Gt1 - α1B-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 71.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 15.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 A 230 5x65 G.H5 L 349 G.H5.25
Polar C-term Y 388 - G.s4h3 N 237 G.s4h3.15
Van-der-waals C-term Y 388 - G.s4h3 N 237 G.s4h3.15
Polar TM3 Y 149 3x56 G.HN E 24 G.HN.52
Hydrophobic TM3 Y 149 3x56 G.HN E 24 G.HN.52
Van-der-waals TM3 Y 149 3x56 G.HN E 24 G.HN.52
Hydrophobic TM6 R 288 6x29 G.H5 K 341 G.H5.17
Ionic TM3 R 148 3x55 G.HN E 24 G.HN.52
Polar TM3 R 148 3x55 G.HN E 24 G.HN.52
Hydrophobic ICL2 L 151 34x51 G.S3 L 190 G.S3.01
Polar ICL2 Q 152 34x52 G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 Q 152 34x52 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 Q 152 34x52 G.hns1 A 27 G.hns1.02
Hydrophobic TM3 R 143 3x50 G.H5 L 349 G.H5.25
Van-der-waals TM3 R 143 3x50 G.H5 L 349 G.H5.25
Van-der-waals ICL2 Q 152 34x52 G.hns1 R 28 G.hns1.03
Hydrophobic C-term C 384 - G.h4s6 M 308 G.h4s6.03
Van-der-waals C-term C 384 - G.h4s6 M 308 G.h4s6.03
Polar TM6 A 292 6x33 G.H5 L 349 G.H5.25
Hydrophobic TM6 L 296 6x37 G.H5 L 349 G.H5.25
Hydrophobic ICL2 L 151 34x51 G.S1 T 29 G.S1.01
Polar TM7 S 351 7x56 G.H5 G 348 G.H5.24
Ionic H8 R 357 8x52 G.h4s6 D 311 G.h4s6.09
Polar H8 R 357 8x52 G.h4s6 D 311 G.h4s6.09
Hydrophobic H8 R 357 8x52 G.h4s6 D 311 G.h4s6.09
Van-der-waals H8 R 357 8x52 G.h4s6 D 311 G.h4s6.09
Polar C-term W 391 - G.HG I 281 G.HG.17
Hydrophobic C-term W 391 - G.HG I 281 G.HG.17
Van-der-waals C-term W 391 - G.HG I 281 G.HG.17
Polar TM6 K 291 6x32 G.H5 F 350 G.H5.26
Hydrophobic TM6 K 291 6x32 G.H5 F 350 G.H5.26
Van-der-waals TM6 K 291 6x32 G.H5 F 350 G.H5.26
Polar C-term C 384 - G.H3 N 247 G.H3.10
Van-der-waals C-term C 384 - G.H3 N 247 G.H3.10
Hydrophobic ICL3 E 244 - G.H5 F 330 G.H5.06
Van-der-waals ICL3 E 244 - G.H5 F 330 G.H5.06
Hydrophobic TM3 V 147 3x54 G.H5 L 349 G.H5.25
Van-der-waals TM3 V 147 3x54 G.H5 L 349 G.H5.25
Polar TM3 G 146 3x53 G.H5 C 347 G.H5.23
Hydrophobic TM3 G 146 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 G 146 3x53 G.H5 C 347 G.H5.23
Van-der-waals ICL2 Q 152 34x52 G.HN A 23 G.HN.51
Polar ICL2 Q 152 34x52 G.HN E 24 G.HN.52
Hydrophobic ICL2 Q 152 34x52 G.HN E 24 G.HN.52
Van-der-waals ICL2 Q 152 34x52 G.HN E 24 G.HN.52
Ionic H8 R 361 8x56 G.h4s6 D 311 G.h4s6.09
Polar H8 R 361 8x56 G.h4s6 D 311 G.h4s6.09
Hydrophobic C-term W 391 - G.s4h3 V 229 G.s4h3.07
Van-der-waals C-term W 391 - G.s4h3 V 229 G.s4h3.07
Polar C-term Y 388 - G.s4h3 E 235 G.s4h3.13
Van-der-waals C-term Y 388 - G.s4h3 E 235 G.s4h3.13
Hydrophobic TM6 R 288 6x29 G.H5 F 350 G.H5.26
Van-der-waals TM6 R 288 6x29 G.H5 F 350 G.H5.26
Hydrophobic C-term Y 388 - G.s4h3 V 236 G.s4h3.14
Van-der-waals C-term Y 388 - G.s4h3 V 236 G.s4h3.14
