Gq - ACKR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 23.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 Y 77 2x37 G.H5 K 354 G.H5.21
Hydrophobic TM5 L 235 5x61 G.H5 L 358 G.H5.25
Hydrophobic H8 F 332 8x60 G.h4s6 S 320 G.h4s6.11
Van-der-waals H8 F 332 8x60 G.h4s6 S 320 G.h4s6.11
Polar TM3 R 142 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 142 3x50 G.H5 Y 356 G.H5.23
Polar H8 N 321 8x49 G.H5 K 354 G.H5.21
Hydrophobic H8 N 321 8x49 G.H5 K 354 G.H5.21
Van-der-waals H8 N 321 8x49 G.H5 K 354 G.H5.21
Hydrophobic TM3 I 146 3x54 G.H5 Y 356 G.H5.23
Hydrophobic H8 Y 324 8x52 G.h4s6 I 323 G.h4s6.20
Van-der-waals H8 Y 324 8x52 G.h4s6 I 323 G.h4s6.20
Polar TM3 T 147 3x55 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 T 147 3x55 G.hns1 R 37 G.hns1.02
Van-der-waals TM3 T 147 3x55 G.hns1 R 37 G.hns1.02
Polar H8 K 328 8x56 G.h4s6 S 320 G.h4s6.11
Hydrophobic H8 K 328 8x56 G.h4s6 S 320 G.h4s6.11
Van-der-waals H8 K 328 8x56 G.h4s6 S 320 G.h4s6.11
Hydrophobic TM5 S 242 5x68 G.s2s3 S 198 G.s2s3.02
Van-der-waals TM5 S 242 5x68 G.s2s3 S 198 G.s2s3.02
Polar TM5 A 238 5x64 G.hns1 R 38 G.hns1.03
Van-der-waals TM5 A 238 5x64 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 I 253 6x36 G.H5 L 358 G.H5.25
Polar ICL1 T 75 12x50 G.h4s6 D 321 G.h4s6.12
Hydrophobic ICL1 T 75 12x50 G.h4s6 D 321 G.h4s6.12
Van-der-waals ICL1 T 75 12x50 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM2 Y 77 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 Y 77 2x37 G.H5 E 355 G.H5.22
Polar TM6 S 250 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 S 250 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 S 250 6x33 G.H5 L 358 G.H5.25
Polar TM2 T 79 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM2 T 79 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 T 79 2x39 G.H5 E 355 G.H5.22
Hydrophobic H8 R 320 8x48 G.H5 K 354 G.H5.21
Polar ICL1 T 74 12x49 G.h4s6 D 321 G.h4s6.12
Hydrophobic ICL1 T 74 12x49 G.h4s6 D 321 G.h4s6.12
Van-der-waals ICL1 T 74 12x49 G.h4s6 D 321 G.h4s6.12
Polar ICL2 T 150 - G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 T 150 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 T 150 - G.hns1 R 37 G.hns1.02
Polar H8 R 320 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 R 320 8x48 G.H5 V 359 G.H5.26
Polar TM5 A 241 5x67 G.hns1 R 38 G.hns1.03
Hydrophobic TM5 A 241 5x67 G.hns1 R 38 G.hns1.03
Van-der-waals TM5 A 241 5x67 G.hns1 R 38 G.hns1.03
Polar ICL3 D 244 - G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL3 D 244 - G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL3 D 244 - G.s2s3 S 198 G.s2s3.02
Polar ICL2 N 151 - G.hns1 A 36 G.hns1.01
Hydrophobic ICL2 N 151 - G.hns1 A 36 G.hns1.01
Van-der-waals ICL2 N 151 - G.hns1 A 36 G.hns1.01
Polar TM3 S 145 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 S 145 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 S 145 3x53 G.H5 Y 356 G.H5.23
