G13 - α1B-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 69.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 K 291 6x32 G.H5 Q 377 G.H5.26
Hydrophobic TM6 K 291 6x32 G.H5 Q 377 G.H5.26
Van-der-waals TM6 K 291 6x32 G.H5 Q 377 G.H5.26
Hydrophobic H8 S 352 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 S 352 8x47 G.H5 L 376 G.H5.25
Hydrophobic TM5 L 237 5x72 G.H5 H 368 G.H5.17
Polar TM3 R 143 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 143 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 143 3x50 G.H5 L 374 G.H5.23
Hydrophobic ICL2 S 150 34x50 G.H5 I 366 G.H5.15
Hydrophobic ICL2 P 154 34x54 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 P 154 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 L 151 34x51 G.S1 V 49 G.S1.02
Hydrophobic ICL3 M 245 - G.H4 R 331 G.H4.16
Van-der-waals ICL3 M 245 - G.H4 R 331 G.H4.16
Ionic ICL3 E 244 - G.S6 H 344 G.S6.03
Polar ICL3 E 244 - G.S6 H 344 G.S6.03
Hydrophobic ICL3 E 244 - G.S6 H 344 G.S6.03
Van-der-waals ICL3 E 244 - G.S6 H 344 G.S6.03
Hydrophobic TM5 V 226 5x61 G.H5 M 375 G.H5.24
Van-der-waals TM5 V 226 5x61 G.H5 M 375 G.H5.24
Hydrophobic TM3 G 146 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 G 146 3x53 G.H5 L 374 G.H5.23
Polar ICL3 K 243 - G.S6 H 344 G.S6.03
Hydrophobic ICL3 K 243 - G.S6 H 344 G.S6.03
Van-der-waals ICL3 K 243 - G.S6 H 344 G.S6.03
Polar TM3 G 146 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 G 146 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 G 146 3x53 G.H5 N 370 G.H5.19
Polar ICL2 Q 152 34x52 G.s2s3 K 214 G.s2s3.01
Polar ICL2 S 150 34x50 G.H5 K 363 G.H5.12
Hydrophobic ICL3 E 244 - G.H4 V 327 G.H4.12
Van-der-waals ICL3 E 244 - G.H4 V 327 G.H4.12
Hydrophobic ICL2 L 151 34x51 G.H5 K 363 G.H5.12
Hydrophobic TM6 L 296 6x37 G.H5 M 375 G.H5.24
Van-der-waals TM6 L 296 6x37 G.H5 M 375 G.H5.24
Polar TM6 T 295 6x36 G.H5 M 375 G.H5.24
Hydrophobic TM6 T 295 6x36 G.H5 M 375 G.H5.24
Van-der-waals TM6 T 295 6x36 G.H5 M 375 G.H5.24
Hydrophobic TM5 T 233 5x68 G.H5 D 364 G.H5.13
Hydrophobic TM5 V 229 5x64 G.H5 L 367 G.H5.16
Hydrophobic ICL2 S 150 34x50 G.H5 L 367 G.H5.16
Hydrophobic TM7 S 351 7x56 G.H5 L 376 G.H5.25
Van-der-waals TM7 S 351 7x56 G.H5 L 376 G.H5.25
Hydrophobic TM3 V 147 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 V 147 3x54 G.H5 L 367 G.H5.16
Hydrophobic TM5 T 233 5x68 G.H5 L 367 G.H5.16
Van-der-waals TM5 T 233 5x68 G.H5 L 367 G.H5.16
Polar TM6 R 288 6x29 G.H5 H 368 G.H5.17
Aromatic TM6 R 288 6x29 G.H5 H 368 G.H5.17
Hydrophobic TM6 R 288 6x29 G.H5 H 368 G.H5.17
Van-der-waals TM6 R 288 6x29 G.H5 H 368 G.H5.17
Hydrophobic TM6 A 292 6x33 G.H5 M 375 G.H5.24
Van-der-waals TM6 A 292 6x33 G.H5 M 375 G.H5.24
Polar TM7 S 351 7x56 G.H5 Q 377 G.H5.26
Hydrophobic ICL2 L 151 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 L 151 34x51 G.H5 I 366 G.H5.15
Hydrophobic ICL2 L 151 34x51 G.H5 F 359 G.H5.08
Van-der-waals ICL2 L 151 34x51 G.H5 F 359 G.H5.08
Hydrophobic TM2 T 80 2x39 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 143 3x50 G.H5 L 376 G.H5.25
Van-der-waals TM3 R 143 3x50 G.H5 L 376 G.H5.25
Hydrophobic TM5 A 230 5x65 G.H5 L 371 G.H5.20
Hydrophobic ICL3 V 241 - G.h4s6 P 341 G.h4s6.20
Hydrophobic TM7 Y 348 7x53 G.H5 L 376 G.H5.25
Van-der-waals TM7 Y 348 7x53 G.H5 L 376 G.H5.25
Ionic ICL3 E 244 - G.H4 R 331 G.H4.16
Polar ICL3 E 244 - G.H4 R 331 G.H4.16
Hydrophobic ICL3 E 244 - G.H4 R 331 G.H4.16
Van-der-waals ICL3 E 244 - G.H4 R 331 G.H4.16
Hydrophobic TM6 F 284 6x25 G.h4s6 Q 338 G.h4s6.12
Van-der-waals TM6 F 284 6x25 G.h4s6 Q 338 G.h4s6.12
Hydrophobic ICL3 G 240 - G.H5 R 360 G.H5.09
Polar H8 K 353 8x48 G.H5 Q 377 G.H5.26
Hydrophobic H8 K 353 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 K 353 8x48 G.H5 Q 377 G.H5.26
Polar ICL2 Q 152 34x52 G.s2s3 N 215 G.s2s3.02
Van-der-waals ICL2 Q 152 34x52 G.s2s3 N 215 G.s2s3.02
Hydrophobic ICL2 P 154 34x54 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 Q 152 34x52 G.S3 V 216 G.S3.01
Hydrophobic TM5 L 237 5x72 G.S6 Y 343 G.S6.02
Van-der-waals TM5 L 237 5x72 G.S6 Y 343 G.S6.02
Hydrophobic TM3 V 147 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 V 147 3x54 G.H5 L 371 G.H5.20
Hydrophobic ICL2 L 151 34x51 G.S3 V 216 G.S3.01
Van-der-waals ICL2 L 151 34x51 G.S3 V 216 G.S3.01
Polar ICL2 S 150 34x50 G.H5 N 370 G.H5.19
Hydrophobic ICL2 S 150 34x50 G.H5 N 370 G.H5.19
Van-der-waals ICL2 S 150 34x50 G.H5 N 370 G.H5.19
Hydrophobic TM3 V 147 3x54 G.H5 L 374 G.H5.23
Polar ICL2 T 155 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 T 155 34x55 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 T 155 34x55 G.hns1 R 47 G.hns1.03
Polar TM5 L 237 5x72 G.H5 D 364 G.H5.13
Hydrophobic TM5 L 237 5x72 G.H5 D 364 G.H5.13
Van-der-waals TM5 L 237 5x72 G.H5 D 364 G.H5.13
Hydrophobic TM5 N 236 5x71 G.H5 D 364 G.H5.13
Van-der-waals TM5 N 236 5x71 G.H5 D 364 G.H5.13