.H5.25
Polar TM5 Q 229 5x72 G.H5 D 346 G.H5.13
Hydrophobic TM5 Q 229 5x72 G.H5 D 346 G.H5.13
Hydrophobic TM6 I 241 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 I 241 6x36 G.H5 L 358 G.H5.25
Hydrophobic TM2 A 63 2x39 G.H5 E 355 G.H5.22
Van-der-waals ICL2 R 137 - G.S3 V 199 G.S3.01
Polar TM4 T 141 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic TM4 T 141 4x38 G.hns1 R 37 G.hns1.02
Polar TM3 D 125 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 125 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 125 3x49 G.H5 Y 356 G.H5.23
Hydrophobic H8 K 308 8x49 G.H5 K 354 G.H5.21
Polar H8 K 307 8x48 G.H5 V 359 G.H5.26
Hydrophobic H8 K 307 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 K 307 8x48 G.H5 V 359 G.H5.26
Polar H8 F 309 8x50 G.H5 N 357 G.H5.24
Hydrophobic H8 F 309 8x50 G.H5 N 357 G.H5.24
Van-der-waals H8 F 309 8x50 G.H5 N 357 G.H5.24
Hydrophobic TM7 G 303 7x54 G.H5 N 357 G.H5.24
Van-der-waals TM7 G 303 7x54 G.H5 N 357 G.H5.24
Polar TM3 R 126 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 M 134 - G.s2s3 S 198 G.s2s3.02
Hydrophobic TM5 Q 229 5x72 G.S6 Y 325 G.S6.02
Hydrophobic TM3 I 130 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 130 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 P 133 - G.H5 L 349 G.H5.16
Hydrophobic ICL2 M 134 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 M 134 - G.H5 I 348 G.H5.15
Polar ICL4 G 306 - G.H5 N 357 G.H5.24
Hydrophobic ICL4 G 306 - G.H5 N 357 G.H5.24
Polar ICL2 R 137 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 137 - G.hns1 R 37 G.hns1.02
Ionic H8 K 307 8x48 G.h4s6 D 321 G.h4s6.12
Ionic ICL2 R 140 - G.H5 E 355 G.H5.22
Polar ICL2 R 140 - G.H5 E 355 G.H5.22
Hydrophobic TM3 A 129 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 129 3x53 G.H5 Y 356 G.H5.23