G15 - ACKR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 76.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 16.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 K 142 3x50 G.H5 L 373 G.H5.25
Hydrophobic TM5 L 237 5x65 G.H5 L 368 G.H5.20
Van-der-waals TM5 L 237 5x65 G.H5 L 368 G.H5.20
Polar ICL2 Y 152 34x53 G.S1 E 42 G.S1.01
Hydrophobic ICL2 Y 152 34x53 G.S1 E 42 G.S1.01
Van-der-waals ICL2 Y 152 34x53 G.S1 E 42 G.S1.01
Hydrophobic TM6 A 243 6x28 G.h4s6 R 335 G.h4s6.17
Van-der-waals TM6 A 243 6x28 G.h4s6 R 335 G.h4s6.17
Polar TM6 A 248 6x33 G.H5 L 373 G.H5.25
Hydrophobic TM6 A 248 6x33 G.H5 L 373 G.H5.25
Van-der-waals TM6 A 248 6x33 G.H5 L 373 G.H5.25
Polar H8 H 317 8x48 G.H5 N 372 G.H5.24
Hydrophobic H8 H 317 8x48 G.H5 N 372 G.H5.24
Van-der-waals H8 H 317 8x48 G.H5 N 372 G.H5.24
Polar H8 R 320 8x51 G.H5 N 372 G.H5.24
Van-der-waals H8 R 320 8x51 G.H5 N 372 G.H5.24
Hydrophobic TM3 I 146 3x54 G.H5 L 373 G.H5.25
Hydrophobic TM6 A 243 6x28 G.H5 L 374 G.H5.26
Van-der-waals TM6 A 243 6x28 G.H5 L 374 G.H5.26
Hydrophobic ICL3 P 242 - G.H5 L 368 G.H5.20
Ionic H8 R 318 8x49 G.H5 E 370 G.H5.22
Polar H8 R 318 8x49 G.H5 E 370 G.H5.22
Hydrophobic H8 R 318 8x49 G.H5 E 370 G.H5.22
Van-der-waals H8 R 318 8x49 G.H5 E 370 G.H5.22
Hydrophobic ICL2 A 149 34x50 G.H5 L 364 G.H5.16
Hydrophobic ICL2 Y 152 34x53 G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 Y 152 34x53 G.s2s3 K 201 G.s2s3.02
Polar C-term M 359 - G.H2 K 217 G.H2.05
Hydrophobic TM3 I 146 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 I 146 3x54 G.H5 L 364 G.H5.16
Hydrophobic TM6 A 248 6x33 G.H5 L 374 G.H5.26
Van-der-waals TM6 A 248 6x33 G.H5 L 374 G.H5.26
Van-der-waals TM3 K 142 3x50 G.H5 I 371 G.H5.23
Polar H8 H 317 8x48 G.H5 I 371 G.H5.23
Hydrophobic H8 H 317 8x48 G.H5 I 371 G.H5.23
Van-der-waals H8 H 317 8x48 G.H5 I 371 G.H5.23
Hydrophobic ICL2 P 151 34x52 G.H5 V 363 G.H5.15
Hydrophobic TM5 L 240 5x68 G.H5 L 364 G.H5.16
Van-der-waals TM5 L 240 5x68 G.H5 L 364 G.H5.16
Hydrophobic TM3 I 146 3x54 G.H5 L 368 G.H5.20
Polar ICL2 Y 152 34x53 G.S3 N 203 G.S3.02
Hydrophobic ICL2 Y 152 34x53 G.S3 N 203 G.S3.02
Van-der-waals ICL2 Y 152 34x53 G.S3 N 203 G.S3.02
Hydrophobic TM6 Q 245 6x30 G.H5 L 374 G.H5.26
Van-der-waals TM6 Q 245 6x30 G.H5 L 374 G.H5.26
Polar ICL2 Y 152 34x53 G.hns1 G 41 G.hns1.03
Hydrophobic ICL2 Y 152 34x53 G.hns1 G 41 G.hns1.03
Van-der-waals ICL2 Y 152 34x53 G.hns1 G 41 G.hns1.03
Polar ICL2 Q 150 34x51 G.s2s3 Q 200 G.s2s3.01
Hydrophobic TM5 R 239 5x67 G.H5 K 357 G.H5.09
Van-der-waals TM5 R 239 5x67 G.H5 K 357 G.H5.09
Hydrophobic ICL3 P 242 - G.H5 L 374 G.H5.26
Van-der-waals ICL3 P 242 - G.H5 L 374 G.H5.26
Polar ICL3 R 241 - G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL3 R 241 - G.h4s6 R 338 G.h4s6.20
Van-der-waals ICL3 R 241 - G.h4s6 R 338 G.h4s6.20
Hydrophobic TM3 E 145 3x53 G.H5 I 371 G.H5.23
Van-der-waals TM3 E 145 3x53 G.H5 I 371 G.H5.23
Hydrophobic C-term M 362 - G.H2 R 216 G.H2.04
Van-der-waals C-term M 362 - G.H2 R 216 G.H2.04
Hydrophobic TM5 L 240 5x68 G.H5 D 361 G.H5.13
Van-der-waals TM5 L 240 5x68 G.H5 D 361 G.H5.13
Polar TM3 E 145 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM3 E 145 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 E 145 3x53 G.H5 Y 367 G.H5.19
Polar TM6 R 247 6x32 G.H5 L 374 G.H5.26
Hydrophobic TM6 R 247 6x32 G.H5 L 374 G.H5.26
Van-der-waals TM6 R 247 6x32 G.H5 L 374 G.H5.26
Hydrophobic TM6 I 251 6x36 G.H5 L 373 G.H5.25
Hydrophobic ICL2 Y 152 34x53 G.S3 T 202 G.S3.01
Van-der-waals ICL2 Y 152 34x53 G.S3 T 202 G.S3.01
Hydrophobic ICL2 P 151 34x52 G.S3 T 202 G.S3.01
Van-der-waals ICL2 P 151 34x52 G.S3 T 202 G.S3.01
Hydrophobic ICL3 P 242 - G.h4s6 R 338 G.h4s6.20
Van-der-waals ICL3 P 242 - G.h4s6 R 338 G.h4s6.20
Van-der-waals ICL2 A 149 34x50 G.H5 R 360 G.H5.12
Hydrophobic ICL2 P 151 34x52 G.S1 L 43 G.S1.02
Van-der-waals ICL2 P 151 34x52 G.S1 L 43 G.S1.02
Polar TM5 L 240 5x68 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM5 L 240 5x68 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM5 L 240 5x68 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM6 G 244 6x29 G.H5 L 374 G.H5.26
Van-der-waals TM6 G 244 6x29 G.H5 L 374 G.H5.26
Hydrophobic TM5 V 236 5x64 G.H5 L 364 G.H5.16
Van-der-waals TM5 V 236 5x64 G.H5 L 364 G.H5.16