G12 - M3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 254 5x61 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 170 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 170 3x54 G.H5 L 375 G.H5.20
Polar ICL3 T 273 - G.H4 R 329 G.H4.09
Hydrophobic ICL3 T 273 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 T 273 - G.H4 R 329 G.H4.09
Hydrophobic ICL2 L 174 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 174 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 174 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 174 34x51 G.H5 I 370 G.H5.15
Polar TM6 A 489 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 489 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 170 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM5 L 265 5x72 G.S6 F 347 G.S6.02
Van-der-waals TM5 L 265 5x72 G.S6 F 347 G.S6.02
Hydrophobic ICL2 A 178 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 177 34x54 G.H5 I 378 G.H5.23
Hydrophobic TM7 C 547 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 C 547 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 173 34x50 G.H5 I 370 G.H5.15
Polar TM2 N 103 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 N 103 2x39 G.H5 D 377 G.H5.22
Polar TM3 R 166 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 A 178 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 A 178 34x55 G.hns1 R 55 G.hns1.02
Polar TM6 K 488 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 488 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 488 6x32 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 548 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 548 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM2 L 107 2x43 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 174 34x51 G.H5 V 366 G.H5.11
Van-der-waals TM5 L 268 5x75 G.H5 D 368 G.H5.13
Polar TM6 K 485 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 485 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 485 6x29 G.H5 Q 381 G.H5.26
Polar TM5 L 268 5x75 G.S6 H 348 G.S6.03
Polar TM6 T 492 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 492 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 493 6x37 G.H5 L 380 G.H5.25
Hydrophobic ICL2 T 175 34x52 G.S3 I 221 G.S3.01
Polar C-term R 576 - G.H3 K 284 G.H3.16
Van-der-waals C-term R 576 - G.H3 K 284 G.H3.16
Hydrophobic TM3 I 170 3x54 G.H5 N 374 G.H5.19
Hydrophobic TM7 Y 544 7x53 G.H5 M 379 G.H5.24
Van-der-waals TM7 Y 544 7x53 G.H5 M 379 G.H5.24
Polar TM3 S 169 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 169 3x53 G.H5 N 374 G.H5.19
Ionic TM5 R 261 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 261 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 261 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 261 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 L 268 5x75 G.H5 F 361 G.H5.06
Van-der-waals TM5 L 268 5x75 G.H5 F 361 G.H5.06
Hydrophobic ICL2 P 173 34x50 G.H5 L 371 G.H5.16
Polar C-term Q 577 - G.H3 K 284 G.H3.16
Hydrophobic C-term Q 577 - G.H3 K 284 G.H3.16
Van-der-waals C-term Q 577 - G.H3 K 284 G.H3.16
Hydrophobic ICL3 Q 269 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 Q 269 - G.h4s6 P 345 G.h4s6.20
Polar ICL3 S 271 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 S 271 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 S 271 - G.S6 H 348 G.S6.03
Hydrophobic TM7 A 545 7x54 G.H5 M 379 G.H5.24
Hydrophobic TM5 R 261 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 R 261 5x68 G.H5 Q 372 G.H5.17
Polar H8 N 548 8x47 G.H5 D 377 G.H5.22
Hydrophobic ICL2 L 174 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM5 T 258 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 K 179 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 L 265 5x72 G.H5 D 368 G.H5.13
Polar ICL3 E 274 - G.H4 Q 333 G.H4.13
Hydrophobic ICL3 E 274 - G.H4 Q 333 G.H4.13
Van-der-waals ICL3 E 274 - G.H4 Q 333 G.H4.13
Hydrophobic ICL2 L 174 34x51 G.H5 K 367 G.H5.12
Hydrophobic C-term I 580 - G.H3 K 284 G.H3.16
Van-der-waals C-term I 580 - G.H3 K 284 G.H3.16
Hydrophobic ICL2 P 173 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM5 L 268 5x75 G.S6 F 347 G.S6.02
Hydrophobic TM5 L 265 5x72 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 Q 269 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 Q 269 - G.S6 H 348 G.S6.03
Ionic TM5 E 257 5x64 G.H5 K 367 G.H5.12
Polar TM5 E 257 5x64 G.H5 K 367 G.H5.12
Polar TM5 R 261 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM5 R 261 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 261 5x68 G.H5 L 371 G.H5.16
Hydrophobic C-term F 581 - G.H2 Q 236 G.H2.05
Van-der-waals C-term F 581 - G.H2 Q 236 G.H2.05
Ionic ICL2 R 177 34x54 G.H5 D 377 G.H5.22
Polar ICL2 R 177 34x54 G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 177 34x54 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 177 34x54 G.H5 D 377 G.H5.22
Polar ICL2 R 177 34x54 G.H5 N 374 G.H5.19
Hydrophobic ICL2 R 177 34x54 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 177 34x54 G.H5 N 374 G.H5.19
Hydrophobic TM5 L 265 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 L 265 5x72 G.H5 Q 372 G.H5.17
Hydrophobic TM3 I 170 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 170 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM5 R 261 5x68 G.H5 L 375 G.H5.20
Van-der-waals TM5 R 261 5x68 G.H5 L 375 G.H5.20
Hydrophobic TM3 S 169 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 S 169 3x53 G.H5 I 378 G.H5.23