Gs - 5-HT1E receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 L 222 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 L 222 - G.H4 L 346 G.H4.16
Polar TM3 T 125 3x55 G.H5 Q 384 G.H5.16
Polar TM6 R 285 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 R 285 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 R 285 6x29 G.h4s6 Y 358 G.h4s6.20
Polar TM3 I 124 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 124 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 124 3x54 G.H5 Q 384 G.H5.16
Polar ICL2 R 134 34x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 134 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 134 34x57 G.H5 H 387 G.H5.19
Hydrophobic TM5 R 216 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 R 216 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM5 I 205 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 205 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 I 128 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 I 128 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 R 220 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 I 128 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 I 128 34x51 G.S3 V 217 G.S3.01
Polar TM6 K 288 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 288 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 288 6x32 G.H5 L 394 G.H5.26
Polar ICL1 H 54 12x51 G.HN K 34 G.HN.51
Hydrophobic ICL3 H 221 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 H 221 - G.hgh4 D 323 G.hgh4.13
Ionic TM5 R 216 5x72 G.H5 D 381 G.H5.13
Polar TM5 R 220 5x76 G.h4s6 G 353 G.h4s6.09
Van-der-waals TM5 R 220 5x76 G.h4s6 G 353 G.h4s6.09
Hydrophobic TM6 I 292 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 I 292 6x36 G.H5 E 392 G.H5.24
Polar TM5 L 212 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 212 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 L 212 5x68 G.H5 R 385 G.H5.17
Polar TM2 Q 55 2x37 G.hns1 R 38 G.hns1.02
Hydrophobic TM2 Q 55 2x37 G.hns1 R 38 G.hns1.02
Van-der-waals TM2 Q 55 2x37 G.hns1 R 38 G.hns1.02
Hydrophobic ICL3 L 222 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 L 222 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 L 222 - G.H4 D 343 G.H4.13
Aromatic TM3 R 120 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 120 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 A 127 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL3 L 222 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 L 222 - G.H4 R 342 G.H4.12
Hydrophobic TM3 I 124 3x54 G.H5 H 387 G.H5.19
Polar TM5 R 216 5x72 G.h4s6 Y 358 G.h4s6.20
Aromatic TM5 R 216 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 216 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 R 216 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 R 285 6x29 G.h4s6 G 355 G.h4s6.11
Hydrophobic ICL2 I 128 34x51 G.S1 H 41 G.S1.02
Polar TM5 Y 213 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 Y 213 5x69 G.H5 L 394 G.H5.26
Van-der-waals TM5 Y 213 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM3 I 124 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 L 222 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 L 222 - G.hgh4 P 321 G.hgh4.11
Hydrophobic TM6 L 293 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 293 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 I 128 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM6 I 292 6x36 G.H5 L 393 G.H5.25
Polar ICL1 H 54 12x51 G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 H 54 12x51 G.hns1 R 38 G.hns1.02
Polar ICL2 R 132 34x55 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 R 132 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM7 F 347 7x56 G.H5 E 392 G.H5.24
Polar ICL3 R 225 - G.hgh4 T 319 G.hgh4.09
Hydrophobic ICL3 R 225 - G.hgh4 T 319 G.hgh4.09
Van-der-waals ICL3 R 225 - G.hgh4 T 319 G.hgh4.09
Hydrophobic TM5 A 209 5x65 G.H5 L 388 G.H5.20
Polar TM5 Y 213 5x69 G.H5 L 393 G.H5.25
Van-der-waals TM5 Y 213 5x69 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 212 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 127 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 A 127 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 124 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 124 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 I 128 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 I 128 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 R 132 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 L 212 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 L 212 5x68 G.H5 D 381 G.H5.13
Hydrophobic ICL2 I 128 34x51 G.H5 I 383 G.H5.15
Aromatic ICL3 R 225 - G.hgh4 Y 318 G.hgh4.08
Hydrophobic ICL3 R 225 - G.hgh4 Y 318 G.hgh4.08
Hydrophobic TM5 L 212 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 212 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 A 131 34x54 G.S1 H 41 G.S1.02
Polar ICL3 S 223 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 S 223 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 S 223 - G.h4s6 T 350 G.h4s6.03
Polar TM6 A 289 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 289 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 289 6x33 G.H5 L 393 G.H5.25
Ionic TM6 K 288 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 288 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 288 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 288 6x32 G.H5 E 392 G.H5.24
Polar ICL3 R 225 - G.hgh4 R 317 G.hgh4.07
Van-der-waals ICL3 R 225 - G.hgh4 R 317 G.hgh4.07
Polar TM5 S 218 5x74 G.hgh4 D 323 G.hgh4.13
Polar TM3 A 123 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 123 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 123 3x53 G.H5 H 387 G.H5.19
Polar TM5 R 216 5x72 G.S6 Y 360 G.S6.02
Van-der-waals TM5 R 216 5x72 G.S6 Y 360 G.S6.02
Hydrophobic TM4 T 135 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 135 4x38 G.HN Q 35 G.HN.52
Polar ICL2 R 134 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 134 34x57 G.H5 Y 391 G.H5.23