Ionic TM5 R 232 5x67 G.s2s3 D 189 G.s2s3.02
Polar TM5 R 232 5x67 G.s2s3 D 189 G.s2s3.02
Van-der-waals TM5 R 232 5x67 G.s2s3 D 189 G.s2s3.02
Polar TM5 N 236 5x71 G.s2s3 D 189 G.s2s3.02
Hydrophobic TM5 V 226 5x61 G.H5 L 349 G.H5.25
Polar TM3 R 143 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 R 143 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM5 L 237 5x72 G.H5 D 337 G.H5.13
Van-der-waals TM5 L 237 5x72 G.H5 D 337 G.H5.13
Hydrophobic ICL3 E 244 - G.H5 A 334 G.H5.10
Hydrophobic TM5 L 237 5x72 G.H5 I 340 G.H5.16
Hydrophobic C-term G 383 - G.h4s6 M 308 G.h4s6.03
Hydrophobic C-term Y 386 - G.H3 L 243 G.H3.06
Van-der-waals C-term Y 386 - G.H3 L 243 G.H3.06
Aromatic C-term Y 388 - G.H3 H 240 G.H3.03
Hydrophobic C-term Y 388 - G.H3 H 240 G.H3.03
Van-der-waals C-term Y 388 - G.H3 H 240 G.H3.03
Aromatic C-term W 447 - G.H3 H 244 G.H3.07
Hydrophobic C-term W 447 - G.H3 H 244 G.H3.07
Van-der-waals C-term W 447 - G.H3 H 244 G.H3.07
Polar TM3 R 143 3x50 G.H5 G 348 G.H5.24
Hydrophobic TM3 R 143 3x50 G.H5 G 348 G.H5.24
Van-der-waals TM3 R 143 3x50 G.H5 G 348 G.H5.24
Hydrophobic ICL3 G 240 - G.s2s3 K 188 G.s2s3.01
Hydrophobic TM5 T 233 5x68 G.H5 L 344 G.H5.20
Polar C-term Y 386 - G.H3 H 240 G.H3.03
Aromatic C-term Y 386 - G.H3 H 240 G.H3.03
Hydrophobic C-term Y 386 - G.H3 H 240 G.H3.03
Van-der-waals C-term Y 386 - G.H3 H 240 G.H3.03
Van-der-waals C-term Y 386 - G.H3 N 247 G.H3.10
Hydrophobic TM3 V 147 3x54 G.H5 L 344 G.H5.20
Hydrophobic ICL2 L 151 34x51 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 L 151 34x51 G.hns1 R 28 G.hns1.03
Hydrophobic ICL3 G 240 - G.H5 D 333 G.H5.09
Van-der-waals ICL3 G 240 - G.H5 D 333 G.H5.09
Van-der-waals C-term A 385 - G.H3 N 247 G.H3.10
Hydrophobic C-term Y 386 - G.H3 H 244 G.H3.07
Hydrophobic C-term W 391 - G.s4h3 N 237 G.s4h3.15
Hydrophobic ICL2 L 151 34x51 G.H5 I 339 G.H5.15
Hydrophobic C-term Y 386 - G.h4s6 L 306 G.h4s6.01
Hydrophobic ICL2 L 151 34x51 G.S1 V 30 G.S1.02
Van-der-waals ICL2 L 151 34x51 G.S1 V 30 G.S1.02
Polar TM3 V 147 3x54 G.H5 C 347 G.H5.23
Hydrophobic TM3 V 147 3x54 G.H5 C 347 G.H5.23
Hydrophobic ICL2 L 151 34x51 G.H5 N 343 G.H5.19
Van-der-waals ICL2 L 151 34x51 G.H5 N 343 G.H5.19
Hydrophobic ICL2 L 151 34x51 G.h2s4 T 215 G.h2s4.05
Van-der-waals ICL2 L 151 34x51 G.h2s4 T 215 G.h2s4.05
Hydrophobic ICL3 V 241 - G.H5 D 337 G.H5.13
Van-der-waals ICL3 V 241 - G.H5 D 337 G.H5.13
Ionic C-term R 389 - G.hgh4 D 285 G.hgh4.04
Polar C-term R 389 - G.hgh4 D 285 G.hgh4.04
Ionic C-term R 393 - H.HD E 141 H.HD.12
Hydrophobic TM5 T 233 5x68 G.H5 I 340 G.H5.16
Van-der-waals TM5 T 233 5x68 G.H5 I 340 G.H5.16
Polar ICL2 S 150 34x50 G.H5 N 343 G.H5.19
Hydrophobic ICL2 S 150 34x50 G.H5 N 343 G.H5.19
Van-der-waals ICL2 S 150 34x50 G.H5 N 343 G.H5.19