G13 - A3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 T 115 34x50 G.H5 N 370 G.H5.19
Van-der-waals ICL2 T 115 34x50 G.H5 N 370 G.H5.19
Hydrophobic ICL2 V 116 34x51 G.H5 K 363 G.H5.12
Polar TM5 N 211 5x72 G.H5 D 364 G.H5.13
Hydrophobic TM6 T 228 6x33 G.H5 Q 377 G.H5.26
Van-der-waals TM6 T 228 6x33 G.H5 Q 377 G.H5.26
Hydrophobic TM3 V 112 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 V 112 3x54 G.H5 L 367 G.H5.16
Polar ICL2 R 120 34x55 G.s2s3 N 215 G.s2s3.02
Hydrophobic ICL2 R 120 34x55 G.s2s3 N 215 G.s2s3.02
Van-der-waals ICL2 R 120 34x55 G.s2s3 N 215 G.s2s3.02
Hydrophobic TM7 Y 282 7x53 G.H5 L 376 G.H5.25
Polar H8 K 287 8x48 G.H5 L 376 G.H5.25
Van-der-waals H8 K 287 8x48 G.H5 L 376 G.H5.25
Hydrophobic TM6 T 218 6x23 G.h4s6 P 341 G.h4s6.20
Van-der-waals TM6 T 218 6x23 G.h4s6 P 341 G.h4s6.20
Hydrophobic TM2 I 51 2x43 G.H5 L 376 G.H5.25
Polar TM6 Y 222 6x27 G.H5 D 364 G.H5.13
Hydrophobic H8 K 287 8x48 G.H5 Q 377 G.H5.26
Hydrophobic TM6 T 228 6x33 G.H5 M 375 G.H5.24
Van-der-waals TM6 T 228 6x33 G.H5 M 375 G.H5.24
Hydrophobic TM6 F 221 6x26 G.h4s6 P 341 G.h4s6.20
Van-der-waals TM6 F 221 6x26 G.h4s6 P 341 G.h4s6.20
Hydrophobic ICL2 V 116 34x51 G.S1 V 49 G.S1.02
Van-der-waals ICL2 V 116 34x51 G.S1 V 49 G.S1.02
Hydrophobic TM5 I 204 5x65 G.H5 L 371 G.H5.20
Van-der-waals TM5 I 204 5x65 G.H5 L 371 G.H5.20
Hydrophobic ICL2 R 117 34x52 G.S3 V 216 G.S3.01
Van-der-waals ICL2 R 117 34x52 G.S3 V 216 G.S3.01
Hydrophobic ICL2 V 116 34x51 G.S3 V 216 G.S3.01
Van-der-waals ICL2 V 116 34x51 G.S3 V 216 G.S3.01
Hydrophobic TM3 R 111 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 111 3x53 G.H5 L 374 G.H5.23
Ionic TM6 E 225 6x30 G.H5 H 368 G.H5.17
Polar TM6 E 225 6x30 G.H5 H 368 G.H5.17
Hydrophobic TM6 E 225 6x30 G.H5 H 368 G.H5.17
Van-der-waals TM6 E 225 6x30 G.H5 H 368 G.H5.17
Polar TM3 R 111 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 R 111 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 R 111 3x53 G.H5 N 370 G.H5.19
Hydrophobic ICL2 T 115 34x50 G.H5 L 367 G.H5.16
Hydrophobic TM5 I 204 5x65 G.H5 M 375 G.H5.24
Ionic TM6 E 217 6x22 G.H4 R 331 G.H4.16
Polar TM6 E 217 6x22 G.H4 R 331 G.H4.16
Hydrophobic TM6 E 217 6x22 G.H4 R 331 G.H4.16
Van-der-waals TM6 E 217 6x22 G.H4 R 331 G.H4.16
Hydrophobic TM2 F 48 2x40 G.H5 L 376 G.H5.25
Van-der-waals TM2 F 48 2x40 G.H5 L 376 G.H5.25
Polar TM6 Y 222 6x27 G.S6 Y 343 G.S6.02
Ionic ICL2 R 120 34x55 G.S2 E 212 G.S2.07
Polar ICL2 R 120 34x55 G.S2 E 212 G.S2.07
Van-der-waals ICL2 R 120 34x55 G.S2 E 212 G.S2.07
Polar ICL2 K 119 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 K 119 34x54 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 K 119 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic TM3 V 112 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 V 112 3x54 G.H5 L 374 G.H5.23