Polar H8 N 319 8x47 G.H5 K 354 G.H5.21
Hydrophobic H8 N 319 8x47 G.H5 K 354 G.H5.21
Van-der-waals H8 N 319 8x47 G.H5 K 354 G.H5.21
Polar ICL3 S 243 - G.s2s3 S 198 G.s2s3.02
Polar TM2 T 79 2x39 G.H5 N 357 G.H5.24
Van-der-waals TM2 T 79 2x39 G.H5 N 357 G.H5.24
Hydrophobic TM6 I 254 6x37 G.H5 L 358 G.H5.25
Polar H8 N 319 8x47 G.H5 V 359 G.H5.26
Hydrophobic H8 N 319 8x47 G.H5 V 359 G.H5.26
Van-der-waals H8 N 319 8x47 G.H5 V 359 G.H5.26
Hydrophobic TM3 I 146 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM2 I 83 2x43 G.H5 N 357 G.H5.24
Van-der-waals TM2 I 83 2x43 G.H5 N 357 G.H5.24
Hydrophobic TM5 S 242 5x68 G.s2s3 Q 197 G.s2s3.01
Van-der-waals TM5 S 242 5x68 G.s2s3 Q 197 G.s2s3.01
Polar TM4 R 161 4x42 G.H5 Y 356 G.H5.23
Hydrophobic TM4 R 161 4x42 G.H5 Y 356 G.H5.23
Van-der-waals TM4 R 161 4x42 G.H5 Y 356 G.H5.23
Polar TM2 Y 77 2x37 G.H5 L 351 G.H5.18
Hydrophobic TM2 Y 77 2x37 G.H5 L 351 G.H5.18
Van-der-waals TM2 Y 77 2x37 G.H5 L 351 G.H5.18
Polar TM6 Y 257 6x40 G.H5 N 357 G.H5.24
Van-der-waals TM6 Y 257 6x40 G.H5 N 357 G.H5.24
Polar ICL2 S 154 - G.h3s5 N 266 G.h3s5.02
Hydrophobic TM6 I 253 6x36 G.H5 V 359 G.H5.26
Polar TM6 E 246 6x29 G.H5 Q 350 G.H5.17
Hydrophobic TM6 E 246 6x29 G.H5 Q 350 G.H5.17
Van-der-waals TM6 E 246 6x29 G.H5 Q 350 G.H5.17
Polar TM3 Y 148 3x56 G.HN R 34 G.HN.52
Hydrophobic TM3 Y 148 3x56 G.HN R 34 G.HN.52
Van-der-waals TM3 Y 148 3x56 G.HN R 34 G.HN.52
Polar ICL3 S 243 - G.S2 L 196 G.S2.08
Polar TM3 R 142 3x50 G.H5 N 357 G.H5.24
Van-der-waals TM3 R 142 3x50 G.H5 N 357 G.H5.24
Hydrophobic TM5 I 239 5x65 G.H5 L 358 G.H5.25
Ionic ICL3 D 244 - G.H5 K 345 G.H5.12
Polar ICL3 D 244 - G.H5 K 345 G.H5.12
Hydrophobic ICL3 D 244 - G.H5 K 345 G.H5.12
Van-der-waals ICL3 D 244 - G.H5 K 345 G.H5.12
Ionic H8 K 328 8x56 G.h4s6 D 321 G.h4s6.12
Polar H8 K 328 8x56 G.h4s6 D 321 G.h4s6.12
Hydrophobic H8 K 328 8x56 G.h4s6 D 321 G.h4s6.12
Van-der-waals H8 K 328 8x56 G.h4s6 D 321 G.h4s6.12
Polar ICL3 S 243 - G.s2s3 Q 197 G.s2s3.01
Hydrophobic ICL3 S 243 - G.s2s3 Q 197 G.s2s3.01
Van-der-waals ICL3 S 243 - G.s2s3 Q 197 G.s2s3.01
Hydrophobic TM3 R 142 3x50 G.H5 L 358 G.H5.25
Hydrophobic ICL2 N 151 - G.hns1 R 37 G.hns1.02
Hydrophobic TM6 Y 257 6x40 G.H5 L 358 G.H5.25
Polar H8 N 319 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 N 319 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 N 319 8x47 G.H5 N 357 G.H5.24
Polar TM3 Y 148 3x56 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 Y 148 3x56 G.hns1 R 37 G.hns1.02
Van-der-waals TM3 Y 148 3x56 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 I 146 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 146 3x54 G.H5 L 358 G.H5.25
Polar TM2 T 79 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 T 79 2x39 G.H5 Y 356 G.H5.23
Ionic TM4 R 161 4x42 G.H5 E 355 G.H5.22
Polar TM4 R 161 4x42 G.H5 E 355 G.H5.22
Van-der-waals TM4 R 161 4x42 G.H5 E 355 G.H5.22
Polar ICL2 K 158 - G.h3s5 N 266 G.h3s5.02