GPR17 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7Y89

RESOLUTION

3.0 Å

REFERENCE

10.1002/MCO2.159

PUBLICATION DATE

Oct. 12, 2022

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

ENDOGENOUS LIGANDS

LTE4, UDP-galactose, LTC4, ATP, LTD4, UDP-glucose, UDP



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL4 E 330 - G.H5 F 354 G.H5.26
Polar ICL1 T 92 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 T 92 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 T 92 - G.H5 D 350 G.H5.22
Ionic ICL3 R 252 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 252 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 252 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 252 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 E 254 6x26 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 E 254 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 A 261 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 261 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 165 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 165 - G.S3 L 194 G.S3.01
Hydrophobic TM6 M 264 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 M 264 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL3 V 253 - G.H5 L 348 G.H5.20
Hydrophobic TM6 K 260 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 161 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 161 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 161 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 161 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM4 P 173 4x39 G.HN E 28 G.HN.52
Hydrophobic ICL4 K 331 - G.H5 G 352 G.H5.24
Hydrophobic TM6 A 261 6x33 G.H5 L 348 G.H5.20
Polar ICL2 L 168 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 168 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 247 5x65 G.H5 L 348 G.H5.20
Ionic ICL2 R 171 - G.H5 D 350 G.H5.22
Hydrophobic TM3 A 160 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 I 265 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 265 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 164 - G.H5 T 340 G.H5.12
Hydrophobic TM3 R 157 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL4 A 329 - G.H5 G 352 G.H5.24
Polar ICL3 R 252 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 252 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 252 - G.H5 D 341 G.H5.13
Aromatic ICL3 R 252 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 252 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 252 - G.S6 Y 320 G.S6.02
Polar ICL2 R 171 - G.H5 C 351 G.H5.23
Polar ICL4 K 331 - G.H5 D 350 G.H5.22
Hydrophobic ICL4 K 331 - G.H5 D 350 G.H5.22
Hydrophobic ICL3 V 253 - G.H5 K 345 G.H5.17
Hydrophobic TM6 M 264 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 257 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 257 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 165 - G.H5 F 336 G.H5.08
Hydrophobic TM3 I 161 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 257 6x29 G.H5 K 345 G.H5.17
Hydrophobic ICL3 L 251 - G.H5 I 344 G.H5.16
Ionic TM4 R 172 4x38 G.HN E 28 G.HN.52
Polar TM3 A 160 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 160 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 160 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 164 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 164 - G.H5 I 344 G.H5.16
Polar TM6 E 254 6x26 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM6 E 254 6x26 G.h4s6 T 316 G.h4s6.10
Van-der-waals TM6 E 254 6x26 G.h4s6 T 316 G.h4s6.10
Hydrophobic ICL4 K 331 - G.H5 C 351 G.H5.23
Polar TM3 R 157 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 157 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 157 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 164 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 168 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 168 - G.S3 L 194 G.S3.01