Hydrophobic TM6 L 232 6x37 G.H5 M 375 G.H5.24
Hydrophobic TM6 E 225 6x30 G.H5 L 371 G.H5.20
Van-der-waals TM6 E 225 6x30 G.H5 L 371 G.H5.20
Polar ICL2 K 119 34x54 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 K 119 34x54 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 K 119 34x54 G.hns1 R 47 G.hns1.03
Polar TM4 H 124 4x39 G.hns1 K 46 G.hns1.02
Hydrophobic TM3 V 112 3x54 G.H5 L 371 G.H5.20
Hydrophobic H8 I 286 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 I 286 8x47 G.H5 L 376 G.H5.25
Van-der-waals TM3 R 108 3x50 G.H5 L 376 G.H5.25
Polar ICL2 R 120 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 R 120 34x55 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 R 120 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic TM6 F 221 6x26 G.h4s6 K 340 G.h4s6.19
Ionic TM6 E 217 6x22 G.h4s6 R 334 G.h4s6.08
Polar TM6 E 217 6x22 G.h4s6 R 334 G.h4s6.08
Hydrophobic TM6 E 217 6x22 G.h4s6 R 334 G.h4s6.08
Van-der-waals TM6 E 217 6x22 G.h4s6 R 334 G.h4s6.08
Aromatic TM6 F 221 6x26 G.H5 H 368 G.H5.17
Hydrophobic TM6 F 221 6x26 G.H5 H 368 G.H5.17
Van-der-waals TM6 F 221 6x26 G.H5 H 368 G.H5.17
Hydrophobic TM4 T 123 4x38 G.hns1 R 47 G.hns1.03
Van-der-waals TM4 T 123 4x38 G.hns1 R 47 G.hns1.03
Ionic TM5 K 207 5x68 G.H5 D 364 G.H5.13
Polar TM5 K 207 5x68 G.H5 D 364 G.H5.13
Van-der-waals TM5 K 207 5x68 G.H5 D 364 G.H5.13
Polar TM3 R 111 3x53 G.H5 Q 373 G.H5.22
Hydrophobic TM3 R 111 3x53 G.H5 Q 373 G.H5.22
Van-der-waals TM3 R 111 3x53 G.H5 Q 373 G.H5.22
Hydrophobic TM6 A 229 6x34 G.H5 M 375 G.H5.24
Van-der-waals TM6 A 229 6x34 G.H5 M 375 G.H5.24
Hydrophobic ICL2 T 115 34x50 G.H5 K 363 G.H5.12
Van-der-waals ICL2 T 115 34x50 G.H5 K 363 G.H5.12
Hydrophobic ICL2 V 116 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 V 116 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 R 117 34x52 G.s2s3 K 214 G.s2s3.01
Polar TM6 R 224 6x29 G.h4s6 Q 338 G.h4s6.12
Hydrophobic TM6 R 224 6x29 G.h4s6 Q 338 G.h4s6.12
Van-der-waals TM6 R 224 6x29 G.h4s6 Q 338 G.h4s6.12
Polar TM6 E 217 6x22 G.S6 L 342 G.S6.01
Hydrophobic TM6 T 218 6x23 G.S6 Y 343 G.S6.02
Hydrophobic TM6 F 221 6x26 G.h4s6 Q 339 G.h4s6.13
Van-der-waals TM6 F 221 6x26 G.h4s6 Q 339 G.h4s6.13
Hydrophobic TM5 K 207 5x68 G.H5 L 367 G.H5.16
Van-der-waals TM5 K 207 5x68 G.H5 L 367 G.H5.16
Hydrophobic ICL2 T 115 34x50 G.H5 I 366 G.H5.15
Van-der-waals ICL2 T 115 34x50 G.H5 I 366 G.H5.15
Polar TM3 R 108 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 108 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 108 3x50 G.H5 L 374 G.H5.23